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Compile Data Set for Download or QSAR

Found 4456 hits with Last Name = 'rech' and Initial = 'jc'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Mus musculus)
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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0.400n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM160091
PNG
(US10047092, 32 | US10053463, 32 | US9040534, 32)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cscn1 |r|
Show InChI InChI=1/C17H13ClF3N5OS/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160091
PNG
(US10047092, 32 | US10053463, 32 | US9040534, 32)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cscn1 |r|
Show InChI InChI=1/C17H13ClF3N5OS/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160091
PNG
(US10047092, 32 | US10053463, 32 | US9040534, 32)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cscn1 |r|
Show InChI InChI=1/C17H13ClF3N5OS/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254320
PNG
(US10112937, Example 220 | US10150765, Example 220 ...)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1cccc(c1F)C(F)(F)F)nnn2-c1ncc(F)cn1 |r|
Show InChI InChI=1/C18H13F5N6O/c1-9-5-14-13(26-27-29(14)17-24-6-10(19)7-25-17)8-28(9)16(30)11-3-2-4-12(15(11)20)18(21,22)23/h2-4,6-7,9H,5,8H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM160085
PNG
(US10047092, 26 | US10053463, 26 | US9040534, 26)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc(C)[nH]n1 |r|
Show InChI InChI=1/C18H16ClF3N6O/c1-9-6-13(24-23-9)15-25-26-16-17(29)27(10(2)7-28(15)16)8-11-4-3-5-12(14(11)19)18(20,21)22/h3-6,10H,7-8H2,1-2H3,(H,23,24)/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160085
PNG
(US10047092, 26 | US10053463, 26 | US9040534, 26)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc(C)[nH]n1 |r|
Show InChI InChI=1/C18H16ClF3N6O/c1-9-6-13(24-23-9)15-25-26-16-17(29)27(10(2)7-28(15)16)8-11-4-3-5-12(14(11)19)18(20,21)22/h3-6,10H,7-8H2,1-2H3,(H,23,24)/t10-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160085
PNG
(US10047092, 26 | US10053463, 26 | US9040534, 26)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc(C)[nH]n1 |r|
Show InChI InChI=1/C18H16ClF3N6O/c1-9-6-13(24-23-9)15-25-26-16-17(29)27(10(2)7-28(15)16)8-11-4-3-5-12(14(11)19)18(20,21)22/h3-6,10H,7-8H2,1-2H3,(H,23,24)/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160075
PNG
(US10047092, 16 | US9040534, 16)
Show SMILES C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(13-7-23-5-6-24-13)25-26-16(28)17(29)27(10)9-11-3-2-4-12(14(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM246865
PNG
(6-(trifluoromethyl)picolinohydrazide | US10053463,...)
Show SMILES NNC(=O)c1cccc(n1)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160075
PNG
(US10047092, 16 | US9040534, 16)
Show SMILES C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(13-7-23-5-6-24-13)25-26-16(28)17(29)27(10)9-11-3-2-4-12(14(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254320
PNG
(US10112937, Example 220 | US10150765, Example 220 ...)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1cccc(c1F)C(F)(F)F)nnn2-c1ncc(F)cn1 |r|
Show InChI InChI=1/C18H13F5N6O/c1-9-5-14-13(26-27-29(14)17-24-6-10(19)7-25-17)8-28(9)16(30)11-3-2-4-12(15(11)20)18(21,22)23/h2-4,6-7,9H,5,8H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160130
PNG
(US10047092, 72 | US10053463, 72 | US9040534, 71 | ...)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H16ClF3N6O/c1-2-12-10-29-16(15-24-7-4-8-25-15)26-27-17(29)18(30)28(12)9-11-5-3-6-13(14(11)20)19(21,22)23/h3-8,12H,2,9-10H2,1H3/t12-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM227806
PNG
((6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethy...)
Show SMILES CC[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM227806
PNG
((6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethy...)
Show SMILES CC[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM227806
PNG
((6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethy...)
Show SMILES CC[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160080
PNG
(US10047092, 21 | US10053463, 21 | US9040534, 21)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cocn1 |r|
Show InChI InChI=1/C17H13ClF3N5O2/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160072
PNG
(US10047092, 13 | US9040534, 13)
Show SMILES C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(Cl)c1Cl |r|
Show InChI InChI=1/C17H14Cl2N6O/c1-10-8-25-15(13-7-20-5-6-21-13)22-23-16(25)17(26)24(10)9-11-3-2-4-12(18)14(11)19/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160080
PNG
(US10047092, 21 | US10053463, 21 | US9040534, 21)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cocn1 |r|
Show InChI InChI=1/C17H13ClF3N5O2/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160072
PNG
(US10047092, 13 | US9040534, 13)
Show SMILES C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(Cl)c1Cl |r|
Show InChI InChI=1/C17H14Cl2N6O/c1-10-8-25-15(13-7-20-5-6-21-13)22-23-16(25)17(26)24(10)9-11-3-2-4-12(18)14(11)19/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM246862
PNG
(6-methylpicolinohydrazide | US10053463, 13)
Show SMILES Cc1cccc(n1)C(=O)NN
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160080
PNG
(US10047092, 21 | US10053463, 21 | US9040534, 21)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cocn1 |r|
Show InChI InChI=1/C17H13ClF3N5O2/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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1.40n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM246862
PNG
(6-methylpicolinohydrazide | US10053463, 13)
Show SMILES Cc1cccc(n1)C(=O)NN
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1.40n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160075
PNG
(US10047092, 16 | US9040534, 16)
Show SMILES C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(13-7-23-5-6-24-13)25-26-16(28)17(29)27(10)9-11-3-2-4-12(14(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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1.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254247
PNG
(US10112937, Example 133 | US10150765, Example 133 ...)
Show SMILES C[C@H]1N(CCc2c1nnn2-c1cc[nH]n1)C(=O)c1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C17H14ClF3N6O/c1-9-15-12(27(25-24-15)13-5-7-22-23-13)6-8-26(9)16(28)10-3-2-4-11(14(10)18)17(19,20)21/h2-5,7,9H,6,8H2,1H3,(H,22,23)/t9-/s2
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1.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160135
PNG
(US10047092, 76 | US10053463, 76 | US9040534, 76)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C20H16ClF4N5O/c1-2-13-10-30-17(15-7-6-12(22)8-26-15)27-28-18(30)19(31)29(13)9-11-4-3-5-14(16(11)21)20(23,24)25/h3-8,13H,2,9-10H2,1H3/t13-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254247
PNG
(US10112937, Example 133 | US10150765, Example 133 ...)
Show SMILES C[C@H]1N(CCc2c1nnn2-c1cc[nH]n1)C(=O)c1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C17H14ClF3N6O/c1-9-15-12(27(25-24-15)13-5-7-22-23-13)6-8-26(9)16(28)10-3-2-4-11(14(10)18)17(19,20)21/h2-5,7,9H,6,8H2,1H3,(H,22,23)/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM246865
PNG
(6-(trifluoromethyl)picolinohydrazide | US10053463,...)
Show SMILES NNC(=O)c1cccc(n1)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160135
PNG
(US10047092, 76 | US10053463, 76 | US9040534, 76)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C20H16ClF4N5O/c1-2-13-10-30-17(15-7-6-12(22)8-26-15)27-28-18(30)19(31)29(13)9-11-4-3-5-14(16(11)21)20(23,24)25/h3-8,13H,2,9-10H2,1H3/t13-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160075
PNG
(US10047092, 16 | US9040534, 16)
Show SMILES C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(13-7-23-5-6-24-13)25-26-16(28)17(29)27(10)9-11-3-2-4-12(14(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254364
PNG
(US10112937, Example 271 | US10150765, Example 271 ...)
Show SMILES C[C@H]1N(CCc2c1nnn2-c1ncccn1)C(=O)c1cccc(c1F)C(F)(F)F |r|
Show InChI InChI=1/C18H14F4N6O/c1-10-15-13(28(26-25-15)17-23-7-3-8-24-17)6-9-27(10)16(29)11-4-2-5-12(14(11)19)18(20,21)22/h2-5,7-8,10H,6,9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM160135
PNG
(US10047092, 76 | US10053463, 76 | US9040534, 76)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C20H16ClF4N5O/c1-2-13-10-30-17(15-7-6-12(22)8-26-15)27-28-18(30)19(31)29(13)9-11-4-3-5-14(16(11)21)20(23,24)25/h3-8,13H,2,9-10H2,1H3/t13-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160134
PNG
(US10047092, 75 | US10053463, 75 | US9040534, 75)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H15ClF4N6O/c1-2-12-9-30-16(15-25-6-11(21)7-26-15)27-28-17(30)18(31)29(12)8-10-4-3-5-13(14(10)20)19(22,23)24/h3-7,12H,2,8-9H2,1H3/t12-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM160134
PNG
(US10047092, 75 | US10053463, 75 | US9040534, 75)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H15ClF4N6O/c1-2-12-9-30-16(15-25-6-11(21)7-26-15)27-28-17(30)18(31)29(12)8-10-4-3-5-13(14(10)20)19(22,23)24/h3-7,12H,2,8-9H2,1H3/t12-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160134
PNG
(US10047092, 75 | US10053463, 75 | US9040534, 75)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H15ClF4N6O/c1-2-12-9-30-16(15-25-6-11(21)7-26-15)27-28-17(30)18(31)29(12)8-10-4-3-5-13(14(10)20)19(22,23)24/h3-7,12H,2,8-9H2,1H3/t12-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254310
PNG
(US10112937, Example 208 | US10150765, Example 208 ...)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1cccc(c1C)C(F)(F)F)nnn2-c1ncc(F)cn1 |r|
Show InChI InChI=1/C19H16F4N6O/c1-10-6-16-15(26-27-29(16)18-24-7-12(20)8-25-18)9-28(10)17(30)13-4-3-5-14(11(13)2)19(21,22)23/h3-5,7-8,10H,6,9H2,1-2H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM160087
PNG
(US10047092, 28 | US10053463, 28 | US9040534, 28)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc[nH]n1 |r|
Show InChI InChI=1/C17H14ClF3N6O/c1-9-7-27-14(12-5-6-22-23-12)24-25-15(27)16(28)26(9)8-10-3-2-4-11(13(10)18)17(19,20)21/h2-6,9H,7-8H2,1H3,(H,22,23)/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM160077
PNG
(US10047092, 18 | US10053463, 18 | US9040534, 18)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H15ClF3N5O/c1-11-9-28-16(14-7-2-3-8-24-14)25-26-17(28)18(29)27(11)10-12-5-4-6-13(15(12)20)19(21,22)23/h2-8,11H,9-10H2,1H3/t11-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160091
PNG
(US10047092, 32 | US10053463, 32 | US9040534, 32)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cscn1 |r|
Show InChI InChI=1/C17H13ClF3N5OS/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10053463 (2018)


BindingDB Entry DOI: 10.7270/Q2FT8P24
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160087
PNG
(US10047092, 28 | US10053463, 28 | US9040534, 28)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc[nH]n1 |r|
Show InChI InChI=1/C17H14ClF3N6O/c1-9-7-27-14(12-5-6-22-23-12)24-25-15(27)16(28)26(9)8-10-3-2-4-11(13(10)18)17(19,20)21/h2-6,9H,7-8H2,1H3,(H,22,23)/t9-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM160077
PNG
(US10047092, 18 | US10053463, 18 | US9040534, 18)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H15ClF3N5O/c1-11-9-28-16(14-7-2-3-8-24-14)25-26-17(28)18(29)27(11)10-12-5-4-6-13(15(12)20)19(21,22)23/h2-8,11H,9-10H2,1H3/t11-/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparation...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160077
PNG
(US10047092, 18 | US10053463, 18 | US9040534, 18)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C19H15ClF3N5O/c1-11-9-28-16(14-7-2-3-8-24-14)25-26-17(28)18(29)27(11)10-12-5-4-6-13(15(12)20)19(21,22)23/h2-8,11H,9-10H2,1H3/t11-/s2
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Janssen Pharmaceutica NV

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US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160096
PNG
(US10047092, 37 | US10053463, 37 | US9040534, 37)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cncs1 |r|
Show InChI InChI=1/C17H13ClF3N5OS/c1-9-6-26-14(12-5-22-8-28-12)23-24-15(26)16(27)25(9)7-10-3-2-4-11(13(10)18)17(19,20)21/h2-5,8-9H,6-7H2,1H3/t9-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM160094
PNG
(US10047092, 35 | US10053463, 35 | US9040534, 35)
Show SMILES C[C@H]1Cn2c(nnc2-c2cc(CO)ccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1/C20H17ClF3N5O2/c1-11-8-29-17(15-7-12(10-30)5-6-25-15)26-27-18(29)19(31)28(11)9-13-3-2-4-14(16(13)21)20(22,23)24/h2-7,11,30H,8-10H2,1H3/t11-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US10047092 (2018)


BindingDB Entry DOI: 10.7270/Q27D2X4N
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM254310
PNG
(US10112937, Example 208 | US10150765, Example 208 ...)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1cccc(c1C)C(F)(F)F)nnn2-c1ncc(F)cn1 |r|
Show InChI InChI=1/C19H16F4N6O/c1-10-6-16-15(26-27-29(16)18-24-7-12(20)8-25-18)9-28(10)17(30)13-4-3-5-14(11(13)2)19(21,22)23/h3-5,7-8,10H,6,9H2,1-2H3/t10-/s2
PDB

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UniProtKB/SwissProt

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2n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US10112937 (2018)


BindingDB Entry DOI: 10.7270/Q25H7J9N
More data for this
Ligand-Target Pair
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