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Compile Data Set for Download or QSAR

Found 862 hits with Last Name = 'tsou' and Initial = 'hr'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314350
PNG
(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-meth...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1CC2CCC(C1)O2
Show InChI InChI=1S/C23H21N3O4/c1-25-10-13(9-19-22(28)21-17(27)3-2-4-18(21)30-19)20-16(7-8-24-23(20)25)26-11-14-5-6-15(12-26)29-14/h2-4,7-10,14-15,27H,5-6,11-12H2,1H3/b19-9-
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n/an/a 0.380n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314367
PNG
(4-hydroxy-2-((4-(4-(4-(2-hydroxyethyl)piperazine-1...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C30H28N4O5/c1-32-18-21(17-25-28(37)27-23(36)3-2-4-24(27)39-25)26-22(9-10-31-29(26)32)19-5-7-20(8-6-19)30(38)34-13-11-33(12-14-34)15-16-35/h2-10,17-18,35-36H,11-16H2,1H3/b25-17-
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n/an/a 0.390n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314357
PNG
(4,6-dihydroxy-2-((1-methyl-4-phenyl-1H-pyrrolo[2,3...)
Show SMILES Cn1cc(\C=C2/Oc3cc(O)cc(O)c3C2=O)c2c(ccnc12)-c1ccccc1
Show InChI InChI=1S/C23H16N2O4/c1-25-12-14(9-19-22(28)21-17(27)10-15(26)11-18(21)29-19)20-16(7-8-24-23(20)25)13-5-3-2-4-6-13/h2-12,26-27H,1H3/b19-9-
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n/an/a 0.460n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314361
PNG
((Z)-4-hydroxy-2-((1-methyl-4-(4-(morpholine-4-carb...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C28H23N3O5/c1-30-16-19(15-23-26(33)25-21(32)3-2-4-22(25)36-23)24-20(9-10-29-27(24)30)17-5-7-18(8-6-17)28(34)31-11-13-35-14-12-31/h2-10,15-16,32H,11-14H2,1H3/b23-15-
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n/an/a 0.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314359
PNG
(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccnc2n(C)cc(\C=C3/Oc4cccc(O)c4C3=O)c12
Show InChI InChI=1S/C26H21N3O4/c1-28(2)26(32)16-9-7-15(8-10-16)18-11-12-27-25-22(18)17(14-29(25)3)13-21-24(31)23-19(30)5-4-6-20(23)33-21/h4-14,30H,1-3H3/b21-13-
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n/an/a 0.550n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314363
PNG
((Z)-2-((4-(4-(8-oxa-3-azabicyclo[3.2.1]octane-3-ca...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C30H25N3O5/c1-32-14-19(13-25-28(35)27-23(34)3-2-4-24(27)38-25)26-22(11-12-31-29(26)32)17-5-7-18(8-6-17)30(36)33-15-20-9-10-21(16-33)37-20/h2-8,11-14,20-21,34H,9-10,15-16H2,1H3/b25-13-
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n/an/a 0.560n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314360
PNG
(1-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES CN(C)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4cccc(O)c4C3=O)c12
Show InChI InChI=1S/C25H26N4O4/c1-27(2)25(32)15-8-11-29(12-9-15)17-7-10-26-24-21(17)16(14-28(24)3)13-20-23(31)22-18(30)5-4-6-19(22)33-20/h4-7,10,13-15,30H,8-9,11-12H2,1-3H3/b20-13-
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n/an/a 0.670n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314346
PNG
(1-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1CCC(CC1)C(N)=O
Show InChI InChI=1S/C23H22N4O4/c1-26-12-14(11-18-21(29)20-16(28)3-2-4-17(20)31-18)19-15(5-8-25-23(19)26)27-9-6-13(7-10-27)22(24)30/h2-5,8,11-13,28H,6-7,9-10H2,1H3,(H2,24,30)/b18-11-
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n/an/a 0.720n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314353
PNG
((2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperaz...)
Show SMILES CN1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4cc(O)cc(O)c4C3=O)c12
Show InChI InChI=1S/C22H22N4O4/c1-24-5-7-26(8-6-24)15-3-4-23-22-19(15)13(12-25(22)2)9-18-21(29)20-16(28)10-14(27)11-17(20)30-18/h3-4,9-12,27-28H,5-8H2,1-2H3/b18-9-
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n/an/a 0.940n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314365
PNG
(4-hydroxy-2-((1-methyl-4-(4-(4-methylpiperazine-1-...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccnc2n(C)cc(\C=C3/Oc4cccc(O)c4C3=O)c12
Show InChI InChI=1S/C29H26N4O4/c1-31-12-14-33(15-13-31)29(36)19-8-6-18(7-9-19)21-10-11-30-28-25(21)20(17-32(28)2)16-24-27(35)26-22(34)4-3-5-23(26)37-24/h3-11,16-17,34H,12-15H2,1-2H3/b24-16-
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314362
PNG
(4-hydroxy-2-((1-methyl-4-(4-(morpholine-4-carbonyl...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1CCC(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H28N4O5/c1-29-16-18(15-22-25(33)24-20(32)3-2-4-21(24)36-22)23-19(5-8-28-26(23)29)30-9-6-17(7-10-30)27(34)31-11-13-35-14-12-31/h2-5,8,15-17,32H,6-7,9-14H2,1H3/b22-15-
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n/an/a 1.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314368
PNG
(4-hydroxy-2-((4-(4-(4-(2-hydroxyethyl)piperazine-1...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1CCC(CC1)C(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C29H33N5O5/c1-31-18-20(17-24-27(37)26-22(36)3-2-4-23(26)39-24)25-21(5-8-30-28(25)31)33-9-6-19(7-10-33)29(38)34-13-11-32(12-14-34)15-16-35/h2-5,8,17-19,35-36H,6-7,9-16H2,1H3/b24-17-
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n/an/a 1.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4567
PNG
(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1
Show InChI InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptor


J Med Chem 46: 49-63 (2002)


Article DOI: 10.1021/jm020241c
BindingDB Entry DOI: 10.7270/Q2PV6M3H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314364
PNG
(2-((4-(4-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbon...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1CCC(CC1)C(=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C29H30N4O5/c1-31-14-18(13-24-27(35)26-22(34)3-2-4-23(26)38-24)25-21(7-10-30-28(25)31)32-11-8-17(9-12-32)29(36)33-15-19-5-6-20(16-33)37-19/h2-4,7,10,13-14,17,19-20,34H,5-6,8-9,11-12,15-16H2,1H3/b24-13-
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267899
PNG
((4Z)-6-(3-Furyl)-4-{[(3-hydroxy-4-methoxybenzyl)am...)
Show SMILES COc1ccc(CNC=C2C(=O)NC(=O)c3ccc(cc23)-c2ccoc2)cc1O |w:8.7|
Show InChI InChI=1S/C22H18N2O5/c1-28-20-5-2-13(8-19(20)25)10-23-11-18-17-9-14(15-6-7-29-12-15)3-4-16(17)21(26)24-22(18)27/h2-9,11-12,23,25H,10H2,1H3,(H,24,26,27)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4582
PNG
(4-anilinoquinazoline deriv. 10o | N-{4-[(3-bromoph...)
Show SMILES OCC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C18H13BrN4O2/c19-12-3-1-4-13(9-12)23-18-15-10-14(22-17(25)5-2-8-24)6-7-16(15)20-11-21-18/h1,3-4,6-7,9-11,24H,8H2,(H,22,25)(H,20,21,23)
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n/an/a 2n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 44: 2719-34 (2001)


Article DOI: 10.1016/j.bmcl.2006.08.072
BindingDB Entry DOI: 10.7270/Q2PN93TS
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267898
PNG
((4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylen...)
Show SMILES COc1ccc(CNC=C2C(=O)NC(=O)c3ccc(cc23)-c2ccsc2)cc1O |w:8.7|
Show InChI InChI=1S/C22H18N2O4S/c1-28-20-5-2-13(8-19(20)25)10-23-11-18-17-9-14(15-6-7-29-12-15)3-4-16(17)21(26)24-22(18)27/h2-9,11-12,23,25H,10H2,1H3,(H,24,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4567
PNG
(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1
Show InChI InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
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n/an/a 2n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 44: 2719-34 (2001)


Article DOI: 10.1016/j.bmcl.2006.08.072
BindingDB Entry DOI: 10.7270/Q2PN93TS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314351
PNG
(2-((4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-meth...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1C2CCC1COC2
Show InChI InChI=1S/C23H21N3O4/c1-25-10-13(9-19-22(28)21-17(27)3-2-4-18(21)30-19)20-16(7-8-24-23(20)25)26-14-5-6-15(26)12-29-11-14/h2-4,7-10,14-15,27H,5-6,11-12H2,1H3/b19-9-
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n/an/a 2.10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314349
PNG
(4-hydroxy-2-((1-methyl-4-morpholino-1H-pyrrolo[2,3...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)N1CCOCC1
Show InChI InChI=1S/C21H19N3O4/c1-23-12-13(11-17-20(26)19-15(25)3-2-4-16(19)28-17)18-14(5-6-22-21(18)23)24-7-9-27-10-8-24/h2-6,11-12,25H,7-10H2,1H3/b17-11-
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n/an/a 2.20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314352
PNG
(4-hydroxy-2-((1-methyl-4-(4-methylpiperazin-1-yl)-...)
Show SMILES CN1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4cccc(O)c4C3=O)c12
Show InChI InChI=1S/C22H22N4O3/c1-24-8-10-26(11-9-24)15-6-7-23-22-19(15)14(13-25(22)2)12-18-21(28)20-16(27)4-3-5-17(20)29-18/h3-7,12-13,27H,8-11H2,1-2H3/b18-12-
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n/an/a 2.80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314366
PNG
(4-hydroxy-2-((1-methyl-4-(4-(4-methylpiperazine-1-...)
Show SMILES CN1CCN(CC1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4cccc(O)c4C3=O)c12
Show InChI InChI=1S/C28H31N5O4/c1-30-12-14-33(15-13-30)28(36)18-7-10-32(11-8-18)20-6-9-29-27-24(20)19(17-31(27)2)16-23-26(35)25-21(34)4-3-5-22(25)37-23/h3-6,9,16-18,34H,7-8,10-15H2,1-2H3/b23-16-
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314332
PNG
(4-hydroxy-2-((1-methyl-4-phenyl-1H-pyrrolo[2,3-b]p...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccccc1
Show InChI InChI=1S/C23H16N2O3/c1-25-13-15(12-19-22(27)21-17(26)8-5-9-18(21)28-19)20-16(10-11-24-23(20)25)14-6-3-2-4-7-14/h2-13,26H,1H3/b19-12-
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314332
PNG
(4-hydroxy-2-((1-methyl-4-phenyl-1H-pyrrolo[2,3-b]p...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccccc1
Show InChI InChI=1S/C23H16N2O3/c1-25-13-15(12-19-22(27)21-17(26)8-5-9-18(21)28-19)20-16(10-11-24-23(20)25)14-6-3-2-4-7-14/h2-13,26H,1H3/b19-12-
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n/an/a 3.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267867
PNG
((4Z)-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylen...)
Show SMILES COc1ccc(CNC=C2C(=O)NC(=O)c3ccc(cc23)-n2cccc2)cc1O |w:8.7|
Show InChI InChI=1S/C22H19N3O4/c1-29-20-7-4-14(10-19(20)26)12-23-13-18-17-11-15(25-8-2-3-9-25)5-6-16(17)21(27)24-22(18)28/h2-11,13,23,26H,12H2,1H3,(H,24,27,28)
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n/an/a 4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314369
PNG
(2-((1-ethyl-4-(4-(4-(2-hydroxyethyl)piperazine-1-c...)
Show SMILES CCn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C31H30N4O5/c1-2-34-19-22(18-26-29(38)28-24(37)4-3-5-25(28)40-26)27-23(10-11-32-30(27)34)20-6-8-21(9-7-20)31(39)35-14-12-33(13-15-35)16-17-36/h3-11,18-19,36-37H,2,12-17H2,1H3/b26-18-
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n/an/a 4.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267482
PNG
(6-Cyclopentyl-4-{[(4-hydroxy-5-propoxy-pyridin-2-y...)
Show SMILES CCCOc1cnc(CNC=C2C(=O)NC(=O)c3ccc(cc23)C2CCCC2)cc1O |w:10.9|
Show InChI InChI=1S/C24H27N3O4/c1-2-9-31-22-14-26-17(11-21(22)28)12-25-13-20-19-10-16(15-5-3-4-6-15)7-8-18(19)23(29)27-24(20)30/h7-8,10-11,13-15,25H,2-6,9,12H2,1H3,(H,26,28)(H,27,29,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267540
PNG
(6-Cyclopentyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-...)
Show SMILES Oc1cc(CNC=C2C(=O)NC(=O)c3ccc(cc23)C2CCCC2)ncc1-c1ccoc1 |w:6.5|
Show InChI InChI=1S/C25H23N3O4/c29-23-10-18(27-13-21(23)17-7-8-32-14-17)11-26-12-22-20-9-16(15-3-1-2-4-15)5-6-19(20)24(30)28-25(22)31/h5-10,12-15,26H,1-4,11H2,(H,27,29)(H,28,30,31)
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n/an/a<5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314317
PNG
((Z)-1-(2-((4-(4-(3-oxa-8-azabicyclo[3.2.1]octane-8...)
Show SMILES Cn1cc(\C=C2/Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(ccnc12)N1CCC(CC1)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C35H35N7O5/c1-40-18-22(15-30-32(43)27-16-23(4-7-29(27)47-30)38-35(45)39-24-3-2-11-36-17-24)31-28(8-12-37-33(31)40)41-13-9-21(10-14-41)34(44)42-25-5-6-26(42)20-46-19-25/h2-4,7-8,11-12,15-18,21,25-26H,5-6,9-10,13-14,19-20H2,1H3,(H2,38,39,45)/b30-15-
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n/an/a 5.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314327
PNG
((Z)-1-(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)...)
Show SMILES CN(C)CCNC(=O)Nc1ccc2O\C(=C/c3cn(C)c4nccc(N5CC6CCC(C5)O6)c34)C(=O)c2c1
Show InChI InChI=1S/C28H32N6O4/c1-32(2)11-10-30-28(36)31-18-4-7-23-21(13-18)26(35)24(38-23)12-17-14-33(3)27-25(17)22(8-9-29-27)34-15-19-5-6-20(16-34)37-19/h4,7-9,12-14,19-20H,5-6,10-11,15-16H2,1-3H3,(H2,30,31,36)/b24-12-
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n/an/a 5.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50314344
PNG
(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C26H21N3O5/c1-29-14-17(13-21-24(32)23-19(31)3-2-4-20(23)34-21)22-18(9-10-27-25(22)29)15-5-7-16(8-6-15)26(33)28-11-12-30/h2-10,13-14,30-31H,11-12H2,1H3,(H,28,33)/b21-13-
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n/an/a 5.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4568
PNG
(4-anilinoquinazoline deriv. 10a | N-{4-[(3-bromoph...)
Show SMILES CN(C)CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C20H18BrN5O/c1-26(2)10-4-7-19(27)24-16-8-9-18-17(12-16)20(23-13-22-18)25-15-6-3-5-14(21)11-15/h3,5-6,8-9,11-13H,10H2,1-2H3,(H,24,27)(H,22,23,25)
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n/an/a 6n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 44: 2719-34 (2001)


Article DOI: 10.1016/j.bmcl.2006.08.072
BindingDB Entry DOI: 10.7270/Q2PN93TS
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM50314344
PNG
(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C26H21N3O5/c1-29-14-17(13-21-24(32)23-19(31)3-2-4-20(23)34-21)22-18(9-10-27-25(22)29)15-5-7-16(8-6-15)26(33)28-11-12-30/h2-10,13-14,30-31H,11-12H2,1H3,(H,28,33)/b21-13-
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n/an/a 6.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of MK2


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50161879
PNG
(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(3...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(Cl)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C31H29Cl2N5O3/c1-4-40-29-16-26-24(15-27(29)37-30(39)9-6-12-38(2)3)31(21(17-34)18-35-26)36-23-10-11-28(25(33)14-23)41-19-20-7-5-8-22(32)13-20/h5-11,13-16,18H,4,12,19H2,1-3H3,(H,35,36)(H,37,39)/b9-6+
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n/an/a 7n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylation


J Med Chem 48: 1107-31 (2005)


Article DOI: 10.1021/jm040159c
BindingDB Entry DOI: 10.7270/Q2BP03KG
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50003643
PNG
(CHEMBL484477)
Show SMILES COc1cc(CN\C=C2/C(=O)NC(=O)c3ccc(Br)cc23)cc(O)c1OC
Show InChI InChI=1S/C19H17BrN2O5/c1-26-16-6-10(5-15(23)17(16)27-2)8-21-9-14-13-7-11(20)3-4-12(13)18(24)22-19(14)25/h3-7,9,21,23H,8H2,1-2H3,(H,22,24,25)/b14-9-
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314322
PNG
((Z)-1-(2-((4-(2-oxa-5-azabicyclo[2.2.2]octan-5-yl)...)
Show SMILES Cn1cc(\C=C2/Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(ccnc12)N1CC2CCC1CO2
Show InChI InChI=1S/C29H26N6O4/c1-34-14-17(26-23(8-10-31-28(26)34)35-15-21-6-5-20(35)16-38-21)11-25-27(36)22-12-18(4-7-24(22)39-25)32-29(37)33-19-3-2-9-30-13-19/h2-4,7-14,20-21H,5-6,15-16H2,1H3,(H2,32,33,37)/b25-11-
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n/an/a 7.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50161879
PNG
(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(3...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(Cl)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C31H29Cl2N5O3/c1-4-40-29-16-26-24(15-27(29)37-30(39)9-6-12-38(2)3)31(21(17-34)18-35-26)36-23-10-11-28(25(33)14-23)41-19-20-7-5-8-22(32)13-20/h5-11,13-16,18H,4,12,19H2,1-3H3,(H,35,36)(H,37,39)/b9-6+
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n/an/a 8n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylation


J Med Chem 48: 1107-31 (2005)


Article DOI: 10.1021/jm040159c
BindingDB Entry DOI: 10.7270/Q2BP03KG
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4566
PNG
(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Show SMILES CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)
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n/an/a 8n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 44: 2719-34 (2001)


Article DOI: 10.1016/j.bmcl.2006.08.072
BindingDB Entry DOI: 10.7270/Q2PN93TS
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267399
PNG
(4-[(3-Hydroxy-4-pyridin-4-yl-benzylamino)-methylen...)
Show SMILES Oc1cc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)ccc1-c1ccncc1 |w:6.5|
Show InChI InChI=1S/C22H16IN3O3/c23-15-2-4-17-18(10-15)19(22(29)26-21(17)28)12-25-11-13-1-3-16(20(27)9-13)14-5-7-24-8-6-14/h1-10,12,25,27H,11H2,(H,26,28,29)
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n/an/a 8n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314342
PNG
((Z)-1-(2-((1-methyl-4-(4-(pyrrolidine-1-carbonyl)p...)
Show SMILES Cn1cc(\C=C2/Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(ccnc12)N1CCC(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C33H33N7O4/c1-38-20-22(29-26(8-12-35-31(29)38)39-15-9-21(10-16-39)32(42)40-13-2-3-14-40)17-28-30(41)25-18-23(6-7-27(25)44-28)36-33(43)37-24-5-4-11-34-19-24/h4-8,11-12,17-21H,2-3,9-10,13-16H2,1H3,(H2,36,37,43)/b28-17-
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n/an/a 8.20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314339
PNG
((Z)-1-(2-((4-(4-(3-methoxypyrrolidine-1-carbonyl)p...)
Show SMILES COC1CCN(C1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c12
Show InChI InChI=1S/C34H35N7O5/c1-39-19-22(16-29-31(42)26-17-23(5-6-28(26)46-29)37-34(44)38-24-4-3-11-35-18-24)30-27(7-12-36-32(30)39)40-13-8-21(9-14-40)33(43)41-15-10-25(20-41)45-2/h3-7,11-12,16-19,21,25H,8-10,13-15,20H2,1-2H3,(H2,37,38,44)/b29-16-
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n/an/a 8.20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314335
PNG
((Z)-N-methyl-1-(1-methyl-3-((3-oxo-5-(3-pyridin-3-...)
Show SMILES CN(Cc1ccccn1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c12
Show InChI InChI=1S/C36H34N8O4/c1-42-21-24(18-31-33(45)28-19-25(8-9-30(28)48-31)40-36(47)41-26-7-5-13-37-20-26)32-29(10-15-39-34(32)42)44-16-11-23(12-17-44)35(46)43(2)22-27-6-3-4-14-38-27/h3-10,13-15,18-21,23H,11-12,16-17,22H2,1-2H3,(H2,40,41,47)/b31-18-
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314338
PNG
((Z)-1-(1-methyl-3-((3-oxo-5-(3-pyridin-3-ylureido)...)
Show SMILES Cn1cc(\C=C2/Oc3ccc(NC(=O)Nc4cccnc4)cc3C2=O)c2c(ccnc12)N1CCC(CC1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C35H32N8O4/c1-42-21-24(16-30-32(44)27-17-25(6-7-29(27)47-30)40-35(46)41-26-5-3-12-37-20-26)31-28(8-13-38-33(31)42)43-14-9-23(10-15-43)34(45)39-19-22-4-2-11-36-18-22/h2-8,11-13,16-18,20-21,23H,9-10,14-15,19H2,1H3,(H,39,45)(H2,40,41,46)/b30-16-
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n/an/a 9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4579
PNG
(4-anilinoquinazoline deriv. 10l | N-{4-[(3-bromoph...)
Show SMILES COCC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C19H15BrN4O2/c1-26-9-3-6-18(25)23-15-7-8-17-16(11-15)19(22-12-21-17)24-14-5-2-4-13(20)10-14/h2,4-5,7-8,10-12H,9H2,1H3,(H,23,25)(H,21,22,24)
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n/an/a 9n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 44: 2719-34 (2001)


Article DOI: 10.1016/j.bmcl.2006.08.072
BindingDB Entry DOI: 10.7270/Q2PN93TS
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314336
PNG
((Z)-N-methyl-1-(1-methyl-3-((3-oxo-5-(3-pyridin-3-...)
Show SMILES CN(Cc1ccncc1)C(=O)C1CCN(CC1)c1ccnc2n(C)cc(\C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c12
Show InChI InChI=1S/C36H34N8O4/c1-42-22-25(18-31-33(45)28-19-26(5-6-30(28)48-31)40-36(47)41-27-4-3-12-38-20-27)32-29(9-15-39-34(32)42)44-16-10-24(11-17-44)35(46)43(2)21-23-7-13-37-14-8-23/h3-9,12-15,18-20,22,24H,10-11,16-17,21H2,1-2H3,(H2,40,41,47)/b31-18-
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50314329
PNG
((Z)-1-(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)...)
Show SMILES CNC(=O)Nc1ccc2O\C(=C/c3cn(C)c4nccc(N5CC6CCC(C5)O6)c34)C(=O)c2c1
Show InChI InChI=1S/C25H25N5O4/c1-26-25(32)28-15-3-6-20-18(10-15)23(31)21(34-20)9-14-11-29(2)24-22(14)19(7-8-27-24)30-12-16-4-5-17(13-30)33-16/h3,6-11,16-17H,4-5,12-13H2,1-2H3,(H2,26,28,32)/b21-9-
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n/an/a 9.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2259-63 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.012
BindingDB Entry DOI: 10.7270/Q2TB1717
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50314344
PNG
(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C26H21N3O5/c1-29-14-17(13-21-24(32)23-19(31)3-2-4-20(23)34-21)22-18(9-10-27-25(22)29)15-5-7-16(8-6-15)26(33)28-11-12-30/h2-10,13-14,30-31H,11-12H2,1H3,(H,28,33)/b21-13-
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n/an/a 9.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of ABL1


Bioorg Med Chem Lett 20: 2321-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.135
BindingDB Entry DOI: 10.7270/Q2PK0G82
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50161948
PNG
(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(n...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc5ccccc45)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C35H32ClN5O3/c1-4-43-33-19-30-28(18-31(33)40-34(42)13-8-16-41(2)3)35(25(20-37)21-38-30)39-26-14-15-32(29(36)17-26)44-22-24-11-7-10-23-9-5-6-12-27(23)24/h5-15,17-19,21H,4,16,22H2,1-3H3,(H,38,39)(H,40,42)/b13-8+
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n/an/a 10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylation


J Med Chem 48: 1107-31 (2005)


Article DOI: 10.1021/jm040159c
BindingDB Entry DOI: 10.7270/Q2BP03KG
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50161903
PNG
(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4Cl)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C31H29Cl2N5O3/c1-4-40-29-16-26-23(15-27(29)37-30(39)10-7-13-38(2)3)31(21(17-34)18-35-26)36-22-11-12-28(25(33)14-22)41-19-20-8-5-6-9-24(20)32/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,35,36)(H,37,39)/b10-7+
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylation


J Med Chem 48: 1107-31 (2005)


Article DOI: 10.1021/jm040159c
BindingDB Entry DOI: 10.7270/Q2BP03KG
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267479
PNG
(6-Iodo-4-{[(4-hydroxy-5-methoxy-pyridin-2-ylmethyl...)
Show SMILES COc1cnc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)cc1O |w:8.7|
Show InChI InChI=1S/C17H14IN3O4/c1-25-15-8-20-10(5-14(15)22)6-19-7-13-12-4-9(18)2-3-11(12)16(23)21-17(13)24/h2-5,7-8,19H,6H2,1H3,(H,20,22)(H,21,23,24)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair
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