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Compile Data Set for Download or QSAR

Found 88 hits with Last Name = 'sakowicz' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
kinesin spindle protein


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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1.70n/an/an/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220180
PNG
(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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3.5n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220182
PNG
(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)18-21(17,19)20/h1-8,18H,(H2,17,19,20)
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6.20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (A356T)


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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66n/an/an/an/an/an/a6.8n/a



GlaxoSmithKline





Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (A356T)


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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109n/an/an/an/an/an/a6.8n/a



GlaxoSmithKline





Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220169
PNG
(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c1-21(19,20)18-13-8-4-11(5-9-13)10-2-6-12(7-3-10)14(15,16)17/h2-9,18H,1H3
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120n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.180n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.200n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.230n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.300n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.310n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.350n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 0.450n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM50220156
PNG
((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H32ClFN4O2/c1-19(2)27(35(15-7-14-33)29(37)22-11-10-20(3)25(32)16-22)28-34-26-17-23(31)12-13-24(26)30(38)36(28)18-21-8-5-4-6-9-21/h4-6,8-13,16-17,19,27H,7,14-15,18,33H2,1-3H3/t27-/m1/s1
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n/an/a 0.460n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 0.590n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM50220156
PNG
((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H32ClFN4O2/c1-19(2)27(35(15-7-14-33)29(37)22-11-10-20(3)25(32)16-22)28-34-26-17-23(31)12-13-24(26)30(38)36(28)18-21-8-5-4-6-9-21/h4-6,8-13,16-17,19,27H,7,14-15,18,33H2,1-3H3/t27-/m1/s1
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n/an/a 0.720n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 0.830n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM50220156
PNG
((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H32ClFN4O2/c1-19(2)27(35(15-7-14-33)29(37)22-11-10-20(3)25(32)16-22)28-34-26-17-23(31)12-13-24(26)30(38)36(28)18-21-8-5-4-6-9-21/h4-6,8-13,16-17,19,27H,7,14-15,18,33H2,1-3H3/t27-/m1/s1
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n/an/a 1n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 3.30n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220180
PNG
(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 6.90n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36351
PNG
(CID148124 | Docetaxel)
Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39|
Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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n/an/a 8.70n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220195
PNG
(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NC(=S)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2S/c15-14(16,17)11-5-1-9(2-6-11)10-3-7-12(8-4-10)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 11n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220159
PNG
(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-12-7-9(3-6-11(12)13(15,16)17)8-1-4-10(5-2-8)19-22(18,20)21/h1-7,19H,(H2,18,20,21)
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n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220185
PNG
(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)
Show SMILES NC(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F4N2O/c15-11-7-9(3-6-12(11)20-13(19)21)8-1-4-10(5-2-8)14(16,17)18/h1-7H,(H3,19,20,21)
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n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220182
PNG
(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)18-21(17,19)20/h1-8,18H,(H2,17,19,20)
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n/an/a 18n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM50220156
PNG
((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H32ClFN4O2/c1-19(2)27(35(15-7-14-33)29(37)22-11-10-20(3)25(32)16-22)28-34-26-17-23(31)12-13-24(26)30(38)36(28)18-21-8-5-4-6-9-21/h4-6,8-13,16-17,19,27H,7,14-15,18,33H2,1-3H3/t27-/m1/s1
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n/an/a 22n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220201
PNG
(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)
Show SMILES Nc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H12F3N3O2S/c14-13(15,16)10-4-1-8(2-5-10)9-3-6-12(11(17)7-9)19-22(18,20)21/h1-7,19H,17H2,(H2,18,20,21)
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n/an/a 24n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220155
PNG
(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(c1)[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C13H10F3N3O4S/c14-13(15,16)11-6-3-9(7-12(11)19(20)21)8-1-4-10(5-2-8)18-24(17,22)23/h1-7,18H,(H2,17,22,23)
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n/an/a 28n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220176
PNG
(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OC(F)(F)Oc2c1
Show InChI InChI=1S/C13H10F2N2O4S/c14-13(15)20-11-6-3-9(7-12(11)21-13)8-1-4-10(5-2-8)17-22(16,18)19/h1-7,17H,(H2,16,18,19)
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n/an/a 31n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 36n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 36n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220162
PNG
(CHEMBL243883 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O/c15-14(16,17)11-5-1-9(2-6-11)10-3-7-12(8-4-10)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 39n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220188
PNG
(CHEMBL244126 | N-(4'-t-butyl-4-biphenylyl)urea)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C17H20N2O/c1-17(2,3)14-8-4-12(5-9-14)13-6-10-15(11-7-13)19-16(18)20/h4-11H,1-3H3,(H3,18,19,20)
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n/an/a 54n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220192
PNG
(CHEMBL397249 | N-(4'-isopropyl-4-biphenylyl)urea)
Show SMILES CC(C)c1ccc(cc1)-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C16H18N2O/c1-11(2)12-3-5-13(6-4-12)14-7-9-15(10-8-14)18-16(17)19/h3-11H,1-2H3,(H3,17,18,19)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220177
PNG
(CHEMBL389588 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O3S/c15-14(16,17)23(21,22)12-7-3-10(4-8-12)9-1-5-11(6-2-9)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 58n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220172
PNG
(4'-(trifluoromethyl)-4-biphenylyl sulfamate | CHEM...)
Show SMILES NS(=O)(=O)Oc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F3NO3S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)20-21(17,18)19/h1-8H,(H2,17,18,19)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220209
PNG
(CHEMBL242780 | N-[3-(methoxy)-4'-(trifluoromethyl)...)
Show SMILES COc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O3S/c1-22-13-8-10(4-7-12(13)19-23(18,20)21)9-2-5-11(6-3-9)14(15,16)17/h2-8,19H,1H3,(H2,18,20,21)
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n/an/a 66n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220170
PNG
(CHEMBL243649 | N-[3-Chloro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1Cl)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10ClF3N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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n/an/a 67n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220181
PNG
(CHEMBL397673 | N-[4-(2,2,3,3-tetrafluoro-2,3-dihyd...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc2OC(F)(F)C(F)(F)Oc2c1
Show InChI InChI=1S/C14H10F4N2O4S/c15-13(16)14(17,18)24-12-7-9(3-6-11(12)23-13)8-1-4-10(5-2-8)20-25(19,21)22/h1-7,20H,(H2,19,21,22)
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n/an/a 67n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein Mutant (D130V)


(Homo sapiens (Human))
BDBM50220156
PNG
((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H32ClFN4O2/c1-19(2)27(35(15-7-14-33)29(37)22-11-10-20(3)25(32)16-22)28-34-26-17-23(31)12-13-24(26)30(38)36(28)18-21-8-5-4-6-9-21/h4-6,8-13,16-17,19,27H,7,14-15,18,33H2,1-3H3/t27-/m1/s1
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n/an/a 87.3n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for ispinesib-resistant DCT116-D130V cell


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220174
PNG
(1-[4'-(trifluoromethyl)-4-biphenylyl]methanesulfon...)
Show SMILES NS(=O)(=O)Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c15-14(16,17)13-7-5-12(6-8-13)11-3-1-10(2-4-11)9-21(18,19)20/h1-8H,9H2,(H2,18,19,20)
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n/an/a 118n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220197
PNG
(CHEMBL242357 | N-[3-methyl-4'-(trifluoromethyl)-4-...)
Show SMILES Cc1cc(ccc1NS(N)(=O)=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O2S/c1-9-8-11(4-7-13(9)19-22(18,20)21)10-2-5-12(6-3-10)14(15,16)17/h2-8,19H,1H3,(H2,18,20,21)
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n/an/a 141n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220169
PNG
(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO2S/c1-21(19,20)18-13-8-4-11(5-9-13)10-2-6-12(7-3-10)14(15,16)17/h2-9,18H,1H3
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n/an/a 161n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens (Human))
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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n/an/a 162n/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Nat Chem Biol 3: 722-6 (2007)


Article DOI: 10.1038/nchembio.2007.34
BindingDB Entry DOI: 10.7270/Q2PK0DHC
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220157
PNG
(CHEMBL395487 | N-[3'-amino-4'-(trifluoromethyl)-4-...)
Show SMILES Nc1cc(ccc1C(F)(F)F)-c1ccc(NS(N)(=O)=O)cc1
Show InChI InChI=1S/C13H12F3N3O2S/c14-13(15,16)11-6-3-9(7-12(11)17)8-1-4-10(5-2-8)19-22(18,20)21/h1-7,19H,17H2,(H2,18,20,21)
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n/an/a 167n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220179
PNG
(CHEMBL243906 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO4S2/c1-23(19,20)18-12-6-2-10(3-7-12)11-4-8-13(9-5-11)24(21,22)14(15,16)17/h2-9,18H,1H3
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n/an/a 176n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220189
PNG
(CHEMBL243681 | N-[3-cyano-4'-(trifluoromethyl)-4-b...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1C#N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F3N3O2S/c15-14(16,17)12-4-1-9(2-5-12)10-3-6-13(11(7-10)8-18)20-23(19,21)22/h1-7,20H,(H2,19,21,22)
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n/an/a 196n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220203
PNG
(CHEMBL244511 | N-{4'-[(trifluoromethyl)thio]-4-bip...)
Show SMILES NC(=O)Nc1ccc(cc1)-c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C14H11F3N2OS/c15-14(16,17)21-12-7-3-10(4-8-12)9-1-5-11(6-2-9)19-13(18)20/h1-8H,(H3,18,19,20)
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n/an/a 240n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50220178
PNG
(CHEMBL244510 | N-(4'-bromo-3,3'-difluoro-4-bipheny...)
Show SMILES NC(=O)Nc1ccc(cc1F)-c1ccc(Br)c(F)c1
Show InChI InChI=1S/C13H9BrF2N2O/c14-9-3-1-7(5-10(9)15)8-2-4-12(11(16)6-8)18-13(17)19/h1-6H,(H3,17,18,19)
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n/an/a 262n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


J Med Chem 50: 4939-52 (2007)


Article DOI: 10.1021/jm070435y
BindingDB Entry DOI: 10.7270/Q29023H4
More data for this
Ligand-Target Pair
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