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Compile Data Set for Download or QSAR

Found 468 hits with Last Name = 'thompson' and Initial = 'ad'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122268
PNG
(CHEMBL3617624)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cc(F)ccc1F |r|
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(16-6-12(20)2-4-15(16)22)19(27)17-7-14(24-26(11)17)10-28-18-5-3-13(21)8-23-18/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122268
PNG
(CHEMBL3617624)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cc(F)ccc1F |r|
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(16-6-12(20)2-4-15(16)22)19(27)17-7-14(24-26(11)17)10-28-18-5-3-13(21)8-23-18/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122278
PNG
(CHEMBL3617614)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1Cl |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-3-2-4-15(16)20)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122278
PNG
(CHEMBL3617614)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1Cl |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-3-2-4-15(16)20)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122277
PNG
(CHEMBL3617615)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(Cl)c1 |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-4-2-3-13(20)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122277
PNG
(CHEMBL3617615)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(Cl)c1 |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-4-2-3-13(20)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122280
PNG
(CHEMBL3617612)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1F |r|
Show InChI InChI=1/C19H16F2N4O2/c1-12-10-24(16-5-3-2-4-15(16)21)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122280
PNG
(CHEMBL3617612)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1F |r|
Show InChI InChI=1/C19H16F2N4O2/c1-12-10-24(16-5-3-2-4-15(16)21)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122267
PNG
(CHEMBL3617625)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1c(F)cccc1F |r|
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(18-14(21)3-2-4-15(18)22)19(27)16-7-13(24-26(11)16)10-28-17-6-5-12(20)8-23-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122267
PNG
(CHEMBL3617625)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1c(F)cccc1F |r|
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(18-14(21)3-2-4-15(18)22)19(27)16-7-13(24-26(11)16)10-28-17-6-5-12(20)8-23-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122269
PNG
(CHEMBL3617623)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(F)c1F |r|
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(15-4-2-3-14(21)18(15)22)19(27)16-7-13(24-26(11)16)10-28-17-6-5-12(20)8-23-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122269
PNG
(CHEMBL3617623)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(F)c1F |r|
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(15-4-2-3-14(21)18(15)22)19(27)16-7-13(24-26(11)16)10-28-17-6-5-12(20)8-23-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122279
PNG
(CHEMBL3617613)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(F)c1 |r|
Show InChI InChI=1/C19H16F2N4O2/c1-12-10-24(16-4-2-3-13(20)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122279
PNG
(CHEMBL3617613)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(F)c1 |r|
Show InChI InChI=1/C19H16F2N4O2/c1-12-10-24(16-4-2-3-13(20)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122276
PNG
(CHEMBL3617616)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-2-13(20)3-6-16)19(26)17-8-15(23-25(12)17)11-27-18-7-4-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122276
PNG
(CHEMBL3617616)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-2-13(20)3-6-16)19(26)17-8-15(23-25(12)17)11-27-18-7-4-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122271
PNG
(CHEMBL3617621)
Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(F)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19FN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122271
PNG
(CHEMBL3617621)
Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(F)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19FN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122261
PNG
(CHEMBL3617631)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(F)c1 |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-4-2-3-14(21)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122261
PNG
(CHEMBL3617631)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(F)c1 |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-4-2-3-14(21)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122274
PNG
(CHEMBL3617618)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(C)c1 |r|
Show InChI InChI=1/C20H19FN4O2/c1-13-4-3-5-17(8-13)24-11-14(2)25-18(20(24)26)9-16(23-25)12-27-19-7-6-15(21)10-22-19/h3-10,14H,11-12H2,1-2H3/t14-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122274
PNG
(CHEMBL3617618)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(C)c1 |r|
Show InChI InChI=1/C20H19FN4O2/c1-13-4-3-5-17(8-13)24-11-14(2)25-18(20(24)26)9-16(23-25)12-27-19-7-6-15(21)10-22-19/h3-10,14H,11-12H2,1-2H3/t14-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122262
PNG
(CHEMBL3617630)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccccc1F |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-3-2-4-15(16)21)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122246
PNG
(CHEMBL3617646)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1c(F)cccc1F |r|
Show InChI InChI=1/C19H15ClF2N4O2/c1-11-9-25(18-14(21)3-2-4-15(18)22)19(27)16-7-13(24-26(11)16)10-28-17-6-5-12(20)8-23-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122246
PNG
(CHEMBL3617646)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1c(F)cccc1F |r|
Show InChI InChI=1/C19H15ClF2N4O2/c1-11-9-25(18-14(21)3-2-4-15(18)22)19(27)16-7-13(24-26(11)16)10-28-17-6-5-12(20)8-23-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122262
PNG
(CHEMBL3617630)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccccc1F |r|
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-3-2-4-15(16)21)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122176
PNG
(CHEMBL3617654)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccc(F)cn1 |r|
Show InChI InChI=1/C18H15ClFN5O2/c1-11-9-24(16-4-3-13(20)8-21-16)18(26)15-6-14(23-25(11)15)10-27-17-5-2-12(19)7-22-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122176
PNG
(CHEMBL3617654)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccc(F)cn1 |r|
Show InChI InChI=1/C18H15ClFN5O2/c1-11-9-24(16-4-3-13(20)8-21-16)18(26)15-6-14(23-25(11)15)10-27-17-5-2-12(19)7-22-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122118
PNG
(CHEMBL3617495)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccccc3)nn12)c1ccc(F)cc1 |r|
Show InChI InChI=1/C20H18FN3O2/c1-14-12-23(17-9-7-15(21)8-10-17)20(25)19-11-16(22-24(14)19)13-26-18-5-3-2-4-6-18/h2-11,14H,12-13H2,1H3/t14-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122118
PNG
(CHEMBL3617495)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccccc3)nn12)c1ccc(F)cc1 |r|
Show InChI InChI=1/C20H18FN3O2/c1-14-12-23(17-9-7-15(21)8-10-17)20(25)19-11-16(22-24(14)19)13-26-18-5-3-2-4-6-18/h2-11,14H,12-13H2,1H3/t14-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122273
PNG
(CHEMBL3617619)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccc(C)cc1 |r|
Show InChI InChI=1/C20H19FN4O2/c1-13-3-6-17(7-4-13)24-11-14(2)25-18(20(24)26)9-16(23-25)12-27-19-8-5-15(21)10-22-19/h3-10,14H,11-12H2,1-2H3/t14-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122273
PNG
(CHEMBL3617619)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccc(C)cc1 |r|
Show InChI InChI=1/C20H19FN4O2/c1-13-3-6-17(7-4-13)24-11-14(2)25-18(20(24)26)9-16(23-25)12-27-19-8-5-15(21)10-22-19/h3-10,14H,11-12H2,1-2H3/t14-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122247
PNG
(CHEMBL3617645)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccc(F)cc1F |r|
Show InChI InChI=1/C19H15ClF2N4O2/c1-11-9-25(16-4-3-13(21)6-15(16)22)19(27)17-7-14(24-26(11)17)10-28-18-5-2-12(20)8-23-18/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122247
PNG
(CHEMBL3617645)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccc(F)cc1F |r|
Show InChI InChI=1/C19H15ClF2N4O2/c1-11-9-25(16-4-3-13(21)6-15(16)22)19(27)17-7-14(24-26(11)17)10-28-18-5-2-12(20)8-23-18/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122175
PNG
(CHEMBL3616489)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(F)n1 |r|
Show InChI InChI=1/C18H15ClFN5O2/c1-11-9-24(16-4-2-3-15(20)22-16)18(26)14-7-13(23-25(11)14)10-27-17-6-5-12(19)8-21-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122175
PNG
(CHEMBL3616489)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(F)n1 |r|
Show InChI InChI=1/C18H15ClFN5O2/c1-11-9-24(16-4-2-3-15(20)22-16)18(26)14-7-13(23-25(11)14)10-27-17-6-5-12(19)8-21-17/h2-8,11H,9-10H2,1H3/t11-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122253
PNG
(CHEMBL3617639)
Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(Cl)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19ClN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122241
PNG
(CHEMBL3617649)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cc(F)cc(c1)C#N |r|
Show InChI InChI=1/C20H15ClFN5O2/c1-12-10-26(17-5-13(8-23)4-15(22)6-17)20(28)18-7-16(25-27(12)18)11-29-19-3-2-14(21)9-24-19/h2-7,9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122253
PNG
(CHEMBL3617639)
Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(Cl)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19ClN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122241
PNG
(CHEMBL3617649)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cc(F)cc(c1)C#N |r|
Show InChI InChI=1/C20H15ClFN5O2/c1-12-10-26(17-5-13(8-23)4-15(22)6-17)20(28)18-7-16(25-27(12)18)11-29-19-3-2-14(21)9-24-19/h2-7,9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122270
PNG
(CHEMBL3617622)
Show SMILES COc1ccc(cc1)N1C[C@@H](C)n2nc(COc3ccc(F)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19FN4O3/c1-13-11-24(16-4-6-17(27-2)7-5-16)20(26)18-9-15(23-25(13)18)12-28-19-8-3-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122270
PNG
(CHEMBL3617622)
Show SMILES COc1ccc(cc1)N1C[C@@H](C)n2nc(COc3ccc(F)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19FN4O3/c1-13-11-24(16-4-6-17(27-2)7-5-16)20(26)18-9-15(23-25(13)18)12-28-19-8-3-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122240
PNG
(CHEMBL3617650)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccccn1 |r|
Show InChI InChI=1/C18H16ClN5O2/c1-12-10-23(16-4-2-3-7-20-16)18(25)15-8-14(22-24(12)15)11-26-17-6-5-13(19)9-21-17/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122260
PNG
(CHEMBL3617632)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccccc1Cl |r|
Show InChI InChI=1/C19H16Cl2N4O2/c1-12-10-24(16-5-3-2-4-15(16)21)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122240
PNG
(CHEMBL3617650)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccccn1 |r|
Show InChI InChI=1/C18H16ClN5O2/c1-12-10-23(16-4-2-3-7-20-16)18(25)15-8-14(22-24(12)15)11-26-17-6-5-13(19)9-21-17/h2-9,12H,10-11H2,1H3/t12-/s2
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n/an/a 331n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122260
PNG
(CHEMBL3617632)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1ccccc1Cl |r|
Show InChI InChI=1/C19H16Cl2N4O2/c1-12-10-24(16-5-3-2-4-15(16)21)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(20)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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UniProtKB/SwissProt

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UniChem
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n/an/a 331n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122272
PNG
(CHEMBL3617620)
Show SMILES COc1ccccc1N1C[C@@H](C)n2nc(COc3ccc(F)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19FN4O3/c1-13-11-24(16-5-3-4-6-18(16)27-2)20(26)17-9-15(23-25(13)17)12-28-19-8-7-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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n/an/a 339n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122272
PNG
(CHEMBL3617620)
Show SMILES COc1ccccc1N1C[C@@H](C)n2nc(COc3ccc(F)cn3)cc2C1=O |r|
Show InChI InChI=1/C20H19FN4O3/c1-13-11-24(16-5-3-4-6-18(16)27-2)20(26)17-9-15(23-25(13)17)12-28-19-8-7-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/s2
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UniProtKB/SwissProt

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n/an/a 339n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122275
PNG
(CHEMBL3617617)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1C |r|
Show InChI InChI=1/C20H19FN4O2/c1-13-5-3-4-6-17(13)24-11-14(2)25-18(20(24)26)9-16(23-25)12-27-19-8-7-15(21)10-22-19/h3-10,14H,11-12H2,1-2H3/t14-/s2
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UniProtKB/SwissProt

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UniChem
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n/an/a 346n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50122263
PNG
(CHEMBL3617629)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccc(F)cn1 |r|
Show InChI InChI=1/C18H15F2N5O2/c1-11-9-24(16-4-2-12(19)7-21-16)18(26)15-6-14(23-25(11)15)10-27-17-5-3-13(20)8-22-17/h2-8,11H,9-10H2,1H3/t11-/s2
PDB

UniProtKB/SwissProt

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AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 347n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
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