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Compile Data Set for Download or QSAR

Found 184 hits with Last Name = 'sun' and Initial = 'lp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210697
PNG
(CHEMBL3962233)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 1n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210747
PNG
(CHEMBL3968039)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 10n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 11n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210695
PNG
(CHEMBL3929448)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210748
PNG
(CHEMBL3920551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
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n/an/a 14n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210705
PNG
(CHEMBL3979264)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 14n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210752
PNG
(CHEMBL3938494)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 15n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210701
PNG
(CHEMBL3957025)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
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n/an/a 17n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210698
PNG
(CHEMBL3939588)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
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n/an/a 18n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144600
PNG
(CHEMBL3759190)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccccc4Cl)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H33ClN6O3/c1-36-13-15-37(16-14-36)12-5-17-40-28-19-26-24(18-27(28)39-2)29(33-20-32-26)34-21-8-10-22(11-9-21)35-30(38)23-6-3-4-7-25(23)31/h3-4,6-11,18-20H,5,12-17H2,1-2H3,(H,35,38)(H,32,33,34)
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n/an/a 20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210748
PNG
(CHEMBL3920551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
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n/an/a 51n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210695
PNG
(CHEMBL3929448)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 78n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210747
PNG
(CHEMBL3968039)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 79n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 80n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144602
PNG
(CHEMBL3759127)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34N6O3/c1-35-14-16-36(17-15-35)13-6-18-39-28-20-26-25(19-27(28)38-2)29(32-21-31-26)33-23-9-11-24(12-10-23)34-30(37)22-7-4-3-5-8-22/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,34,37)(H,31,32,33)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144601
PNG
(CHEMBL3758749)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H33ClN6O3/c1-36-12-14-37(15-13-36)11-4-16-40-28-19-26-25(18-27(28)39-2)29(33-20-32-26)34-23-7-9-24(10-8-23)35-30(38)21-5-3-6-22(31)17-21/h3,5-10,17-20H,4,11-16H2,1-2H3,(H,35,38)(H,32,33,34)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210752
PNG
(CHEMBL3938494)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 178n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210707
PNG
(CHEMBL3923551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 194n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210704
PNG
(CHEMBL3948354)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
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n/an/a 212n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210746
PNG
(CHEMBL3905552)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144590
PNG
(CHEMBL3759015)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C29H30ClN5O4/c1-37-26-17-24-25(18-27(26)39-13-3-10-35-11-14-38-15-12-35)31-19-32-28(24)33-22-6-8-23(9-7-22)34-29(36)20-4-2-5-21(30)16-20/h2,4-9,16-19H,3,10-15H2,1H3,(H,34,36)(H,31,32,33)
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n/an/a 230n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210696
PNG
(CHEMBL3905242)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210705
PNG
(CHEMBL3979264)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210694
PNG
(CHEMBL3975598)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1
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n/an/a 275n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210697
PNG
(CHEMBL3962233)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 279n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144589
PNG
(CHEMBL3759848)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4cccc(Cl)c4)cc3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C29H30ClN5O3/c1-37-26-17-24-25(18-27(26)38-15-14-35-12-3-2-4-13-35)31-19-32-28(24)33-22-8-10-23(11-9-22)34-29(36)20-6-5-7-21(30)16-20/h5-11,16-19H,2-4,12-15H2,1H3,(H,34,36)(H,31,32,33)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210749
PNG
(CHEMBL3904787)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)cc1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210699
PNG
(CHEMBL3896615)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 500n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210706
PNG
(CHEMBL3933568)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210701
PNG
(CHEMBL3957025)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50144602
PNG
(CHEMBL3759127)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34N6O3/c1-35-14-16-36(17-15-35)13-6-18-39-28-20-26-25(19-27(28)38-2)29(32-21-31-26)33-23-9-11-24(12-10-23)34-30(37)22-7-4-3-5-8-22/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,34,37)(H,31,32,33)
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n/an/a 560n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210707
PNG
(CHEMBL3923551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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n/an/a 576n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210699
PNG
(CHEMBL3896615)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
PDB
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n/an/a 588n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210694
PNG
(CHEMBL3975598)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1
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n/an/a 611n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210746
PNG
(CHEMBL3905552)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144598
PNG
(CHEMBL3758585)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccc(C)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H36N6O3/c1-22-5-7-23(8-6-22)31(38)35-25-11-9-24(10-12-25)34-30-26-19-28(39-3)29(20-27(26)32-21-33-30)40-18-4-13-37-16-14-36(2)15-17-37/h5-12,19-21H,4,13-18H2,1-3H3,(H,35,38)(H,32,33,34)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144606
PNG
(CHEMBL3759203)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccccc4Cl)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H23ClN4O3/c1-36-26-15-23-25(16-27(26)37-17-19-7-3-2-4-8-19)31-18-32-28(23)33-20-11-13-21(14-12-20)34-29(35)22-9-5-6-10-24(22)30/h2-16,18H,17H2,1H3,(H,34,35)(H,31,32,33)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144593
PNG
(CHEMBL3758875)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccc(C)cc4)cc3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C30H33N5O4/c1-21-4-6-22(7-5-21)30(36)34-24-10-8-23(9-11-24)33-29-25-18-27(37-2)28(19-26(25)31-20-32-29)39-15-3-12-35-13-16-38-17-14-35/h4-11,18-20H,3,12-17H2,1-2H3,(H,34,36)(H,31,32,33)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210749
PNG
(CHEMBL3904787)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)cc1
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n/an/a 763n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210696
PNG
(CHEMBL3905242)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
PDB
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n/an/a 815n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50210698
PNG
(CHEMBL3939588)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
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n/an/a 817n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50144598
PNG
(CHEMBL3758585)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccc(C)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H36N6O3/c1-22-5-7-23(8-6-22)31(38)35-25-11-9-24(10-12-25)34-30-26-19-28(39-3)29(20-27(26)32-21-33-30)40-18-4-13-37-16-14-36(2)15-17-37/h5-12,19-21H,4,13-18H2,1-3H3,(H,35,38)(H,32,33,34)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50210751
PNG
(CHEMBL3917723)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCN4CCCCC4)c(OC)cc23)cc1
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n/an/a 966n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...


Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144597
PNG
(CHEMBL3759830)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1
Show InChI InChI=1S/C31H36N6O4/c1-36-14-16-37(17-15-36)13-4-18-41-29-20-27-26(19-28(29)40-3)30(33-21-32-27)34-23-7-9-24(10-8-23)35-31(38)22-5-11-25(39-2)12-6-22/h5-12,19-21H,4,13-18H2,1-3H3,(H,35,38)(H,32,33,34)
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n/an/a 1.11E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50351780
PNG
(CHEMBL1823762)
Show SMILES OC(=O)C(Cc1ccc2cc(OCc3ccccc3F)ccc2c1)NC(=O)\C=C\c1ccccc1Cl
Show InChI InChI=1S/C29H23ClFNO4/c30-25-7-3-1-5-20(25)12-14-28(33)32-27(29(34)35)16-19-9-10-22-17-24(13-11-21(22)15-19)36-18-23-6-2-4-8-26(23)31/h1-15,17,27H,16,18H2,(H,32,33)(H,34,35)/b14-12+
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n/an/a 1.25E+3n/an/an/an/an/an/a



Yanbian University

Curated by ChEMBL


Assay Description
Inhibition of PTP1B using p-nitrophenyl phosphate as substrate


Eur J Med Chem 46: 3630-8 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.027
BindingDB Entry DOI: 10.7270/Q2W09685
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144599
PNG
(CHEMBL3760090)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccc(Cl)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H33ClN6O3/c1-36-13-15-37(16-14-36)12-3-17-40-28-19-26-25(18-27(28)39-2)29(33-20-32-26)34-23-8-10-24(11-9-23)35-30(38)21-4-6-22(31)7-5-21/h4-11,18-20H,3,12-17H2,1-2H3,(H,35,38)(H,32,33,34)
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n/an/a 1.33E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50144595
PNG
(CHEMBL3759754)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4ccc(Cl)cc4)cc3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C29H30ClN5O4/c1-37-26-17-24-25(18-27(26)39-14-2-11-35-12-15-38-16-13-35)31-19-32-28(24)33-22-7-9-23(10-8-22)34-29(36)20-3-5-21(30)6-4-20/h3-10,17-19H,2,11-16H2,1H3,(H,34,36)(H,31,32,33)
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n/an/a 1.35E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...


Eur J Med Chem 109: 371-9 (2016)


BindingDB Entry DOI: 10.7270/Q2M32XKS
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50351784
PNG
(CHEMBL1823958)
Show SMILES OC(=O)C(Cc1ccc2cc(OCc3ccccc3F)ccc2c1)NC(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C29H23BrFNO4/c30-24-11-6-19(7-12-24)8-14-28(33)32-27(29(34)35)16-20-5-9-22-17-25(13-10-21(22)15-20)36-18-23-3-1-2-4-26(23)31/h1-15,17,27H,16,18H2,(H,32,33)(H,34,35)/b14-8+
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n/an/a 1.57E+3n/an/an/an/an/an/a



Yanbian University

Curated by ChEMBL


Assay Description
Inhibition of PTP1B using p-nitrophenyl phosphate as substrate


Eur J Med Chem 46: 3630-8 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.027
BindingDB Entry DOI: 10.7270/Q2W09685
More data for this
Ligand-Target Pair
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