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Compile Data Set for Download or QSAR

Found 1003 hits with Last Name = 'patel' and Initial = 'nc'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<0.488n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<0.488n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<0.669n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<0.669n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285537
PNG
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.51n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285537
PNG
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.51n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.59n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.59n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285538
PNG
(N-cyclopropyl-3-(3,4-di-chlorophenyl)imidazo[1,2-b...)
Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285538
PNG
(N-cyclopropyl-3-(3,4-di-chlorophenyl)imidazo[1,2-b...)
Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<1.89n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<1.89n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285572
PNG
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.97n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285572
PNG
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.97n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.35n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.35n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.77n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.77n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.82n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.82n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285572
PNG
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.91n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285572
PNG
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.91n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285568
PNG
(N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...)
Show SMILES Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.13n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285568
PNG
(N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...)
Show SMILES Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.13n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM193022
PNG
(US9193726, 10)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(c(F)c1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)18-3-4-19-24(36)33(7-8-34(19)23(18)35)14(2)20-5-6-21(37-20)15-9-16(26)22(17(27)10-15)25(28,29)30/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

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US Patent
n/an/a 3.34n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...


US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285556
PNG
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.48n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285556
PNG
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.48n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285537
PNG
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285537
PNG
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285536
PNG
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)|
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n/an/a 3.83n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285536
PNG
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)|
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Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285574
PNG
(US10077269, Example 47 | US9598421, Example 47 | a...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
PDB

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n/an/a 3.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285574
PNG
(US10077269, Example 47 | US9598421, Example 47 | a...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
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n/an/a 3.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285571
PNG
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F
PDB

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n/an/a 3.92n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285571
PNG
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F
PDB

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n/an/a 3.92n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285576
PNG
(US10077269, Example 49 | US9598421, Example 49 | a...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
PDB
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Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285576
PNG
(US10077269, Example 49 | US9598421, Example 49 | a...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
PDB

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Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
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Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
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Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285540
PNG
(US10077269, Example 13 | US9598421, Example 13 | a...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
PDB

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n/an/a 4.63n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285540
PNG
(US10077269, Example 13 | US9598421, Example 13 | a...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
PDB

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n/an/a 4.63n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB
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n/an/a 4.69n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
PDB

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n/an/a 4.69n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285551
PNG
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1C#N |(-2.3,-23.34,;-3.79,-23.74,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,;-6.77,-24.54,;-8.25,-24.93,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,)|
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Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285551
PNG
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1C#N |(-2.3,-23.34,;-3.79,-23.74,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,;-6.77,-24.54,;-8.25,-24.93,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,)|
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Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285556
PNG
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
PDB

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n/an/a 5.05n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285556
PNG
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
PDB

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n/an/a 5.05n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285540
PNG
(US10077269, Example 13 | US9598421, Example 13 | a...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
PDB

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n/an/a 5.13n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
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