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Compile Data Set for Download or QSAR

Found 52 hits with Last Name = 'pomè' and Initial = 'dy'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50140291
PNG
(CHEMBL3758455)
Show SMILES Ic1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12IN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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4.70n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50140291
PNG
(CHEMBL3758455)
Show SMILES Ic1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12IN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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11n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50143314
PNG
((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Show SMILES Clc1ccc(cn1)[C@H]1C[C@@H]2CC[C@H]1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1
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16n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50143314
PNG
((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Show SMILES Clc1ccc(cn1)[C@H]1C[C@@H]2CC[C@H]1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1
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22n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from human alpha7 nACh receptor incubated for 20 secs


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50140289
PNG
(CHEMBL3759225)
Show SMILES Brc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12BrN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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30n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM109773
PNG
(US8609708, 74 Anabaseine)
Show SMILES C1CCC(=NC1)c1cccnc1 |c:3|
Show InChI InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8H,1-2,5,7H2
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32n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50140289
PNG
(CHEMBL3759225)
Show SMILES Brc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12BrN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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43n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50140303
PNG
(CHEMBL3759863)
Show SMILES Fc1cc(Br)cc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C11H11BrFN/c12-9-5-8(6-10(13)7-9)11-3-1-2-4-14-11/h5-7H,1-4H2
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48n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM109773
PNG
(US8609708, 74 Anabaseine)
Show SMILES C1CCC(=NC1)c1cccnc1 |c:3|
Show InChI InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8H,1-2,5,7H2
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67n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50140292
PNG
(CHEMBL3759852)
Show SMILES Brc1cc(Br)cc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C11H11Br2N/c12-9-5-8(6-10(13)7-9)11-3-1-2-4-14-11/h5-7H,1-4H2
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71n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50140288
PNG
(CHEMBL3759731)
Show SMILES Clc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12ClN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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77n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50139124
PNG
(CHEMBL3759208)
Show SMILES OCc1cccc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C12H15NO/c14-9-10-4-3-5-11(8-10)12-6-1-2-7-13-12/h3-5,8,14H,1-2,6-7,9H2
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80n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50142626
PNG
(CHEMBL3758480)
Show SMILES OCc1cc(F)cc(c1)C1=NCCCC1 |t:10|
Show InChI InChI=1S/C12H14FNO/c13-11-6-9(8-15)5-10(7-11)12-3-1-2-4-14-12/h5-7,15H,1-4,8H2
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80n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50139125
PNG
(CHEMBL3760021)
Show SMILES [H][C@@]12CC[C@@]([H])(N1)[C@H](C2)c1cccc(O)c1 |r|
Show InChI InChI=1/C12H15NO/c14-10-3-1-2-8(6-10)11-7-9-4-5-12(11)13-9/h1-3,6,9,11-14H,4-5,7H2/t9-,11+,12+/s2
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80n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50142625
PNG
(CHEMBL3758513)
Show SMILES [H][C@@]12CC[C@@]([H])(N1)[C@H](C2)c1cccc(CO)c1 |r|
Show InChI InChI=1/C13H17NO/c15-8-9-2-1-3-10(6-9)12-7-11-4-5-13(12)14-11/h1-3,6,11-15H,4-5,7-8H2/t11-,12+,13+/s2
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92n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM109773
PNG
(US8609708, 74 Anabaseine)
Show SMILES C1CCC(=NC1)c1cccnc1 |c:3|
Show InChI InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8H,1-2,5,7H2
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107n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50140287
PNG
(CHEMBL3758648)
Show SMILES Fc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12FN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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108n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50139125
PNG
(CHEMBL3760021)
Show SMILES [H][C@@]12CC[C@@]([H])(N1)[C@H](C2)c1cccc(O)c1 |r|
Show InChI InChI=1/C12H15NO/c14-10-3-1-2-8(6-10)11-7-9-4-5-12(11)13-9/h1-3,6,9,11-14H,4-5,7H2/t9-,11+,12+/s2
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127n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50142623
PNG
(CHEMBL3758565)
Show SMILES Cc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C12H15N/c1-10-5-4-6-11(9-10)12-7-2-3-8-13-12/h4-6,9H,2-3,7-8H2,1H3
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155n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50139124
PNG
(CHEMBL3759208)
Show SMILES OCc1cccc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C12H15NO/c14-9-10-4-3-5-11(8-10)12-6-1-2-7-13-12/h3-5,8,14H,1-2,6-7,9H2
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158n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50142624
PNG
(CHEMBL3759403)
Show SMILES C1CCC(=NC1)c1ccccc1 |c:3|
Show InChI InChI=1S/C11H13N/c1-2-6-10(7-3-1)11-8-4-5-9-12-11/h1-3,6-7H,4-5,8-9H2
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194n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50140303
PNG
(CHEMBL3759863)
Show SMILES Fc1cc(Br)cc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C11H11BrFN/c12-9-5-8(6-10(13)7-9)11-3-1-2-4-14-11/h5-7H,1-4H2
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204n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50140292
PNG
(CHEMBL3759852)
Show SMILES Brc1cc(Br)cc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C11H11Br2N/c12-9-5-8(6-10(13)7-9)11-3-1-2-4-14-11/h5-7H,1-4H2
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343n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50142623
PNG
(CHEMBL3758565)
Show SMILES Cc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C12H15N/c1-10-5-4-6-11(9-10)12-7-2-3-8-13-12/h4-6,9H,2-3,7-8H2,1H3
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384n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50140288
PNG
(CHEMBL3759731)
Show SMILES Clc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12ClN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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394n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50142625
PNG
(CHEMBL3758513)
Show SMILES [H][C@@]12CC[C@@]([H])(N1)[C@H](C2)c1cccc(CO)c1 |r|
Show InChI InChI=1/C13H17NO/c15-8-9-2-1-3-10(6-9)12-7-11-4-5-13(12)14-11/h1-3,6,11-15H,4-5,7-8H2/t11-,12+,13+/s2
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429n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50139125
PNG
(CHEMBL3760021)
Show SMILES [H][C@@]12CC[C@@]([H])(N1)[C@H](C2)c1cccc(O)c1 |r|
Show InChI InChI=1/C12H15NO/c14-10-3-1-2-8(6-10)11-7-9-4-5-12(11)13-9/h1-3,6,9,11-14H,4-5,7H2/t9-,11+,12+/s2
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609n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50142627
PNG
(CHEMBL3758367)
Show SMILES Oc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H13NO/c13-10-5-3-4-9(8-10)11-6-1-2-7-12-11/h3-5,8,13H,1-2,6-7H2
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680n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50142626
PNG
(CHEMBL3758480)
Show SMILES OCc1cc(F)cc(c1)C1=NCCCC1 |t:10|
Show InChI InChI=1S/C12H14FNO/c13-11-6-9(8-15)5-10(7-11)12-3-1-2-4-14-12/h5-7,15H,1-4,8H2
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744n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50142626
PNG
(CHEMBL3758480)
Show SMILES OCc1cc(F)cc(c1)C1=NCCCC1 |t:10|
Show InChI InChI=1S/C12H14FNO/c13-11-6-9(8-15)5-10(7-11)12-3-1-2-4-14-12/h5-7,15H,1-4,8H2
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821n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50142623
PNG
(CHEMBL3758565)
Show SMILES Cc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C12H15N/c1-10-5-4-6-11(9-10)12-7-2-3-8-13-12/h4-6,9H,2-3,7-8H2,1H3
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1.45E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50140303
PNG
(CHEMBL3759863)
Show SMILES Fc1cc(Br)cc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C11H11BrFN/c12-9-5-8(6-10(13)7-9)11-3-1-2-4-14-11/h5-7H,1-4H2
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1.77E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50142625
PNG
(CHEMBL3758513)
Show SMILES [H][C@@]12CC[C@@]([H])(N1)[C@H](C2)c1cccc(CO)c1 |r|
Show InChI InChI=1/C13H17NO/c15-8-9-2-1-3-10(6-9)12-7-11-4-5-13(12)14-11/h1-3,6,11-15H,4-5,7-8H2/t11-,12+,13+/s2
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1.80E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50140287
PNG
(CHEMBL3758648)
Show SMILES Fc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12FN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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2.04E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50142624
PNG
(CHEMBL3759403)
Show SMILES C1CCC(=NC1)c1ccccc1 |c:3|
Show InChI InChI=1S/C11H13N/c1-2-6-10(7-3-1)11-8-4-5-9-12-11/h1-3,6-7H,4-5,8-9H2
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2.08E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50140287
PNG
(CHEMBL3758648)
Show SMILES Fc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12FN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
PDB

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2.37E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50142624
PNG
(CHEMBL3759403)
Show SMILES C1CCC(=NC1)c1ccccc1 |c:3|
Show InChI InChI=1S/C11H13N/c1-2-6-10(7-3-1)11-8-4-5-9-12-11/h1-3,6-7H,4-5,8-9H2
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2.40E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50140291
PNG
(CHEMBL3758455)
Show SMILES Ic1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12IN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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3.79E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50140289
PNG
(CHEMBL3759225)
Show SMILES Brc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12BrN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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5.02E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50142627
PNG
(CHEMBL3758367)
Show SMILES Oc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H13NO/c13-10-5-3-4-9(8-10)11-6-1-2-7-12-11/h3-5,8,13H,1-2,6-7H2
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9.30E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50140288
PNG
(CHEMBL3759731)
Show SMILES Clc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H12ClN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
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1.15E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50140292
PNG
(CHEMBL3759852)
Show SMILES Brc1cc(Br)cc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C11H11Br2N/c12-9-5-8(6-10(13)7-9)11-3-1-2-4-14-11/h5-7H,1-4H2
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1.88E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50142627
PNG
(CHEMBL3758367)
Show SMILES Oc1cccc(c1)C1=NCCCC1 |t:8|
Show InChI InChI=1S/C11H13NO/c13-10-5-3-4-9(8-10)11-6-1-2-7-12-11/h3-5,8,13H,1-2,6-7H2
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3.20E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50139124
PNG
(CHEMBL3759208)
Show SMILES OCc1cccc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C12H15NO/c14-9-10-4-3-5-11(8-10)12-6-1-2-7-13-12/h3-5,8,14H,1-2,6-7,9H2
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3.50E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50388829
PNG
(CHEMBL2062753)
Show SMILES CN(C)CCCOc1ccc(\C=C2/SC(=S)N(CC=C)C2=O)cc1
Show InChI InChI=1S/C18H22N2O2S2/c1-4-10-20-17(21)16(24-18(20)23)13-14-6-8-15(9-7-14)22-12-5-11-19(2)3/h4,6-9,13H,1,5,10-12H2,2-3H3/b16-13-
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n/an/a 5.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...


ACS Med Chem Lett 3: 352-356 (2012)


Article DOI: 10.1021/ml200284s
BindingDB Entry DOI: 10.7270/Q2V40W83
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50388828
PNG
(CHEMBL2062743)
Show SMILES CCN1C(=S)S\C(=C/c2ccc(OCCCN(C)C)cc2)C1=O
Show InChI InChI=1S/C17H22N2O2S2/c1-4-19-16(20)15(23-17(19)22)12-13-6-8-14(9-7-13)21-11-5-10-18(2)3/h6-9,12H,4-5,10-11H2,1-3H3/b15-12-
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n/an/a 7.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...


ACS Med Chem Lett 3: 352-356 (2012)


Article DOI: 10.1021/ml200284s
BindingDB Entry DOI: 10.7270/Q2V40W83
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50388827
PNG
(CHEMBL2062731)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Cl)cc(Cl)c1 |w:7.8,t:1|
Show InChI InChI=1S/C10H5Cl2NOS2/c11-6-1-5(2-7(12)4-6)3-8-9(14)13-10(15)16-8/h1-4H,(H,13,14,15)
PDB
MMDB

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UniProtKB/SwissProt

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antibodypedia
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UniChem
Article
PubMed
n/an/a 1.81E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...


ACS Med Chem Lett 3: 352-356 (2012)


Article DOI: 10.1021/ml200284s
BindingDB Entry DOI: 10.7270/Q2V40W83
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50388830
PNG
(CHEMBL2062756)
Show SMILES OC(=O)CN1C(=S)S\C(=C/c2csc3ccc(Cl)cc23)C1=O
Show InChI InChI=1S/C14H8ClNO3S3/c15-8-1-2-10-9(4-8)7(6-21-10)3-11-13(19)16(5-12(17)18)14(20)22-11/h1-4,6H,5H2,(H,17,18)/b11-3-
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...


ACS Med Chem Lett 3: 352-356 (2012)


Article DOI: 10.1021/ml200284s
BindingDB Entry DOI: 10.7270/Q2V40W83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Homo sapiens (Human))
BDBM50139124
PNG
(CHEMBL3759208)
Show SMILES OCc1cccc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C12H15NO/c14-9-10-4-3-5-11(8-10)12-6-1-2-7-13-12/h3-5,8,14H,1-2,6-7,9H2
PDB

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n/an/an/an/a 2.00E+4n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at human alpha3beta4 nACh receptor expressed in rat GH4C1 cells assessed as increase in current amplitudes after 2 to 3 days by patc...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50139124
PNG
(CHEMBL3759208)
Show SMILES OCc1cccc(c1)C1=NCCCC1 |t:9|
Show InChI InChI=1S/C12H15NO/c14-9-10-4-3-5-11(8-10)12-6-1-2-7-13-12/h3-5,8,14H,1-2,6-7,9H2
PDB

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n/an/an/an/a 6.00E+4n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at human alpha7 nACh receptor expressed in rat GH4C1 cells assessed as increase in current amplitudes after 2 to 3 days by patch cla...


Eur J Med Chem 108: 392-405 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
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