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Compile Data Set for Download or QSAR

Found 1133 hits with Last Name = 'stupple' and Initial = 'pa'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM30547
PNG
(US8846698, 583)
Show SMILES Nc1ncc2c(cn(c2n1)C12CC(C1)C2)C(=O)c1cncc(NC(=O)Cc2ccc(Cl)cn2)c1
Show InChI InChI=1S/C24H20ClN7O2/c25-15-1-2-16(28-9-15)4-20(33)30-17-3-14(8-27-10-17)21(34)19-12-32(24-5-13(6-24)7-24)22-18(19)11-29-23(26)31-22/h1-3,8-13H,4-7H2,(H,30,33)(H2,26,29,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.681n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM30449
PNG
(US8846698, 580)
Show SMILES Nc1ncc2c(cn(c2n1)C12CC(C1)C2)C(=O)c1cncc(NC(=O)Cn2ccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N8O2/c24-23(25,26)17-1-2-33(32-17)11-18(35)30-14-3-13(7-28-8-14)19(36)16-10-34(22-4-12(5-22)6-22)20-15(16)9-29-21(27)31-20/h1-3,7-10,12H,4-6,11H2,(H,30,35)(H2,27,29,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.825n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202409
PNG
(US9238644, 16)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C27H31ClN6O/c1-34-14-10-19(11-15-34)23-9-7-20(16-30-23)32-26-31-17-22(28)24(33-26)8-6-18-4-2-3-5-21(18)27(12-13-27)25(29)35/h2-5,7,9,16-17,19H,6,8,10-15H2,1H3,(H2,29,35)(H,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134792
PNG
(US8846698, 256)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C25H23F3N6O3/c1-24(2,13-35)34-12-19(18-11-31-23(29)33-22(18)34)21(37)15-8-17(10-30-9-15)32-20(36)7-14-4-3-5-16(6-14)25(26,27)28/h3-6,8-12,35H,7,13H2,1-2H3,(H,32,36)(H2,29,31,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.09n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135053
PNG
(US8846698, 538)
Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C3CC3)c2)c2cncnc12
Show InChI InChI=1S/C25H27N7O3/c1-25(2,14-35-3)32-12-20(19-11-27-15-28-24(19)32)23(34)17-8-18(10-26-9-17)29-22(33)13-31-7-6-21(30-31)16-4-5-16/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.51n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135100
PNG
(US8846698, 526)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Nc3cc(nn3-c3cnn(C)c3)C3CC3)c2)c2cncnc12
Show InChI InChI=1S/C26H26N10O2/c1-15(2)35-13-21(20-11-28-14-29-25(20)35)24(37)17-6-18(9-27-8-17)31-26(38)32-23-7-22(16-4-5-16)33-36(23)19-10-30-34(3)12-19/h6-16H,4-5H2,1-3H3,(H2,31,32,38)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.51n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135051
PNG
(US8846698, 536)
Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cncnc12
Show InChI InChI=1S/C24H23ClN6O3/c1-24(2,13-34-3)31-12-20(19-11-27-14-29-23(19)31)22(33)15-6-18(10-26-8-15)30-21(32)7-17-5-4-16(25)9-28-17/h4-6,8-12,14H,7,13H2,1-3H3,(H,30,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.57n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135077
PNG
(US8846698, 564)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(NS(C)(=O)=O)cc3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C25H27N7O5S/c1-25(2,14-33)32-13-20(19-12-28-24(26)30-23(19)32)22(35)16-9-18(11-27-10-16)29-21(34)8-15-4-6-17(7-5-15)31-38(3,36)37/h4-7,9-13,31,33H,8,14H2,1-3H3,(H,29,34)(H2,26,28,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.57n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135089
PNG
(US8846698, 577)
Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C3CC3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H26N8O2/c1-24(2,3)32-12-19(18-10-27-23(25)30-22(18)32)21(34)15-6-17(9-26-7-15)29-20(33)13-31-11-16(8-28-31)14-4-5-14/h6-12,14H,4-5,13H2,1-3H3,(H,29,33)(H2,25,27,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202417
PNG
(US9238644, 24)
Show SMILES CC(NC(=O)OC(C)(C)C)c1ccc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cc1
Show InChI InChI=1/C29H34ClN5O3/c1-18(33-27(37)38-28(2,3)4)19-9-12-21(13-10-19)34-26-32-17-23(30)24(35-26)14-11-20-7-5-6-8-22(20)29(15-16-29)25(31)36/h5-10,12-13,17-18H,11,14-16H2,1-4H3,(H2,31,36)(H,33,37)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
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UniChem
US Patent
n/an/a 2n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM50257167
PNG
(CHEMBL2325619)
Show InChI InChI=1S/C20H13F3N6O3S2/c1-11-16(9-26-28-11)15-7-13(20(21,22)23)2-4-18(15)32-17-5-3-14(6-12(17)8-24)34(30,31)29-19-25-10-27-33-19/h2-7,9-10H,1H3,(H,26,28)(H,25,27,29)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.

Curated by ChEMBL




J Med Chem 60: 7029-7042 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00598
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135043
PNG
(US8846698, 528)
Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3nc4ccccc4[nH]3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C25H24N8O2/c1-25(2,3)33-13-17(16-12-28-24(26)32-23(16)33)22(35)14-8-15(11-27-10-14)29-21(34)9-20-30-18-6-4-5-7-19(18)31-20/h4-8,10-13H,9H2,1-3H3,(H,29,34)(H,30,31)(H2,26,28,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.25n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135064
PNG
(US8846698, 551)
Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C23H23F3N8O3/c1-22(2,12-37-3)34-10-17(16-8-29-21(27)32-20(16)34)19(36)13-4-15(7-28-5-13)31-18(35)11-33-9-14(6-30-33)23(24,25)26/h4-10H,11-12H2,1-3H3,(H,31,35)(H2,27,29,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.78n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM186567
PNG
(US9163021, 235)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-21(20-13-30-7-6-22(20)33)24(36)17-10-19(12-31-11-17)32-23(35)9-16-4-3-5-18(8-16)26(27,28)29/h3-8,10-14,34H,9,15H2,1-2H3,(H,32,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.87n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...


US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135083
PNG
(US8846698, 571)
Show SMILES CC1(COC1)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H20F3N5O3/c1-24(12-36-13-24)33-11-20(19-10-30-14-31-23(19)33)22(35)16-7-18(9-29-8-16)32-21(34)6-15-2-4-17(5-3-15)25(26,27)28/h2-5,7-11,14H,6,12-13H2,1H3,(H,32,34)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC sid
UniChem
US Patent
n/an/a 2.92n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM186437
PNG
(US9163021, 95)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C23H20F4N6O3/c1-22(2,12-34)33-10-16(15-8-29-9-17(24)20(15)33)21(36)13-5-14(7-28-6-13)30-19(35)11-32-4-3-18(31-32)23(25,26)27/h3-10,34H,11-12H2,1-2H3,(H,30,35)
PDB
MMDB

UniProtKB/SwissProt

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US Patent
n/an/a 2.92n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...


US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135058
PNG
(US8846698, 545)
Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cncnc12
Show InChI InChI=1S/C24H22ClN5O2/c1-24(2,3)30-13-20(19-12-27-14-28-23(19)30)22(32)16-9-18(11-26-10-16)29-21(31)8-15-4-6-17(25)7-5-15/h4-7,9-14H,8H2,1-3H3,(H,29,31)
PDB
MMDB

UniProtKB/SwissProt

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antibodypedia
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PC sid
UniChem
US Patent
n/an/a 2.95n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM50257179
PNG
(CHEMBL2325622)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.

Curated by ChEMBL




J Med Chem 60: 7029-7042 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00598
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202463
PNG
(US9238644, 65)
Show SMILES Cn1cc(Nc2ncc(c(CCc3ccccc3C3(CC3)C(N)=O)n2)C(F)(F)F)cn1
Show InChI InChI=1S/C21H21F3N6O/c1-30-12-14(10-27-30)28-19-26-11-16(21(22,23)24)17(29-19)7-6-13-4-2-3-5-15(13)20(8-9-20)18(25)31/h2-5,10-12H,6-9H2,1H3,(H2,25,31)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202476
PNG
(US9238644, 77)
Show SMILES COCCn1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C22H25ClN6O2/c1-31-11-10-29-14-16(12-26-29)27-21-25-13-18(23)19(28-21)7-6-15-4-2-3-5-17(15)22(8-9-22)20(24)30/h2-5,12-14H,6-11H2,1H3,(H2,24,30)(H,25,27,28)
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n/an/a 3n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202411
PNG
(US9238644, 18)
Show SMILES CN1CCC(CC1)n1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C25H30ClN7O/c1-32-12-8-19(9-13-32)33-16-18(14-29-33)30-24-28-15-21(26)22(31-24)7-6-17-4-2-3-5-20(17)25(10-11-25)23(27)34/h2-5,14-16,19H,6-13H2,1H3,(H2,27,34)(H,28,30,31)
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n/an/a 3n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202412
PNG
(US9238644, 19)
Show SMILES NC(=O)C1(CC1)c1ccccc1CCc1nc(Nc2cn[nH]c2)ncc1Cl
Show InChI InChI=1S/C19H19ClN6O/c20-15-11-22-18(25-13-9-23-24-10-13)26-16(15)6-5-12-3-1-2-4-14(12)19(7-8-19)17(21)27/h1-4,9-11H,5-8H2,(H2,21,27)(H,23,24)(H,22,25,26)
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n/an/a 3n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202440
PNG
(US9238644, 45)
Show SMILES Cn1cc(Nc2ncc(Cl)c(CCc3ccccc3C(C)(C)C(N)=O)n2)cn1
Show InChI InChI=1S/C20H23ClN6O/c1-20(2,18(22)28)15-7-5-4-6-13(15)8-9-17-16(21)11-23-19(26-17)25-14-10-24-27(3)12-14/h4-7,10-12H,8-9H2,1-3H3,(H2,22,28)(H,23,25,26)
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n/an/a 3n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134750
PNG
(US8846698, 213 | US8846698, 215)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1/C24H21F3N6O3/c1-13(12-34)33-11-19(18-10-30-23(28)32-22(18)33)21(36)15-7-17(9-29-8-15)31-20(35)6-14-3-2-4-16(5-14)24(25,26)27/h2-5,7-11,13,34H,6,12H2,1H3,(H,31,35)(H2,28,30,32)
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n/an/a 3.03n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135087
PNG
(US8846698, 575)
Show SMILES CC1(COC1)n1cc(C(=O)c2cncc(NC(=O)c3cccc(OC(F)(F)F)c3)c2)c2cncnc12
Show InChI InChI=1S/C24H18F3N5O4/c1-23(11-35-12-23)32-10-19(18-9-29-13-30-21(18)32)20(33)15-5-16(8-28-7-15)31-22(34)14-3-2-4-17(6-14)36-24(25,26)27/h2-10,13H,11-12H2,1H3,(H,31,34)
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n/an/a 3.09n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM186376
PNG
(US9163021, 33)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-21(20-13-30-8-7-22(20)33)24(36)17-10-19(12-31-11-17)32-23(35)9-16-3-5-18(6-4-16)26(27,28)29/h3-8,10-14,34H,9,15H2,1-2H3,(H,32,35)
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n/an/a 3.11n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...


US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135076
PNG
(US8846698, 563)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C22H21F3N8O3/c1-21(2,11-34)33-9-16(15-7-28-20(26)31-19(15)33)18(36)12-3-14(6-27-4-12)30-17(35)10-32-8-13(5-29-32)22(23,24)25/h3-9,34H,10-11H2,1-2H3,(H,30,35)(H2,26,28,31)
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n/an/a 3.11n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135069
PNG
(US8846698, 556)
Show SMILES Cc1ccc(CC(=O)Nc2cncc(c2)C(=O)c2cn(c3nc(N)ncc23)C(C)(C)CO)nc1
Show InChI InChI=1S/C24H25N7O3/c1-14-4-5-16(27-8-14)7-20(33)29-17-6-15(9-26-10-17)21(34)19-12-31(24(2,3)13-32)22-18(19)11-28-23(25)30-22/h4-6,8-12,32H,7,13H2,1-3H3,(H,29,33)(H2,25,28,30)
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n/an/a 3.16n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM30532
PNG
(US8846698, 581)
Show SMILES Nc1ncc2c(cn(c2n1)C12CC(C1)C2)C(=O)c1cncc(NC(=O)Cn2cc(nn2)C(F)(F)F)c1
Show InChI InChI=1S/C22H18F3N9O2/c23-22(24,25)16-9-33(32-31-16)10-17(35)29-13-1-12(5-27-6-13)18(36)15-8-34(21-2-11(3-21)4-21)19-14(15)7-28-20(26)30-19/h1,5-9,11H,2-4,10H2,(H,29,35)(H2,26,28,30)
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n/an/a 3.21n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135062
PNG
(US8846698, 549)
Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C23H23F3N8O3/c1-22(2,12-37-3)34-10-16(15-9-29-21(27)31-20(15)34)19(36)13-6-14(8-28-7-13)30-18(35)11-33-5-4-17(32-33)23(24,25)26/h4-10H,11-12H2,1-3H3,(H,30,35)(H2,27,29,31)
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n/an/a 3.22n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134787
PNG
(US8846698, 250)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C23H21ClN6O2/c1-13(2)30-12-19(18-11-27-23(25)29-22(18)30)21(32)15-8-17(10-26-9-15)28-20(31)7-14-3-5-16(24)6-4-14/h3-6,8-13H,7H2,1-2H3,(H,28,31)(H2,25,27,29)
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n/an/a 3.48n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134603
PNG
(US8846698, 66)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C24H20F3N5O2/c1-14(2)32-12-20(19-11-29-13-30-23(19)32)22(34)16-8-18(10-28-9-16)31-21(33)7-15-4-3-5-17(6-15)24(25,26)27/h3-6,8-14H,7H2,1-2H3,(H,31,33)
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n/an/a 3.55n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134763
PNG
(US8846698, 226)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H22F3N5O3/c1-24(2,13-34)33-12-20(19-11-30-14-31-23(19)33)22(36)16-8-18(10-29-9-16)32-21(35)7-15-4-3-5-17(6-15)25(26,27)28/h3-6,8-12,14,34H,7,13H2,1-2H3,(H,32,35)
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n/an/a 3.61n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135075
PNG
(US8846698, 562)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cn3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H22F3N7O3/c1-23(2,12-35)34-11-18(17-10-31-22(28)33-21(17)34)20(37)13-5-16(9-29-7-13)32-19(36)6-15-4-3-14(8-30-15)24(25,26)27/h3-5,7-11,35H,6,12H2,1-2H3,(H,32,36)(H2,28,31,33)
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n/an/a 3.75n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM186509
PNG
(US9163021, 173)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)c3cccc(OC(F)(F)F)c3)c2)c2cnccc12
Show InChI InChI=1S/C24H19F3N4O3/c1-14(2)31-13-19(18-12-28-8-7-20(18)31)22(32)15-6-9-29-21(11-15)30-23(33)16-4-3-5-17(10-16)34-24(25,26)27/h3-14H,1-2H3,(H,29,30,33)
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n/an/a 3.85n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...


US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135060
PNG
(US8846698, 547)
Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H24ClN7O3/c1-24(2,13-35-3)32-12-19(18-11-29-23(26)31-22(18)32)21(34)14-6-17(10-27-8-14)30-20(33)7-16-5-4-15(25)9-28-16/h4-6,8-12H,7,13H2,1-3H3,(H,30,33)(H2,26,29,31)
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n/an/a 3.88n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134790
PNG
(US8846698, 253)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C3CC3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C23H24N8O2/c1-13(2)31-11-18(17-10-26-23(24)28-22(17)31)21(33)15-7-16(9-25-8-15)27-20(32)12-30-6-5-19(29-30)14-3-4-14/h5-11,13-14H,3-4,12H2,1-2H3,(H,27,32)(H2,24,26,28)
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n/an/a 3.92n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135044
PNG
(US8846698, 529)
Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Br)cn3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C23H22BrN7O2/c1-23(2,3)31-12-18(17-11-28-22(25)30-21(17)31)20(33)13-6-16(10-26-8-13)29-19(32)7-15-5-4-14(24)9-27-15/h4-6,8-12H,7H2,1-3H3,(H,29,32)(H2,25,28,30)
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n/an/a 3.93n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134632
PNG
(US8846698, 95)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ncc4cc(F)ccc34)c2)c2cncnc12
Show InChI InChI=1S/C24H20FN7O2/c1-14(2)31-11-20(19-10-27-13-28-24(19)31)23(34)16-6-18(9-26-7-16)30-22(33)12-32-21-4-3-17(25)5-15(21)8-29-32/h3-11,13-14H,12H2,1-2H3,(H,30,33)
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n/an/a 3.95n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM50257166
PNG
(CHEMBL2325330)
Show InChI InChI=1S/C18H11ClN6O3S2/c19-13-1-3-17(15(6-13)12-8-22-23-9-12)28-16-4-2-14(5-11(16)7-20)30(26,27)25-18-21-10-24-29-18/h1-6,8-10H,(H,22,23)(H,21,24,25)
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PubMed
n/an/a 4n/an/an/an/an/an/a



Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.

Curated by ChEMBL




J Med Chem 60: 7029-7042 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00598
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202475
PNG
(US9238644, 76)
Show SMILES NC(=O)C1(CC1)c1ccccc1CCc1nc(Nc2cnn(CCO)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O2/c22-17-12-24-20(26-15-11-25-28(13-15)9-10-29)27-18(17)6-5-14-3-1-2-4-16(14)21(7-8-21)19(23)30/h1-4,11-13,29H,5-10H2,(H2,23,30)(H,24,26,27)
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n/an/a 4n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202409
PNG
(US9238644, 16)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C27H31ClN6O/c1-34-14-10-19(11-15-34)23-9-7-20(16-30-23)32-26-31-17-22(28)24(33-26)8-6-18-4-2-3-5-21(18)27(12-13-27)25(29)35/h2-5,7,9,16-17,19H,6,8,10-15H2,1H3,(H2,29,35)(H,31,32,33)
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n/an/a 4n/an/an/an/a7.237



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
Adult human dermal lymphatic microvascular endothelial cells (HMVEC-dLyAD) (Cat# CC-2810, Lonza) were seeded into clear-bottom, TC treated 12 well pl...


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202406
PNG
(US9238644, 13)
Show SMILES Cn1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C20H21ClN6O/c1-27-12-14(10-24-27)25-19-23-11-16(21)17(26-19)7-6-13-4-2-3-5-15(13)20(8-9-20)18(22)28/h2-5,10-12H,6-9H2,1H3,(H2,22,28)(H,23,25,26)
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n/an/a 4n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202424
PNG
(US9238644, 30)
Show SMILES CC(C)n1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C22H25ClN6O/c1-14(2)29-13-16(11-26-29)27-21-25-12-18(23)19(28-21)8-7-15-5-3-4-6-17(15)22(9-10-22)20(24)30/h3-6,11-14H,7-10H2,1-2H3,(H2,24,30)(H,25,27,28)
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n/an/a 4n/an/an/an/a7.4n/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)


BindingDB Entry DOI: 10.7270/Q2JM28FP
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134977
PNG
(US8846698, 459)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)c3csc(n3)C3CCC3)c2)c2cncnc12
Show InChI InChI=1S/C23H22N6O2S/c1-13(2)29-10-18(17-9-25-12-26-21(17)29)20(30)15-6-16(8-24-7-15)27-22(31)19-11-32-23(28-19)14-4-3-5-14/h6-14H,3-5H2,1-2H3,(H,27,31)
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n/an/a 4.06n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135054
PNG
(US8846698, 539)
Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(F)cc3)c2)c2cncnc12
Show InChI InChI=1S/C25H24FN5O3/c1-25(2,14-34-3)31-13-21(20-12-28-15-29-24(20)31)23(33)17-9-19(11-27-10-17)30-22(32)8-16-4-6-18(26)7-5-16/h4-7,9-13,15H,8,14H2,1-3H3,(H,30,32)
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n/an/a 4.08n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134604
PNG
(US8846698, 67)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C24H20F3N5O2/c1-14(2)32-12-20(19-11-29-13-30-23(19)32)22(34)16-8-18(10-28-9-16)31-21(33)7-15-3-5-17(6-4-15)24(25,26)27/h3-6,8-14H,7H2,1-2H3,(H,31,33)
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n/an/a 4.15n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134741
PNG
(US8846698, 204)
Show SMILES C[C@@H](CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C24H20F3N5O3/c1-14(12-33)32-11-20(19-10-29-13-30-23(19)32)22(35)16-7-18(9-28-8-16)31-21(34)6-15-3-2-4-17(5-15)24(25,26)27/h2-5,7-11,13-14,33H,6,12H2,1H3,(H,31,34)/t14-/m0/s1
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n/an/a 4.24n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134750
PNG
(US8846698, 213 | US8846698, 215)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1/C24H21F3N6O3/c1-13(12-34)33-11-19(18-10-30-23(28)32-22(18)33)21(36)15-7-17(9-29-8-15)31-20(35)6-14-3-2-4-16(5-14)24(25,26)27/h2-5,7-11,13,34H,6,12H2,1H3,(H,31,35)(H2,28,30,32)
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n/an/a 4.40n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135066
PNG
(US8846698, 553)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc4ccccc4n3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C25H24N8O3/c1-25(2,14-34)33-12-19(18-10-28-24(26)30-23(18)33)22(36)16-7-17(9-27-8-16)29-21(35)13-32-11-15-5-3-4-6-20(15)31-32/h3-12,34H,13-14H2,1-2H3,(H,29,35)(H2,26,28,30)
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n/an/a 4.40n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
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