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Compile Data Set for Download or QSAR

Found 245 hits with Last Name = 'sheen' and Initial = 'jt'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194105
PNG
(US9200001, 19)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccccn3)nc(C)n2)cc1OC
Show InChI InChI=1S/C24H24N6O2/c1-16-26-20(10-9-19-7-5-6-12-25-19)15-24(27-16)30-23(28-17(2)29-30)14-18-8-11-21(31-3)22(13-18)32-4/h5-13,15H,14H2,1-4H3/b10-9+
PDB

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US Patent
0.00200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194104
PNG
(US9200001, 18)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccc4ccccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C28H26N6O2/c1-18-29-23(13-12-22-11-10-21-7-5-6-8-24(21)32-22)17-28(30-18)34-27(31-19(2)33-34)16-20-9-14-25(35-3)26(15-20)36-4/h5-15,17H,16H2,1-4H3/b13-12+
PDB

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0.00200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194113
PNG
(US9200001, 28)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2nc3ccccc3n2C)cc1OC
Show InChI InChI=1/C28H29N7O2/c1-16-29-22(19-14-20(19)28-32-21-8-6-7-9-23(21)34(28)3)15-27(30-16)35-26(31-17(2)33-35)13-18-10-11-24(36-4)25(12-18)37-5/h6-12,15,19-20H,13-14H2,1-5H3
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0.00300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194090
PNG
(US9200001, 3)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C28H28N6O2/c1-18-29-23(13-12-22-11-10-21-7-5-6-8-24(21)32-22)17-28(30-18)34-27(31-19(2)33-34)16-20-9-14-25(35-3)26(15-20)36-4/h5-11,14-15,17H,12-13,16H2,1-4H3
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0.00400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194122
PNG
(US9200001, 38)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2nc3ccccc3[nH]2)cc1OC
Show InChI InChI=1/C27H27N7O2/c1-15-28-22(18-13-19(18)27-31-20-7-5-6-8-21(20)32-27)14-26(29-15)34-25(30-16(2)33-34)12-17-9-10-23(35-3)24(11-17)36-4/h5-11,14,18-19H,12-13H2,1-4H3,(H,31,32)
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0.00500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194223
PNG
(US9200001, 26)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)[C@@H]2C[C@H]2c2nc3ccccc3[nH]2)cc1OC |r|
Show InChI InChI=1/C27H27N7O2/c1-15-28-22(18-13-19(18)27-31-20-7-5-6-8-21(20)32-27)14-26(29-15)34-25(30-16(2)33-34)12-17-9-10-23(35-3)24(11-17)36-4/h5-11,14,18-19H,12-13H2,1-4H3,(H,31,32)/t18-,19-/s2
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0.00500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194099
PNG
(US9200001, 13)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccc4ncccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C27H25N7O2/c1-17-29-21(9-8-20-10-11-22-23(32-20)6-5-13-28-22)16-27(30-17)34-26(31-18(2)33-34)15-19-7-12-24(35-3)25(14-19)36-4/h5-14,16H,15H2,1-4H3/b9-8+
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0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194089
PNG
(US9200001, 2)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C#Cc2ccc3ccccc3n2)cc1OC
Show InChI InChI=1S/C28H24N6O2/c1-18-29-23(13-12-22-11-10-21-7-5-6-8-24(21)32-22)17-28(30-18)34-27(31-19(2)33-34)16-20-9-14-25(35-3)26(15-20)36-4/h5-11,14-15,17H,16H2,1-4H3
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0.0230n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194111
PNG
(US9200001, 25)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)[C@H]2C[C@@H]2c2nc3ccccc3[nH]2)cc1OC |r|
Show InChI InChI=1/C27H27N7O2/c1-15-28-22(18-13-19(18)27-31-20-7-5-6-8-21(20)32-27)14-26(29-15)34-25(30-16(2)33-34)12-17-9-10-23(35-3)24(11-17)36-4/h5-11,14,18-19H,12-13H2,1-4H3,(H,31,32)/t18-,19-/s2
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0.0270n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194102
PNG
(US9200001, 16)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ncccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C27H27N7O2/c1-17-29-21(9-8-20-10-11-22-23(32-20)6-5-13-28-22)16-27(30-17)34-26(31-18(2)33-34)15-19-7-12-24(35-3)25(14-19)36-4/h5-7,10-14,16H,8-9,15H2,1-4H3
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0.0270n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194095
PNG
(US9200001, 8)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)nc1OC
Show InChI InChI=1S/C27H27N7O2/c1-17-28-21(12-11-20-10-9-19-7-5-6-8-23(19)31-20)15-25(29-17)34-26(30-18(2)33-34)16-22-13-14-24(35-3)27(32-22)36-4/h5-10,13-15H,11-12,16H2,1-4H3
PDB

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0.0280n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194101
PNG
(US9200001, 15)
Show SMILES COc1ncc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)nc1OC
Show InChI InChI=1S/C26H26N8O2/c1-16-28-20(12-11-19-10-9-18-7-5-6-8-22(18)31-19)13-23(29-16)34-24(30-17(2)33-34)14-21-15-27-25(35-3)26(32-21)36-4/h5-10,13,15H,11-12,14H2,1-4H3
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0.0560n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236019
PNG
(US9365562, 57)
Show SMILES Cc1nc(Cc2cc(F)ccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H24F2N8/c1-15-29-23(35-13-18(14-35)26-32-21-6-4-5-7-22(21)34(26)3)12-25(30-15)36-24(31-16(2)33-36)11-17-10-19(27)8-9-20(17)28/h4-10,12,18H,11,13-14H2,1-3H3
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0.0650 -58.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194119
PNG
(US9200001, 34)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2ccc3ncccc3n2)cc1OC
Show InChI InChI=1/C28H27N7O2/c1-16-30-24(20-14-19(20)21-8-9-22-23(33-21)6-5-11-29-22)15-28(31-16)35-27(32-17(2)34-35)13-18-7-10-25(36-3)26(12-18)37-4/h5-12,15,19-20H,13-14H2,1-4H3
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0.0680n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194094
PNG
(US9200001, 7)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C#Cc2ccc3ccccc3n2)nc1OC
Show InChI InChI=1S/C27H23N7O2/c1-17-28-21(12-11-20-10-9-19-7-5-6-8-23(19)31-20)15-25(29-17)34-26(30-18(2)33-34)16-22-13-14-24(35-3)27(32-22)36-4/h5-10,13-15H,16H2,1-4H3
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0.0730n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194145
PNG
(US9200001, 61)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C#N)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C20H18N8/c1-11-22-12(2)28(26-11)19-9-16(23-18(10-21)25-19)13-8-14(13)20-24-15-6-4-5-7-17(15)27(20)3/h4-7,9,13-14H,8H2,1-3H3/t13-,14-/s2
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0.0850n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194106
PNG
(US9200001, 20)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccc(C)cn3)nc(C)n2)cc1OC
Show InChI InChI=1S/C25H26N6O2/c1-16-6-8-20(26-15-16)9-10-21-14-25(28-17(2)27-21)31-24(29-18(3)30-31)13-19-7-11-22(32-4)23(12-19)33-5/h6-12,14-15H,13H2,1-5H3/b10-9+
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0.110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236020
PNG
(US9365562, 58)
Show SMILES Cc1nc(Cc2ccc(F)cc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H25FN8/c1-16-28-23(34-14-19(15-34)26-31-21-6-4-5-7-22(21)33(26)3)13-25(29-16)35-24(30-17(2)32-35)12-18-8-10-20(27)11-9-18/h4-11,13,19H,12,14-15H2,1-3H3
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0.120 -56.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236035
PNG
(US9365562, 73)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccnn2C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H26N10O/c1-15-26-16(2)34(30-15)22-11-21(28-24(29-22)35-14-18-9-10-25-32(18)4)33-12-17(13-33)23-27-19-7-5-6-8-20(19)31(23)3/h5-11,17H,12-14H2,1-4H3
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0.130 -56.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194134
PNG
(US9200001, 50)
Show SMILES Cc1nc(C)n(n1)-c1cc(CCc2ccc(C)cn2)nc(C)n1
Show InChI InChI=1S/C17H20N6/c1-11-5-6-15(18-10-11)7-8-16-9-17(21-12(2)20-16)23-14(4)19-13(3)22-23/h5-6,9-10H,7-8H2,1-4H3
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0.140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194092
PNG
(US9200001, 5)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc(C)cn3)nc(C)n2)cc1OC
Show InChI InChI=1S/C25H28N6O2/c1-16-6-8-20(26-15-16)9-10-21-14-25(28-17(2)27-21)31-24(29-18(3)30-31)13-19-7-11-22(32-4)23(12-19)33-5/h6-8,11-12,14-15H,9-10,13H2,1-5H3
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0.140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235985
PNG
(US9365562, 23)
Show SMILES CSc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H22N8S/c1-12-21-13(2)28(25-12)18-9-17(23-20(24-18)29-4)27-10-14(11-27)19-22-15-7-5-6-8-16(15)26(19)3/h5-9,14H,10-11H2,1-4H3
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0.200 -55.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194133
PNG
(US9200001, 49)
Show SMILES Cc1nc(Cc2ccccc2)n(n1)-c1cc(nc(C)n1)C1CC1c1ccc(C)cn1
Show InChI InChI=1/C24H24N6/c1-15-9-10-21(25-14-15)19-12-20(19)22-13-24(27-16(2)26-22)30-23(28-17(3)29-30)11-18-7-5-4-6-8-18/h4-10,13-14,19-20H,11-12H2,1-3H3
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US Patent
0.210n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194120
PNG
(US9200001, 35)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2ccc(C)cn2)cc1OC
Show InChI InChI=1/C26H28N6O2/c1-15-6-8-21(27-14-15)19-12-20(19)22-13-26(29-16(2)28-22)32-25(30-17(3)31-32)11-18-7-9-23(33-4)24(10-18)34-5/h6-10,13-14,19-20H,11-12H2,1-5H3
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0.210n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236018
PNG
(US9365562, 56)
Show SMILES Cc1nc(-c2c(F)cccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C |(-6.46,-3.49,;-5.96,-2.03,;-6.8,-.72,;-5.9,.53,;-6.29,2.02,;-7.78,2.41,;-8.87,1.33,;-8.18,3.9,;-7.09,4.99,;-5.6,4.59,;-5.21,3.11,;-3.72,3.5,;-4.43,.05,;-4.43,-1.49,;-3.1,.82,;-1.76,.05,;-.43,.82,;-.43,2.36,;-1.76,3.19,;-1.76,4.73,;-3.1,2.36,;.9,.05,;1.3,-1.43,;2.79,-1.04,;2.39,.45,;4.12,-1.81,;4.28,-3.34,;5.79,-3.66,;6.56,-4.99,;8.1,-4.99,;8.87,-3.66,;8.1,-2.32,;6.56,-2.32,;5.53,-1.18,;5.85,.33,)|
Show InChI InChI=1S/C25H22F2N8/c1-14-28-21(34-12-16(13-34)24-31-19-9-4-5-10-20(19)33(24)3)11-22(29-14)35-25(30-15(2)32-35)23-17(26)7-6-8-18(23)27/h4-11,16H,12-13H2,1-3H3
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0.240 -54.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236039
PNG
(US9365562, 77)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1ccnc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H24N10/c1-14-25-16(3)33(29-14)21-11-20(27-23(28-21)32-10-9-24-15(32)2)31-12-17(13-31)22-26-18-7-5-6-8-19(18)30(22)4/h5-11,17H,12-13H2,1-4H3
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0.260 -54.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236010
PNG
(US9365562, 48)
Show SMILES Cc1nc(CN2CCCC2=O)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H27N9O/c1-15-25-20(32-12-17(13-32)24-28-18-7-4-5-8-19(18)30(24)3)11-21(26-15)33-22(27-16(2)29-33)14-31-10-6-9-23(31)34/h4-5,7-8,11,17H,6,9-10,12-14H2,1-3H3
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0.260 -54.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236034
PNG
(US9365562, 72)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2nccs2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9OS/c1-14-25-15(2)32(29-14)20-10-19(27-23(28-20)33-13-21-24-8-9-34-21)31-11-16(12-31)22-26-17-6-4-5-7-18(17)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.280 -54.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236029
PNG
(US9365562, 67)
Show SMILES CCc1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8/c1-4-16-25-12(2)29-32(16)18-9-17(27-20(28-18)21(22,23)24)31-10-13(11-31)19-26-14-7-5-6-8-15(14)30(19)3/h5-9,13H,4,10-11H2,1-3H3
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0.280 -54.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236041
PNG
(US9365562, 79)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C#N)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H19N9/c1-12-22-13(2)29(26-12)19-8-18(24-17(9-21)25-19)28-10-14(11-28)20-23-15-6-4-5-7-16(15)27(20)3/h4-8,14H,10-11H2,1-3H3
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0.280 -54.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236040
PNG
(US9365562, 78)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CCCC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H27N9/c1-15-24-16(2)32(28-15)21-12-20(26-23(27-21)30-10-6-7-11-30)31-13-17(14-31)22-25-18-8-4-5-9-19(18)29(22)3/h4-5,8-9,12,17H,6-7,10-11,13-14H2,1-3H3
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0.290 -54.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236012
PNG
(US9365562, 50)
Show SMILES Cc1nc(-c2ccccc2Cl)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H23ClN8/c1-15-27-22(33-13-17(14-33)24-30-20-10-6-7-11-21(20)32(24)3)12-23(28-15)34-25(29-16(2)31-34)18-8-4-5-9-19(18)26/h4-12,17H,13-14H2,1-3H3
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0.350 -54.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194153
PNG
(US9200001, 69)
Show SMILES CSc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C20H21N7S/c1-11-21-12(2)27(25-11)18-10-16(23-20(24-18)28-4)13-9-14(13)19-22-15-7-5-6-8-17(15)26(19)3/h5-8,10,13-14H,9H2,1-4H3/t13-,14-/s2
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0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194217
PNG
(US9200001, 133)
Show SMILES C[C@@H]1CCCN1c1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C24H28N8/c1-14-8-7-11-31(14)24-27-20(13-22(28-24)32-16(3)25-15(2)29-32)17-12-18(17)23-26-19-9-5-6-10-21(19)30(23)4/h5-6,9-10,13-14,17-18H,7-8,11-12H2,1-4H3/t14-,17-,18-/s2
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0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236032
PNG
(US9365562, 70)
Show SMILES CC(C)Oc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-13(2)31-22-25-19(10-20(26-22)30-15(4)23-14(3)27-30)29-11-16(12-29)21-24-17-8-6-7-9-18(17)28(21)5/h6-10,13,16H,11-12H2,1-5H3
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0.380 -53.8n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194127
PNG
(US9200001, 43)
Show SMILES COc1ccc(nc1)C1CC1c1cc(nc(C)n1)-n1nc(C)nc1Cc1ccc(OC)c(OC)c1
Show InChI InChI=1/C26H28N6O3/c1-15-28-22(20-12-19(20)21-8-7-18(33-3)14-27-21)13-26(29-15)32-25(30-16(2)31-32)11-17-6-9-23(34-4)24(10-17)35-5/h6-10,13-14,19-20H,11-12H2,1-5H3
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0.390n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194176
PNG
(US9200001, 92)
Show SMILES CCc1nc(C)nn1-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C21H23N7/c1-5-19-24-13(3)26-28(19)20-11-17(22-12(2)23-20)14-10-15(14)21-25-16-8-6-7-9-18(16)27(21)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236026
PNG
(US9365562, 64)
Show SMILES CCc1nc(C)nn1-c1cc(nc(OC)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H24N8O/c1-5-17-22-13(2)26-29(17)19-10-18(24-21(25-19)30-4)28-11-14(12-28)20-23-15-8-6-7-9-16(15)27(20)3/h6-10,14H,5,11-12H2,1-4H3
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0.400 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236033
PNG
(US9365562, 71)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccno2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9O2/c1-14-25-15(2)32(29-14)21-10-20(27-23(28-21)33-13-17-8-9-24-34-17)31-11-16(12-31)22-26-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.400 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236000
PNG
(US9365562, 38)
Show SMILES CCCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8/c1-5-8-19-25-15(3)27-30(19)21-11-20(23-14(2)24-21)29-12-16(13-29)22-26-17-9-6-7-10-18(17)28(22)4/h6-7,9-11,16H,5,8,12-13H2,1-4H3
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0.410 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194220
PNG
(US9200001, 136)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OC2CCC2)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C23H25N7O/c1-13-24-14(2)30(28-13)21-12-19(26-23(27-21)31-15-7-6-8-15)16-11-17(16)22-25-18-9-4-5-10-20(18)29(22)3/h4-5,9-10,12,15-17H,6-8,11H2,1-3H3/t16-,17-/s2
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0.420n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236023
PNG
(US9365562, 61)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H24N8/c1-13-23-14(2)30(27-13)20-10-19(25-21(26-20)15-8-9-15)29-11-16(12-29)22-24-17-6-4-5-7-18(17)28(22)3/h4-7,10,15-16H,8-9,11-12H2,1-3H3
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0.460 -53.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236005
PNG
(US9365562, 43)
Show SMILES COC(=O)CCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O2/c1-14-24-20(11-21(25-14)31-19(26-15(2)28-31)9-10-22(32)33-4)30-12-16(13-30)23-27-17-7-5-6-8-18(17)29(23)3/h5-8,11,16H,9-10,12-13H2,1-4H3
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0.490 -53.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236036
PNG
(US9365562, 74)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccon2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9O2/c1-14-24-15(2)32(28-14)21-10-20(26-23(27-21)33-13-17-8-9-34-29-17)31-11-16(12-31)22-25-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3
PDB

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PC sid
UniChem
US Patent
0.490 -53.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194175
PNG
(US9200001, 91)
Show SMILES CCOc1nc(C)nn1-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C21H23N7O/c1-5-29-21-24-13(3)26-28(21)19-11-17(22-12(2)23-19)14-10-15(14)20-25-16-8-6-7-9-18(16)27(20)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
PDB

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UniChem
US Patent
0.490n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194126
PNG
(US9200001, 42)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2cc3CCCn3n2)cc1OC
Show InChI InChI=1/C26H29N7O2/c1-15-27-21(19-13-20(19)22-12-18-6-5-9-32(18)31-22)14-26(28-15)33-25(29-16(2)30-33)11-17-7-8-23(34-3)24(10-17)35-4/h7-8,10,12,14,19-20H,5-6,9,11,13H2,1-4H3
PDB

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US Patent
0.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235968
PNG
(US9365562, 6)
Show SMILES Cc1cnn(c1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H23N7/c1-14-10-23-29(11-14)20-9-19(25-21(26-20)15-7-8-15)28-12-16(13-28)22-24-17-5-3-4-6-18(17)27(22)2/h3-6,9-11,15-16H,7-8,12-13H2,1-2H3
PDB

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PC sid
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US Patent
0.530 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194147
PNG
(US9200001, 63)
Show SMILES CCOc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C21H23N7O/c1-5-29-21-24-17(11-19(25-21)28-13(3)22-12(2)26-28)14-10-15(14)20-23-16-8-6-7-9-18(16)27(20)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
PDB

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PC cid
PC sid
UniChem
US Patent
0.540n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235995
PNG
(US9365562, 33)
Show SMILES Cc1cnn(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H22N8/c1-13-10-22-29(26-13)19-9-18(24-20(25-19)14-7-8-14)28-11-15(12-28)21-23-16-5-3-4-6-17(16)27(21)2/h3-6,9-10,14-15H,7-8,11-12H2,1-2H3
PDB

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PC cid
PC sid
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US Patent
0.540 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194218
PNG
(US9200001, 134)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC[C@@H](F)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r|
Show InChI InChI=1/C23H25FN8/c1-13-25-14(2)32(29-13)21-11-19(27-23(28-21)31-9-8-15(24)12-31)16-10-17(16)22-26-18-6-4-5-7-20(18)30(22)3/h4-7,11,15-17H,8-10,12H2,1-3H3/t15-,16-,17-/s2
PDB

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PC cid
PC sid
UniChem
US Patent
0.580n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01M3
More data for this
Ligand-Target Pair
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