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Compile Data Set for Download or QSAR

Found 207 hits with Last Name = 'sootome' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161438
PNG
(US10124003, Ex. Compound 51 | US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12 |c:26,t:13,28|
Show InChI InChI=1/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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n/an/a 0.100n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161438
PNG
(US10124003, Ex. Compound 51 | US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12 |c:26,t:13,28|
Show InChI InChI=1/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10124003 (2018)


BindingDB Entry DOI: 10.7270/Q2B27XBQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161453
PNG
(US10124003, Ex. Compound 66 | US9108973, 66)
Show SMILES COC(=O)[C@@H]1C[C@@H](CN1C(=O)C=C)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12 |r|
Show InChI InChI=1/C25H25N5O5/c1-5-21(31)30-13-17(10-20(30)25(32)35-4)29-12-16(22-23(26)27-14-28-24(22)29)7-6-15-8-18(33-2)11-19(9-15)34-3/h5,8-9,11-12,14,17,20H,1,10,13H2,2-4H3,(H2,26,27,28)/t17-,20-/s2
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n/an/a<0.300n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161453
PNG
(US10124003, Ex. Compound 66 | US9108973, 66)
Show SMILES COC(=O)[C@@H]1C[C@@H](CN1C(=O)C=C)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12 |r|
Show InChI InChI=1/C25H25N5O5/c1-5-21(31)30-13-17(10-20(30)25(32)35-4)29-12-16(22-23(26)27-14-28-24(22)29)7-6-15-8-18(33-2)11-19(9-15)34-3/h5,8-9,11-12,14,17,20H,1,10,13H2,2-4H3,(H2,26,27,28)/t17-,20-/s2
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10124003 (2018)


BindingDB Entry DOI: 10.7270/Q2B27XBQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161438
PNG
(US10124003, Ex. Compound 51 | US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12 |c:26,t:13,28|
Show InChI InChI=1/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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n/an/a<0.300n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US9108973, 9)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155565
PNG
(US10092556, Example 1 | US9012475, 1 | US9346787, ...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(26)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)25/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155569
PNG
(US10092556, Example 13 | US9012475, 13 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C23H22ClF2N5O3/c1-13-11-18(30-29-13)28-20-17(25)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)26/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161419
PNG
(US10124003, Ex. Compound 32 | US9108973, 32)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/s2
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n/an/a 0.400n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161426
PNG
(US10124003, Ex. Compound 39 | US9108973, 39 | US91...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C23H23N5O3/c1-4-20(29)27-8-7-17(13-27)28-12-16(21-22(24)25-14-26-23(21)28)6-5-15-9-18(30-2)11-19(10-15)31-3/h4,9-12,14,17H,1,7-8,13H2,2-3H3,(H2,24,25,26)/t17-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155568
PNG
(US10092556, Example 12 | US9012475, 12 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2Cl)n[nH]1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(25)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)26/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155565
PNG
(US10092556, Example 1 | US9012475, 1 | US9346787, ...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(26)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)25/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155568
PNG
(US10092556, Example 12 | US9012475, 12 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2Cl)n[nH]1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(25)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)26/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155569
PNG
(US10092556, Example 13 | US9012475, 13 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C23H22ClF2N5O3/c1-13-11-18(30-29-13)28-20-17(25)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)26/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161419
PNG
(US10124003, Ex. Compound 32 | US9108973, 32)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10124003 (2018)


BindingDB Entry DOI: 10.7270/Q2B27XBQ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155569
PNG
(US10092556, Example 13 | US9012475, 13 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C23H22ClF2N5O3/c1-13-11-18(30-29-13)28-20-17(25)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)26/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161426
PNG
(US10124003, Ex. Compound 39 | US9108973, 39 | US91...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C23H23N5O3/c1-4-20(29)27-8-7-17(13-27)28-12-16(21-22(24)25-14-26-23(21)28)6-5-15-9-18(30-2)11-19(10-15)31-3/h4,9-12,14,17H,1,7-8,13H2,2-3H3,(H2,24,25,26)/t17-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10124003 (2018)


BindingDB Entry DOI: 10.7270/Q2B27XBQ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155568
PNG
(US10092556, Example 12 | US9012475, 12 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2Cl)n[nH]1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(25)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)26/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155565
PNG
(US10092556, Example 1 | US9012475, 1 | US9346787, ...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(26)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)25/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.400n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161434
PNG
(US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12 |r|
Show InChI InChI=1/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US9108973, 2)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12 |r|
Show InChI InChI=1/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155574
PNG
(US10092556, Example 24 | US9012475, 24 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3ncon3)ccc2F)n[nH]1
Show InChI InChI=1S/C24H22ClF2N7O2/c1-14-11-19(32-31-14)30-21-18(26)6-5-15(29-21)12-24(23-28-13-36-33-23)7-9-34(10-8-24)22(35)16-3-2-4-17(25)20(16)27/h2-6,11,13H,7-10,12H2,1H3,(H2,29,30,31,32)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155566
PNG
(US10092556, Example 2 | US9012475, 2 | US9346787, ...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(c3F)C(F)(F)F)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C24H22F5N5O3/c1-13-11-18(33-32-13)31-20-17(25)6-5-14(30-20)12-23(22(36)37)7-9-34(10-8-23)21(35)15-3-2-4-16(19(15)26)24(27,28)29/h2-6,11H,7-10,12H2,1H3,(H,36,37)(H2,30,31,32,33)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155566
PNG
(US10092556, Example 2 | US9012475, 2 | US9346787, ...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(c3F)C(F)(F)F)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C24H22F5N5O3/c1-13-11-18(33-32-13)31-20-17(25)6-5-14(30-20)12-23(22(36)37)7-9-34(10-8-23)21(35)15-3-2-4-16(19(15)26)24(27,28)29/h2-6,11H,7-10,12H2,1H3,(H,36,37)(H2,30,31,32,33)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155574
PNG
(US10092556, Example 24 | US9012475, 24 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3ncon3)ccc2F)n[nH]1
Show InChI InChI=1S/C24H22ClF2N7O2/c1-14-11-19(32-31-14)30-21-18(26)6-5-15(29-21)12-24(23-28-13-36-33-23)7-9-34(10-8-24)22(35)16-3-2-4-17(25)20(16)27/h2-6,11,13H,7-10,12H2,1H3,(H2,29,30,31,32)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155566
PNG
(US10092556, Example 2 | US9012475, 2 | US9346787, ...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(c3F)C(F)(F)F)C(O)=O)ccc2F)n[nH]1
Show InChI InChI=1S/C24H22F5N5O3/c1-13-11-18(33-32-13)31-20-17(25)6-5-14(30-20)12-23(22(36)37)7-9-34(10-8-23)21(35)15-3-2-4-16(19(15)26)24(27,28)29/h2-6,11H,7-10,12H2,1H3,(H,36,37)(H2,30,31,32,33)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155574
PNG
(US10092556, Example 24 | US9012475, 24 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3ncon3)ccc2F)n[nH]1
Show InChI InChI=1S/C24H22ClF2N7O2/c1-14-11-19(32-31-14)30-21-18(26)6-5-15(29-21)12-24(23-28-13-36-33-23)7-9-34(10-8-24)22(35)16-3-2-4-17(25)20(16)27/h2-6,11,13H,7-10,12H2,1H3,(H2,29,30,31,32)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155567
PNG
(US10092556, Example 11 | US9012475, 11 | US9346787...)
Show SMILES COc1ccc(CC2(CCN(CC2)C(=O)c2cccc(Cl)c2F)C(O)=O)nc1Nc1cc(C)[nH]n1
Show InChI InChI=1S/C24H25ClFN5O4/c1-14-12-19(30-29-14)28-21-18(35-2)7-6-15(27-21)13-24(23(33)34)8-10-31(11-9-24)22(32)16-4-3-5-17(25)20(16)26/h3-7,12H,8-11,13H2,1-2H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.600n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161440
PNG
(US10124003, Ex. Compound 53 | US9108973, 53)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O3/c1-35-22-12-19(13-23(14-22)36-2)7-8-20-15-33(27-25(20)26(28)29-18-30-27)21-16-32(17-21)24(34)6-5-11-31-9-3-4-10-31/h5-6,12-15,18,21H,3-4,9-11,16-17H2,1-2H3,(H2,28,29,30)/b6-5+
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Taiho Pharmaceutical Co., Ltd.

US Patent




US Patent US10124003 (2018)


BindingDB Entry DOI: 10.7270/Q2B27XBQ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155567
PNG
(US10092556, Example 11 | US9012475, 11 | US9346787...)
Show SMILES COc1ccc(CC2(CCN(CC2)C(=O)c2cccc(Cl)c2F)C(O)=O)nc1Nc1cc(C)[nH]n1
Show InChI InChI=1S/C24H25ClFN5O4/c1-14-12-19(30-29-14)28-21-18(35-2)7-6-15(27-21)13-24(23(33)34)8-10-31(11-9-24)22(32)16-4-3-5-17(25)20(16)26/h3-7,12H,8-11,13H2,1-2H3,(H,33,34)(H2,27,28,29,30)
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n/an/a 0.600n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM47238
PNG
(US9012475, MLN8237)
Show SMILES COc1cc(Nc2ncc3CN=C(c4c(F)cccc4OC)c4c(Cl)cccc4-c3n2)ccc1C(O)=O |t:11|
Show InChI InChI=1S/C27H20ClFN4O4/c1-36-20-8-4-7-19(29)23(20)25-22-17(5-3-6-18(22)28)24-14(12-30-25)13-31-27(33-24)32-15-9-10-16(26(34)35)21(11-15)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50277545
PNG
(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Show SMILES COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O |c:11|
Show InChI InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (Human))
BDBM50277545
PNG
(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Show SMILES COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O |c:11|
Show InChI InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase A


(Homo sapiens (Human))
BDBM155567
PNG
(US10092556, Example 11 | US9012475, 11 | US9346787...)
Show SMILES COc1ccc(CC2(CCN(CC2)C(=O)c2cccc(Cl)c2F)C(O)=O)nc1Nc1cc(C)[nH]n1
Show InChI InChI=1S/C24H25ClFN5O4/c1-14-12-19(30-29-14)28-21-18(35-2)7-6-15(27-21)13-24(23(33)34)8-10-31(11-9-24)22(32)16-4-3-5-17(25)20(16)26/h3-7,12H,8-11,13H2,1-2H3,(H,33,34)(H2,27,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161440
PNG
(US10124003, Ex. Compound 53 | US9108973, 53)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O3/c1-35-22-12-19(13-23(14-22)36-2)7-8-20-15-33(27-25(20)26(28)29-18-30-27)21-16-32(17-21)24(34)6-5-11-31-9-3-4-10-31/h5-6,12-15,18,21H,3-4,9-11,16-17H2,1-2H3,(H2,28,29,30)/b6-5+
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n/an/a 0.600n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155575
PNG
(US10092556, Example 28 | US9012475, 28 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3nnc(C)o3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-31-14)30-22-19(27)7-6-16(29-22)13-25(24-34-32-15(2)37-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,29,30,31,33)
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n/an/a 0.700n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155573
PNG
(US10092556, Example 22 | US9012475, 22 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3noc(C)n3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-32-14)31-22-19(27)7-6-16(30-22)13-25(24-29-15(2)37-34-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,30,31,32,33)
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n/an/a 0.700n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155575
PNG
(US10092556, Example 28 | US9012475, 28 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3nnc(C)o3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-31-14)30-22-19(27)7-6-16(29-22)13-25(24-34-32-15(2)37-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,29,30,31,33)
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n/an/a 0.700n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155573
PNG
(US10092556, Example 22 | US9012475, 22 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3noc(C)n3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-32-14)31-22-19(27)7-6-16(30-22)13-25(24-29-15(2)37-34-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,30,31,32,33)
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n/an/a 0.700n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155575
PNG
(US10092556, Example 28 | US9012475, 28 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3nnc(C)o3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-31-14)30-22-19(27)7-6-16(29-22)13-25(24-34-32-15(2)37-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,29,30,31,33)
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n/an/a 0.700n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155573
PNG
(US10092556, Example 22 | US9012475, 22 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3noc(C)n3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-32-14)31-22-19(27)7-6-16(30-22)13-25(24-29-15(2)37-34-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,30,31,32,33)
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n/an/a 0.700n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161449
PNG
(US9108973, 62)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@H](O)C2)c2ncnc(N)c12 |r|
Show InChI InChI=1/C27H30N6O4/c1-36-22-10-18(11-23(12-22)37-2)5-6-19-13-33(27-25(19)26(28)29-17-30-27)20-14-32(15-20)24(35)4-3-8-31-9-7-21(34)16-31/h3-4,10-13,17,20-21,34H,7-9,14-16H2,1-2H3,(H2,28,29,30)/b4-3+/t21-/s2
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n/an/a 0.700n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US9108973, 52 | US91...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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n/an/a 0.700n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155576
PNG
(US10092556, Example 29 | US9012475, 29 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3nc(C)no3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-32-14)31-22-19(27)7-6-16(30-22)13-25(24-29-15(2)34-37-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,30,31,32,33)
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n/an/a 0.800n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155576
PNG
(US10092556, Example 29 | US9012475, 29 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3nc(C)no3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-32-14)31-22-19(27)7-6-16(30-22)13-25(24-29-15(2)34-37-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,30,31,32,33)
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n/an/a 0.800n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155576
PNG
(US10092556, Example 29 | US9012475, 29 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)c3nc(C)no3)ccc2F)n[nH]1
Show InChI InChI=1S/C25H24ClF2N7O2/c1-14-12-20(33-32-14)31-22-19(27)7-6-16(30-22)13-25(24-29-15(2)34-37-24)8-10-35(11-9-25)23(36)17-4-3-5-18(26)21(17)28/h3-7,12H,8-11,13H2,1-2H3,(H2,30,31,32,33)
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n/an/a 0.800n/an/an/an/a7.425



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...


US Patent US9346787 (2016)


BindingDB Entry DOI: 10.7270/Q28K77Z2
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155570
PNG
(US10092556, Example 14 | US9012475, 14 | US9346787...)
Show SMILES CNC(=O)C1(Cc2ccc(F)c(Nc3cc(C)[nH]n3)n2)CCN(CC1)C(=O)c1cccc(Cl)c1F
Show InChI InChI=1S/C24H25ClF2N6O2/c1-14-12-19(32-31-14)30-21-18(26)7-6-15(29-21)13-24(23(35)28-2)8-10-33(11-9-24)22(34)16-4-3-5-17(25)20(16)27/h3-7,12H,8-11,13H2,1-2H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 0.900n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...


US Patent US9012475 (2015)


BindingDB Entry DOI: 10.7270/Q2MW2FWZ
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM155571
PNG
(US10092556, Example 17 | US9012475, 17 | US9346787...)
Show SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(=O)NC3CC3)ccc2F)n[nH]1
Show InChI InChI=1S/C26H27ClF2N6O2/c1-15-13-21(34-33-15)32-23-20(28)8-7-17(30-23)14-26(25(37)31-16-5-6-16)9-11-35(12-10-26)24(36)18-3-2-4-19(27)22(18)29/h2-4,7-8,13,16H,5-6,9-12,14H2,1H3,(H,31,37)(H2,30,32,33,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent




US Patent US10092556 (2018)


BindingDB Entry DOI: 10.7270/Q2ZG6V8B
More data for this
Ligand-Target Pair
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