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Compile Data Set for Download or QSAR

Found 50 hits with Last Name = 'scott' and Initial = 'md'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375165
PNG
(CHEMBL271696)
Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C15H15N3O3/c1-18(2)11-8-6-10(7-9-11)4-3-5-12-13(19)16-15(21)17-14(12)20/h3-9H,1-2H3,(H2,16,17,19,20,21)/b4-3+
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10n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375162
PNG
(CHEMBL257930)
Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C15H15N3O2S/c1-18(2)11-8-6-10(7-9-11)4-3-5-12-13(19)16-15(21)17-14(12)20/h3-9H,1-2H3,(H2,16,17,19,20,21)/b4-3+
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1.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375171
PNG
(CHEMBL255586)
Show SMILES [#8-]-[#7+](=O)-c1cccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)c1
Show InChI InChI=1S/C11H7N3O5/c15-9-8(10(16)13-11(17)12-9)5-6-2-1-3-7(4-6)14(18)19/h1-5H,(H2,12,13,15,16,17)
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2.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375169
PNG
(CHEMBL270813)
Show SMILES Fc1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C11H7FN2O3/c12-7-3-1-6(2-4-7)5-8-9(15)13-11(17)14-10(8)16/h1-5H,(H2,13,14,15,16,17)
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2.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375167
PNG
(CHEMBL270356)
Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C12H10N2O4/c1-18-8-4-2-7(3-5-8)6-9-10(15)13-12(17)14-11(9)16/h2-6H,1H3,(H2,13,14,15,16,17)
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2.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375170
PNG
(CHEMBL255143)
Show SMILES [#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C12H8N2O5/c15-9-8(10(16)14-12(19)13-9)5-6-1-3-7(4-2-6)11(17)18/h1-5H,(H,17,18)(H2,13,14,15,16,19)
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5.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375182
PNG
(CHEMBL270596)
Show SMILES Fc1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C11H7FN2O2S/c12-7-3-1-6(2-4-7)5-8-9(15)13-11(17)14-10(8)16/h1-5H,(H2,13,14,15,16,17)
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6.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375172
PNG
(CHEMBL404480)
Show SMILES [#8-]-[#7+](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C11H7N3O5/c15-9-8(10(16)13-11(17)12-9)5-6-1-3-7(4-2-6)14(18)19/h1-5H,(H2,12,13,15,16,17)
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8.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375166
PNG
(CHEMBL270142)
Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]\[#6]=[#6]\c2ccccc2)-[#6](=O)-[#7]-1
Show InChI InChI=1S/C13H10N2O3/c16-11-10(12(17)15-13(18)14-11)8-4-7-9-5-2-1-3-6-9/h1-8H,(H2,14,15,16,17,18)/b7-4+
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9.00E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375168
PNG
(CHEMBL258080)
Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C13H13N3O3/c1-16(2)9-5-3-8(4-6-9)7-10-11(17)14-13(19)15-12(10)18/h3-7H,1-2H3,(H2,14,15,17,18,19)
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1.00E+4n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50237549
PNG
(5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)...)
Show SMILES [#8]-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C11H8N2O4/c14-7-3-1-6(2-4-7)5-8-9(15)12-11(17)13-10(8)16/h1-5,14H,(H2,12,13,15,16,17)
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1.00E+4n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375163
PNG
(CHEMBL402646)
Show SMILES O=[#6]1-[#7]-[#6](=S)-[#7]-[#6](=O)\[#6]-1=[#6]/[#6]=[#6]/c1ccccc1
Show InChI InChI=1S/C13H10N2O2S/c16-11-10(12(17)15-13(18)14-11)8-4-7-9-5-2-1-3-6-9/h1-8H,(H2,14,15,16,17,18)/b7-4+
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9.80E+4n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50237564
PNG
(5-(4-Hydroxybenzylidene)-2-thioxodihydropyrimidine...)
Show SMILES [#8]-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C11H8N2O3S/c14-7-3-1-6(2-4-7)5-8-9(15)12-11(17)13-10(8)16/h1-5,14H,(H2,12,13,15,16,17)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375188
PNG
(CHEMBL408042)
Show SMILES [#8-]-[#7+](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C11H7N3O4S/c15-9-8(10(16)13-11(19)12-9)5-6-1-3-7(4-2-6)14(17)18/h1-5H,(H2,12,13,15,16,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375187
PNG
(CHEMBL403400)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C13H12N2O3/c1-14-11(16)10(12(17)15(2)13(14)18)8-9-6-4-3-5-7-9/h3-8H,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375186
PNG
(CHEMBL273177)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(-[#8])cc2)-[#6]-1=O
Show InChI InChI=1S/C13H12N2O4/c1-14-11(17)10(12(18)15(2)13(14)19)7-8-3-5-9(16)6-4-8/h3-7,16H,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375185
PNG
(CHEMBL256878)
Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7](-[#6])-[#6](=O)-[#7](-[#6])-[#6]-2=O)cc1
Show InChI InChI=1S/C14H14N2O4/c1-15-12(17)11(13(18)16(2)14(15)19)8-9-4-6-10(20-3)7-5-9/h4-8H,1-3H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375184
PNG
(CHEMBL408043)
Show SMILES [#8-]-[#7+](=O)-c1cccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)c1
Show InChI InChI=1S/C11H7N3O4S/c15-9-8(10(16)13-11(19)12-9)5-6-2-1-3-7(4-6)14(17)18/h1-5H,(H2,12,13,15,16,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375183
PNG
(CHEMBL439416)
Show SMILES [#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C12H8N2O4S/c15-9-8(10(16)14-12(19)13-9)5-6-1-3-7(4-2-6)11(17)18/h1-5H,(H,17,18)(H2,13,14,15,16,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375181
PNG
(CHEMBL271859)
Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C12H10N2O3S/c1-17-8-4-2-7(3-5-8)6-9-10(15)13-12(18)14-11(9)16/h2-6H,1H3,(H2,13,14,15,16,18)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375180
PNG
(CHEMBL256269)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(cc2)-[#7+](-[#8-])=O)-[#6]-1=O
Show InChI InChI=1S/C13H11N3O5/c1-14-11(17)10(12(18)15(2)13(14)19)7-8-3-5-9(6-4-8)16(20)21/h3-7H,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375179
PNG
(CHEMBL257927)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2cccc(c2)-[#7+](-[#8-])=O)-[#6]-1=O
Show InChI InChI=1S/C13H11N3O5/c1-14-11(17)10(12(18)15(2)13(14)19)7-8-4-3-5-9(6-8)16(20)21/h3-7H,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375178
PNG
(CHEMBL404693)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(cc2)-[#6](-[#8])=O)-[#6]-1=O
Show InChI InChI=1S/C14H12N2O5/c1-15-11(17)10(12(18)16(2)14(15)21)7-8-3-5-9(6-4-8)13(19)20/h3-7H,1-2H3,(H,19,20)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375177
PNG
(CHEMBL403366)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(F)cc2)-[#6]-1=O
Show InChI InChI=1S/C13H11FN2O3/c1-15-11(17)10(12(18)16(2)13(15)19)7-8-3-5-9(14)6-4-8/h3-7H,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375176
PNG
(CHEMBL404233)
Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7](-[#6])-[#6](=O)-[#7](-[#6])-[#6]-2=O)cc1
Show InChI InChI=1S/C15H17N3O3/c1-16(2)11-7-5-10(6-8-11)9-12-13(19)17(3)15(21)18(4)14(12)20/h5-9H,1-4H3
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375175
PNG
(CHEMBL256879)
Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/[#6]=[#6]/c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C15H14N2O3/c1-16-13(18)12(14(19)17(2)15(16)20)10-6-9-11-7-4-3-5-8-11/h3-10H,1-2H3/b9-6+
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375174
PNG
(CHEMBL258079)
Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]\[#6]=[#6]-2\[#6](=O)-[#7](-[#6])-[#6](=O)-[#7](-[#6])-[#6]-2=O)cc1
Show InChI InChI=1S/C17H19N3O3/c1-18(2)13-10-8-12(9-11-13)6-5-7-14-15(21)19(3)17(23)20(4)16(14)22/h5-11H,1-4H3/b6-5+
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375173
PNG
(CHEMBL256700)
Show SMILES O=[#6]1-[#7]-[#6](=S)-[#7]-[#6](=O)\[#6]-1=[#6]\c1ccccc1
Show InChI InChI=1S/C11H8N2O2S/c14-9-8(10(15)13-11(16)12-9)6-7-4-2-1-3-5-7/h1-6H,(H2,12,13,14,15,16)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375164
PNG
(CHEMBL269821)
Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1
Show InChI InChI=1S/C13H13N3O2S/c1-16(2)9-5-3-8(4-6-9)7-10-11(17)14-13(19)15-12(10)18/h3-7H,1-2H3,(H2,14,15,17,18,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (Human))
BDBM50375161
PNG
(CHEMBL272757)
Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2ccccc2)-[#6](=O)-[#7]-1
Show InChI InChI=1S/C11H8N2O3/c14-9-8(10(15)13-11(16)12-9)6-7-4-2-1-3-5-7/h1-6H,(H2,12,13,14,15,16)
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1.62E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1


Bioorg Med Chem Lett 18: 2373-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.066
BindingDB Entry DOI: 10.7270/Q2348M7J
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 263n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 263n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 283n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 283n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 380n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 380n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 467n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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n/an/a 467n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM227458
PNG
(US9333217, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)CC1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17?,19+,20+,23+/s2
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n/an/a 2.50E+3n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM139690
PNG
(US8895245, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17-,19-,20-,23-/s2
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n/an/a 2.50E+3n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM139690
PNG
(US8895245, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17-,19-,20-,23-/s2
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n/an/a 4.10E+3n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM227458
PNG
(US9333217, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)CC1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17?,19+,20+,23+/s2
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM139690
PNG
(US8895245, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17-,19-,20-,23-/s2
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n/an/a 7.18E+3n/an/an/an/a7.6n/a



Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM227458
PNG
(US9333217, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)CC1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17?,19+,20+,23+/s2
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM139690
PNG
(US8895245, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17-,19-,20-,23-/s2
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM227458
PNG
(US9333217, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)CC1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17?,19+,20+,23+/s2
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM227458
PNG
(US9333217, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)CC1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17?,19+,20+,23+/s2
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US9333217 (2016)


BindingDB Entry DOI: 10.7270/Q2XP73TJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM139690
PNG
(US8895245, 75)
Show SMILES N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Show InChI InChI=1/C24H33ClN8O5/c25-15-3-1-14(2-4-15)5-7-28-8-10-32(9-6-16(26)24(36)37)11-17-19(34)20(35)23(38-17)33-13-31-18-21(27)29-12-30-22(18)33/h1-4,12-13,16-17,19-20,23,28,34-35H,5-11,26H2,(H,36,37)(H2,27,29,30)/t16-,17-,19-,20-,23-/s2
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Epizyme, Inc.

US Patent


Assay Description
Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...


US Patent US8895245 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7GBK
More data for this
Ligand-Target Pair