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Compile Data Set for Download or QSAR

Found 239 hits with Last Name = 'starnes' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222500
PNG
(CHEMBL250482 | N-(4-cyclohexylphenyl)-2-(pyridin-4...)
Show SMILES O=C(Nc1ccc(cc1)C1CCCCC1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H26N4O/c29-24(28-21-10-8-20(9-11-21)19-5-2-1-3-6-19)22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18/h4,7-16,19H,1-3,5-6,17H2,(H,26,27)(H,28,29)
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2n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222499
PNG
(CHEMBL401153 | N-(3-chlorophenyl)-2-(pyridin-4-ylm...)
Show SMILES Clc1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1
Show InChI InChI=1S/C18H15ClN4O/c19-14-3-1-4-15(11-14)23-18(24)16-5-2-8-21-17(16)22-12-13-6-9-20-10-7-13/h1-11H,12H2,(H,21,22)(H,23,24)
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2n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222501
PNG
(CHEMBL250684 | N-(4-chloro-3-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cccnc2NCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C19H14ClF3N4O/c20-16-4-3-13(10-15(16)19(21,22)23)27-18(28)14-2-1-7-25-17(14)26-11-12-5-8-24-9-6-12/h1-10H,11H2,(H,25,26)(H,27,28)
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4n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222498
PNG
(CHEMBL400512 | N-(3,5-bis(trifluoromethyl)phenyl)-...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cccnc2NCc2ccncc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C20H14F6N4O/c21-19(22,23)13-8-14(20(24,25)26)10-15(9-13)30-18(31)16-2-1-5-28-17(16)29-11-12-3-6-27-7-4-12/h1-10H,11H2,(H,28,29)(H,30,31)
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8n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222509
PNG
(CHEMBL250228 | N-(4-chlorophenyl)-2-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C18H15ClN4O/c19-14-3-5-15(6-4-14)23-18(24)16-2-1-9-21-17(16)22-12-13-7-10-20-11-8-13/h1-11H,12H2,(H,21,22)(H,23,24)
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8n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of unphosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222512
PNG
(2-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C19H15F3N4O/c20-19(21,22)14-3-5-15(6-4-14)26-18(27)16-2-1-9-24-17(16)25-12-13-7-10-23-11-8-13/h1-11H,12H2,(H,24,25)(H,26,27)
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9n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM15019
PNG
(CHEMBL385178 | N-(4-phenoxyphenyl)-2-[(pyridin-4-y...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H20N4O2/c29-24(22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18)28-19-8-10-21(11-9-19)30-20-5-2-1-3-6-20/h1-16H,17H2,(H,26,27)(H,28,29)
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10n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50132151
PNG
(CHEMBL101683 | N-(4-Chloro-phenyl)-2-[(pyridin-4-y...)
Show SMILES Clc1ccc(NC(=O)c2ccccc2NCc2ccncc2)cc1
Show InChI InChI=1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)
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15n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222513
PNG
(CHEMBL248781 | N-(3,4-dichlorophenyl)-2-(pyridin-4...)
Show SMILES Clc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C18H14Cl2N4O/c19-15-4-3-13(10-16(15)20)24-18(25)14-2-1-7-22-17(14)23-11-12-5-8-21-9-6-12/h1-10H,11H2,(H,22,23)(H,24,25)
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17n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222516
PNG
(CHEMBL400140 | N-(4-butylphenyl)-2-(pyridin-4-ylme...)
Show SMILES CCCCc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C22H24N4O/c1-2-3-5-17-7-9-19(10-8-17)26-22(27)20-6-4-13-24-21(20)25-16-18-11-14-23-15-12-18/h4,6-15H,2-3,5,16H2,1H3,(H,24,25)(H,26,27)
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19n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222503
PNG
(CHEMBL248976 | N-biphenyl-4-yl-2-[(pyridin-4-ylmet...)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H20N4O/c29-24(28-21-10-8-20(9-11-21)19-5-2-1-3-6-19)22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18/h1-16H,17H2,(H,26,27)(H,28,29)
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23n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222517
PNG
(2-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C19H15F3N4O2/c20-19(21,22)28-15-5-3-14(4-6-15)26-18(27)16-2-1-9-24-17(16)25-12-13-7-10-23-11-8-13/h1-11H,12H2,(H,24,25)(H,26,27)
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23n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222504
PNG
(CHEMBL249192 | ethyl 5-(3-(2-(pyridin-4-ylmethylam...)
Show SMILES CCOC(=O)c1coc(c1)-c1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1
Show InChI InChI=1S/C25H22N4O4/c1-2-32-25(31)19-14-22(33-16-19)18-5-3-6-20(13-18)29-24(30)21-7-4-10-27-23(21)28-15-17-8-11-26-12-9-17/h3-14,16H,2,15H2,1H3,(H,27,28)(H,29,30)
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29n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222508
PNG
(2-(benzo[d][1,3]dioxol-5-ylmethylamino)-N-(4-pheno...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1NCc1ccc2OCOc2c1
Show InChI InChI=1S/C26H21N3O4/c30-26(29-19-9-11-21(12-10-19)33-20-5-2-1-3-6-20)22-7-4-14-27-25(22)28-16-18-8-13-23-24(15-18)32-17-31-23/h1-15H,16-17H2,(H,27,28)(H,29,30)
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38n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222496
PNG
(2-(1H-indazol-6-ylamino)-N-(4-phenoxyphenyl)nicoti...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1Nc1ccc2cn[nH]c2c1
Show InChI InChI=1S/C25H19N5O2/c31-25(29-18-10-12-21(13-11-18)32-20-5-2-1-3-6-20)22-7-4-14-26-24(22)28-19-9-8-17-16-27-30-23(17)15-19/h1-16H,(H,26,28)(H,27,30)(H,29,31)
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70n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222507
PNG
(CHEMBL399546 | N-biphenyl-3-yl-2-[(pyridin-4-ylmet...)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H20N4O/c29-24(28-21-9-4-8-20(16-21)19-6-2-1-3-7-19)22-10-5-13-26-23(22)27-17-18-11-14-25-15-12-18/h1-16H,17H2,(H,26,27)(H,28,29)
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91n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222520
PNG
(CHEMBL248980 | N-(3-ethylphenyl)-2-(pyridin-4-ylme...)
Show SMILES CCc1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H20N4O/c1-2-15-5-3-6-17(13-15)24-20(25)18-7-4-10-22-19(18)23-14-16-8-11-21-12-9-16/h3-13H,2,14H2,1H3,(H,22,23)(H,24,25)
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106n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222497
PNG
(CHEMBL250842 | N-(4-chlorophenyl)-3-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2sccc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H14ClN3OS/c18-13-1-3-14(4-2-13)21-17(22)16-15(7-10-23-16)20-11-12-5-8-19-9-6-12/h1-10,20H,11H2,(H,21,22)
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120n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of unphosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222522
PNG
(2-(4-fluorophenylamino)-N-(4-phenoxyphenyl)nicotin...)
Show SMILES Fc1ccc(Nc2ncccc2C(=O)Nc2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H18FN3O2/c25-17-8-10-18(11-9-17)27-23-22(7-4-16-26-23)24(29)28-19-12-14-21(15-13-19)30-20-5-2-1-3-6-20/h1-16H,(H,26,27)(H,28,29)
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135n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222519
PNG
(CHEMBL250665 | N-(4-chlorophenyl)-4-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2cncnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H14ClN5O/c18-13-1-3-14(4-2-13)23-17(24)15-10-20-11-22-16(15)21-9-12-5-7-19-8-6-12/h1-8,10-11H,9H2,(H,23,24)(H,20,21,22)
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140n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222510
PNG
(CHEMBL249194 | N-(3-phenoxyphenyl)-2-(pyridin-4-yl...)
Show SMILES O=C(Nc1cccc(Oc2ccccc2)c1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H20N4O2/c29-24(22-10-5-13-26-23(22)27-17-18-11-14-25-15-12-18)28-19-6-4-9-21(16-19)30-20-7-2-1-3-8-20/h1-16H,17H2,(H,26,27)(H,28,29)
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259n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222515
PNG
(2-(pyridin-4-ylmethylamino)-N-p-tolylnicotinamide ...)
Show SMILES Cc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C19H18N4O/c1-14-4-6-16(7-5-14)23-19(24)17-3-2-10-21-18(17)22-13-15-8-11-20-12-9-15/h2-12H,13H2,1H3,(H,21,22)(H,23,24)
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320n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222523
PNG
(5-bromo-N-(4-chlorophenyl)-2-(pyridin-4-ylmethylam...)
Show SMILES Clc1ccc(NC(=O)c2cc(Br)cnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C18H14BrClN4O/c19-13-9-16(18(25)24-15-3-1-14(20)2-4-15)17(23-11-13)22-10-12-5-7-21-8-6-12/h1-9,11H,10H2,(H,22,23)(H,24,25)
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490n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222514
PNG
(CHEMBL249599 | N-(3-(1-hydroxyethyl)phenyl)-2-(pyr...)
Show SMILES CC(O)c1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1 |w:1.0|
Show InChI InChI=1S/C20H20N4O2/c1-14(25)16-4-2-5-17(12-16)24-20(26)18-6-3-9-22-19(18)23-13-15-7-10-21-11-8-15/h2-12,14,25H,13H2,1H3,(H,22,23)(H,24,26)
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>6.66E+3n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222506
PNG
(CHEMBL400102 | N-(4-(4-methylpiperazin-1-yl)phenyl...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C23H26N6O/c1-28-13-15-29(16-14-28)20-6-4-19(5-7-20)27-23(30)21-3-2-10-25-22(21)26-17-18-8-11-24-12-9-18/h2-12H,13-17H2,1H3,(H,25,26)(H,27,30)
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>6.66E+3n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222505
PNG
(CHEMBL250472 | N-(4-chlorophenyl)-3-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2ncccc2NCc2ccncc2)cc1
Show InChI InChI=1S/C18H15ClN4O/c19-14-3-5-15(6-4-14)23-18(24)17-16(2-1-9-21-17)22-12-13-7-10-20-11-8-13/h1-11,22H,12H2,(H,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222511
PNG
(CHEMBL400584 | N-(4-chlorophenyl)-2-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)C2CCCCC2NCc2ccncc2)cc1 |w:8.7,13.14|
Show InChI InChI=1S/C19H22ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h5-12,17-18,22H,1-4,13H2,(H,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222521
PNG
(CHEMBL250470 | N-(4-chlorophenyl)-6-methyl-2-(pyri...)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Cl)cc2)c(NCc2ccncc2)n1
Show InChI InChI=1S/C19H17ClN4O/c1-13-2-7-17(19(25)24-16-5-3-15(20)4-6-16)18(23-13)22-12-14-8-10-21-11-9-14/h2-11H,12H2,1H3,(H,22,23)(H,24,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of unphosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222518
PNG
(2-(benzo[b]thiophen-3-ylamino)-N-(4-phenoxyphenyl)...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1Nc1csc2ccccc12
Show InChI InChI=1S/C26H19N3O2S/c30-26(28-18-12-14-20(15-13-18)31-19-7-2-1-3-8-19)22-10-6-16-27-25(22)29-23-17-32-24-11-5-4-9-21(23)24/h1-17H,(H,27,29)(H,28,30)
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>2.00E+4n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222502
PNG
(CHEMBL249606 | N-(2-phenoxyphenyl)-2-(pyridin-4-yl...)
Show SMILES O=C(Nc1ccccc1Oc1ccccc1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H20N4O2/c29-24(20-9-6-14-26-23(20)27-17-18-12-15-25-16-13-18)28-21-10-4-5-11-22(21)30-19-7-2-1-3-8-19/h1-16H,17H2,(H,26,27)(H,28,29)
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>2.00E+4n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
BindingDB Entry DOI: 10.7270/Q27P8Z3N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376042
PNG
(CHEMBL409512)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1C(N)=O
Show InChI InChI=1S/C28H20ClN3O4/c1-35-26-15-24-22(14-23(26)27(30)33)25(11-12-31-24)36-19-9-10-20-16(13-19)3-2-4-21(20)28(34)32-18-7-5-17(29)6-8-18/h2-15H,1H3,(H2,30,33)(H,32,34)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376040
PNG
(CHEMBL272824)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c2cc1OC
Show InChI InChI=1S/C28H22N2O4/c1-32-26-16-23-24(17-27(26)33-2)29-14-13-25(23)34-20-11-12-21-18(15-20)7-6-10-22(21)28(31)30-19-8-4-3-5-9-19/h3-17H,1-2H3,(H,30,31)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376025
PNG
(AMG-0309 | CHEMBL409538)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccon3)c2cc1OC
Show InChI InChI=1S/C25H19N3O5/c1-30-22-13-19-20(14-23(22)31-2)26-10-8-21(19)33-16-6-7-17-15(12-16)4-3-5-18(17)25(29)27-24-9-11-32-28-24/h3-14H,1-2H3,(H,27,28,29)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376026
PNG
(CHEMBL272691)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3nccs3)c2cc1OC
Show InChI InChI=1S/C25H19N3O4S/c1-30-22-13-19-20(14-23(22)31-2)26-9-8-21(19)32-16-6-7-17-15(12-16)4-3-5-18(17)24(29)28-25-27-10-11-33-25/h3-14H,1-2H3,(H,27,28,29)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376019
PNG
(CHEMBL429585)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H20ClFN2O4/c1-34-25-14-21-22(15-26(25)35-2)31-13-12-23(21)36-24-11-10-18-19(27(24)30)4-3-5-20(18)28(33)32-17-8-6-16(29)7-9-17/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376036
PNG
(CHEMBL270092)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376030
PNG
(CHEMBL269916)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H20Cl2N2O4/c1-34-26-14-23-24(15-27(26)35-2)31-9-8-25(23)36-20-6-7-21-16(10-20)4-3-5-22(21)28(33)32-19-12-17(29)11-18(30)13-19/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375996
PNG
(CHEMBL272250)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1C(N)=O
Show InChI InChI=1S/C25H21N3O4/c1-31-23-13-21-19(12-20(23)24(26)29)22(9-10-27-21)32-16-7-8-17-14(11-16)3-2-4-18(17)25(30)28-15-5-6-15/h2-4,7-13,15H,5-6H2,1H3,(H2,26,29)(H,28,30)
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n/an/a 0.370n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375999
PNG
(CHEMBL270342)
Show SMILES COc1ccc2c(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)ccnc2c1
Show InChI InChI=1S/C24H20N2O3/c1-28-17-7-10-21-22(14-17)25-12-11-23(21)29-18-8-9-19-15(13-18)3-2-4-20(19)24(27)26-16-5-6-16/h2-4,7-14,16H,5-6H2,1H3,(H,26,27)
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n/an/a 0.450n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.480n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376033
PNG
(CHEMBL270985)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H21F3N2O4/c1-36-26-15-23-24(16-27(26)37-2)33-13-12-25(23)38-20-10-11-21-17(14-20)4-3-5-22(21)28(35)34-19-8-6-18(7-9-19)29(30,31)32/h3-16H,1-2H3,(H,34,35)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376034
PNG
(CHEMBL271563)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H21F3N2O4/c1-36-26-15-23-24(16-27(26)37-2)33-12-11-25(23)38-20-9-10-21-17(13-20)5-3-8-22(21)28(35)34-19-7-4-6-18(14-19)29(30,31)32/h3-16H,1-2H3,(H,34,35)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376035
PNG
(AMG-6168 | CHEMBL411091)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C29H24N2O4/c1-18-7-9-20(10-8-18)31-29(32)23-6-4-5-19-15-21(11-12-22(19)23)35-26-13-14-30-25-17-28(34-3)27(33-2)16-24(25)26/h4-17H,1-3H3,(H,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236856
PNG
(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC
Show InChI InChI=1S/C25H22N2O4/c1-29-23-13-20-21(14-24(23)30-2)26-11-10-22(20)31-17-8-9-18-15(12-17)4-3-5-19(18)25(28)27-16-6-7-16/h3-5,8-14,16H,6-7H2,1-2H3,(H,27,28)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376038
PNG
(CHEMBL412291)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236856
PNG
(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC
Show InChI InChI=1S/C25H22N2O4/c1-29-23-13-20-21(14-24(23)30-2)26-11-10-22(20)31-17-8-9-18-15(12-17)4-3-5-19(18)25(28)27-16-6-7-16/h3-5,8-14,16H,6-7H2,1-2H3,(H,27,28)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376024
PNG
(CHEMBL259461)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(C)on3)c2cc1OC
Show InChI InChI=1S/C26H21N3O5/c1-15-11-25(29-34-15)28-26(30)19-6-4-5-16-12-17(7-8-18(16)19)33-22-9-10-27-21-14-24(32-3)23(31-2)13-20(21)22/h4-14H,1-3H3,(H,28,29,30)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376032
PNG
(CHEMBL407715)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C32H30N2O4/c1-32(2,3)21-9-11-22(12-10-21)34-31(35)25-8-6-7-20-17-23(13-14-24(20)25)38-28-15-16-33-27-19-30(37-5)29(36-4)18-26(27)28/h6-19H,1-5H3,(H,34,35)
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
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