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Compile Data Set for Download or QSAR

Found 115 hits with Last Name = 'selway' and Initial = 'cn'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437403
PNG
(CHEMBL2408771)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-2-[#6]-[#6]-[#6]-[#7]-[#6]-2-[#6]-1
Show InChI InChI=1S/C26H32N6O3/c1-17(2)11-13-31-22-23(28-25(31)30-14-19-10-7-12-27-20(19)15-30)29(3)26(35)32(24(22)34)16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11,19-20,27H,7,10,12-16H2,1-3H3
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n/an/a 0.0500n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427749
PNG
(CHEMBL2324924)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4nccn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-22(15-21(20)6-8-25-17-33-18-27-34-9-10-38(25)27)28(39)35-24-7-5-23(26(16-24)29(30,31)32)19-37-13-11-36(2)12-14-37/h3-5,7,9-10,15-18H,11-14,19H2,1-2H3,(H,35,39)
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n/an/a 0.200n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437403
PNG
(CHEMBL2408771)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-2-[#6]-[#6]-[#6]-[#7]-[#6]-2-[#6]-1
Show InChI InChI=1S/C26H32N6O3/c1-17(2)11-13-31-22-23(28-25(31)30-14-19-10-7-12-27-20(19)15-30)29(3)26(35)32(24(22)34)16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11,19-20,27H,7,10,12-16H2,1-3H3
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n/an/a 0.270n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427748
PNG
(CHEMBL2324925)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-31-24-16-30-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 0.400n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427749
PNG
(CHEMBL2324924)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4nccn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-22(15-21(20)6-8-25-17-33-18-27-34-9-10-38(25)27)28(39)35-24-7-5-23(26(16-24)29(30,31)32)19-37-13-11-36(2)12-14-37/h3-5,7,9-10,15-18H,11-14,19H2,1-2H3,(H,35,39)
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n/an/a 0.600n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of wild type Abl1 kinase (unknown origin)


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50228407
PNG
(8-((R)-3-amino-piperidin-1-yl)-3-methyl-7-(3-methy...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H](-[#7])-[#6]-1
Show InChI InChI=1S/C24H30N6O3/c1-16(2)11-13-29-20-21(26-23(29)28-12-7-10-18(25)14-28)27(3)24(33)30(22(20)32)15-19(31)17-8-5-4-6-9-17/h4-6,8-9,11,18H,7,10,12-15,25H2,1-3H3/t18-/m1/s1
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n/an/a 0.730n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50228407
PNG
(8-((R)-3-amino-piperidin-1-yl)-3-methyl-7-(3-methy...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H](-[#7])-[#6]-1
Show InChI InChI=1S/C24H30N6O3/c1-16(2)11-13-29-20-21(26-23(29)28-12-7-10-18(25)14-28)27(3)24(33)30(22(20)32)15-19(31)17-8-5-4-6-9-17/h4-6,8-9,11,18H,7,10,12-15,25H2,1-3H3/t18-/m1/s1
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Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437404
PNG
(CHEMBL2408655)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-2-[#6]-[#7]-[#6]-[#6]-1-2
Show InChI InChI=1S/C25H30N6O3/c1-16(2)9-11-30-21-22(27-24(30)29-12-10-18-13-26-14-19(18)29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-9,18-19,26H,10-15H2,1-3H3
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Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427749
PNG
(CHEMBL2324924)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4nccn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-22(15-21(20)6-8-25-17-33-18-27-34-9-10-38(25)27)28(39)35-24-7-5-23(26(16-24)29(30,31)32)19-37-13-11-36(2)12-14-37/h3-5,7,9-10,15-18H,11-14,19H2,1-2H3,(H,35,39)
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Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427749
PNG
(CHEMBL2324924)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4nccn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-22(15-21(20)6-8-25-17-33-18-27-34-9-10-38(25)27)28(39)35-24-7-5-23(26(16-24)29(30,31)32)19-37-13-11-36(2)12-14-37/h3-5,7,9-10,15-18H,11-14,19H2,1-2H3,(H,35,39)
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Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427748
PNG
(CHEMBL2324925)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-31-24-16-30-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 1n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of wild type Abl1 kinase (unknown origin)


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427747
PNG
(CHEMBL2324926)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cccnn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-10-12-37(13-11-35)17-18-5-6-19(14-22(18)26(27,28)29)32-25(39)33-23-15-20(36(2)34-23)7-8-21-16-30-24-4-3-9-31-38(21)24/h3-6,9,14-16H,10-13,17H2,1-2H3,(H2,32,33,34,39)
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Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of wild type Abl1 kinase (unknown origin)


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50228407
PNG
(8-((R)-3-amino-piperidin-1-yl)-3-methyl-7-(3-methy...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H](-[#7])-[#6]-1
Show InChI InChI=1S/C24H30N6O3/c1-16(2)11-13-29-20-21(26-23(29)28-12-7-10-18(25)14-28)27(3)24(33)30(22(20)32)15-19(31)17-8-5-4-6-9-17/h4-6,8-9,11,18H,7,10,12-15,25H2,1-3H3/t18-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427750
PNG
(CHEMBL2324923)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cncc5nccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-30-16-24-31-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 1.60n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of wild type Abl1 kinase (unknown origin)


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50437403
PNG
(CHEMBL2408771)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-2-[#6]-[#6]-[#6]-[#7]-[#6]-2-[#6]-1
Show InChI InChI=1S/C26H32N6O3/c1-17(2)11-13-31-22-23(28-25(31)30-14-19-10-7-12-27-20(19)15-30)29(3)26(35)32(24(22)34)16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11,19-20,27H,7,10,12-16H2,1-3H3
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Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437404
PNG
(CHEMBL2408655)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-2-[#6]-[#7]-[#6]-[#6]-1-2
Show InChI InChI=1S/C25H30N6O3/c1-16(2)9-11-30-21-22(27-24(30)29-12-10-18-13-26-14-19(18)29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-9,18-19,26H,10-15H2,1-3H3
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Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427750
PNG
(CHEMBL2324923)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cncc5nccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-30-16-24-31-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427749
PNG
(CHEMBL2324924)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cncc4nccn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-22(15-21(20)6-8-25-17-33-18-27-34-9-10-38(25)27)28(39)35-24-7-5-23(26(16-24)29(30,31)32)19-37-13-11-36(2)12-14-37/h3-5,7,9-10,15-18H,11-14,19H2,1-2H3,(H,35,39)
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Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427748
PNG
(CHEMBL2324925)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-31-24-16-30-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 3n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427747
PNG
(CHEMBL2324926)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cccnn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-10-12-37(13-11-35)17-18-5-6-19(14-22(18)26(27,28)29)32-25(39)33-23-15-20(36(2)34-23)7-8-21-16-30-24-4-3-9-31-38(21)24/h3-6,9,14-16H,10-13,17H2,1-2H3,(H2,32,33,34,39)
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Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129516
PNG
(CHEMBL71918 | N-[2-(3,4-Dichloro-phenyl)-4-piperid...)
Show SMILES CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H28Cl2N2O/c1-26(23(28)18-8-4-2-5-9-18)17-20(12-15-27-13-6-3-7-14-27)19-10-11-21(24)22(25)16-19/h2,4-5,8-11,16,20H,3,6-7,12-15,17H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129511
PNG
(2-Cyclopropyl-1-{3-(3,4-dichloro-phenyl)-3-[2-(3-m...)
Show SMILES Clc1ccc(cc1Cl)C1(CCN2CC(C2)N2CCOCC2)CCN(C1)C(=O)CC1CC1
Show InChI InChI=1S/C24H33Cl2N3O2/c25-21-4-3-19(14-22(21)26)24(6-8-29(17-24)23(30)13-18-1-2-18)5-7-27-15-20(16-27)28-9-11-31-12-10-28/h3-4,14,18,20H,1-2,5-13,15-17H2
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129509
PNG
(CHEMBL69065 | N-[2-(3,4-Dichloro-phenyl)-4-(4-hydr...)
Show SMILES CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H28Cl2N2O2/c1-26(23(29)17-5-3-2-4-6-17)16-19(18-7-8-21(24)22(25)15-18)9-12-27-13-10-20(28)11-14-27/h2-8,15,19-20,28H,9-14,16H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129506
PNG
(CHEMBL308901 | {3-(3,4-Dichloro-phenyl)-3-[2-(3-mo...)
Show SMILES COc1ccccc1C(=O)N1CCC(CCN2CC(C2)N2CCOCC2)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H33Cl2N3O3/c1-34-25-5-3-2-4-22(25)26(33)32-11-9-27(19-32,20-6-7-23(28)24(29)16-20)8-10-30-17-21(18-30)31-12-14-35-15-13-31/h2-7,16,21H,8-15,17-19H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437395
PNG
(CHEMBL2408638)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(-[#8]-[#6]C([#6])([#6])[#6]-[#7])nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H31N5O4/c1-16(2)11-12-28-19-20(26-22(28)33-15-24(3,4)14-25)27(5)23(32)29(21(19)31)13-18(30)17-9-7-6-8-10-17/h6-11H,12-15,25H2,1-5H3
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Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129517
PNG
(CHEMBL307338 | N-{2-(3,4-Dichloro-phenyl)-4-[4-hyd...)
Show SMILES CN(CC(CCN1CCC(O)(CC1)c1ncc[nH]1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H30Cl2N4O2/c1-31(24(33)19-5-3-2-4-6-19)18-21(20-7-8-22(27)23(28)17-20)9-14-32-15-10-26(34,11-16-32)25-29-12-13-30-25/h2-8,12-13,17,21,34H,9-11,14-16,18H2,1H3,(H,29,30)
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n/an/a 6.60n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129519
PNG
(4-(1-{2-[1-Benzenesulfonyl-3-(3,4-dichloro-phenyl)...)
Show SMILES Clc1ccc(cc1Cl)C1(CCN2CC(C2)N2CCOCC2)CCN(C1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H31Cl2N3O3S/c26-23-7-6-20(16-24(23)27)25(8-10-28-17-21(18-28)29-12-14-33-15-13-29)9-11-30(19-25)34(31,32)22-4-2-1-3-5-22/h1-7,16,21H,8-15,17-19H2
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n/an/a 6.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129510
PNG
(CHEMBL71704 | N-[2-(3,4-Dichloro-phenyl)-4-(3-imid...)
Show SMILES CN(CC(CCN1CC(C1)n1ccnc1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H26Cl2N4O/c1-28(24(31)18-5-3-2-4-6-18)14-20(19-7-8-22(25)23(26)13-19)9-11-29-15-21(16-29)30-12-10-27-17-30/h2-8,10,12-13,17,20-21H,9,11,14-16H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129508
PNG
(CHEMBL305191 | N-[2-(3,4-Dichloro-phenyl)-4-(4-[1,...)
Show SMILES CN(CC(CCN1CCC(CC1)n1cncn1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-30(25(33)19-5-3-2-4-6-19)16-21(20-7-8-23(26)24(27)15-20)9-12-31-13-10-22(11-14-31)32-18-28-17-29-32/h2-8,15,17-18,21-22H,9-14,16H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50427748
PNG
(CHEMBL2324925)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-31-24-16-30-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 7n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129520
PNG
(CHEMBL69335 | N-[2-(3,4-Dichloro-phenyl)-4-(4-phen...)
Show SMILES CN(CC(CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H32Cl2N2O/c1-32(29(34)24-10-6-3-7-11-24)21-26(25-12-13-27(30)28(31)20-25)16-19-33-17-14-23(15-18-33)22-8-4-2-5-9-22/h2-13,20,23,26H,14-19,21H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129518
PNG
(CHEMBL71394 | N-{2-(3,4-Dichloro-phenyl)-4-[3-(2-o...)
Show SMILES CN(CC(CCN1CCCC(C1)n1c2ccccc2[nH]c1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C30H32Cl2N4O2/c1-34(29(37)21-8-3-2-4-9-21)19-23(22-13-14-25(31)26(32)18-22)15-17-35-16-7-10-24(20-35)36-28-12-6-5-11-27(28)33-30(36)38/h2-6,8-9,11-14,18,23-24H,7,10,15-17,19-20H2,1H3,(H,33,38)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129514
PNG
(CHEMBL71644 | {3-(3,4-Dichloro-phenyl)-3-[2-(3-mor...)
Show SMILES Clc1ccc(cc1Cl)C1(CCN2CC(C2)N2CCOCC2)CN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H29Cl2N3O2/c26-22-7-6-20(14-23(22)27)25(17-30(18-25)24(31)19-4-2-1-3-5-19)8-9-28-15-21(16-28)29-10-12-32-13-11-29/h1-7,14,21H,8-13,15-18H2
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129512
PNG
(CHEMBL304807 | N-[4-[4-(1H-Benzoimidazol-2-yl)-pip...)
Show SMILES CN(CC(CCN1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C30H32Cl2N4O/c1-35(30(37)22-7-3-2-4-8-22)20-24(23-11-12-25(31)26(32)19-23)15-18-36-16-13-21(14-17-36)29-33-27-9-5-6-10-28(27)34-29/h2-12,19,21,24H,13-18,20H2,1H3,(H,33,34)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129515
PNG
(CHEMBL71226 | N-{2-(3,4-Dichloro-phenyl)-4-[3-(2-o...)
Show SMILES CN(CC(CCN1CCC(C1)n1c2ccccc2[nH]c1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H30Cl2N4O2/c1-33(28(36)20-7-3-2-4-8-20)18-22(21-11-12-24(30)25(31)17-21)13-15-34-16-14-23(19-34)35-27-10-6-5-9-26(27)32-29(35)37/h2-12,17,22-23H,13-16,18-19H2,1H3,(H,32,37)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129505
PNG
(CHEMBL69889 | {3-(3,4-Dichloro-phenyl)-3-[2-(3-mor...)
Show SMILES Clc1ccc(cc1Cl)C1(CCN2CC(C2)N2CCOCC2)CCN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H31Cl2N3O2/c27-23-7-6-21(16-24(23)28)26(8-10-29-17-22(18-29)30-12-14-33-15-13-30)9-11-31(19-26)25(32)20-4-2-1-3-5-20/h1-7,16,22H,8-15,17-19H2
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n/an/a 7.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129521
PNG
(CHEMBL71647 | N-[2-(3,4-Dichloro-phenyl)-4-(3-morp...)
Show SMILES CN(CC(CCN1CC(C1)N1CCOCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H31Cl2N3O2/c1-28(25(31)19-5-3-2-4-6-19)16-21(20-7-8-23(26)24(27)15-20)9-10-29-17-22(18-29)30-11-13-32-14-12-30/h2-8,15,21-22H,9-14,16-18H2,1H3
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n/an/a 7.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129522
PNG
(CHEMBL68917 | N-[2-(3,4-Dichloro-phenyl)-4-(4-imid...)
Show SMILES CN(CC(CCN1CCC(CC1)n1ccnc1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H30Cl2N4O/c1-30(26(33)20-5-3-2-4-6-20)18-22(21-7-8-24(27)25(28)17-21)9-13-31-14-10-23(11-15-31)32-16-12-29-19-32/h2-8,12,16-17,19,22-23H,9-11,13-15,18H2,1H3
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n/an/a 7.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427742
PNG
(CHEMBL2324930)
Show SMILES CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)C#Cc2cnc3cccnn23)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-9-24(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)35-28(39)22-6-7-23(26(17-22)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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n/an/a 8n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129507
PNG
(CHEMBL305236 | N-[4-(4-Benzoimidazol-1-yl-piperidi...)
Show SMILES CN(CC(CCN1CCC(CC1)n1cnc2ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C30H32Cl2N4O/c1-34(30(37)22-7-3-2-4-8-22)20-24(23-11-12-26(31)27(32)19-23)13-16-35-17-14-25(15-18-35)36-21-33-28-9-5-6-10-29(28)36/h2-12,19,21,24-25H,13-18,20H2,1H3
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n/an/a 8.10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129524
PNG
(CHEMBL74127 | N-{2-(3,4-Dichloro-phenyl)-4-[4-(2-o...)
Show SMILES CN(CC(CCN1CCCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C31H34Cl2N4O2/c1-35(30(38)22-8-3-2-4-9-22)21-24(23-13-14-26(32)27(33)20-23)15-18-36-17-7-10-25(16-19-36)37-29-12-6-5-11-28(29)34-31(37)39/h2-6,8-9,11-14,20,24-25H,7,10,15-19,21H2,1H3,(H,34,39)
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n/an/a 8.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129513
PNG
(CHEMBL71397 | N-[2-(3,4-Dichloro-phenyl)-4-(4-hydr...)
Show SMILES CN(CC(CCN1CCC(O)(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H32Cl2N2O2/c1-32(28(34)22-8-4-2-5-9-22)21-24(23-12-13-26(30)27(31)20-23)14-17-33-18-15-29(35,16-19-33)25-10-6-3-7-11-25/h2-13,20,24,35H,14-19,21H2,1H3
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50129523
PNG
(CHEMBL68440 | N-{2-(3,4-Dichloro-phenyl)-4-[4-(2-o...)
Show SMILES CN(CC(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C30H32Cl2N4O2/c1-34(29(37)21-7-3-2-4-8-21)20-23(22-11-12-25(31)26(32)19-22)13-16-35-17-14-24(15-18-35)36-28-10-6-5-9-27(28)33-30(36)38/h2-12,19,23-24H,13-18,20H2,1H3,(H,33,38)
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50071112
PNG
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Show SMILES CN(CC(CCN1CCC(CC1)(NC(C)=O)c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells


Bioorg Med Chem Lett 13: 2211-5 (2003)


BindingDB Entry DOI: 10.7270/Q2D799TN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437395
PNG
(CHEMBL2408638)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(-[#8]-[#6]C([#6])([#6])[#6]-[#7])nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H31N5O4/c1-16(2)11-12-28-19-20(26-22(28)33-15-24(3,4)14-25)27(5)23(32)29(21(19)31)13-18(30)17-9-7-6-8-10-17/h6-11H,12-15,25H2,1-5H3
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n/an/a 9n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of porcine DPP4


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50437404
PNG
(CHEMBL2408655)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-2-[#6]-[#7]-[#6]-[#6]-1-2
Show InChI InChI=1S/C25H30N6O3/c1-16(2)9-11-30-21-22(27-24(30)29-12-10-18-13-26-14-19(18)29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-9,18-19,26H,10-15H2,1-3H3
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n/an/a 9n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427748
PNG
(CHEMBL2324925)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-31-24-16-30-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 10n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50437404
PNG
(CHEMBL2408655)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-n1c(nc2n(-[#6])c(=O)n(-[#6]-[#6](=O)-c3ccccc3)c(=O)c12)-[#7]-1-[#6]-[#6]-[#6]-2-[#6]-[#7]-[#6]-[#6]-1-2
Show InChI InChI=1S/C25H30N6O3/c1-16(2)9-11-30-21-22(27-24(30)29-12-10-18-13-26-14-19(18)29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-9,18-19,26H,10-15H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



Sanofi-Aventis , Industriepark Höchst, Gebäude K703, 65929 Frankfurt, Germany.

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


ACS Med Chem Lett 4: 768-72 (2013)


Article DOI: 10.1021/ml400171b
BindingDB Entry DOI: 10.7270/Q2HQ41BX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427750
PNG
(CHEMBL2324923)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cncc5nccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H26F3N9O/c1-35-9-11-37(12-10-35)17-18-3-4-19(13-22(18)26(27,28)29)32-25(39)33-23-14-20(36(2)34-23)5-6-21-15-30-16-24-31-7-8-38(21)24/h3-4,7-8,13-16H,9-12,17H2,1-2H3,(H2,32,33,34,39)
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n/an/a 11n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL2


(Homo sapiens (Human))
BDBM50427745
PNG
(CHEMBL2324927)
Show SMILES CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5ccccn45)n(C)n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H27F3N8O/c1-35-11-13-37(14-12-35)18-19-6-7-20(15-23(19)27(28,29)30)32-26(39)33-24-16-21(36(2)34-24)8-9-22-17-31-25-5-3-4-10-38(22)25/h3-7,10,15-17H,11-14,18H2,1-2H3,(H2,32,33,34,39)
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n/an/a 12n/an/an/an/an/an/a



Cyclofluidic Ltd

Curated by ChEMBL


Assay Description
Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...


J Med Chem 56: 3033-47 (2013)


Article DOI: 10.1021/jm400099d
BindingDB Entry DOI: 10.7270/Q24T6KPD
More data for this
Ligand-Target Pair
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