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Compile Data Set for Download or QSAR

Found 165 hits with Last Name = 'porras' and Initial = 'e'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50154716
PNG
((-)-1-Methyl-4-(8-methylsulfanyl-10,11-dihydro-dib...)
Show SMILES CSc1ccc2Sc3ccccc3C[C@H](N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3/t18-/m0/s1
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1n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095801
PNG
(2-{4-[4-(2-Butoxy-phenyl)-piperazin-1-yl]-butyl}-t...)
Show SMILES CCCCOc1ccccc1N1CCN(CCCCn2c(O)c3CCCCn3c2=O)CC1
Show InChI InChI=1S/C25H38N4O3/c1-2-3-20-32-23-12-5-4-10-21(23)27-18-16-26(17-19-27)13-8-9-15-29-24(30)22-11-6-7-14-28(22)25(29)31/h4-5,10,12,30H,2-3,6-9,11,13-20H2,1H3
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1.20n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50403759
PNG
(CHEMBL428494)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCN(CC1)c1ccccn1)c23
Show InChI InChI=1S/C24H30N4O/c29-23-24(12-6-8-19-7-5-9-20(26-23)22(19)24)11-2-4-14-27-15-17-28(18-16-27)21-10-1-3-13-25-21/h1,3,5,7,9-10,13H,2,4,6,8,11-12,14-18H2,(H,26,29)
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2n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50403780
PNG
(CHEMBL12846)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCC(CC1)c1ccccc1)c23
Show InChI InChI=1S/C26H32N2O/c29-25-26(16-7-11-22-10-6-12-23(27-25)24(22)26)15-4-5-17-28-18-13-21(14-19-28)20-8-2-1-3-9-20/h1-3,6,8-10,12,21H,4-5,7,11,13-19H2,(H,27,29)
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2n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054393
PNG
(2-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H27F3N4O2/c22-21(23,24)16-5-3-6-17(15-16)26-13-11-25(12-14-26)8-1-2-9-28-19(29)18-7-4-10-27(18)20(28)30/h3,5-6,15,29H,1-2,4,7-14H2
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2.40n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50054359
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C20H28N4O3/c1-27-18-8-3-2-6-16(18)22-14-12-21(13-15-22)9-5-11-24-19(25)17-7-4-10-23(17)20(24)26/h2-3,6,8,25H,4-5,7,9-15H2,1H3
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3.10n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50130279
PNG
((R)-4-Methyl-1-(2-(1-toluene-3-sulfonyl)-pyrrolidi...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(C)c2)CC1
Show InChI InChI=1S/C19H30N2O2S/c1-16-8-12-20(13-9-16)14-10-18-6-4-11-21(18)24(22,23)19-7-3-5-17(2)15-19/h3,5,7,15-16,18H,4,6,8-14H2,1-2H3/t18-/m1/s1
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3.20n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50403770
PNG
(CHEMBL12427)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCN(CC1)c1ccccc1)c23
Show InChI InChI=1S/C25H31N3O/c29-24-25(14-7-9-20-8-6-12-22(26-24)23(20)25)13-4-5-15-27-16-18-28(19-17-27)21-10-2-1-3-11-21/h1-3,6,8,10-12H,4-5,7,9,13-19H2,(H,26,29)
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3.20n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095818
PNG
(2-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2CC(=O)N3CCCC3C2=O)CC1
Show InChI InChI=1S/C22H29F3N4O2/c23-22(24,25)17-5-3-6-18(15-17)27-13-11-26(12-14-27)8-1-2-9-28-16-20(30)29-10-4-7-19(29)21(28)31/h3,5-6,15,19H,1-2,4,7-14,16H2
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3.60n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095817
PNG
(2-{4-[4-(1,3-Dioxo-tetrahydro-pyrrolo[1,2-c]imidaz...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCCN1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C21H27N5O2/c22-16-17-6-1-2-7-18(17)24-14-12-23(13-15-24)9-3-4-10-26-20(27)19-8-5-11-25(19)21(26)28/h1-2,6-7,27H,3-5,8-15H2
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3.70n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054392
PNG
(2-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H25F3N4O2/c21-20(22,23)15-4-1-5-16(14-15)25-12-10-24(11-13-25)7-3-9-27-18(28)17-6-2-8-26(17)19(27)29/h1,4-5,14,28H,2-3,6-13H2
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3.80n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095800
PNG
(2-{4-[4-(1,3-Dioxo-tetrahydro-pyrrolo[1,2-c]imidaz...)
Show SMILES CCCOC(=O)c1ccccc1N1CCN(CCCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C24H34N4O4/c1-2-18-32-23(30)19-8-3-4-9-20(19)26-16-14-25(15-17-26)11-5-6-12-28-22(29)21-10-7-13-27(21)24(28)31/h3-4,8-9,29H,2,5-7,10-18H2,1H3
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3.90n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095816
PNG
(2-{4-[4-(3-Bromo-phenyl)-piperazin-1-yl]-butyl}-te...)
Show SMILES Oc1c2CCCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(Br)c1
Show InChI InChI=1S/C21H29BrN4O2/c22-17-6-5-7-18(16-17)24-14-12-23(13-15-24)9-3-4-11-26-20(27)19-8-1-2-10-25(19)21(26)28/h5-7,16,27H,1-4,8-15H2
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4n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50403768
PNG
(CHEMBL273246)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCN(CC1)c1ccccc1C#N)c23
Show InChI InChI=1S/C26H30N4O/c27-19-21-7-1-2-11-23(21)30-17-15-29(16-18-30)14-4-3-12-26-13-6-9-20-8-5-10-22(24(20)26)28-25(26)31/h1-2,5,7-8,10-11H,3-4,6,9,12-18H2,(H,28,31)
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4n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054387
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCn2c(O)c3CCCCn3c2=O)CC1
Show InChI InChI=1S/C21H30N4O3/c1-28-19-9-3-2-7-17(19)23-15-13-22(14-16-23)10-6-12-25-20(26)18-8-4-5-11-24(18)21(25)27/h2-3,7,9,26H,4-6,8,10-16H2,1H3
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4.10n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054359
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C20H28N4O3/c1-27-18-8-3-2-6-16(18)22-14-12-21(13-15-22)9-5-11-24-19(25)17-7-4-10-23(17)20(24)26/h2-3,6,8,25H,4-5,7,9-15H2,1H3
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4.40n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50130272
PNG
(2a-[3-(4-Phenyl-piperazin-1-yl)-propyl]-2a,3,4,5-t...)
Show SMILES O=C1Nc2cccc3CCCC1(CCCN1CCN(CC1)c1ccccc1)c23
Show InChI InChI=1S/C24H29N3O/c28-23-24(12-5-8-19-7-4-11-21(25-23)22(19)24)13-6-14-26-15-17-27(18-16-26)20-9-2-1-3-10-20/h1-4,7,9-11H,5-6,8,12-18H2,(H,25,28)
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5n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50403777
PNG
(CHEMBL12702)
Show SMILES COc1ccccc1N1CCN(CCCCC23CCCc4cccc(NC2=O)c34)CC1
Show InChI InChI=1S/C26H33N3O2/c1-31-23-12-3-2-11-22(23)29-18-16-28(17-19-29)15-5-4-13-26-14-7-9-20-8-6-10-21(24(20)26)27-25(26)30/h2-3,6,8,10-12H,4-5,7,9,13-19H2,1H3,(H,27,30)
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5n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50059470
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2CC3CCCCN3C2)CC1
Show InChI InChI=1S/C22H36N4O/c1-27-22-10-3-2-9-21(22)25-16-14-23(15-17-25)11-6-7-12-24-18-20-8-4-5-13-26(20)19-24/h2-3,9-10,20H,4-8,11-19H2,1H3
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5.10n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054395
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C21H30N4O3/c1-28-19-9-3-2-7-17(19)23-15-13-22(14-16-23)10-4-5-11-25-20(26)18-8-6-12-24(18)21(25)27/h2-3,7,9,26H,4-6,8,10-16H2,1H3
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5.5n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054391
PNG
(2-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES Oc1c2CCCCn2c(=O)n1CCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H27F3N4O2/c22-21(23,24)16-5-3-6-17(15-16)26-13-11-25(12-14-26)8-4-10-28-19(29)18-7-1-2-9-27(18)20(28)30/h3,5-6,15,29H,1-2,4,7-14H2
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5.70n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM30704
PNG
((phenylmethyl) N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a...)
Show SMILES CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]2[C@H]1Cc1cn(C)c3cccc2c13
Show InChI InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095829
PNG
(2-{4-[4-(2-Butoxy-phenyl)-piperazin-1-yl]-butyl}-h...)
Show SMILES CCCCOc1ccccc1N1CCN(CCCCN2CC(=O)N3CCCC3C2=O)CC1
Show InChI InChI=1S/C25H38N4O3/c1-2-3-19-32-23-11-5-4-9-21(23)27-17-15-26(16-18-27)12-6-7-13-28-20-24(30)29-14-8-10-22(29)25(28)31/h4-5,9,11,22H,2-3,6-8,10,12-20H2,1H3
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6.5n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50267832
PNG
(1-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)butyl]-1,3-d...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1
Show InChI InChI=1S/C21H24N2O/c24-21-15-18-8-3-4-10-20(18)23(21)13-6-5-12-22-14-11-17-7-1-2-9-19(17)16-22/h1-4,7-10H,5-6,11-16H2
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7n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells


J Med Chem 52: 2384-92 (2009)


Article DOI: 10.1021/jm8014553
BindingDB Entry DOI: 10.7270/Q2B8580P
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054354
PNG
(2-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-t...)
Show SMILES Oc1c2CCCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H29ClN4O2/c22-17-6-5-7-18(16-17)24-14-12-23(13-15-24)9-3-4-11-26-20(27)19-8-1-2-10-25(19)21(26)28/h5-7,16,27H,1-4,8-15H2
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7.20n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50024204
PNG
(1H-imidazo[4,5-c]pyridine derivative | 2N-[4,7-dim...)
Show SMILES CN(C)S(=O)(=O)N[C@H]1C[C@H]2[C@@H](Cc3cn(C)c4cccc2c34)N(C)C1
Show InChI InChI=1S/C18H26N4O2S/c1-20(2)25(23,24)19-13-9-15-14-6-5-7-16-18(14)12(10-21(16)3)8-17(15)22(4)11-13/h5-7,10,13,15,17,19H,8-9,11H2,1-4H3/t13-,15+,17+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50054395
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C21H30N4O3/c1-28-19-9-3-2-7-17(19)23-15-13-22(14-16-23)10-4-5-11-25-20(26)18-8-6-12-24(18)21(25)27/h2-3,7,9,26H,4-6,8,10-16H2,1H3
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8.30n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095803
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2CC(=O)N3CCCC3C2=O)CC1
Show InChI InChI=1S/C22H32N4O3/c1-29-20-9-3-2-7-18(20)24-15-13-23(14-16-24)10-4-5-11-25-17-21(27)26-12-6-8-19(26)22(25)28/h2-3,7,9,19H,4-6,8,10-17H2,1H3
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8.60n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50054362
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCn2c(O)c3CCCCn3c2=O)CC1
Show InChI InChI=1S/C22H32N4O3/c1-29-20-10-3-2-8-18(20)24-16-14-23(15-17-24)11-6-7-13-26-21(27)19-9-4-5-12-25(19)22(26)28/h2-3,8,10,27H,4-7,9,11-17H2,1H3
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8.60n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054362
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCn2c(O)c3CCCCn3c2=O)CC1
Show InChI InChI=1S/C22H32N4O3/c1-29-20-10-3-2-8-18(20)24-16-14-23(15-17-24)11-6-7-13-26-21(27)19-9-4-5-12-25(19)22(26)28/h2-3,8,10,27H,4-7,9,11-17H2,1H3
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8.80n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50054351
PNG
(2-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-t...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H27ClN4O2/c21-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-1-2-9-25-19(26)18-7-4-10-24(18)20(25)27/h3,5-6,15,26H,1-2,4,7-14H2
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9.60n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054355
PNG
(2-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES Oc1c2CCCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H29F3N4O2/c23-22(24,25)17-6-5-7-18(16-17)27-14-12-26(13-15-27)9-3-4-11-29-20(30)19-8-1-2-10-28(19)21(29)31/h5-7,16,30H,1-4,8-15H2
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9.90n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50054387
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCn2c(O)c3CCCCn3c2=O)CC1
Show InChI InChI=1S/C21H30N4O3/c1-28-19-9-3-2-7-17(19)23-15-13-22(14-16-23)10-6-12-25-20(26)18-8-4-5-11-24(18)21(25)27/h2-3,7,9,26H,4-6,8,10-16H2,1H3
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9.90n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50130269
PNG
((6aR,9R)-5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-i...)
Show SMILES CCN(CC)C(=O)[C@H]1CN(C)[C@@H]2Cc3c(Br)[nH]c4cccc(C2=C1)c34 |c:23|
Show InChI InChI=1S/C20H24BrN3O/c1-4-24(5-2)20(25)12-9-14-13-7-6-8-16-18(13)15(19(21)22-16)10-17(14)23(3)11-12/h6-9,12,17,22H,4-5,10-11H2,1-3H3/t12-,17-/m1/s1
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10n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095810
PNG
(2-{3-[4-(2-Butoxy-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES CCCCOc1ccccc1N1CCN(CCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C23H34N4O3/c1-2-3-18-30-21-10-5-4-8-19(21)25-16-14-24(15-17-25)11-7-13-27-22(28)20-9-6-12-26(20)23(27)29/h4-5,8,10,28H,2-3,6-7,9,11-18H2,1H3
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11n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054351
PNG
(2-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-t...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H27ClN4O2/c21-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-1-2-9-25-19(26)18-7-4-10-24(18)20(25)27/h3,5-6,15,26H,1-2,4,7-14H2
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11.3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50267739
PNG
(1-{(2Z)-4-[4-(1-Naphthyl)piperazin-1-yl]but-2-enyl...)
Show SMILES O=C1Cc2ccccc2N1C\C=C/CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27N3O/c30-26-20-22-9-2-4-12-24(22)29(26)15-6-5-14-27-16-18-28(19-17-27)25-13-7-10-21-8-1-3-11-23(21)25/h1-13H,14-20H2/b6-5-
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11.5n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells


J Med Chem 52: 2384-92 (2009)


Article DOI: 10.1021/jm8014553
BindingDB Entry DOI: 10.7270/Q2B8580P
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50054354
PNG
(2-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-t...)
Show SMILES Oc1c2CCCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H29ClN4O2/c22-17-6-5-7-18(16-17)24-14-12-23(13-15-24)9-3-4-11-26-20(27)19-8-1-2-10-25(19)21(26)28/h5-7,16,27H,1-4,8-15H2
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12.1n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50059476
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2CC3CCCN3C2)CC1
Show InChI InChI=1S/C20H32N4O/c1-25-20-8-3-2-7-19(20)23-14-12-21(13-15-23)9-5-10-22-16-18-6-4-11-24(18)17-22/h2-3,7-8,18H,4-6,9-17H2,1H3
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12.2n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50059471
PNG
(2-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2CC3CCCN3C2)CC1
Show InChI InChI=1S/C21H31F3N4/c22-21(23,24)18-5-3-6-19(15-18)27-13-11-25(12-14-27)8-1-2-9-26-16-20-7-4-10-28(20)17-26/h3,5-6,15,20H,1-2,4,7-14,16-17H2
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12.3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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13n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50031942
PNG
((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)
Show SMILES CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34 |r,c:24|
Show InChI InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1
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13n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50059468
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2CC3CCCCN3C2)CC1
Show InChI InChI=1S/C21H34N4O/c1-26-21-9-3-2-8-20(21)24-15-13-22(14-16-24)10-6-11-23-17-19-7-4-5-12-25(19)18-23/h2-3,8-9,19H,4-7,10-18H2,1H3
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13.9n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095825
PNG
(2-{4-[4-(1,4-Dioxo-octahydro-pyrido[1,2-a]pyrazin-...)
Show SMILES O=C1CN(CCCCN2CCN(CC2)c2ccccc2C#N)C(=O)C2CCCCN12
Show InChI InChI=1S/C23H31N5O2/c24-17-19-7-1-2-8-20(19)26-15-13-25(14-16-26)10-5-6-11-27-18-22(29)28-12-4-3-9-21(28)23(27)30/h1-2,7-8,21H,3-6,9-16,18H2
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14n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50059472
PNG
(2-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2CC3CCCCN3C2)CC1
Show InChI InChI=1S/C22H33F3N4/c23-22(24,25)19-6-5-8-20(16-19)28-14-12-26(13-15-28)9-3-4-10-27-17-21-7-1-2-11-29(21)18-27/h5-6,8,16,21H,1-4,7,9-15,17-18H2
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15.3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50267737
PNG
(1-{5-[4-(1-Naphthyl)piperazin-1-yl]pentyl}-1,3-dih...)
Show SMILES O=C1Cc2ccccc2N1CCCCCN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C27H31N3O/c31-27-21-23-10-3-5-13-25(23)30(27)16-7-1-6-15-28-17-19-29(20-18-28)26-14-8-11-22-9-2-4-12-24(22)26/h2-5,8-14H,1,6-7,15-21H2
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16n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells


J Med Chem 52: 2384-92 (2009)


Article DOI: 10.1021/jm8014553
BindingDB Entry DOI: 10.7270/Q2B8580P
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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16n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50403758
PNG
(CHEMBL274595)
Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cc(Br)c(Br)s1
Show InChI InChI=1S/C15H24Br2N2O2S2/c1-11-4-7-19(8-5-11)9-6-12(2)18(3)23(20,21)14-10-13(16)15(17)22-14/h10-12H,4-9H2,1-3H3/t12-/m1/s1
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16n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells


Bioorg Med Chem Lett 10: 1097-100 (2000)


BindingDB Entry DOI: 10.7270/Q2JS9RNJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50095806
PNG
(2-[4-(4-o-Tolyl-piperazin-1-yl)-butyl]-tetrahydro-...)
Show SMILES Cc1ccccc1N1CCN(CCCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C21H30N4O2/c1-17-7-2-3-8-18(17)23-15-13-22(14-16-23)10-4-5-11-25-20(26)19-9-6-12-24(19)21(25)27/h2-3,7-8,26H,4-6,9-16H2,1H3
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16n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT


J Med Chem 44: 186-97 (2001)


BindingDB Entry DOI: 10.7270/Q2RN38MH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50059475
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2CC3CCCN3C2)CC1
Show InChI InChI=1S/C21H34N4O/c1-26-21-9-3-2-8-20(21)24-15-13-22(14-16-24)10-4-5-11-23-17-19-7-6-12-25(19)18-23/h2-3,8-9,19H,4-7,10-18H2,1H3
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17.5n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane


J Med Chem 40: 2653-6 (1997)


Article DOI: 10.1021/jm970216k
BindingDB Entry DOI: 10.7270/Q2X34WKX
More data for this
Ligand-Target Pair
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