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Compile Data Set for Download or QSAR

Found 548 hits with Last Name = 'romeo' and Initial = 'e'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045892
PNG
(2-[5-Chloro-2-(4-fluoro-phenyl)-1H-indol-3-yl]-N,N...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H36ClFN2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-22(29)13-16-26(24)31-28(25)21-11-14-23(30)15-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3
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2.30n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045882
PNG
(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H36Cl2N2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-23(30)15-16-26(24)31-28(25)21-11-13-22(29)14-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3
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3.60n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045880
PNG
(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N2O/c1-3-11-26(12-4-2)21(27)14-19-18-13-17(24)9-10-20(18)25-22(19)15-5-7-16(23)8-6-15/h5-10,13,25H,3-4,11-12,14H2,1-2H3
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3.90n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045878
PNG
(2-(5-Chloro-2-phenyl-1H-indol-3-yl)-N,N-dihexyl-ac...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1ccccc1
Show InChI InChI=1S/C28H37ClN2O/c1-3-5-7-12-18-31(19-13-8-6-4-2)27(32)21-25-24-20-23(29)16-17-26(24)30-28(25)22-14-10-9-11-15-22/h9-11,14-17,20,30H,3-8,12-13,18-19,21H2,1-2H3
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4.10n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045877
PNG
(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
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4.40n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045883
PNG
(CHEMBL99808 | N,N-Dihexyl-2-(6H-isoindolo[2,1-a]in...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c2-c3ccccc3Cn2c2ccccc12
Show InChI InChI=1S/C29H38N2O/c1-3-5-7-13-19-30(20-14-8-6-4-2)28(32)21-26-25-17-11-12-18-27(25)31-22-23-15-9-10-16-24(23)29(26)31/h9-12,15-18H,3-8,13-14,19-22H2,1-2H3
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7.70n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045894
PNG
(CHEMBL98081 | N,N-Dihexyl-2-(2-phenyl-1H-indol-3-y...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C28H38N2O/c1-3-5-7-14-20-30(21-15-8-6-4-2)27(31)22-25-24-18-12-13-19-26(24)29-28(25)23-16-10-9-11-17-23/h9-13,16-19,29H,3-8,14-15,20-22H2,1-2H3
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9.70n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045863
PNG
(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N,N-dipentyl...)
Show SMILES CCCCCN(CCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C26H33FN2O/c1-3-5-9-17-29(18-10-6-4-2)25(30)19-23-22-11-7-8-12-24(22)28-26(23)20-13-15-21(27)16-14-20/h7-8,11-16,28H,3-6,9-10,17-19H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045861
PNG
(2-(6H-Isoindolo[2,1-a]indol-11-yl)-N,N-dipropyl-ac...)
Show SMILES CCCN(CCC)C(=O)Cc1c2-c3ccccc3Cn2c2ccccc12
Show InChI InChI=1S/C23H26N2O/c1-3-13-24(14-4-2)22(26)15-20-19-11-7-8-12-21(19)25-16-17-9-5-6-10-18(17)23(20)25/h5-12H,3-4,13-16H2,1-2H3
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20n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045867
PNG
(CHEMBL316711 | N,N-Dibutyl-2-[2-(4-fluoro-phenyl)-...)
Show SMILES CCCCN(CCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN2O/c1-3-5-15-27(16-6-4-2)23(28)17-21-20-9-7-8-10-22(20)26-24(21)18-11-13-19(25)14-12-18/h7-14,26H,3-6,15-17H2,1-2H3
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45n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045896
PNG
(2-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClN2O/c1-3-13-25(14-4-2)21(26)15-19-18-7-5-6-8-20(18)24-22(19)16-9-11-17(23)12-10-16/h5-12,24H,3-4,13-15H2,1-2H3
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66n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045870
PNG
(2-(5-Methyl-2-p-tolyl-1H-indol-3-yl)-N,N-dipropyl-...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccc(C)cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C24H30N2O/c1-5-13-26(14-6-2)23(27)16-21-20-15-18(4)9-12-22(20)25-24(21)19-10-7-17(3)8-11-19/h7-12,15,25H,5-6,13-14,16H2,1-4H3
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66n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045873
PNG
(3-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Show SMILES CCCN(CCC)C(=O)CCc1c([nH]c2ccc(Cl)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26Cl2N2O/c1-3-13-27(14-4-2)22(28)12-10-19-20-15-18(25)9-11-21(20)26-23(19)16-5-7-17(24)8-6-16/h5-9,11,15,26H,3-4,10,12-14H2,1-2H3
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71n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045889
PNG
(2-(5-Chloro-2-thiophen-2-yl-1H-indol-3-yl)-N,N-dip...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1cccs1
Show InChI InChI=1S/C20H23ClN2OS/c1-3-9-23(10-4-2)19(24)13-16-15-12-14(21)7-8-17(15)22-20(16)18-6-5-11-25-18/h5-8,11-12,22H,3-4,9-10,13H2,1-2H3
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78n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045876
PNG
(CHEMBL329499 | N-Hexyl-2-(2-phenyl-1H-indol-3-yl)-...)
Show SMILES CCCCCCNC(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H26N2O/c1-2-3-4-10-15-23-21(25)16-19-18-13-8-9-14-20(18)24-22(19)17-11-6-5-7-12-17/h5-9,11-14,24H,2-4,10,15-16H2,1H3,(H,23,25)
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96n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045857
PNG
(2-(2-Phenyl-1H-indol-3-yl)-N,N-dipropyl-acetamide ...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H26N2O/c1-3-14-24(15-4-2)21(25)16-19-18-12-8-9-13-20(18)23-22(19)17-10-6-5-7-11-17/h5-13,23H,3-4,14-16H2,1-2H3
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100n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045887
PNG
(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-3-13-25(14-4-2)21(26)15-19-18-7-5-6-8-20(18)24-22(19)16-9-11-17(23)12-10-16/h5-12,24H,3-4,13-15H2,1-2H3
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100n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045859
PNG
(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N-hexyl-N-me...)
Show SMILES CCCCCCN(C)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C23H27FN2O/c1-3-4-5-8-15-26(2)22(27)16-20-19-9-6-7-10-21(19)25-23(20)17-11-13-18(24)14-12-17/h6-7,9-14,25H,3-5,8,15-16H2,1-2H3
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135n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045866
PNG
(CHEMBL95249 | N,N-Dimethyl-2-(5-methyl-2-p-tolyl-1...)
Show SMILES CN(C)C(=O)Cc1c([nH]c2ccc(C)cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C20H22N2O/c1-13-5-8-15(9-6-13)20-17(12-19(23)22(3)4)16-11-14(2)7-10-18(16)21-20/h5-11,21H,12H2,1-4H3
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150n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045858
PNG
(CHEMBL99509 | N,N-Diethyl-2-(2-phenyl-1H-indol-3-y...)
Show SMILES CCN(CC)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H22N2O/c1-3-22(4-2)19(23)14-17-16-12-8-9-13-18(16)21-20(17)15-10-6-5-7-11-15/h5-13,21H,3-4,14H2,1-2H3
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156n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045869
PNG
(CHEMBL320626 | N,N-Dimethyl-2-(2-phenyl-1H-indol-3...)
Show SMILES CN(C)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C18H18N2O/c1-20(2)17(21)12-15-14-10-6-7-11-16(14)19-18(15)13-8-4-3-5-9-13/h3-11,19H,12H2,1-2H3
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170n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045856
PNG
(2-[1-(4-Bromo-benzyl)-1H-indol-3-yl]-N,N-dipropyl-...)
Show SMILES CCCN(CCC)C(=O)Cc1cn(Cc2ccc(Br)cc2)c2ccccc12
Show InChI InChI=1S/C23H27BrN2O/c1-3-13-25(14-4-2)23(27)15-19-17-26(22-8-6-5-7-21(19)22)16-18-9-11-20(24)12-10-18/h5-12,17H,3-4,13-16H2,1-2H3
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200n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045890
PNG
(CHEMBL99069 | {2-[2-(4-Fluoro-phenyl)-1H-indol-3-y...)
Show SMILES CCCCCCN(CCCCCC)CCc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H39FN2/c1-3-5-7-11-20-31(21-12-8-6-4-2)22-19-26-25-13-9-10-14-27(25)30-28(26)23-15-17-24(29)18-16-23/h9-10,13-18,30H,3-8,11-12,19-22H2,1-2H3
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200n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045868
PNG
(2-(6-Fluoro-2-phenyl-1H-indol-3-yl)-N,N-dipropyl-a...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2cc(F)ccc12)-c1ccccc1
Show InChI InChI=1S/C22H25FN2O/c1-3-12-25(13-4-2)21(26)15-19-18-11-10-17(23)14-20(18)24-22(19)16-8-6-5-7-9-16/h5-11,14,24H,3-4,12-13,15H2,1-2H3
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202n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045871
PNG
(2-(7-Fluoro-2-phenyl-1H-indol-3-yl)-N,N-dipropyl-a...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2c(F)cccc12)-c1ccccc1
Show InChI InChI=1S/C22H25FN2O/c1-3-13-25(14-4-2)20(26)15-18-17-11-8-12-19(23)22(17)24-21(18)16-9-6-5-7-10-16/h5-12,24H,3-4,13-15H2,1-2H3
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211n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045874
PNG
(2-[2-(4-Iodo-phenyl)-1H-indol-3-yl]-N,N-dipropyl-a...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(I)cc1
Show InChI InChI=1S/C22H25IN2O/c1-3-13-25(14-4-2)21(26)15-19-18-7-5-6-8-20(18)24-22(19)16-9-11-17(23)12-10-16/h5-12,24H,3-4,13-15H2,1-2H3
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216n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045879
PNG
(2-[2-(4-Bromo-phenyl)-1H-indol-3-yl]-N,N-dipropyl-...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(Br)cc1
Show InChI InChI=1S/C22H25BrN2O/c1-3-13-25(14-4-2)21(26)15-19-18-7-5-6-8-20(18)24-22(19)16-9-11-17(23)12-10-16/h5-12,24H,3-4,13-15H2,1-2H3
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216n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045885
PNG
(CHEMBL100256 | N,N-Dipropyl-2-(2-thiophen-2-yl-1H-...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1cccs1
Show InChI InChI=1S/C20H24N2OS/c1-3-11-22(12-4-2)19(23)14-16-15-8-5-6-9-17(15)21-20(16)18-10-7-13-24-18/h5-10,13,21H,3-4,11-12,14H2,1-2H3
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304n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045888
PNG
(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N-hexyl-acet...)
Show SMILES CCCCCCNC(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-2-3-4-7-14-24-21(26)15-19-18-8-5-6-9-20(18)25-22(19)16-10-12-17(23)13-11-16/h5-6,8-13,25H,2-4,7,14-15H2,1H3,(H,24,26)
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323n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045855
PNG
(2-(6,7-Dihydro-5H-benzo[3,4]azepino[1,2-a]indol-13...)
Show SMILES CCCN(CCC)C(=O)Cc1c2-c3ccccc3CCCn2c2ccccc12
Show InChI InChI=1S/C25H30N2O/c1-3-15-26(16-4-2)24(28)18-22-21-13-7-8-14-23(21)27-17-9-11-19-10-5-6-12-20(19)25(22)27/h5-8,10,12-14H,3-4,9,11,15-18H2,1-2H3
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328n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045862
PNG
(2-(2-Phenyl-1H-indol-3-yl)-1-pyrrolidin-1-yl-ethan...)
Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N1CCCC1
Show InChI InChI=1S/C20H20N2O/c23-19(22-12-6-7-13-22)14-17-16-10-4-5-11-18(16)21-20(17)15-8-2-1-3-9-15/h1-5,8-11,21H,6-7,12-14H2
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338n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045864
PNG
(2-[2-(4-Chloro-phenyl)-1-methyl-1H-indol-3-yl]-N,N...)
Show SMILES CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)n(C)c2ccccc12
Show InChI InChI=1S/C23H27ClN2O/c1-4-14-26(15-5-2)22(27)16-20-19-8-6-7-9-21(19)25(3)23(20)17-10-12-18(24)13-11-17/h6-13H,4-5,14-16H2,1-3H3
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340n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045865
PNG
(2-(2-Phenyl-1H-indol-3-yl)-1-piperidin-1-yl-ethano...)
Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N1CCCCC1
Show InChI InChI=1S/C21H22N2O/c24-20(23-13-7-2-8-14-23)15-18-17-11-5-6-12-19(17)22-21(18)16-9-3-1-4-10-16/h1,3-6,9-12,22H,2,7-8,13-15H2
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350n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045886
PNG
(3-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Show SMILES CCCN(CCC)C(=O)\C=C\c1c([nH]c2ccccc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN2O/c1-3-15-26(16-4-2)22(27)14-13-20-19-7-5-6-8-21(19)25-23(20)17-9-11-18(24)12-10-17/h5-14,25H,3-4,15-16H2,1-2H3/b14-13+
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400n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045881
PNG
(CHEMBL98382 | N-(2-Bromo-phenyl)-2-[2-(4-fluoro-ph...)
Show SMILES Fc1ccc(cc1)-c1[nH]c2ccccc2c1CC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C22H16BrFN2O/c23-18-6-2-4-8-20(18)25-21(27)13-17-16-5-1-3-7-19(16)26-22(17)14-9-11-15(24)12-10-14/h1-12,26H,13H2,(H,25,27)
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476n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045895
PNG
(2-[2-(3-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C22H25ClN2O/c1-3-12-25(13-4-2)21(26)15-19-18-10-5-6-11-20(18)24-22(19)16-8-7-9-17(23)14-16/h5-11,14,24H,3-4,12-13,15H2,1-2H3
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678n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045891
PNG
(2-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Show SMILES CCCN(CCC)C(=O)C(C)c1c([nH]c2ccccc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H27ClN2O/c1-4-14-26(15-5-2)23(27)16(3)21-19-8-6-7-9-20(19)25-22(21)17-10-12-18(24)13-11-17/h6-13,16,25H,4-5,14-15H2,1-3H3
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800n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045860
PNG
(CHEMBL327273 | N-Decyl-2-(2-phenyl-1H-indol-3-yl)-...)
Show SMILES CCCCCCCCCCNC(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C26H34N2O/c1-2-3-4-5-6-7-8-14-19-27-25(29)20-23-22-17-12-13-18-24(22)28-26(23)21-15-10-9-11-16-21/h9-13,15-18,28H,2-8,14,19-20H2,1H3,(H,27,29)
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>1.00E+3n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045872
PNG
(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N,N-dihexyl-...)
Show SMILES CCCCCCN(CCCCCC)C(=S)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H37FN2S/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045893
PNG
(CHEMBL98636 | N,N-Dioctyl-2-(2-phenyl-1H-indol-3-y...)
Show SMILES CCCCCCCCN(CCCCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C32H46N2O/c1-3-5-7-9-11-18-24-34(25-19-12-10-8-6-4-2)31(35)26-29-28-22-16-17-23-30(28)33-32(29)27-20-14-13-15-21-27/h13-17,20-23,33H,3-12,18-19,24-26H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL


Assay Description
Binding affinity against mitochondrial DBI complex (peripheral benzodiazepine receptor) using primary cultures of glial cells


J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM189867
PNG
(US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-...)
Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O |r|
Show InChI InChI=1/C27H23N5O3S/c1-16-11-19(14-20(12-16)29-26-30-23-6-2-3-10-32(23)31-26)22-15-28-25(36-22)27(35)9-4-5-17-13-18(24(33)34)7-8-21(17)27/h2-3,6-8,10-15,35H,4-5,9H2,1H3,(H,29,31)(H,33,34)/t27-/s2
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US Patent
n/an/a 0.129n/an/an/an/a7.525



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)


BindingDB Entry DOI: 10.7270/Q2D798MJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127994
PNG
(US8796310, 22A)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C29H26F3N5O4S2/c1-16-11-22(35-25(12-16)36-24-14-19(8-10-33-24)29(30,31)32)23-15-34-27(42-23)28(39)9-2-3-17-13-18(4-7-21(17)28)26(38)37-43(40,41)20-5-6-20/h4,7-8,10-15,20,39H,2-3,5-6,9H2,1H3,(H,37,38)(H,33,35,36)/t28-/m1/s1
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US Patent
n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127989
PNG
(US8796310, 19)
Show SMILES COc1c2CCCC(O)(c3ncc(s3)-c3cc(C)cc(Nc4cc(ccn4)C(F)(F)F)n3)c2ccc1C(O)=O
Show InChI InChI=1S/C27H23F3N4O4S/c1-14-10-19(33-22(11-14)34-21-12-15(7-9-31-21)27(28,29)30)20-13-32-25(39-20)26(37)8-3-4-16-18(26)6-5-17(24(35)36)23(16)38-2/h5-7,9-13,37H,3-4,8H2,1-2H3,(H,35,36)(H,31,33,34)
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US Patent
n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127993
PNG
(US8796310, 22)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C27H24F3N5O4S2/c1-15-10-20(33-23(11-15)34-22-13-18(7-9-31-22)27(28,29)30)21-14-32-25(40-21)26(37)8-3-4-16-12-17(5-6-19(16)26)24(36)35-41(2,38)39/h5-7,9-14,37H,3-4,8H2,1-2H3,(H,35,36)(H,31,33,34)/t26-/m1/s1
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US Patent
n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127988
PNG
(US8796310, 18)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCCc2c1ccc(C(O)=O)c2C#N
Show InChI InChI=1S/C27H20F3N5O3S/c1-14-9-20(34-23(10-14)35-22-11-15(6-8-32-22)27(28,29)30)21-13-33-25(39-21)26(38)7-2-3-16-18(12-31)17(24(36)37)4-5-19(16)26/h4-6,8-11,13,38H,2-3,7H2,1H3,(H,36,37)(H,32,34,35)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127986
PNG
(US8796310, 17)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCCc2c(Br)c(ccc12)C(O)=O
Show InChI InChI=1S/C26H20BrF3N4O3S/c1-13-9-18(33-21(10-13)34-20-11-14(6-8-31-20)26(28,29)30)19-12-32-24(38-19)25(37)7-2-3-15-17(25)5-4-16(22(15)27)23(35)36/h4-6,8-12,37H,2-3,7H2,1H3,(H,35,36)(H,31,33,34)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127984
PNG
(US8796310, 16B)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@]1(O)CCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C25H19F3N4O3S/c1-13-8-18(31-21(9-13)32-20-11-16(5-7-29-20)25(26,27)28)19-12-30-23(36-19)24(35)6-4-14-10-15(22(33)34)2-3-17(14)24/h2-3,5,7-12,35H,4,6H2,1H3,(H,33,34)(H,29,31,32)/t24-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127975
PNG
(US8796310, 15B | US8796310, 15J)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@]1(O)CCc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C25H19F3N4O3S/c1-13-8-18(31-21(9-13)32-20-11-16(5-7-29-20)25(26,27)28)19-12-30-23(36-19)24(35)6-4-14-2-3-15(22(33)34)10-17(14)24/h2-3,5,7-12,35H,4,6H2,1H3,(H,33,34)(H,29,31,32)/t24-/m0/s1
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US Patent
n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127981
PNG
(US8796310, 15H)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@]1(O)CCCCc2c(cccc12)C(O)=O
Show InChI InChI=1S/C27H23F3N4O3S/c1-15-11-20(33-23(12-15)34-22-13-16(8-10-31-22)27(28,29)30)21-14-32-25(38-21)26(37)9-3-2-5-17-18(24(35)36)6-4-7-19(17)26/h4,6-8,10-14,37H,2-3,5,9H2,1H3,(H,35,36)(H,31,33,34)/t26-/m0/s1
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127980
PNG
(US8796310, 15G)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CCCCc2c(cccc12)C(O)=O
Show InChI InChI=1S/C27H23F3N4O3S/c1-15-11-20(33-23(12-15)34-22-13-16(8-10-31-22)27(28,29)30)21-14-32-25(38-21)26(37)9-3-2-5-17-18(24(35)36)6-4-7-19(17)26/h4,6-8,10-14,37H,2-3,5,9H2,1H3,(H,35,36)(H,31,33,34)/t26-/m1/s1
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
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