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Compile Data Set for Download or QSAR

Found 332 hits with Last Name = 'peifer' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM47167
PNG
(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
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n/an/a 2.5n/an/an/an/an/an/a



Johannes Gutenberg-University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2


J Med Chem 49: 1271-81 (2006)


Article DOI: 10.1021/jm0580297
BindingDB Entry DOI: 10.7270/Q2CC108S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM47167
PNG
(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
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n/an/a 2.5n/an/an/an/an/an/a



Eberhard-Karls University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2


J Med Chem 51: 3814-24 (2008)


Article DOI: 10.1021/jm8001185
BindingDB Entry DOI: 10.7270/Q2057FQS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM47167
PNG
(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
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Eberhard Karls University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2


J Med Chem 49: 7549-53 (2006)


Article DOI: 10.1021/jm0609871
BindingDB Entry DOI: 10.7270/Q2NZ8794
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50300884
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 4n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CK1delta kinase domain by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM47167
PNG
(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
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n/an/a 5n/an/an/an/an/an/a



Eberhard Karls University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 49: 7549-53 (2006)


Article DOI: 10.1021/jm0609871
BindingDB Entry DOI: 10.7270/Q2NZ8794
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM47167
PNG
(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
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n/an/a 5n/an/an/an/an/an/a



Eberhard-Karls University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR3


J Med Chem 51: 3814-24 (2008)


Article DOI: 10.1021/jm8001185
BindingDB Entry DOI: 10.7270/Q2057FQS
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50300893
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 5n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CK1delta kinase domain by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300884
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 5n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300888
PNG
((S)-4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl...)
Show SMILES CC(C)c1onc(c1-c1ccnc(N[C@@H](C)c2ccccc2)c1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C25H24FN3O/c1-16(2)25-23(24(29-30-25)19-9-11-21(26)12-10-19)20-13-14-27-22(15-20)28-17(3)18-7-5-4-6-8-18/h4-17H,1-3H3,(H,27,28)/t17-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300893
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 11n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Pyruvate kinase


(Staphylococcus aureus (strain MRSA252))
BDBM50192869
PNG
(CIS-3,4-DIHYDROHAMACANTHIN B)
Show SMILES Brc1ccc2c(c[nH]c2c1)[C@@H]1CNC(=O)[C@@H](N1)c1c[nH]c2cc(Br)ccc12 |r|
Show InChI InChI=1/C20H16Br2N4O/c21-10-1-3-12-14(7-23-16(12)5-10)18-9-25-20(27)19(26-18)15-8-24-17-6-11(22)2-4-13(15)17/h1-8,18-19,23-24,26H,9H2,(H,25,27)/t18-,19-/s2
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n/an/a 16n/an/an/an/an/an/a



Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of methicillin-resistant Staphylococcus aureus pyruvate kinase by coupled lactate dehydrogenase continuous assay


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300884
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 19n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50192877
PNG
(CHEMBL3358999)
Show SMILES COc1cc(ccc1O)-c1c[nH]c(=O)c(n1)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H20N2O6/c1-25-15-7-11(5-6-14(15)23)13-10-21-20(24)18(22-13)12-8-16(26-2)19(28-4)17(9-12)27-3/h5-10,23H,1-4H3,(H,21,24)
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n/an/a 20n/an/an/an/an/an/a



Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300885
PNG
(CHEMBL569551 | N-sec-butyl-4-(3-(4-fluorophenyl)-5...)
Show SMILES CCC(C)Nc1cc(ccn1)-c1c(noc1C(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O/c1-5-14(4)24-18-12-16(10-11-23-18)19-20(25-26-21(19)13(2)3)15-6-8-17(22)9-7-15/h6-14H,5H2,1-4H3,(H,23,24)
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n/an/a 30n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM13336
PNG
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/a 30n/an/an/an/an/an/a



Eberhard-Karls-University Tübingen

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAPK by non-radioactive immunosorbent assay


J Med Chem 50: 1213-21 (2007)


Article DOI: 10.1021/jm061097o
BindingDB Entry DOI: 10.7270/Q2QZ29NS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50243761
PNG
(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H20N2O4/c1-25-17-8-12(9-18(26-2)20(17)27-3)19-15(11-23-21(19)24)14-10-22-16-7-5-4-6-13(14)16/h4-10,22H,11H2,1-3H3,(H,23,24)
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n/an/a 31n/an/an/an/an/an/a



Eberhard-Karls University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2


J Med Chem 51: 3814-24 (2008)


Article DOI: 10.1021/jm8001185
BindingDB Entry DOI: 10.7270/Q2057FQS
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50300892
PNG
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1
Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+
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n/an/a 33n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CK1delta kinase domain by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50243761
PNG
(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H20N2O4/c1-25-17-8-12(9-18(26-2)20(17)27-3)19-15(11-23-21(19)24)14-10-22-16-7-5-4-6-13(14)16/h4-10,22H,11H2,1-3H3,(H,23,24)
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n/an/a 37n/an/an/an/an/an/a



Eberhard-Karls University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR3


J Med Chem 51: 3814-24 (2008)


Article DOI: 10.1021/jm8001185
BindingDB Entry DOI: 10.7270/Q2057FQS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM13336
PNG
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/a 40n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300893
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300892
PNG
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1
Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM13531
PNG
(4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridy...)
Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300886
PNG
(4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)-N-...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC2CCOCC2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O2/c1-14(2)22-20(21(26-28-22)15-3-5-17(23)6-4-15)16-7-10-24-19(13-16)25-18-8-11-27-12-9-18/h3-7,10,13-14,18H,8-9,11-12H2,1-2H3,(H,24,25)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50182470
PNG
(5,6,7-trimethoxy-1,2,3,8-tetrahydro-benzo[a]pyrrol...)
Show SMILES COc1cc2c3C(=O)NC(=O)c3c3c4ccccc4[nH]c3c2c(OC)c1OC
Show InChI InChI=1S/C21H16N2O5/c1-26-12-8-10-14-16(21(25)23-20(14)24)13-9-6-4-5-7-11(9)22-17(13)15(10)19(28-3)18(12)27-2/h4-8,22H,1-3H3,(H,23,24,25)
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Johannes Gutenberg-University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2


J Med Chem 49: 1271-81 (2006)


Article DOI: 10.1021/jm0580297
BindingDB Entry DOI: 10.7270/Q2CC108S
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM50300884
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CK1epsilon by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300890
PNG
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50192871
PNG
(CHEMBL3358996)
Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C19H18N2O5/c1-24-15-8-12(9-16(25-2)18(15)26-3)17-19(23)20-10-14(21-17)11-4-6-13(22)7-5-11/h4-10,22H,1-3H3,(H,20,23)
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Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50300890
PNG
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CK1delta kinase domain by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM13336
PNG
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM15237
PNG
(4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)
Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1
Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2
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n/an/a 160n/an/an/an/an/an/a



Eberhard-Karls-University Tübingen

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAPK by non-radioactive immunosorbent assay


J Med Chem 50: 1213-21 (2007)


Article DOI: 10.1021/jm061097o
BindingDB Entry DOI: 10.7270/Q2QZ29NS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50192877
PNG
(CHEMBL3358999)
Show SMILES COc1cc(ccc1O)-c1c[nH]c(=O)c(n1)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H20N2O6/c1-25-15-7-11(5-6-14(15)23)13-10-21-20(24)18(22-13)12-8-16(26-2)19(28-4)17(9-12)27-3/h5-10,23H,1-4H3,(H,21,24)
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Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 using poly(Glu,Tyr) substrate


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50192877
PNG
(CHEMBL3358999)
Show SMILES COc1cc(ccc1O)-c1c[nH]c(=O)c(n1)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H20N2O6/c1-25-15-7-11(5-6-14(15)23)13-10-21-20(24)18(22-13)12-8-16(26-2)19(28-4)17(9-12)27-3/h5-10,23H,1-4H3,(H,21,24)
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Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human c-KiT


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM47167
PNG
(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13|
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
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Eberhard-Karls University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FLT3


J Med Chem 51: 3814-24 (2008)


Article DOI: 10.1021/jm8001185
BindingDB Entry DOI: 10.7270/Q2057FQS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50192878
PNG
(CHEMBL3358977)
Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C21H19N3O5/c1-27-17-6-11(7-18(28-2)20(17)29-3)19-21(26)23-10-16(24-19)14-9-22-15-5-4-12(25)8-13(14)15/h4-10,22,25H,1-3H3,(H,23,26)
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Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50229971
PNG
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)
Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta expressed in Escherichia coli using phosphorylated peptide TFRPRTSpSNASTIS as substrate


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300889
PNG
(CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropy...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O2/c1-11(2)19-17(14-8-9-21-16(10-14)22-12(3)24)18(23-25-19)13-4-6-15(20)7-5-13/h4-11H,1-3H3,(H,21,22,24)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300889
PNG
(CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropy...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O2/c1-11(2)19-17(14-8-9-21-16(10-14)22-12(3)24)18(23-25-19)13-4-6-15(20)7-5-13/h4-11H,1-3H3,(H,21,22,24)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300891
PNG
((rac)-N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)C(C)Oc2ccccc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H24FN3O3/c1-16(2)25-23(24(30-33-25)18-9-11-20(27)12-10-18)19-13-14-28-22(15-19)29-26(31)17(3)32-21-7-5-4-6-8-21/h4-17H,1-3H3,(H,28,29,31)
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n/an/a 340n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50192871
PNG
(CHEMBL3358996)
Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1ccc(O)cc1
Show InChI InChI=1S/C19H18N2O5/c1-24-15-8-12(9-16(25-2)18(15)26-3)17-19(23)20-10-14(21-17)11-4-6-13(22)7-5-11/h4-10,22H,1-3H3,(H,20,23)
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n/an/a 400n/an/an/an/an/an/a



Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human c-KiT


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50182471
PNG
(3-(indole-3-yl)-4-(3,4-dimethoxyphenyl)-1H-pyrrole...)
Show SMILES COc1ccc(cc1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:11|
Show InChI InChI=1S/C20H16N2O4/c1-25-15-8-7-11(9-16(15)26-2)17-18(20(24)22-19(17)23)13-10-21-14-6-4-3-5-12(13)14/h3-10,21H,1-2H3,(H,22,23,24)
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n/an/a 430n/an/an/an/an/an/a



Johannes Gutenberg-University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2


J Med Chem 49: 1271-81 (2006)


Article DOI: 10.1021/jm0580297
BindingDB Entry DOI: 10.7270/Q2CC108S
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM50300893
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5|
Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 447n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CK1epsilon by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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n/an/a 450n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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n/an/a 450n/an/an/an/an/an/a



Eberhard-Karls-University Tübingen

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAPK by non-radioactive immunosorbent assay


J Med Chem 50: 1213-21 (2007)


Article DOI: 10.1021/jm061097o
BindingDB Entry DOI: 10.7270/Q2QZ29NS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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n/an/a 450n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha


Bioorg Med Chem Lett 18: 1431-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.073
BindingDB Entry DOI: 10.7270/Q208652M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50300887
PNG
((R)-4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl...)
Show SMILES CC(C)c1onc(c1-c1ccnc(N[C@H](C)c2ccccc2)c1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C25H24FN3O/c1-16(2)25-23(24(29-30-25)19-9-11-21(26)12-10-19)20-13-14-27-22(15-20)28-17(3)18-7-5-4-6-8-18/h4-17H,1-3H3,(H,27,28)/t17-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by Cherenkov counting


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50192858
PNG
(CHEMBL3358966)
Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19-21(25)23-11-16(24-19)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,25)
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Christian-Albrechts-University of Kiel

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate


J Med Chem 58: 170-82 (2015)


Article DOI: 10.1021/jm500373x
BindingDB Entry DOI: 10.7270/Q2ZG6V0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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n/an/a 540n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem Lett 18: 1431-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.073
BindingDB Entry DOI: 10.7270/Q208652M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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n/an/a 540n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)


Article DOI: 10.1021/jm9005127
BindingDB Entry DOI: 10.7270/Q28K7961
More data for this
Ligand-Target Pair
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