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Compile Data Set for Download or QSAR

Found 49 hits with Last Name = 'salvesen' and Initial = 'gs'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin B


(Rattus norvegicus)
BDBM36331
PNG
(Ac-YFR-AMOK 10b)
Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c(-[#6])cccc1-[#6]
Show InChI InChI=1S/C36H44N6O7/c1-22-9-7-10-23(2)32(22)35(48)49-21-31(45)28(13-8-18-39-36(37)38)41-34(47)30(19-25-11-5-4-6-12-25)42-33(46)29(40-24(3)43)20-26-14-16-27(44)17-15-26/h4-7,9-12,14-17,28-30,44H,8,13,18-21H2,1-3H3,(H,40,43)(H,41,47)(H,42,46)(H4,37,38,39)/t28-,29-,30-/m0/s1
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n/an/a 7.30n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Cathepsin B


(Rattus norvegicus)
BDBM36328
PNG
(Z-FR-AMOK 9b)
Show SMILES [#6]-c1cccc(-[#6])c1-[#6](=O)-[#8]-[#6]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1
Show InChI InChI=1S/C33H39N5O6/c1-22-11-9-12-23(2)29(22)31(41)43-21-28(39)26(17-10-18-36-32(34)35)37-30(40)27(19-24-13-5-3-6-14-24)38-33(42)44-20-25-15-7-4-8-16-25/h3-9,11-16,26-27H,10,17-21H2,1-2H3,(H,37,40)(H,38,42)(H4,34,35,36)/t26-,27-/m0/s1
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n/an/a 15n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Legumain


(Homo sapiens (Human))
BDBM50143613
PNG
((E)-3-{(S)-N'-[(S)-2-((S)-2-Benzyloxycarbonylamino...)
Show SMILES CCOC(=O)\C=C\OC(=O)N(CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C22H29N5O9/c1-4-34-18(29)10-11-35-22(33)27(12-17(23)28)26-20(31)15(3)24-19(30)14(2)25-21(32)36-13-16-8-6-5-7-9-16/h5-11,14-15H,4,12-13H2,1-3H3,(H2,23,28)(H,24,30)(H,25,32)(H,26,31)/b11-10+/t14-,15-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated for Irreversible Inhibition of S. mansoni Legumain


J Med Chem 47: 1889-92 (2004)


Article DOI: 10.1021/jm049938j
BindingDB Entry DOI: 10.7270/Q2BZ65G0
More data for this
Ligand-Target Pair
Legumain


(Homo sapiens (Human))
BDBM50143614
PNG
((E)-3-{(S)-N'-[(S)-2-((S)-2-Benzyloxycarbonylamino...)
Show SMILES C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O\C=C\C(=O)OCc1ccccc1
Show InChI InChI=1S/C27H31N5O9/c1-18(30-26(37)41-17-21-11-7-4-8-12-21)24(35)29-19(2)25(36)31-32(15-22(28)33)27(38)39-14-13-23(34)40-16-20-9-5-3-6-10-20/h3-14,18-19H,15-17H2,1-2H3,(H2,28,33)(H,29,35)(H,30,37)(H,31,36)/b14-13+/t18-,19-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated for Irreversible Inhibition of S. mansoni Legumain


J Med Chem 47: 1889-92 (2004)


Article DOI: 10.1021/jm049938j
BindingDB Entry DOI: 10.7270/Q2BZ65G0
More data for this
Ligand-Target Pair
Legumain


(Homo sapiens (Human))
BDBM50143612
PNG
((S)-N'-[(S)-2-((S)-2-Benzyloxycarbonylamino-propio...)
Show SMILES C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O\C=C\C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C28H34N6O8/c1-19(31-27(39)42-18-22-12-8-5-9-13-22)25(37)30-20(2)26(38)32-34(17-23(29)35)28(40)41-15-14-24(36)33(3)16-21-10-6-4-7-11-21/h4-15,19-20H,16-18H2,1-3H3,(H2,29,35)(H,30,37)(H,31,39)(H,32,38)/b15-14+/t19-,20-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated for Irreversible Inhibition of S. mansoni Legumain


J Med Chem 47: 1889-92 (2004)


Article DOI: 10.1021/jm049938j
BindingDB Entry DOI: 10.7270/Q2BZ65G0
More data for this
Ligand-Target Pair
Cathepsin B


(Rattus norvegicus)
BDBM36327
PNG
(Z-FG-AOMK 9a)
Show SMILES Cc1cccc(C)c1C(=O)OCC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C29H30N2O6/c1-20-10-9-11-21(2)26(20)28(34)36-19-24(32)17-30-27(33)25(16-22-12-5-3-6-13-22)31-29(35)37-18-23-14-7-4-8-15-23/h3-15,25H,16-19H2,1-2H3,(H,30,33)(H,31,35)
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n/an/a 120n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Cathepsin B


(Rattus norvegicus)
BDBM36330
PNG
(AC-YFG-AMOK 10a)
Show SMILES CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C32H35N3O7/c1-20-8-7-9-21(2)29(20)32(41)42-19-26(38)18-33-30(39)27(16-23-10-5-4-6-11-23)35-31(40)28(34-22(3)36)17-24-12-14-25(37)15-13-24/h4-15,27-28,37H,16-19H2,1-3H3,(H,33,39)(H,34,36)(H,35,40)/t27-,28-/m0/s1
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n/an/a 220n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81515
PNG
(VEA-499)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C37H38N6O12/c1-20(44)34(42-35(50)27(11-13-30(38)47)41-31(48)15-21-10-12-29(46)28(14-21)43(53)54)36(51)40-18-32(49)39-17-24(45)19-55-37(52)33-25-8-4-2-6-22(25)16-23-7-3-5-9-26(23)33/h2-10,12,14,16,20,27,34,44,46H,11,13,15,17-19H2,1H3,(H2,38,47)(H,39,49)(H,40,51)(H,41,48)(H,42,50)/t20-,27-,34?/m0/s1
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n/an/a 250n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81516
PNG
(VEA-500)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C42H46N8O14/c1-22(51)38(41(60)46-20-36(57)45-19-26(52)21-64-42(61)37-27-8-4-2-6-24(27)18-25-7-3-5-9-28(25)37)49-40(59)30(12-15-34(44)55)48-39(58)29(11-14-33(43)54)47-35(56)17-23-10-13-32(53)31(16-23)50(62)63/h2-10,13,16,18,22,29-30,38,51,53H,11-12,14-15,17,19-21H2,1H3,(H2,43,54)(H2,44,55)(H,45,57)(H,46,60)(H,47,56)(H,48,58)(H,49,59)/t22-,29-,30-,38?/m0/s1
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n/an/a 860n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Cathepsin B


(Rattus norvegicus)
BDBM36329
PNG
(Z-LG-AOMK 9c)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C26H32N2O6/c1-17(2)13-22(28-26(32)34-15-20-11-6-5-7-12-20)24(30)27-14-21(29)16-33-25(31)23-18(3)9-8-10-19(23)4/h5-12,17,22H,13-16H2,1-4H3,(H,27,30)(H,28,32)/t22-/m0/s1
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n/an/a 920n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Legumain


(Homo sapiens (Human))
BDBM50292159
PNG
((S)-N'-[(S)-2-((S)-2-Benzyloxycarbonylamino-propio...)
Show SMILES C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O\C=C\C(=O)NCc1ccccc1
Show InChI InChI=1S/C27H32N6O8/c1-18(31-26(38)41-17-21-11-7-4-8-12-21)24(36)30-19(2)25(37)32-33(16-22(28)34)27(39)40-14-13-23(35)29-15-20-9-5-3-6-10-20/h3-14,18-19H,15-17H2,1-2H3,(H2,28,34)(H,29,35)(H,30,36)(H,31,38)(H,32,37)/b14-13+/t18-,19-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated for irreversible inhibition of S. mansoni Legumain


J Med Chem 47: 1889-92 (2004)


Article DOI: 10.1021/jm049938j
BindingDB Entry DOI: 10.7270/Q2BZ65G0
More data for this
Ligand-Target Pair
Cathepsin B


(Rattus norvegicus)
BDBM36325
PNG
(Cathepsin Inhibitor III)
Show SMILES COc1ccc(cc1)C(=O)ONC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H27N3O7/c1-35-22-14-12-21(13-15-22)26(33)37-30-24(31)17-28-25(32)23(16-19-8-4-2-5-9-19)29-27(34)36-18-20-10-6-3-7-11-20/h2-15,23H,16-18H2,1H3,(H,28,32)(H,29,34)(H,30,31)
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n/an/a 1.20E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Cathepsin Z


(Rattus norvegicus)
BDBM36325
PNG
(Cathepsin Inhibitor III)
Show SMILES COc1ccc(cc1)C(=O)ONC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H27N3O7/c1-35-22-14-12-21(13-15-22)26(33)37-30-24(31)17-28-25(32)23(16-19-8-4-2-5-9-19)29-27(34)36-18-20-10-6-3-7-11-20/h2-15,23H,16-18H2,1H3,(H,28,32)(H,29,34)(H,30,31)
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n/an/a 1.50E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81515
PNG
(VEA-499)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C37H38N6O12/c1-20(44)34(42-35(50)27(11-13-30(38)47)41-31(48)15-21-10-12-29(46)28(14-21)43(53)54)36(51)40-18-32(49)39-17-24(45)19-55-37(52)33-25-8-4-2-6-22(25)16-23-7-3-5-9-26(23)33/h2-10,12,14,16,20,27,34,44,46H,11,13,15,17-19H2,1H3,(H2,38,47)(H,39,49)(H,40,51)(H,41,48)(H,42,50)/t20-,27-,34?/m0/s1
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n/an/a 3.60E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81511
PNG
(VEA-260)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C42H34N4O7/c47-38(30-12-7-13-31(22-30)42(51)52)43-23-26-18-20-29(21-19-26)39(48)44-45-40(49)36-37(53-36)41(50)46(24-32-14-5-10-27-8-1-3-16-34(27)32)25-33-15-6-11-28-9-2-4-17-35(28)33/h1-22,36-37H,23-25H2,(H,43,47)(H,44,48)(H,45,49)(H,51,52)/t36-,37-/m0/s1
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n/an/a 3.70E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81517
PNG
(VEA-561)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])c(c1)N(=O)=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C40H46N8O10/c1-23(2)16-31(46-34(51)18-24-13-14-33(50)32(17-24)48(56)57)38(54)47-30(12-7-15-43-40(41)42)37(53)45-21-35(52)44-20-27(49)22-58-39(55)36-28-10-5-3-8-25(28)19-26-9-4-6-11-29(26)36/h3-6,8-11,13-14,17,19,23,30-31,50H,7,12,15-16,18,20-22H2,1-2H3,(H,44,52)(H,45,53)(H,46,51)(H,47,54)(H4,41,42,43)/t30-,31-/m0/s1
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n/an/a 4.20E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81517
PNG
(VEA-561)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])c(c1)N(=O)=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C40H46N8O10/c1-23(2)16-31(46-34(51)18-24-13-14-33(50)32(17-24)48(56)57)38(54)47-30(12-7-15-43-40(41)42)37(53)45-21-35(52)44-20-27(49)22-58-39(55)36-28-10-5-3-8-25(28)19-26-9-4-6-11-29(26)36/h3-6,8-11,13-14,17,19,23,30-31,50H,7,12,15-16,18,20-22H2,1-2H3,(H,44,52)(H,45,53)(H,46,51)(H,47,54)(H4,41,42,43)/t30-,31-/m0/s1
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n/an/a 4.30E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Cathepsin Z


(Rattus norvegicus)
BDBM36331
PNG
(Ac-YFR-AMOK 10b)
Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c(-[#6])cccc1-[#6]
Show InChI InChI=1S/C36H44N6O7/c1-22-9-7-10-23(2)32(22)35(48)49-21-31(45)28(13-8-18-39-36(37)38)41-34(47)30(19-25-11-5-4-6-12-25)42-33(46)29(40-24(3)43)20-26-14-16-27(44)17-15-26/h4-7,9-12,14-17,28-30,44H,8,13,18-21H2,1-3H3,(H,40,43)(H,41,47)(H,42,46)(H4,37,38,39)/t28-,29-,30-/m0/s1
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n/an/a 4.70E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81517
PNG
(VEA-561)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])c(c1)N(=O)=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C40H46N8O10/c1-23(2)16-31(46-34(51)18-24-13-14-33(50)32(17-24)48(56)57)38(54)47-30(12-7-15-43-40(41)42)37(53)45-21-35(52)44-20-27(49)22-58-39(55)36-28-10-5-3-8-25(28)19-26-9-4-6-11-29(26)36/h3-6,8-11,13-14,17,19,23,30-31,50H,7,12,15-16,18,20-22H2,1-2H3,(H,44,52)(H,45,53)(H,46,51)(H,47,54)(H4,41,42,43)/t30-,31-/m0/s1
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n/an/a 5.70E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36325
PNG
(Cathepsin Inhibitor III)
Show SMILES COc1ccc(cc1)C(=O)ONC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H27N3O7/c1-35-22-14-12-21(13-15-22)26(33)37-30-24(31)17-28-25(32)23(16-19-8-4-2-5-9-19)29-27(34)36-18-20-10-6-3-7-11-20/h2-15,23H,16-18H2,1H3,(H,28,32)(H,29,34)(H,30,31)
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n/an/a 6.60E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81510
PNG
(JCP-666)
Show SMILES OC(=O)CN(NC(=O)c1ccc(CNC(=O)c2cccc(c2)C(O)=O)cc1)C(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C44H36N4O9/c49-37(50)26-48(46-41(52)30-20-18-27(19-21-30)23-45-40(51)31-12-7-13-32(22-31)44(55)56)43(54)39-38(57-39)42(53)47(24-33-14-5-10-28-8-1-3-16-35(28)33)25-34-15-6-11-29-9-2-4-17-36(29)34/h1-22,38-39H,23-26H2,(H,45,51)(H,46,52)(H,49,50)(H,55,56)/t38-,39-/m0/s1
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n/an/a 7.00E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81511
PNG
(VEA-260)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C42H34N4O7/c47-38(30-12-7-13-31(22-30)42(51)52)43-23-26-18-20-29(21-19-26)39(48)44-45-40(49)36-37(53-36)41(50)46(24-32-14-5-10-27-8-1-3-16-34(27)32)25-33-15-6-11-28-9-2-4-17-35(28)33/h1-22,36-37H,23-25H2,(H,43,47)(H,44,48)(H,45,49)(H,51,52)/t36-,37-/m0/s1
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n/an/a 7.10E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36330
PNG
(AC-YFG-AMOK 10a)
Show SMILES CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C32H35N3O7/c1-20-8-7-9-21(2)29(20)32(41)42-19-26(38)18-33-30(39)27(16-23-10-5-4-6-11-23)35-31(40)28(34-22(3)36)17-24-12-14-25(37)15-13-24/h4-15,27-28,37H,16-19H2,1-3H3,(H,33,39)(H,34,36)(H,35,40)/t27-,28-/m0/s1
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n/an/a 7.90E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36329
PNG
(Z-LG-AOMK 9c)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C26H32N2O6/c1-17(2)13-22(28-26(32)34-15-20-11-6-5-7-12-20)24(30)27-14-21(29)16-33-25(31)23-18(3)9-8-10-19(23)4/h5-12,17,22H,13-16H2,1-4H3,(H,27,30)(H,28,32)/t22-/m0/s1
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n/an/a 7.90E+3n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81513
PNG
(VEA-422)
Show SMILES NC(=O)[C@H](CC(O)=O)NC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C38H33N5O8/c39-34(46)30(19-31(44)45)40-35(47)24-15-17-25(18-16-24)36(48)41-42-37(49)32-33(51-32)38(50)43(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,30,32-33H,19-21H2,(H2,39,46)(H,40,47)(H,41,48)(H,42,49)(H,44,45)/t30-,32-,33-/m0/s1
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n/an/a 1.04E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Cathepsin H


(Rattus norvegicus)
BDBM36331
PNG
(Ac-YFR-AMOK 10b)
Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c(-[#6])cccc1-[#6]
Show InChI InChI=1S/C36H44N6O7/c1-22-9-7-10-23(2)32(22)35(48)49-21-31(45)28(13-8-18-39-36(37)38)41-34(47)30(19-25-11-5-4-6-12-25)42-33(46)29(40-24(3)43)20-26-14-16-27(44)17-15-26/h4-7,9-12,14-17,28-30,44H,8,13,18-21H2,1-3H3,(H,40,43)(H,41,47)(H,42,46)(H4,37,38,39)/t28-,29-,30-/m0/s1
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n/an/a 1.20E+4n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81512
PNG
(VEA-417)
Show SMILES NC(=O)CNC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C36H31N5O6/c37-30(42)19-38-33(43)24-15-17-25(18-16-24)34(44)39-40-35(45)31-32(47-31)36(46)41(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,31-32H,19-21H2,(H2,37,42)(H,38,43)(H,39,44)(H,40,45)/t31-,32-/m0/s1
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n/an/a 1.31E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 2 (SENP2)


(Homo sapiens (Human))
BDBM81514
PNG
(VEA-401)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C34H26N2O7/c37-27(20-43-34(42)30-28-10-3-1-6-23(28)16-24-7-2-4-11-29(24)30)19-36-31(38)22-14-12-21(13-15-22)18-35-32(39)25-8-5-9-26(17-25)33(40)41/h1-17H,18-20H2,(H,35,39)(H,36,38)(H,40,41)
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n/an/a 1.34E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81510
PNG
(JCP-666)
Show SMILES OC(=O)CN(NC(=O)c1ccc(CNC(=O)c2cccc(c2)C(O)=O)cc1)C(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C44H36N4O9/c49-37(50)26-48(46-41(52)30-20-18-27(19-21-30)23-45-40(51)31-12-7-13-32(22-31)44(55)56)43(54)39-38(57-39)42(53)47(24-33-14-5-10-28-8-1-3-16-35(28)33)25-34-15-6-11-29-9-2-4-17-36(29)34/h1-22,38-39H,23-26H2,(H,45,51)(H,46,52)(H,49,50)(H,55,56)/t38-,39-/m0/s1
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n/an/a 1.38E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81516
PNG
(VEA-500)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C42H46N8O14/c1-22(51)38(41(60)46-20-36(57)45-19-26(52)21-64-42(61)37-27-8-4-2-6-24(27)18-25-7-3-5-9-28(25)37)49-40(59)30(12-15-34(44)55)48-39(58)29(11-14-33(43)54)47-35(56)17-23-10-13-32(53)31(16-23)50(62)63/h2-10,13,16,18,22,29-30,38,51,53H,11-12,14-15,17,19-21H2,1H3,(H2,43,54)(H2,44,55)(H,45,57)(H,46,60)(H,47,56)(H,48,58)(H,49,59)/t22-,29-,30-,38?/m0/s1
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n/an/a>2.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81514
PNG
(VEA-401)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C34H26N2O7/c37-27(20-43-34(42)30-28-10-3-1-6-23(28)16-24-7-2-4-11-29(24)30)19-36-31(38)22-14-12-21(13-15-22)18-35-32(39)25-8-5-9-26(17-25)33(40)41/h1-17H,18-20H2,(H,35,39)(H,36,38)(H,40,41)
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Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81513
PNG
(VEA-422)
Show SMILES NC(=O)[C@H](CC(O)=O)NC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C38H33N5O8/c39-34(46)30(19-31(44)45)40-35(47)24-15-17-25(18-16-24)36(48)41-42-37(49)32-33(51-32)38(50)43(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,30,32-33H,19-21H2,(H2,39,46)(H,40,47)(H,41,48)(H,42,49)(H,44,45)/t30-,32-,33-/m0/s1
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n/an/a 2.24E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81514
PNG
(VEA-401)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C34H26N2O7/c37-27(20-43-34(42)30-28-10-3-1-6-23(28)16-24-7-2-4-11-29(24)30)19-36-31(38)22-14-12-21(13-15-22)18-35-32(39)25-8-5-9-26(17-25)33(40)41/h1-17H,18-20H2,(H,35,39)(H,36,38)(H,40,41)
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n/an/a 2.31E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81517
PNG
(VEA-561)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])c(c1)N(=O)=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C40H46N8O10/c1-23(2)16-31(46-34(51)18-24-13-14-33(50)32(17-24)48(56)57)38(54)47-30(12-7-15-43-40(41)42)37(53)45-21-35(52)44-20-27(49)22-58-39(55)36-28-10-5-3-8-25(28)19-26-9-4-6-11-29(26)36/h3-6,8-11,13-14,17,19,23,30-31,50H,7,12,15-16,18,20-22H2,1-2H3,(H,44,52)(H,45,53)(H,46,51)(H,47,54)(H4,41,42,43)/t30-,31-/m0/s1
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n/an/a>2.50E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 1 (SENP1)


(Homo sapiens (Human))
BDBM81512
PNG
(VEA-417)
Show SMILES NC(=O)CNC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C36H31N5O6/c37-30(42)19-38-33(43)24-15-17-25(18-16-24)34(44)39-40-35(45)31-32(47-31)36(46)41(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,31-32H,19-21H2,(H2,37,42)(H,38,43)(H,39,44)(H,40,45)/t31-,32-/m0/s1
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n/an/a 3.25E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81511
PNG
(VEA-260)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C42H34N4O7/c47-38(30-12-7-13-31(22-30)42(51)52)43-23-26-18-20-29(21-19-26)39(48)44-45-40(49)36-37(53-36)41(50)46(24-32-14-5-10-27-8-1-3-16-34(27)32)25-33-15-6-11-28-9-2-4-17-35(28)33/h1-22,36-37H,23-25H2,(H,43,47)(H,44,48)(H,45,49)(H,51,52)/t36-,37-/m0/s1
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n/an/a 3.65E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Cathepsin Z


(Rattus norvegicus)
BDBM36330
PNG
(AC-YFG-AMOK 10a)
Show SMILES CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)COC(=O)c1c(C)cccc1C
Show InChI InChI=1S/C32H35N3O7/c1-20-8-7-9-21(2)29(20)32(41)42-19-26(38)18-33-30(39)27(16-23-10-5-4-6-11-23)35-31(40)28(34-22(3)36)17-24-12-14-25(37)15-13-24/h4-15,27-28,37H,16-19H2,1-3H3,(H,33,39)(H,34,36)(H,35,40)/t27-,28-/m0/s1
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n/an/a 3.90E+4n/an/an/an/a5.537



Stanford University



Assay Description
Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H


Nat Chem Biol 1: 33-8 (2005)


Article DOI: 10.1038/nchembio707
BindingDB Entry DOI: 10.7270/Q22V2DGV
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81514
PNG
(VEA-401)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C34H26N2O7/c37-27(20-43-34(42)30-28-10-3-1-6-23(28)16-24-7-2-4-11-29(24)30)19-36-31(38)22-14-12-21(13-15-22)18-35-32(39)25-8-5-9-26(17-25)33(40)41/h1-17H,18-20H2,(H,35,39)(H,36,38)(H,40,41)
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n/an/a>4.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81516
PNG
(VEA-500)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C42H46N8O14/c1-22(51)38(41(60)46-20-36(57)45-19-26(52)21-64-42(61)37-27-8-4-2-6-24(27)18-25-7-3-5-9-28(25)37)49-40(59)30(12-15-34(44)55)48-39(58)29(11-14-33(43)54)47-35(56)17-23-10-13-32(53)31(16-23)50(62)63/h2-10,13,16,18,22,29-30,38,51,53H,11-12,14-15,17,19-21H2,1H3,(H2,43,54)(H2,44,55)(H,45,57)(H,46,60)(H,47,56)(H,48,58)(H,49,59)/t22-,29-,30-,38?/m0/s1
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n/an/a>4.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81515
PNG
(VEA-499)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C37H38N6O12/c1-20(44)34(42-35(50)27(11-13-30(38)47)41-31(48)15-21-10-12-29(46)28(14-21)43(53)54)36(51)40-18-32(49)39-17-24(45)19-55-37(52)33-25-8-4-2-6-22(25)16-23-7-3-5-9-26(23)33/h2-10,12,14,16,20,27,34,44,46H,11,13,15,17-19H2,1H3,(H2,38,47)(H,39,49)(H,40,51)(H,41,48)(H,42,50)/t20-,27-,34?/m0/s1
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n/an/a>6.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81510
PNG
(JCP-666)
Show SMILES OC(=O)CN(NC(=O)c1ccc(CNC(=O)c2cccc(c2)C(O)=O)cc1)C(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C44H36N4O9/c49-37(50)26-48(46-41(52)30-20-18-27(19-21-30)23-45-40(51)31-12-7-13-32(22-31)44(55)56)43(54)39-38(57-39)42(53)47(24-33-14-5-10-28-8-1-3-16-35(28)33)25-34-15-6-11-29-9-2-4-17-36(29)34/h1-22,38-39H,23-26H2,(H,45,51)(H,46,52)(H,49,50)(H,55,56)/t38-,39-/m0/s1
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n/an/a>7.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81513
PNG
(VEA-422)
Show SMILES NC(=O)[C@H](CC(O)=O)NC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C38H33N5O8/c39-34(46)30(19-31(44)45)40-35(47)24-15-17-25(18-16-24)36(48)41-42-37(49)32-33(51-32)38(50)43(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,30,32-33H,19-21H2,(H2,39,46)(H,40,47)(H,41,48)(H,42,49)(H,44,45)/t30-,32-,33-/m0/s1
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n/an/a>7.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81512
PNG
(VEA-417)
Show SMILES NC(=O)CNC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C36H31N5O6/c37-30(42)19-38-33(43)24-15-17-25(18-16-24)34(44)39-40-35(45)31-32(47-31)36(46)41(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,31-32H,19-21H2,(H2,37,42)(H,38,43)(H,39,44)(H,40,45)/t31-,32-/m0/s1
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Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81511
PNG
(VEA-260)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C42H34N4O7/c47-38(30-12-7-13-31(22-30)42(51)52)43-23-26-18-20-29(21-19-26)39(48)44-45-40(49)36-37(53-36)41(50)46(24-32-14-5-10-27-8-1-3-16-34(27)32)25-33-15-6-11-28-9-2-4-17-35(28)33/h1-22,36-37H,23-25H2,(H,43,47)(H,44,48)(H,45,49)(H,51,52)/t36-,37-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81510
PNG
(JCP-666)
Show SMILES OC(=O)CN(NC(=O)c1ccc(CNC(=O)c2cccc(c2)C(O)=O)cc1)C(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C44H36N4O9/c49-37(50)26-48(46-41(52)30-20-18-27(19-21-30)23-45-40(51)31-12-7-13-32(22-31)44(55)56)43(54)39-38(57-39)42(53)47(24-33-14-5-10-28-8-1-3-16-35(28)33)25-34-15-6-11-29-9-2-4-17-36(29)34/h1-22,38-39H,23-26H2,(H,45,51)(H,46,52)(H,49,50)(H,55,56)/t38-,39-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81512
PNG
(VEA-417)
Show SMILES NC(=O)CNC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C36H31N5O6/c37-30(42)19-38-33(43)24-15-17-25(18-16-24)34(44)39-40-35(45)31-32(47-31)36(46)41(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,31-32H,19-21H2,(H2,37,42)(H,38,43)(H,39,44)(H,40,45)/t31-,32-/m0/s1
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Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81515
PNG
(VEA-499)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C37H38N6O12/c1-20(44)34(42-35(50)27(11-13-30(38)47)41-31(48)15-21-10-12-29(46)28(14-21)43(53)54)36(51)40-18-32(49)39-17-24(45)19-55-37(52)33-25-8-4-2-6-22(25)16-23-7-3-5-9-26(23)33/h2-10,12,14,16,20,27,34,44,46H,11,13,15,17-19H2,1H3,(H2,38,47)(H,39,49)(H,40,51)(H,41,48)(H,42,50)/t20-,27-,34?/m0/s1
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MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7 (SENP7)


(Homo sapiens (Human))
BDBM81516
PNG
(VEA-500)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C42H46N8O14/c1-22(51)38(41(60)46-20-36(57)45-19-26(52)21-64-42(61)37-27-8-4-2-6-24(27)18-25-7-3-5-9-28(25)37)49-40(59)30(12-15-34(44)55)48-39(58)29(11-14-33(43)54)47-35(56)17-23-10-13-32(53)31(16-23)50(62)63/h2-10,13,16,18,22,29-30,38,51,53H,11-12,14-15,17,19-21H2,1H3,(H2,43,54)(H2,44,55)(H,45,57)(H,46,60)(H,47,56)(H,48,58)(H,49,59)/t22-,29-,30-,38?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
SUMO-1-specific protease


(Homo sapiens (Human))
BDBM81513
PNG
(VEA-422)
Show SMILES NC(=O)[C@H](CC(O)=O)NC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C38H33N5O8/c39-34(46)30(19-31(44)45)40-35(47)24-15-17-25(18-16-24)36(48)41-42-37(49)32-33(51-32)38(50)43(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,30,32-33H,19-21H2,(H2,39,46)(H,40,47)(H,41,48)(H,42,49)(H,44,45)/t30-,32-,33-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...


Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair