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Compile Data Set for Download or QSAR

Found 31 hits with Last Name = 'underwood' and Initial = 'dc'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TACR3


(GUINEA PIG)
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
Neurokinin 3 receptor


(mouse)
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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17.9n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
Neurokinin 3 receptor


(mouse)
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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82.4n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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2.33E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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5.25E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(GUINEA PIG)
BDBM85845
PNG
(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Show SMILES CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by PDSP Ki Database




J Pharmacol Exp Ther 300: 314-23 (2002)


Article DOI: 10.1124/jpet.300.1.314
BindingDB Entry DOI: 10.7270/Q2SB449D
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280333
PNG
(CHEMBL49207 | [4,4-Diethyl-6-oxo-1-[2'-(1H-tetrazo...)
Show SMILES CCOC(=O)\C=C1/CC(CC)(CC)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H31N5O3/c1-4-27(5-2)16-21(15-25(34)35-6-3)32(24(33)17-27)18-19-11-13-20(14-12-19)22-9-7-8-10-23(22)26-28-30-31-29-26/h7-15H,4-6,16-18H2,1-3H3,(H,28,29,30,31)/b21-15+
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280320
PNG
(CHEMBL51084 | [4-Oxo-3-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCOC(=O)\C=C1/CC2(CCCCC2)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H31N5O3/c1-2-36-26(35)16-22-17-28(14-6-3-7-15-28)18-25(34)33(22)19-20-10-12-21(13-11-20)23-8-4-5-9-24(23)27-29-31-32-30-27/h4-5,8-13,16H,2-3,6-7,14-15,17-19H2,1H3,(H,29,30,31,32)/b22-16+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281522
PNG
(CHEMBL121871 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCCCC1
Show InChI InChI=1S/C28H31N5O3/c1-2-36-26(35)17-24-28(15-7-3-4-8-16-28)18-25(34)33(24)19-20-11-13-21(14-12-20)22-9-5-6-10-23(22)27-29-31-32-30-27/h5-6,9-14,17H,2-4,7-8,15-16,18-19H2,1H3,(H,29,30,31,32)/b24-17-
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TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281520
PNG
(CHEMBL123348 | [3-Ethyl-3-methyl-5-oxo-1-[2'-(1H-t...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC1(C)CC
Show InChI InChI=1S/C25H27N5O3/c1-4-25(3)15-22(31)30(21(25)14-23(32)33-5-2)16-17-10-12-18(13-11-17)19-8-6-7-9-20(19)24-26-28-29-27-24/h6-14H,4-5,15-16H2,1-3H3,(H,26,27,28,29)/b21-14-
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TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280325
PNG
(CHEMBL48459 | [4-Ethyl-6-oxo-4-propyl-1-[2'-(1H-te...)
Show SMILES CCCC1(CC)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OCC
Show InChI InChI=1S/C28H33N5O3/c1-4-15-28(5-2)17-22(16-26(35)36-6-3)33(25(34)18-28)19-20-11-13-21(14-12-20)23-9-7-8-10-24(23)27-29-31-32-30-27/h7-14,16H,4-6,15,17-19H2,1-3H3,(H,29,30,31,32)/b22-16+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281524
PNG
(CHEMBL123713 | [3,3-Diethyl-5-oxo-1-[2'-(1H-tetraz...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC1(CC)CC
Show InChI InChI=1S/C26H29N5O3/c1-4-26(5-2)16-23(32)31(22(26)15-24(33)34-6-3)17-18-11-13-19(14-12-18)20-9-7-8-10-21(20)25-27-29-30-28-25/h7-15H,4-6,16-17H2,1-3H3,(H,27,28,29,30)/b22-15-
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TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280321
PNG
(CHEMBL296731 | [4-Isopropyl-4-methyl-6-oxo-1-[2'-(...)
Show SMILES CCOC(=O)\C=C1/CC(C)(CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)C
Show InChI InChI=1S/C27H31N5O3/c1-5-35-25(34)14-21-15-27(4,18(2)3)16-24(33)32(21)17-19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-28-30-31-29-26/h6-14,18H,5,15-17H2,1-4H3,(H,28,29,30,31)/b21-14+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280329
PNG
(CHEMBL50906 | [4-Methyl-6-oxo-4-propyl-1-[2'-(1H-t...)
Show SMILES CCCC1(C)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OCC
Show InChI InChI=1S/C27H31N5O3/c1-4-14-27(3)16-21(15-25(34)35-5-2)32(24(33)17-27)18-19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-28-30-31-29-26/h6-13,15H,4-5,14,16-18H2,1-3H3,(H,28,29,30,31)/b21-15+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281519
PNG
(CHEMBL124449 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCCC1
Show InChI InChI=1S/C27H29N5O3/c1-2-35-25(34)16-23-27(14-6-3-7-15-27)17-24(33)32(23)18-19-10-12-20(13-11-19)21-8-4-5-9-22(21)26-28-30-31-29-26/h4-5,8-13,16H,2-3,6-7,14-15,17-18H2,1H3,(H,28,29,30,31)/b23-16-
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TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280323
PNG
(CHEMBL51622 | [4-Butyl-4-ethyl-6-oxo-1-[2'-(1H-tet...)
Show SMILES CCCCC1(CC)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OCC
Show InChI InChI=1S/C29H35N5O3/c1-4-7-16-29(5-2)18-23(17-27(36)37-6-3)34(26(35)19-29)20-21-12-14-22(15-13-21)24-10-8-9-11-25(24)28-30-32-33-31-28/h8-15,17H,4-7,16,18-20H2,1-3H3,(H,30,31,32,33)/b23-17+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280322
PNG
(CHEMBL413098 | [4-Methyl-6-oxo-1-[2'-(1H-tetrazol-...)
Show SMILES CCOC(=O)\C=C1/CC(C)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H25N5O3/c1-3-32-23(31)14-19-12-16(2)13-22(30)29(19)15-17-8-10-18(11-9-17)20-6-4-5-7-21(20)24-25-27-28-26-24/h4-11,14,16H,3,12-13,15H2,1-2H3,(H,25,26,27,28)/b19-14+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280328
PNG
(CHEMBL418269 | [4,4-Diethyl-6-oxo-1-[2'-(1H-tetraz...)
Show SMILES CCC1(CC)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OC
Show InChI InChI=1S/C26H29N5O3/c1-4-26(5-2)15-20(14-24(33)34-3)31(23(32)16-26)17-18-10-12-19(13-11-18)21-8-6-7-9-22(21)25-27-29-30-28-25/h6-14H,4-5,15-17H2,1-3H3,(H,27,28,29,30)/b20-14+
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n/an/a 210n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281523
PNG
(CHEMBL421094 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCC1
Show InChI InChI=1S/C26H27N5O3/c1-2-34-24(33)15-22-26(13-5-6-14-26)16-23(32)31(22)17-18-9-11-19(12-10-18)20-7-3-4-8-21(20)25-27-29-30-28-25/h3-4,7-12,15H,2,5-6,13-14,16-17H2,1H3,(H,27,28,29,30)/b22-15-
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049205
PNG
(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Show SMILES CCOC(=O)\C=C1/CC(C)(CC)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H29N5O3/c1-4-26(3)15-20(14-24(33)34-5-2)31(23(32)16-26)17-18-10-12-19(13-11-18)21-8-6-7-9-22(21)25-27-29-30-28-25/h6-14H,4-5,15-17H2,1-3H3,(H,27,28,29,30)/b20-14+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280330
PNG
(CHEMBL51001 | [4-Ethyl-4-methyl-6-oxo-1-[2'-(1H-te...)
Show SMILES CCC1(C)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OC
Show InChI InChI=1S/C25H27N5O3/c1-4-25(2)14-19(13-23(32)33-3)30(22(31)15-25)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)24-26-28-29-27-24/h5-13H,4,14-16H2,1-3H3,(H,26,27,28,29)/b19-13+
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n/an/a 320n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280327
PNG
(CHEMBL295369 | [6-Oxo-4,4-dipropyl-1-[2'-(1H-tetra...)
Show SMILES CCCC1(CCC)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OCC
Show InChI InChI=1S/C29H35N5O3/c1-4-15-29(16-5-2)18-23(17-27(36)37-6-3)34(26(35)19-29)20-21-11-13-22(14-12-21)24-9-7-8-10-25(24)28-30-32-33-31-28/h7-14,17H,4-6,15-16,18-20H2,1-3H3,(H,30,31,32,33)/b23-17+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |t:4|
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |t:4|
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 425n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280319
PNG
(CHEMBL299151 | [4-Butyl-4-methyl-6-oxo-1-[2'-(1H-t...)
Show SMILES CCCCC1(C)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OCC
Show InChI InChI=1S/C28H33N5O3/c1-4-6-15-28(3)17-22(16-26(35)36-5-2)33(25(34)18-28)19-20-11-13-21(14-12-20)23-9-7-8-10-24(23)27-29-31-32-30-27/h7-14,16H,4-6,15,17-19H2,1-3H3,(H,29,30,31,32)/b22-16+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280331
PNG
(CHEMBL49192 | [9-Oxo-8-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCOC(=O)\C=C1/CC2(CCCC2)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H29N5O3/c1-2-35-25(34)15-21-16-27(13-5-6-14-27)17-24(33)32(21)18-19-9-11-20(12-10-19)22-7-3-4-8-23(22)26-28-30-31-29-26/h3-4,7-12,15H,2,5-6,13-14,16-18H2,1H3,(H,28,29,30,31)/b21-15+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280326
PNG
(CHEMBL51078 | [4-Methyl-6-oxo-4-pentyl-1-[2'-(1H-t...)
Show SMILES CCCCCC1(C)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)\C(C1)=C\C(=O)OCC
Show InChI InChI=1S/C29H35N5O3/c1-4-6-9-16-29(3)18-23(17-27(36)37-5-2)34(26(35)19-29)20-21-12-14-22(15-13-21)24-10-7-8-11-25(24)28-30-32-33-31-28/h7-8,10-15,17H,4-6,9,16,18-20H2,1-3H3,(H,30,31,32,33)/b23-17+
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TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281521
PNG
(CHEMBL330866 | [3-Methyl-5-oxo-1-[2'-(1H-tetrazol-...)
Show SMILES CCOC(=O)\C=C1\C(C)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H23N5O3/c1-3-31-22(30)13-20-15(2)12-21(29)28(20)14-16-8-10-17(11-9-16)18-6-4-5-7-19(18)23-24-26-27-25-23/h4-11,13,15H,3,12,14H2,1-2H3,(H,24,25,26,27)/b20-13-
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n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280332
PNG
(4,4-Diethyl-6-[2-oxo-prop-(E)-ylidene]-1-[2'-(1H-t...)
Show SMILES CCC1(CC)CC(=O)N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(C1)=CC(C)=O |w:29.33|
Show InChI InChI=1S/C26H29N5O2/c1-4-26(5-2)15-21(14-18(3)32)31(24(33)16-26)17-19-10-12-20(13-11-19)22-8-6-7-9-23(22)25-27-29-30-28-25/h6-14H,4-5,15-17H2,1-3H3,(H,27,28,29,30)
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n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50280324
PNG
(CHEMBL49262 | [4,4-Dimethyl-6-oxo-1-[2'-(1H-tetraz...)
Show SMILES CCOC(=O)\C=C1/CC(C)(C)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C25H27N5O3/c1-4-33-23(32)13-19-14-25(2,3)15-22(31)30(19)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)24-26-28-29-27-24/h5-13H,4,14-16H2,1-3H3,(H,26,27,28,29)/b19-13+
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n/an/a 5.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes


Bioorg Med Chem Lett 2: 1775-1779 (1992)


Article DOI: 10.1016/S0960-894X(00)80474-6
BindingDB Entry DOI: 10.7270/Q2NP24B9
More data for this
Ligand-Target Pair