new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 201 hits with Last Name = 'stefany' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443217
PNG
(CHEMBL3087669)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2c(C)noc2C)c(C)c1 |r|
Show InChI InChI=1S/C22H30N4O2/c1-14-12-18(25-11-9-19(13-25)26-10-5-6-15(26)2)7-8-20(14)23-22(27)21-16(3)24-28-17(21)4/h7-8,12,15,19H,5-6,9-11,13H2,1-4H3,(H,23,27)/t15-,19-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.400n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50443217
PNG
(CHEMBL3087669)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2c(C)noc2C)c(C)c1 |r|
Show InChI InChI=1S/C22H30N4O2/c1-14-12-18(25-11-9-19(13-25)26-10-5-6-15(26)2)7-8-20(14)23-22(27)21-16(3)24-28-17(21)4/h7-8,12,15,19H,5-6,9-11,13H2,1-4H3,(H,23,27)/t15-,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.900n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylhistamine from rat histamine H3 receptor (445 amino acid residues) transfected in human 293 cells after 1 hr by scintillat...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443216
PNG
(CHEMBL3087667)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(C)no2)c(C)c1 |r|
Show InChI InChI=1S/C21H28N4O2/c1-14-11-17(24-10-8-18(13-24)25-9-4-5-16(25)3)6-7-19(14)22-21(26)20-12-15(2)23-27-20/h6-7,11-12,16,18H,4-5,8-10,13H2,1-3H3,(H,22,26)/t16-,18-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443227
PNG
(CHEMBL3087356)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cccc(C)n2)c(C)c1 |r|
Show InChI InChI=1S/C23H30N4O/c1-16-14-19(26-13-11-20(15-26)27-12-5-7-18(27)3)9-10-21(16)25-23(28)22-8-4-6-17(2)24-22/h4,6,8-10,14,18,20H,5,7,11-13,15H2,1-3H3,(H,25,28)/t18-,20-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.40n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443226
PNG
(CHEMBL3087357)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2ccoc2)c(C)c1 |r|
Show InChI InChI=1S/C21H27N3O2/c1-15-12-18(5-6-20(15)22-21(25)17-8-11-26-14-17)23-10-7-19(13-23)24-9-3-4-16(24)2/h5-6,8,11-12,14,16,19H,3-4,7,9-10,13H2,1-2H3,(H,22,25)/t16-,19-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50437067
PNG
(CHEMBL2403550)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(F)ccc2C)c(C)c1 |r|
Show InChI InChI=1S/C24H30FN3O/c1-16-6-7-19(25)14-22(16)24(29)26-23-9-8-20(13-17(23)2)27-12-10-21(15-27)28-11-4-5-18(28)3/h6-9,13-14,18,21H,4-5,10-12,15H2,1-3H3,(H,26,29)/t18-,21-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.5n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443225
PNG
(CHEMBL3087671)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NS(=O)(=O)c2ccc(F)c(F)c2)c(C)n1 |r|
Show InChI InChI=1S/C21H26F2N4O2S/c1-14-4-3-10-27(14)16-9-11-26(13-16)21-8-7-20(15(2)24-21)25-30(28,29)17-5-6-18(22)19(23)12-17/h5-8,12,14,16,25H,3-4,9-11,13H2,1-2H3/t14-,16-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.5n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443224
PNG
(CHEMBL3087670)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2ccccc2)c(C)n1 |r|
Show InChI InChI=1S/C22H28N4O/c1-16-7-6-13-26(16)19-12-14-25(15-19)21-11-10-20(17(2)23-21)24-22(27)18-8-4-3-5-9-18/h3-5,8-11,16,19H,6-7,12-15H2,1-2H3,(H,24,27)/t16-,19-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443223
PNG
(CHEMBL3087358)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2ccco2)c(C)c1 |r|
Show InChI InChI=1S/C21H27N3O2/c1-15-13-17(7-8-19(15)22-21(25)20-6-4-12-26-20)23-11-9-18(14-23)24-10-3-5-16(24)2/h4,6-8,12-13,16,18H,3,5,9-11,14H2,1-2H3,(H,22,25)/t16-,18-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.90n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443222
PNG
(CHEMBL3087673)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cccc3ccccc23)c(C)n1 |r|
Show InChI InChI=1S/C26H30N4O/c1-18-7-6-15-30(18)21-14-16-29(17-21)25-13-12-24(19(2)27-25)28-26(31)23-11-5-9-20-8-3-4-10-22(20)23/h3-5,8-13,18,21H,6-7,14-17H2,1-2H3,(H,28,31)/t18-,21-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.20n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200837
PNG
(2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidin...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCOCC2)C1=O |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
4.21n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443221
PNG
(CHEMBL3087668)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2coc(C)n2)c(C)c1 |r|
Show InChI InChI=1S/C21H28N4O2/c1-14-11-17(24-10-8-18(12-24)25-9-4-5-15(25)2)6-7-19(14)23-21(26)20-13-27-16(3)22-20/h6-7,11,13,15,18H,4-5,8-10,12H2,1-3H3,(H,23,26)/t15-,18-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.60n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443220
PNG
(CHEMBL3087359)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(C)n[nH]2)c(C)c1 |r|
Show InChI InChI=1S/C21H29N5O/c1-14-11-17(25-10-8-18(13-25)26-9-4-5-16(26)3)6-7-19(14)22-21(27)20-12-15(2)23-24-20/h6-7,11-12,16,18H,4-5,8-10,13H2,1-3H3,(H,22,27)(H,23,24)/t16-,18-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.70n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443219
PNG
(CHEMBL3087672)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)Cc2ccccc2)c(C)n1 |r|
Show InChI InChI=1S/C23H30N4O/c1-17-7-6-13-27(17)20-12-14-26(16-20)22-11-10-21(18(2)24-22)25-23(28)15-19-8-4-3-5-9-19/h3-5,8-11,17,20H,6-7,12-16H2,1-2H3,(H,25,28)/t17-,20-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.90n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200827
PNG
(2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCOCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
7.10n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200831
PNG
(2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
7.57n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443218
PNG
(CHEMBL3087360)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(C)n(C)n2)c(C)c1 |r|
Show InChI InChI=1S/C22H31N5O/c1-15-12-18(26-11-9-19(14-26)27-10-5-6-16(27)2)7-8-20(15)23-22(28)21-13-17(3)25(4)24-21/h7-8,12-13,16,19H,5-6,9-11,14H2,1-4H3,(H,23,28)/t16-,19-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
11n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.081
BindingDB Entry DOI: 10.7270/Q27D2WK2
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200828
PNG
(2-[2-methyl-6-((2s,3'r)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
17.5n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200833
PNG
(2-[5-((2s,3's)-2-methyl-[1,3']bipyrrolidin...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(nc1)N1CCC2(CCOCC2)C1=O |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
22.3n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200830
PNG
(2-[5-((2s,3's)-2-methyl-[1,3']bipyrrolidin...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1cnc(cn1)N1CCC2(CCNCC2)C1=O |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
26.3n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200815
PNG
(1 2-[2-Methyl-6-((2S,3′R)-2-methyl-[1,3̸...)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCOCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
37.6n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200829
PNG
(2-[2-methyl-6-((2s,3'r)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCCC3(CCNCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
38.9n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200832
PNG
(2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidin...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
48.5n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200823
PNG
(2-[2-methyl-6-((2s,3'r)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCCCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
56.5n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200821
PNG
(2-[2-methyl-6-((2s,3'r)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCCC3(CCOCC3)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
95.1n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200836
PNG
(2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(C)n1 |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
95.5n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200834
PNG
(2-[5-((2s,3's)-2-methyl-[1,3']bipyrrolidin...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1cnc(cn1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O |r|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
105n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200822
PNG
(8-hydroxy-2-[2-methyl-6-((2s,3'r)-2-methyl-[1,...)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCC(O)CC3)C2=O)c(C)n1 |r,wU:6.6,wD:1.0,(5.66,-3.46,;6.99,-2.69,;8.46,-3.17,;9.36,-1.92,;8.46,-.68,;6.99,-1.15,;5.66,-.38,;5.66,1.16,;4.2,1.63,;3.29,.38,;4.2,-.86,;1.75,.38,;.98,-.95,;-.56,-.95,;-1.33,.38,;-2.99,.38,;-3.9,-.86,;-5.36,-.39,;-5.36,1.15,;-5.36,2.69,;-6.7,3.46,;-8.03,2.69,;-9.36,3.46,;-8.03,1.15,;-6.7,.38,;-3.9,1.63,;-3.13,2.96,;-.56,1.72,;-1.33,3.05,;.98,1.72,)|
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
267n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


US Patent US9533995 (2017)


BindingDB Entry DOI: 10.7270/Q25H7DFS
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417722
PNG
(CHEMBL1644207)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C(F)(F)C(O)=O
Show InChI InChI=1S/C21H17Cl2F2N3O3/c1-31-20-27-17(13-3-2-4-14(9-13)21(24,25)19(29)30)11-18(28-20)26-8-7-12-5-6-15(22)10-16(12)23/h2-6,9-11H,7-8H2,1H3,(H,29,30)(H,26,27,28)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0200n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417777
PNG
(CHEMBL1644214)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C1(CCOCC1)C(O)=O
Show InChI InChI=1S/C25H25Cl2N3O4/c1-33-24-29-21(15-22(30-24)28-10-7-16-5-6-19(26)14-20(16)27)17-3-2-4-18(13-17)25(23(31)32)8-11-34-12-9-25/h2-6,13-15H,7-12H2,1H3,(H,31,32)(H,28,29,30)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0501n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417721
PNG
(CHEMBL1644206)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C(F)(F)c1nnn[nH]1
Show InChI InChI=1S/C21H17Cl2F2N7O/c1-33-20-27-17(11-18(28-20)26-8-7-12-5-6-15(22)10-16(12)23)13-3-2-4-14(9-13)21(24,25)19-29-31-32-30-19/h2-6,9-11H,7-8H2,1H3,(H,26,27,28)(H,29,30,31,32)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417759
PNG
(CHEMBL1644213)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C20H17Cl2N3O3/c1-28-20-24-17(13-3-2-4-14(9-13)19(26)27)11-18(25-20)23-8-7-12-5-6-15(21)10-16(12)22/h2-6,9-11H,7-8H2,1H3,(H,26,27)(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.302n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417747
PNG
(CHEMBL1644245)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C(C)(C)C(O)=O
Show InChI InChI=1S/C23H23Cl2N3O3/c1-23(2,21(29)30)16-6-4-5-15(11-16)19-13-20(28-22(27-19)31-3)26-10-9-14-7-8-17(24)12-18(14)25/h4-8,11-13H,9-10H2,1-3H3,(H,29,30)(H,26,27,28)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.302n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417725
PNG
(CHEMBL1644211)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C(C)(C)c1nnn[nH]1
Show InChI InChI=1S/C23H23Cl2N7O/c1-23(2,21-29-31-32-30-21)16-6-4-5-15(11-16)19-13-20(28-22(27-19)33-3)26-10-9-14-7-8-17(24)12-18(14)25/h4-8,11-13H,9-10H2,1-3H3,(H,26,27,28)(H,29,30,31,32)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.398n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417764
PNG
(CHEMBL1644227)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2cccc(c2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C21H21N7O2/c1-29-17-8-6-14(7-9-17)10-11-22-19-13-18(23-21(24-19)30-2)15-4-3-5-16(12-15)20-25-27-28-26-20/h3-9,12-13H,10-11H2,1-2H3,(H,22,23,24)(H,25,26,27,28)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.398n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417771
PNG
(CHEMBL1644247)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2ccc(F)c(c2)C(O)=O)cc1
Show InChI InChI=1S/C21H20FN3O4/c1-28-15-6-3-13(4-7-15)9-10-23-19-12-18(24-21(25-19)29-2)14-5-8-17(22)16(11-14)20(26)27/h3-8,11-12H,9-10H2,1-2H3,(H,26,27)(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.398n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417723
PNG
(CHEMBL1644208)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cc(ccc1F)C(C)(C)C(O)=O
Show InChI InChI=1S/C23H22Cl2FN3O3/c1-23(2,21(30)31)14-5-7-18(26)16(10-14)19-12-20(29-22(28-19)32-3)27-9-8-13-4-6-15(24)11-17(13)25/h4-7,10-12H,8-9H2,1-3H3,(H,30,31)(H,27,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.501n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417726
PNG
(CHEMBL1644212)
Show SMILES COc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C25H25Cl2N3O3/c1-33-24-29-21(15-22(30-24)28-12-9-16-7-8-19(26)14-20(16)27)17-5-4-6-18(13-17)25(23(31)32)10-2-3-11-25/h4-8,13-15H,2-3,9-12H2,1H3,(H,31,32)(H,28,29,30)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.501n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417773
PNG
(CHEMBL1644253)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2ccc(OC)c(c2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C22H23N7O3/c1-30-16-7-4-14(5-8-16)10-11-23-20-13-18(24-22(25-20)32-3)15-6-9-19(31-2)17(12-15)21-26-28-29-27-21/h4-9,12-13H,10-11H2,1-3H3,(H,23,24,25)(H,26,27,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.501n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417728
PNG
(CHEMBL1644217)
Show SMILES COc1nc(NCCc2ccc(F)cc2F)cc(n1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C20H17F2N3O3/c1-28-20-24-17(13-3-2-4-14(9-13)19(26)27)11-18(25-20)23-8-7-12-5-6-15(21)10-16(12)22/h2-6,9-11H,7-8H2,1H3,(H,26,27)(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.794n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417763
PNG
(CHEMBL1644224)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2cccc(c2)C#N)cc1
Show InChI InChI=1S/C21H20N4O2/c1-26-18-8-6-15(7-9-18)10-11-23-20-13-19(24-21(25-20)27-2)17-5-3-4-16(12-17)14-22/h3-9,12-13H,10-11H2,1-2H3,(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.891n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417754
PNG
(CHEMBL1644255)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-3-14(4-10-17)11-12-23-19-13-18(24-21(25-19)28-2)15-5-7-16(8-6-15)20(22)26/h3-10,13H,11-12H2,1-2H3,(H2,22,26)(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.29n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417778
PNG
(CHEMBL1644260)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2ccc(s2)-c2cnco2)cc1
Show InChI InChI=1S/C21H20N4O3S/c1-26-15-5-3-14(4-6-15)9-10-23-20-11-16(24-21(25-20)27-2)18-7-8-19(29-18)17-12-22-13-28-17/h3-8,11-13H,9-10H2,1-2H3,(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.29n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417774
PNG
(CHEMBL1644256)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2cccc(c2)-c2cnco2)cc1
Show InChI InChI=1S/C23H22N4O3/c1-28-19-8-6-16(7-9-19)10-11-25-22-13-20(26-23(27-22)29-2)17-4-3-5-18(12-17)21-14-24-15-30-21/h3-9,12-15H,10-11H2,1-2H3,(H,25,26,27)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.57n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417767
PNG
(CHEMBL1644235)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2cccc(c2)-c2nc(C)no2)cc1
Show InChI InChI=1S/C23H23N5O3/c1-15-25-22(31-28-15)18-6-4-5-17(13-18)20-14-21(27-23(26-20)30-3)24-12-11-16-7-9-19(29-2)10-8-16/h4-10,13-14H,11-12H2,1-3H3,(H,24,26,27)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.57n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417719
PNG
(CHEMBL1644204)
Show SMILES COCc1nc(NCCc2ccc(Cl)cc2Cl)cc(n1)-c1cccc(c1)C(C)(C)C(O)=O
Show InChI InChI=1S/C24H25Cl2N3O3/c1-24(2,23(30)31)17-6-4-5-16(11-17)20-13-21(29-22(28-20)14-32-3)27-10-9-15-7-8-18(25)12-19(15)26/h4-8,11-13H,9-10,14H2,1-3H3,(H,30,31)(H,27,28,29)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.69n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417768
PNG
(CHEMBL1644238)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2cccc(c2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C20H22N4O4S/c1-27-16-8-6-14(7-9-16)10-11-22-19-13-18(23-20(24-19)28-2)15-4-3-5-17(12-15)29(21,25)26/h3-9,12-13H,10-11H2,1-2H3,(H2,21,25,26)(H,22,23,24)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.88n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417760
PNG
(CHEMBL1644216)
Show SMILES COc1nc(NCCc2c(F)cccc2Cl)cc(n1)-c1cccc(C=O)c1
Show InChI InChI=1S/C20H17ClFN3O2/c1-27-20-24-18(14-5-2-4-13(10-14)12-26)11-19(25-20)23-9-8-15-16(21)6-3-7-17(15)22/h2-7,10-12H,8-9H2,1H3,(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.63n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417744
PNG
(CHEMBL1644240)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2ccc(s2)C(C)=O)cc1
Show InChI InChI=1S/C20H21N3O3S/c1-13(24)17-8-9-18(27-17)16-12-19(23-20(22-16)26-3)21-11-10-14-4-6-15(25-2)7-5-14/h4-9,12H,10-11H2,1-3H3,(H,21,22,23)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50417749
PNG
(CHEMBL1644248)
Show SMILES COc1ccc(CCNc2cc(nc(OC)n2)-c2ccc(F)c(CN=O)c2)cc1
Show InChI InChI=1S/C21H21FN4O3/c1-28-17-6-3-14(4-7-17)9-10-23-20-12-19(25-21(26-20)29-2)15-5-8-18(22)16(11-15)13-24-27/h3-8,11-12H,9-10,13H2,1-2H3,(H,23,25,26)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.47n/an/an/an/an/an/a



Sanofi Aventis US

Curated by ChEMBL


Assay Description
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...


Bioorg Med Chem Lett 21: 66-75 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.071
BindingDB Entry DOI: 10.7270/Q22F7PPM
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 201 total )  |  Next  |  Last  >>
Jump to: