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Compile Data Set for Download or QSAR

Found 449 hits with Last Name = 'strømgaard' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122077
PNG
(CHEMBL153017 | N-[1-[5-(6-Amino-hexylamino)-pentyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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3.30n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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14n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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26n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
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37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194114
PNG
((S)-N-(1-(9-(6-aminohexylamino)nonylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-8-5-3-4-7-11-20-30-21-12-9-6-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194119
PNG
((S)-N-(1-(4-(7-aminoheptylamino)butylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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38n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122093
PNG
(CHEMBL152879 | N-[1-[4-(7-Amino-heptylamino)-butyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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38n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194120
PNG
((S)-N-(1-(4-(6-aminohexylamino)butylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-7-16-25-15-6-4-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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53n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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63n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122084
PNG
(CHEMBL153996 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccncc1
Show InChI InChI=1S/C26H39N5O3/c27-14-7-16-28-15-5-3-1-2-4-6-17-30-26(34)24(20-21-8-10-23(32)11-9-21)31-25(33)22-12-18-29-19-13-22/h8-13,18-19,24,28,32H,1-7,14-17,20,27H2,(H,30,34)(H,31,33)
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64n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194117
PNG
((S)-N-(1-(5-(9-aminononylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-8-11-20-29-19-10-7-5-3-4-6-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
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65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194122
PNG
((S)-N-(1-(8-(3-aminopropylamino)octylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-6-4-3-5-7-16-26-17-9-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122090
PNG
(CHEMBL147182 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-6-4-3-5-7-16-26-17-9-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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65n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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68n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122096
PNG
(CHEMBL152410 | Hexanoic acid [1-[8-(3-amino-propyl...)
Show SMILES CCCCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-3-8-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-10-7-5-4-6-9-18-28-19-11-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)
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68n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194126
PNG
((S)-N-(1-(8-(6-aminohexylamino)octylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-7-4-3-6-10-19-29-20-11-8-5-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
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77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194112
PNG
((S)-N-(1-(5-(12-aminododecylamino)pentylamino)-3-(...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCCCN
Show InChI InChI=1S/C30H54N4O3/c1-2-16-29(36)34-28(25-26-17-19-27(35)20-18-26)30(37)33-24-15-11-14-23-32-22-13-10-8-6-4-3-5-7-9-12-21-31/h17-20,28,32,35H,2-16,21-25,31H2,1H3,(H,33,37)(H,34,36)/t28-/m0/s1
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77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122087
PNG
(CHEMBL153995 | Cyclohexanecarboxylic acid [1-[8-(3...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCCC1
Show InChI InChI=1S/C27H46N4O3/c28-17-10-19-29-18-8-3-1-2-4-9-20-30-27(34)25(21-22-13-15-24(32)16-14-22)31-26(33)23-11-6-5-7-12-23/h13-16,23,25,29,32H,1-12,17-21,28H2,(H,30,34)(H,31,33)
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78n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122085
PNG
(CHEMBL152425 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1cccnc1
Show InChI InChI=1S/C26H39N5O3/c27-14-8-17-28-15-5-3-1-2-4-6-18-30-26(34)24(19-21-10-12-23(32)13-11-21)31-25(33)22-9-7-16-29-20-22/h7,9-13,16,20,24,28,32H,1-6,8,14-15,17-19,27H2,(H,30,34)(H,31,33)
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88n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Mus musculus)
BDBM50118202
PNG
(6-(4-azido-2,3,5,6-tetrafluorobenzyloxy)-8-(tert-b...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)[C@@H]3OCc3c(F)c(F)c(N=[N+]=[N-])c(F)c3F)OC4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C27H25F4N3O10/c1-7-19(36)42-17-16(35)25-10-5-9(23(2,3)4)24(25)18(20(37)43-22(24)44-27(25,21(38)41-10)26(7,17)39)40-6-8-11(28)13(30)15(33-34-32)14(31)12(8)29/h7,9-10,16-18,22,35,39H,5-6H2,1-4H3/t7-,9+,10?,16+,17+,18+,22?,24?,25+,26-,27?/m1/s1
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90n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)


J Med Chem 45: 4038-46 (2002)


BindingDB Entry DOI: 10.7270/Q29G5M5T
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122086
PNG
(CHEMBL269192 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES CC(C)(C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C25H44N4O3/c1-25(2,3)24(32)29-22(19-20-11-13-21(30)14-12-20)23(31)28-18-9-7-5-4-6-8-16-27-17-10-15-26/h11-14,22,27,30H,4-10,15-19,26H2,1-3H3,(H,28,31)(H,29,32)
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90n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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95n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50123637
PNG
(6-benzyloxy-8-(tert-butyl)-9-flouro-12,17-dihydrox...)
Show SMILES C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C43C([C@H]5F)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C27H29FO10/c1-11-19(30)35-17-15(29)25-16-13(28)14(23(2,3)4)24(25)18(34-10-12-8-6-5-7-9-12)20(31)37-22(24)38-27(25,21(32)36-16)26(11,17)33/h5-9,11,13-18,22,29,33H,10H2,1-4H3/t11-,13-,14?,15+,16?,17?,18+,22?,24?,25?,26-,27?/m1/s1
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100n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane


J Med Chem 46: 601-8 (2003)


Article DOI: 10.1021/jm0203985
BindingDB Entry DOI: 10.7270/Q2CC1023
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122095
PNG
(CHEMBL355977 | N-[8-(3-Amino-propylamino)-octyl]-3...)
Show SMILES CCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-6-4-3-5-7-15-25-16-9-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)
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100n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50123639
PNG
(8-(tert-butyl)-9-chloro-6,12,17-trihydroxy-16-meth...)
Show SMILES C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C43C([C@H]5Cl)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C20H23ClO10/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,22-23,27H,1-4H3/t5-,6-,7?,8+,9+,10?,11?,15?,17?,18?,19-,20?/m1/s1
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110n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane


J Med Chem 46: 601-8 (2003)


Article DOI: 10.1021/jm0203985
BindingDB Entry DOI: 10.7270/Q2CC1023
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122092
PNG
(CHEMBL350228 | N-[8-(3-Amino-propylamino)-octyl]-3...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C28H42N4O3/c29-17-10-19-30-18-8-3-1-2-4-9-20-31-28(35)26(21-24-13-15-25(33)16-14-24)32-27(34)22-23-11-6-5-7-12-23/h5-7,11-16,26,30,33H,1-4,8-10,17-22,29H2,(H,31,35)(H,32,34)
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110n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122091
PNG
(CHEMBL152736 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C29H42N4O3/c30-19-10-21-31-20-8-3-1-2-4-9-22-32-29(36)27(23-25-13-16-26(34)17-14-25)33-28(35)18-15-24-11-6-5-7-12-24/h5-7,11-18,27,31,34H,1-4,8-10,19-23,30H2,(H,32,36)(H,33,35)/b18-15+
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110n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
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110n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50123644
PNG
(6-benzyloxy-8-(tert-butyl)-12,17-dihydroxy-16-meth...)
Show SMILES C[C@@H]1C(=O)OC2[C@H](O)C34C5CC(C(C)(C)C)C33C(OC(=O)[C@@H]3OCc3ccccc3)OC4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C27H30O10/c1-12-19(29)35-17-16(28)25-15-10-14(23(2,3)4)24(25)18(33-11-13-8-6-5-7-9-13)20(30)36-22(24)37-27(25,21(31)34-15)26(12,17)32/h5-9,12,14-18,22,28,32H,10-11H2,1-4H3/t12-,14?,15?,16+,17?,18+,22?,24?,25?,26-,27?/m1/s1
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120n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane


J Med Chem 46: 601-8 (2003)


Article DOI: 10.1021/jm0203985
BindingDB Entry DOI: 10.7270/Q2CC1023
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194116
PNG
((S)-N-(1-(3-(6-aminohexylamino)propylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-7-15-24-14-6-4-3-5-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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126n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Mus musculus)
BDBM50118204
PNG
(6-(4-benzoylphenylcarbonyloxy)-8-(tert-butyl)-12,1...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)[C@@H]3OC(=O)c3ccc(cc3)C(=O)c3ccccc3)OC4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C34H32O12/c1-15-25(37)43-23-22(36)32-20-14-19(30(2,3)4)31(32)24(27(39)45-29(31)46-34(32,28(40)42-20)33(15,23)41)44-26(38)18-12-10-17(11-13-18)21(35)16-8-6-5-7-9-16/h5-13,15,19-20,22-24,29,36,41H,14H2,1-4H3/t15-,19+,20?,22+,23+,24+,29?,31?,32+,33-,34?/m1/s1
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130n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)


J Med Chem 45: 4038-46 (2002)


BindingDB Entry DOI: 10.7270/Q29G5M5T
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122094
PNG
(CHEMBL345521 | Pyridine-2-carboxylic acid [1-[8-(3...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccccn1
Show InChI InChI=1S/C26H39N5O3/c27-15-9-17-28-16-6-3-1-2-4-7-19-30-25(33)24(20-21-11-13-22(32)14-12-21)31-26(34)23-10-5-8-18-29-23/h5,8,10-14,18,24,28,32H,1-4,6-7,9,15-17,19-20,27H2,(H,30,33)(H,31,34)
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130n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122089
PNG
(CHEMBL352030 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccccc1
Show InChI InChI=1S/C27H40N4O3/c28-17-10-19-29-18-8-3-1-2-4-9-20-30-27(34)25(21-22-13-15-24(32)16-14-22)31-26(33)23-11-6-5-7-12-23/h5-7,11-16,25,29,32H,1-4,8-10,17-21,28H2,(H,30,34)(H,31,33)
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130n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122093
PNG
(CHEMBL152879 | N-[1-[4-(7-Amino-heptylamino)-butyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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135n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194115
PNG
((S)-N-(1-(5-(2-aminoethylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCN
Show InChI InChI=1S/C20H34N4O3/c1-2-6-19(26)24-18(15-16-7-9-17(25)10-8-16)20(27)23-13-5-3-4-12-22-14-11-21/h7-10,18,22,25H,2-6,11-15,21H2,1H3,(H,23,27)(H,24,26)/t18-/m0/s1
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140n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122086
PNG
(CHEMBL269192 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES CC(C)(C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C25H44N4O3/c1-25(2,3)24(32)29-22(19-20-11-13-21(30)14-12-20)23(31)28-18-9-7-5-4-6-8-16-27-17-10-15-26/h11-14,22,27,30H,4-10,15-19,26H2,1-3H3,(H,28,31)(H,29,32)
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140n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Mus musculus)
BDBM50118194
PNG
(8-(tert-butyl)-12,17-dihydroxy-16-methyl-6-[4-(3-t...)
Show InChI InChI=1S/C29H29F3N2O10/c1-11-19(36)42-17-16(35)25-15-9-14(23(2,3)4)24(25)18(20(37)43-22(24)44-27(25,21(38)41-15)26(11,17)39)40-10-12-5-7-13(8-6-12)28(33-34-28)29(30,31)32/h5-8,11,14-18,22,35,39H,9-10H2,1-4H3/t11-,14+,15?,16+,17+,18+,22?,24?,25+,26-,27?/m1/s1
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150n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)


J Med Chem 45: 4038-46 (2002)


BindingDB Entry DOI: 10.7270/Q29G5M5T
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Mus musculus)
BDBM50118201
PNG
(6-(4-benzoylbenzyloxy)-8-(tert-butyl)-12,17-dihydr...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)[C@@H]3OCc3ccc(cc3)C(=O)c3ccccc3)OC4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C34H34O11/c1-16-26(37)43-24-23(36)32-21-14-20(30(2,3)4)31(32)25(27(38)44-29(31)45-34(32,28(39)42-21)33(16,24)40)41-15-17-10-12-19(13-11-17)22(35)18-8-6-5-7-9-18/h5-13,16,20-21,23-25,29,36,40H,14-15H2,1-4H3/t16-,20+,21?,23+,24+,25+,29?,31?,32+,33-,34?/m1/s1
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150n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)


J Med Chem 45: 4038-46 (2002)


BindingDB Entry DOI: 10.7270/Q29G5M5T
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194110
PNG
((S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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168n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122078
PNG
(CHEMBL422515 | N-[1-[7-(4-Amino-butylamino)-heptyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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168n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122094
PNG
(CHEMBL345521 | Pyridine-2-carboxylic acid [1-[8-(3...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccccn1
Show InChI InChI=1S/C26H39N5O3/c27-15-9-17-28-16-6-3-1-2-4-7-19-30-25(33)24(20-21-11-13-22(32)14-12-21)31-26(34)23-10-5-8-18-29-23/h5,8,10-14,18,24,28,32H,1-4,6-7,9,15-17,19-20,27H2,(H,30,33)(H,31,34)
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170n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50122091
PNG
(CHEMBL152736 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C29H42N4O3/c30-19-10-21-31-20-8-3-1-2-4-9-22-32-29(36)27(23-25-13-16-26(34)17-14-25)33-28(35)18-15-24-11-6-5-7-12-24/h5-7,11-18,27,31,34H,1-4,8-10,19-23,30H2,(H,32,36)(H,33,35)/b18-15+
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170n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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180n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194108
PNG
((S)-N-(1-(2-(6-aminohexylamino)ethylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCNCCCCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-14-23-13-6-4-3-5-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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208n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194107
PNG
((S)-N-(1-(7-(6-aminohexylamino)heptylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-6-3-5-9-18-28-19-10-7-4-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
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208n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
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