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Compile Data Set for Download or QSAR

Found 470 hits with Last Name = 'salter-cid' and Initial = 'lm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239718
PNG
(CHEMBL4064666 | US10214537, Example 639)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C#N)-c1cc(c2c(N)ncnn12)C(F)(F)F
PDB
MMDB

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UniChem
Article
PubMed
n/an/a<0.100n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267827
PNG
(CHEMBL4076794)
PDB

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n/an/a 0.400n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267796
PNG
(CHEMBL4098840)
PDB

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n/an/a 0.400n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267826
PNG
(CHEMBL4096145)
PDB

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n/an/a 0.400n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50232433
PNG
(CHEMBL4068514 | US10214537, Example 619)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
PDB
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n/an/a 0.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267806
PNG
(CHEMBL4071255)
PDB

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n/an/a 0.5n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267804
PNG
(CHEMBL4070136)
PDB

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n/an/a 0.5n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267852
PNG
(CHEMBL4073562)
PDB

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n/an/a 0.600n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267828
PNG
(CHEMBL4078773)
PDB

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n/an/a 0.600n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM141473
PNG
(US8921368, 192)
Show SMILES C[C@]1(N)CC[C@@H](Nc2c(cnn3cc(cc23)-c2cccnc2)C(N)=O)C1(C)C |r|
Show InChI InChI=1/C21H26N6O/c1-20(2)17(6-7-21(20,3)23)26-18-15(19(22)28)11-25-27-12-14(9-16(18)27)13-5-4-8-24-10-13/h4-5,8-12,17,26H,6-7,23H2,1-3H3,(H2,22,28)/t17-,21+/s2
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n/an/a 0.600n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267852
PNG
(CHEMBL4073562)
PDB

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n/an/a 0.600n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267807
PNG
(CHEMBL4060536)
PDB

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n/an/a 0.700n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM141473
PNG
(US8921368, 192)
Show SMILES C[C@]1(N)CC[C@@H](Nc2c(cnn3cc(cc23)-c2cccnc2)C(N)=O)C1(C)C |r|
Show InChI InChI=1/C21H26N6O/c1-20(2)17(6-7-21(20,3)23)26-18-15(19(22)28)11-25-27-12-14(9-16(18)27)13-5-4-8-24-10-13/h4-5,8-12,17,26H,6-7,23H2,1-3H3,(H2,22,28)/t17-,21+/s2
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n/an/a 0.700n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267810
PNG
(CHEMBL4068856)
PDB

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n/an/a 0.700n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50168472
PNG
(CHEMBL3805348 | US9765060, Compound X)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C21H16ClN7O/c1-12(27-19-17-18(24-10-23-17)25-11-26-19)20-28-15-9-5-8-14(22)16(15)21(30)29(20)13-6-3-2-4-7-13/h2-12H,1H3,(H2,23,24,25,26,27)/t12-/s2
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n/an/a 0.800n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267807
PNG
(CHEMBL4060536)
PDB

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n/an/a 0.800n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267836
PNG
(CHEMBL4105015)
PDB

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n/an/a 0.800n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267840
PNG
(CHEMBL4062062)
PDB

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n/an/a 0.800n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267808
PNG
(CHEMBL4087655)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267797
PNG
(CHEMBL4080797)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267826
PNG
(CHEMBL4096145)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267848
PNG
(CHEMBL4091582)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267840
PNG
(CHEMBL4062062)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267837
PNG
(CHEMBL4060444)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267808
PNG
(CHEMBL4087655)
PDB

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n/an/a 0.900n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267827
PNG
(CHEMBL4076794)
PDB

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n/an/a 1n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267848
PNG
(CHEMBL4091582)
PDB

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n/an/a 1n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239736
PNG
(CHEMBL4074315 | US10214537, Example 637)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C#N)-c1cc(Cl)c2c(N)ncnn12
PDB
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50261794
PNG
(CHEMBL4065693)
PDB

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n/an/a<1n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267839
PNG
(CHEMBL4076823)
PDB

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n/an/a 1n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50035810
PNG
(CHEMBL3359927)
Show SMILES C[C@]1(F)CCC[C@H]1Nc1c(cnn2cccc12)C(N)=O |r|
Show InChI InChI=1/C14H17FN4O/c1-14(15)6-2-5-11(14)18-12-9(13(16)20)8-17-19-7-3-4-10(12)19/h3-4,7-8,11,18H,2,5-6H2,1H3,(H2,16,20)/t11-,14+/s2
PDB

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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) by filter assay


Bioorg Med Chem Lett 24: 5721-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.061
BindingDB Entry DOI: 10.7270/Q2D79D1K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267805
PNG
(CHEMBL4096795)
PDB

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Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239744
PNG
(CHEMBL4071965 | US10214537, Example 643)
Show SMILES C[C@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cc(ccc1C#N)-c1cc(c2c(N)ncnn12)C(F)(F)F |r|
PDB
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239752
PNG
(CHEMBL4067315 | US10214537, Example 585)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C)-c1cc(Cl)c2c(N)ncnn12
PDB
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267798
PNG
(CHEMBL4091096)
PDB

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Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267835
PNG
(CHEMBL4077508)
PDB

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n/an/a 1.20n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267830
PNG
(CHEMBL4071806)
PDB

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n/an/a 1.20n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267804
PNG
(CHEMBL4070136)
PDB

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n/an/a 1.20n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267829
PNG
(CHEMBL4076191)
PDB

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n/an/a 1.20n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267806
PNG
(CHEMBL4071255)
PDB

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n/an/a 1.30n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267836
PNG
(CHEMBL4105015)
PDB

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n/an/a 1.30n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50261773
PNG
(CHEMBL4092337)
PDB

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n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM141474
PNG
(US8921368, 195)
Show SMILES Cc1ccncc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(cnn2c1)C(N)=O |r|
Show InChI InChI=1/C22H28N6O/c1-13-6-8-25-10-15(13)14-9-17-19(16(20(23)29)11-26-28(17)12-14)27-18-5-7-22(4,24)21(18,2)3/h6,8-12,18,27H,5,7,24H2,1-4H3,(H2,23,29)/t18-,22+/s2
PDB

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n/an/a 1.30n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239741
PNG
(CHEMBL4095752)
Show SMILES C[C@@H]1CN(C(C)=O)C(C)(C)C(=O)N1c1cc(ccc1C#N)-c1cc(Cl)c2c(N)ncnn12 |r|
PDB
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n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50267839
PNG
(CHEMBL4076823)
PDB

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n/an/a 1.30n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239746
PNG
(CHEMBL4094693)
Show SMILES CC(C)c1cc(on1)-c1cc(-c2cccc(c2)N2CCN(C(C)=O)C(C)(C)C2=O)n2ncnc(N)c12
PDB
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239723
PNG
(CHEMBL4074193 | US10214537, Example 478)
Show SMILES CC(C)c1nnc(o1)-c1cc(-c2cccc(c2)N2CCN(C(C)=O)C(C)(C)C2=O)n2ncnc(N)c12
PDB
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50239734
PNG
(CHEMBL4097222 | US10214537, Example 628)
Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1Cl)-c1cc(Cl)c2c(N)ncnn12
PDB
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n/an/a 1.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 60: 5193-5208 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00618
BindingDB Entry DOI: 10.7270/Q2WW7KVJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267829
PNG
(CHEMBL4076191)
PDB

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n/an/a 1.5n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50267828
PNG
(CHEMBL4078773)
PDB

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n/an/a 1.5n/an/an/an/an/an/a



Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.

Curated by ChEMBL




Bioorg Med Chem Lett 27: 3101-3106 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.043
More data for this
Ligand-Target Pair
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