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Compile Data Set for Download or QSAR

Found 915 hits with Last Name = 'tichenor' and Initial = 'ms'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145818
PNG
(US8952177, 174 | US9089569, 174 | US9695149, 174)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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0.340n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145818
PNG
(US8952177, 174 | US9089569, 174 | US9695149, 174)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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0.340n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145818
PNG
(US8952177, 174 | US9089569, 174 | US9695149, 174)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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0.340n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145820
PNG
(US8952177, 176 | US9089569, 176 | US9695149, 176)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H36F2N4O3/c1-21-16-28(35)30(36-18-21)20-42-25-10-11-29-31(17-25)39(32(37-29)26-4-2-3-5-27(26)33(40)41)19-22-6-8-24(9-7-22)38-14-12-23(34)13-15-38/h6-11,16-18,23,26-27H,2-5,12-15,19-20H2,1H3,(H,40,41)/t26-,27+/s2
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0.420n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145820
PNG
(US8952177, 176 | US9089569, 176 | US9695149, 176)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H36F2N4O3/c1-21-16-28(35)30(36-18-21)20-42-25-10-11-29-31(17-25)39(32(37-29)26-4-2-3-5-27(26)33(40)41)19-22-6-8-24(9-7-22)38-14-12-23(34)13-15-38/h6-11,16-18,23,26-27H,2-5,12-15,19-20H2,1H3,(H,40,41)/t26-,27+/s2
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0.420n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145820
PNG
(US8952177, 176 | US9089569, 176 | US9695149, 176)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H36F2N4O3/c1-21-16-28(35)30(36-18-21)20-42-25-10-11-29-31(17-25)39(32(37-29)26-4-2-3-5-27(26)33(40)41)19-22-6-8-24(9-7-22)38-14-12-23(34)13-15-38/h6-11,16-18,23,26-27H,2-5,12-15,19-20H2,1H3,(H,40,41)/t26-,27+/s2
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0.420n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145785
PNG
(US8952177, 139 | US9089569, 139 | US9695149, 139)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C35H31F4N3O3/c1-21-16-29(36)31(40-18-21)20-45-26-14-15-30-32(17-26)42(33(41-30)27-4-2-3-5-28(27)34(43)44)19-22-6-8-23(9-7-22)24-10-12-25(13-11-24)35(37,38)39/h6-18,27-28H,2-5,19-20H2,1H3,(H,43,44)/t27-,28+/s2
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0.470n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145785
PNG
(US8952177, 139 | US9089569, 139 | US9695149, 139)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C35H31F4N3O3/c1-21-16-29(36)31(40-18-21)20-45-26-14-15-30-32(17-26)42(33(41-30)27-4-2-3-5-28(27)34(43)44)19-22-6-8-23(9-7-22)24-10-12-25(13-11-24)35(37,38)39/h6-18,27-28H,2-5,19-20H2,1H3,(H,43,44)/t27-,28+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145785
PNG
(US8952177, 139 | US9089569, 139 | US9695149, 139)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C35H31F4N3O3/c1-21-16-29(36)31(40-18-21)20-45-26-14-15-30-32(17-26)42(33(41-30)27-4-2-3-5-28(27)34(43)44)19-22-6-8-23(9-7-22)24-10-12-25(13-11-24)35(37,38)39/h6-18,27-28H,2-5,19-20H2,1H3,(H,43,44)/t27-,28+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145770
PNG
(US8952177, 124 | US9089569, 124 | US9695149, 124)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19-/s2
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0.520n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145770
PNG
(US8952177, 124 | US9089569, 124 | US9695149, 124)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19-/s2
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0.520n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145770
PNG
(US8952177, 124 | US9089569, 124 | US9695149, 124)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19-/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145769
PNG
(US8952177, 123 | US9089569, 123 | US9695149, 123)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19+/s2
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0.610n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145769
PNG
(US8952177, 123 | US9089569, 123 | US9695149, 123)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19+/s2
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0.610n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145769
PNG
(US8952177, 123 | US9089569, 123 | US9695149, 123)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19+/s2
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0.610n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145782
PNG
(US8952177, 136 | US9089569, 136 | US9695149, 136)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C28H29BrFN3O3/c1-4-28(5-2,27(34)35)14-26-32-23-11-10-21(36-17-24-22(30)12-18(3)15-31-24)13-25(23)33(26)16-19-6-8-20(29)9-7-19/h6-13,15H,4-5,14,16-17H2,1-3H3,(H,34,35)
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0.640n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145782
PNG
(US8952177, 136 | US9089569, 136 | US9695149, 136)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C28H29BrFN3O3/c1-4-28(5-2,27(34)35)14-26-32-23-11-10-21(36-17-24-22(30)12-18(3)15-31-24)13-25(23)33(26)16-19-6-8-20(29)9-7-19/h6-13,15H,4-5,14,16-17H2,1-3H3,(H,34,35)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145782
PNG
(US8952177, 136 | US9089569, 136 | US9695149, 136)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C28H29BrFN3O3/c1-4-28(5-2,27(34)35)14-26-32-23-11-10-21(36-17-24-22(30)12-18(3)15-31-24)13-25(23)33(26)16-19-6-8-20(29)9-7-19/h6-13,15H,4-5,14,16-17H2,1-3H3,(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145783
PNG
(US8952177, 137 | US9089569, 137 | US9695149, 137)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C35H29F6N3O3/c1-19-12-29(38)31(42-16-19)18-47-23-10-11-30-32(15-23)44(33(43-30)24-4-2-3-5-25(24)34(45)46)17-26-27(36)13-21(14-28(26)37)20-6-8-22(9-7-20)35(39,40)41/h6-16,24-25H,2-5,17-18H2,1H3,(H,45,46)/t24-,25+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145783
PNG
(US8952177, 137 | US9089569, 137 | US9695149, 137)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C35H29F6N3O3/c1-19-12-29(38)31(42-16-19)18-47-23-10-11-30-32(15-23)44(33(43-30)24-4-2-3-5-25(24)34(45)46)17-26-27(36)13-21(14-28(26)37)20-6-8-22(9-7-20)35(39,40)41/h6-16,24-25H,2-5,17-18H2,1H3,(H,45,46)/t24-,25+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145783
PNG
(US8952177, 137 | US9089569, 137 | US9695149, 137)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C35H29F6N3O3/c1-19-12-29(38)31(42-16-19)18-47-23-10-11-30-32(15-23)44(33(43-30)24-4-2-3-5-25(24)34(45)46)17-26-27(36)13-21(14-28(26)37)20-6-8-22(9-7-20)35(39,40)41/h6-16,24-25H,2-5,17-18H2,1H3,(H,45,46)/t24-,25+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145657
PNG
(US8952177, 11 | US9089569, 11 | US9695149, 11)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4F)c3c2)nc1 |r|
Show InChI InChI=1/C28H27BrFN3O3/c1-17-6-9-20(31-14-17)16-36-21-10-11-25-26(13-21)33(15-18-7-8-19(29)12-24(18)30)27(32-25)22-4-2-3-5-23(22)28(34)35/h6-14,22-23H,2-5,15-16H2,1H3,(H,34,35)/t22-,23+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145657
PNG
(US8952177, 11 | US9089569, 11 | US9695149, 11)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4F)c3c2)nc1 |r|
Show InChI InChI=1/C28H27BrFN3O3/c1-17-6-9-20(31-14-17)16-36-21-10-11-25-26(13-21)33(15-18-7-8-19(29)12-24(18)30)27(32-25)22-4-2-3-5-23(22)28(34)35/h6-14,22-23H,2-5,15-16H2,1H3,(H,34,35)/t22-,23+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145657
PNG
(US8952177, 11 | US9089569, 11 | US9695149, 11)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4F)c3c2)nc1 |r|
Show InChI InChI=1/C28H27BrFN3O3/c1-17-6-9-20(31-14-17)16-36-21-10-11-25-26(13-21)33(15-18-7-8-19(29)12-24(18)30)27(32-25)22-4-2-3-5-23(22)28(34)35/h6-14,22-23H,2-5,15-16H2,1H3,(H,34,35)/t22-,23+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145817
PNG
(US8952177, 173 | US8952177, 175 | US9089569, 175 |...)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145817
PNG
(US8952177, 173 | US8952177, 175 | US9089569, 175 |...)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145817
PNG
(US8952177, 173 | US8952177, 175 | US9089569, 175 |...)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145816
PNG
(US8952177, 172 | US9089569, 172 | US9695149, 172)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H34F4N4O3/c1-19-12-28(37)30(38-16-19)18-44-22-6-7-29-31(15-22)41(32(39-29)23-4-2-3-5-24(23)33(42)43)17-25-26(35)13-21(14-27(25)36)40-10-8-20(34)9-11-40/h6-7,12-16,20,23-24H,2-5,8-11,17-18H2,1H3,(H,42,43)/t23-,24+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145816
PNG
(US8952177, 172 | US9089569, 172 | US9695149, 172)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H34F4N4O3/c1-19-12-28(37)30(38-16-19)18-44-22-6-7-29-31(15-22)41(32(39-29)23-4-2-3-5-24(23)33(42)43)17-25-26(35)13-21(14-27(25)36)40-10-8-20(34)9-11-40/h6-7,12-16,20,23-24H,2-5,8-11,17-18H2,1H3,(H,42,43)/t23-,24+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145816
PNG
(US8952177, 172 | US9089569, 172 | US9695149, 172)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C33H34F4N4O3/c1-19-12-28(37)30(38-16-19)18-44-22-6-7-29-31(15-22)41(32(39-29)23-4-2-3-5-24(23)33(42)43)17-25-26(35)13-21(14-27(25)36)40-10-8-20(34)9-11-40/h6-7,12-16,20,23-24H,2-5,8-11,17-18H2,1H3,(H,42,43)/t23-,24+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM102301
PNG
(US9695149, 192)
Show SMILES Cc1cnc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(CC4)C(F)(F)F)c3c2)c(F)c1 |r|
Show InChI InChI=1/C34H35F5N4O3/c1-20-14-28(36)30(40-17-20)19-46-24-8-9-29-31(16-24)43(32(41-29)25-4-2-3-5-26(25)33(44)45)18-21-6-7-23(15-27(21)35)42-12-10-22(11-13-42)34(37,38)39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,44,45)/t25?,26-/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145807
PNG
(US8952177, 163 | US9089569, 163 | US9695149, 163)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)(F)C4)c3c2)nc1 |r|
Show InChI InChI=1/C32H33F3N4O3/c1-20-6-8-22(36-16-20)18-42-24-10-11-28-29(15-24)39(30(37-28)25-4-2-3-5-26(25)31(40)41)17-21-7-9-23(14-27(21)33)38-13-12-32(34,35)19-38/h6-11,14-16,25-26H,2-5,12-13,17-19H2,1H3,(H,40,41)/t25-,26+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145807
PNG
(US8952177, 163 | US9089569, 163 | US9695149, 163)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)(F)C4)c3c2)nc1 |r|
Show InChI InChI=1/C32H33F3N4O3/c1-20-6-8-22(36-16-20)18-42-24-10-11-28-29(15-24)39(30(37-28)25-4-2-3-5-26(25)31(40)41)17-21-7-9-23(14-27(21)33)38-13-12-32(34,35)19-38/h6-11,14-16,25-26H,2-5,12-13,17-19H2,1H3,(H,40,41)/t25-,26+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145807
PNG
(US8952177, 163 | US9089569, 163 | US9695149, 163)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)(F)C4)c3c2)nc1 |r|
Show InChI InChI=1/C32H33F3N4O3/c1-20-6-8-22(36-16-20)18-42-24-10-11-28-29(15-24)39(30(37-28)25-4-2-3-5-26(25)31(40)41)17-21-7-9-23(14-27(21)33)38-13-12-32(34,35)19-38/h6-11,14-16,25-26H,2-5,12-13,17-19H2,1H3,(H,40,41)/t25-,26+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145821
PNG
(US8952177, 177 | US9089569, 177 | US9695149, 177)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1 |r|
Show InChI InChI=1/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/s2
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145772
PNG
(US8952177, 126 | US9089569, 126 | US9695149, 126)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1 |r|
Show InChI InChI=1/C28H26BrF2N3O3/c1-16-6-7-18(32-13-16)15-37-19-8-9-25-26(12-19)34(14-22-23(30)10-17(29)11-24(22)31)27(33-25)20-4-2-3-5-21(20)28(35)36/h6-13,20-21H,2-5,14-15H2,1H3,(H,35,36)/t20-,21+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145771
PNG
(US8952177, 125 | US9089569, 125 | US9695149, 125)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H27BrFN3O3/c1-17-12-23(30)25(31-14-17)16-36-20-10-11-24-26(13-20)33(15-18-6-8-19(29)9-7-18)27(32-24)21-4-2-3-5-22(21)28(34)35/h6-14,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145739
PNG
(US8952177, 93 | US9089569, 93 | US9695149, 93)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1 |r|
Show InChI InChI=1/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/s2
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1.10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145821
PNG
(US8952177, 177 | US9089569, 177 | US9695149, 177)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1 |r|
Show InChI InChI=1/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/s2
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1.10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145739
PNG
(US8952177, 93 | US9089569, 93 | US9695149, 93)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1 |r|
Show InChI InChI=1/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/s2
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145739
PNG
(US8952177, 93 | US9089569, 93 | US9695149, 93)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1 |r|
Show InChI InChI=1/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145771
PNG
(US8952177, 125 | US9089569, 125 | US9695149, 125)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H27BrFN3O3/c1-17-12-23(30)25(31-14-17)16-36-20-10-11-24-26(13-20)33(15-18-6-8-19(29)9-7-18)27(32-24)21-4-2-3-5-22(21)28(34)35/h6-14,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/s2
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1.10n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145772
PNG
(US8952177, 126 | US9089569, 126 | US9695149, 126)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1 |r|
Show InChI InChI=1/C28H26BrF2N3O3/c1-16-6-7-18(32-13-16)15-37-19-8-9-25-26(12-19)34(14-22-23(30)10-17(29)11-24(22)31)27(33-25)20-4-2-3-5-21(20)28(35)36/h6-13,20-21H,2-5,14-15H2,1H3,(H,35,36)/t20-,21+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145772
PNG
(US8952177, 126 | US9089569, 126 | US9695149, 126)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1 |r|
Show InChI InChI=1/C28H26BrF2N3O3/c1-16-6-7-18(32-13-16)15-37-19-8-9-25-26(12-19)34(14-22-23(30)10-17(29)11-24(22)31)27(33-25)20-4-2-3-5-21(20)28(35)36/h6-13,20-21H,2-5,14-15H2,1H3,(H,35,36)/t20-,21+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145771
PNG
(US8952177, 125 | US9089569, 125 | US9695149, 125)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 |r|
Show InChI InChI=1/C28H27BrFN3O3/c1-17-12-23(30)25(31-14-17)16-36-20-10-11-24-26(13-20)33(15-18-6-8-19(29)9-7-18)27(32-24)21-4-2-3-5-22(21)28(34)35/h6-14,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145821
PNG
(US8952177, 177 | US9089569, 177 | US9695149, 177)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1 |r|
Show InChI InChI=1/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145822
PNG
(US8952177, 178 | US9089569, 178 | US9695149, 178)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r|
Show InChI InChI=1/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145822
PNG
(US8952177, 178 | US9089569, 178 | US9695149, 178)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r|
Show InChI InChI=1/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/s2
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145822
PNG
(US8952177, 178 | US9089569, 178 | US9695149, 178)
Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r|
Show InChI InChI=1/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/s2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145839
PNG
(US8952177, 147 | US9089569, 147 | US9695149, 147)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1
Show InChI InChI=1S/C35H32F3N3O3/c1-22-6-15-27(39-19-22)21-44-28-16-17-31-32(18-28)41(33(40-31)29-4-2-3-5-30(29)34(42)43)20-23-7-9-24(10-8-23)25-11-13-26(14-12-25)35(36,37)38/h6-19,29-30H,2-5,20-21H2,1H3,(H,42,43)/t29-,30+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
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