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Compile Data Set for Download or QSAR

Found 468 hits with Last Name = 'valenti' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054988
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(cc3)N3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C34H39N7O4/c35-11-9-23-19-37-31-7-5-27(17-29(23)31)44-21-33(42)39-25-1-3-26(4-2-25)40-13-15-41(16-14-40)34(43)22-45-28-6-8-32-30(18-28)24(10-12-36)20-38-32/h1-8,17-20,37-38H,9-16,21-22,35-36H2,(H,39,42)
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0.0900n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054974
PNG
(2-(5-((4-((3-(2-aminoethyl)-1H-indol-5-yloxy)methy...)
Show SMILES NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-11-9-21-15-31-27-7-5-23(13-25(21)27)33-17-19-1-2-20(4-3-19)18-34-24-6-8-28-26(14-24)22(10-12-30)16-32-28/h1-8,13-16,31-32H,9-12,17-18,29-30H2
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0.100n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054987
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCCN3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H36N6O3/c29-7-5-20-17-31-26-3-1-22(15-24(20)26)36-14-13-33-9-11-34(12-10-33)28(35)19-37-23-2-4-27-25(16-23)21(6-8-30)18-32-27/h1-4,15-18,31-32H,5-14,19,29-30H2
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0.110n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054974
PNG
(2-(5-((4-((3-(2-aminoethyl)-1H-indol-5-yloxy)methy...)
Show SMILES NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-11-9-21-15-31-27-7-5-23(13-25(21)27)33-17-19-1-2-20(4-3-19)18-34-24-6-8-28-26(14-24)22(10-12-30)16-32-28/h1-8,13-16,31-32H,9-12,17-18,29-30H2
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0.110n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054981
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
Show InChI InChI=1S/C30H32N6O4/c31-11-9-19-15-33-27-7-5-23(13-25(19)27)39-17-29(37)35-21-1-2-22(4-3-21)36-30(38)18-40-24-6-8-28-26(14-24)20(10-12-32)16-34-28/h1-8,13-16,33-34H,9-12,17-18,31-32H2,(H,35,37)(H,36,38)
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0.110n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054988
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(cc3)N3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C34H39N7O4/c35-11-9-23-19-37-31-7-5-27(17-29(23)31)44-21-33(42)39-25-1-3-26(4-2-25)40-13-15-41(16-14-40)34(43)22-45-28-6-8-32-30(18-28)24(10-12-36)20-38-32/h1-8,17-20,37-38H,9-16,21-22,35-36H2,(H,39,42)
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0.140n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054987
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCCN3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H36N6O3/c29-7-5-20-17-31-26-3-1-22(15-24(20)26)36-14-13-33-9-11-34(12-10-33)28(35)19-37-23-2-4-27-25(16-23)21(6-8-30)18-32-27/h1-4,15-18,31-32H,5-14,19,29-30H2
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0.160n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054976
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-...)
Show SMILES NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C24H29N5O3/c25-7-5-16-13-28-22-3-1-18(11-20(16)22)31-10-9-27-24(30)15-32-19-2-4-23-21(12-19)17(6-8-26)14-29-23/h1-4,11-14,28-29H,5-10,15,25-26H2,(H,27,30)
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0.160n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054976
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-...)
Show SMILES NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C24H29N5O3/c25-7-5-16-13-28-22-3-1-18(11-20(16)22)31-10-9-27-24(30)15-32-19-2-4-23-21(12-19)17(6-8-26)14-29-23/h1-4,11-14,28-29H,5-10,15,25-26H2,(H,27,30)
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0.180n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054983
PNG
(1,3-Bis-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-et...)
Show SMILES NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C25H32N6O3/c26-7-5-17-15-30-23-3-1-19(13-21(17)23)33-11-9-28-25(32)29-10-12-34-20-2-4-24-22(14-20)18(6-8-27)16-31-24/h1-4,13-16,30-31H,5-12,26-27H2,(H2,28,29,32)
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0.200n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054980
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(1'-{2-[3...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCC(CC3)C3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C34H44N6O4/c35-11-5-25-19-37-31-3-1-27(17-29(25)31)43-21-33(41)39-13-7-23(8-14-39)24-9-15-40(16-10-24)34(42)22-44-28-2-4-32-30(18-28)26(6-12-36)20-38-32/h1-4,17-20,23-24,37-38H,5-16,21-22,35-36H2
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0.220n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50369048
PNG
(CHEMBL1203216)
Show SMILES CN(C)S(=O)(=O)Nc1ccc(cc1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C24H32N6O4S/c1-28(2)35(32,33)27-19-3-5-20(6-4-19)29-11-13-30(14-12-29)24(31)17-34-21-7-8-23-22(15-21)18(9-10-25)16-26-23/h3-8,15-16,26-27H,9-14,17,25H2,1-2H3
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0.260n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054979
PNG
(2-{5-[2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]...)
Show SMILES NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12
Show InChI InChI=1S/C28H38N6O2/c29-7-5-21-19-31-27-3-1-23(17-25(21)27)35-15-13-33-9-11-34(12-10-33)14-16-36-24-2-4-28-26(18-24)22(6-8-30)20-32-28/h1-4,17-20,31-32H,5-16,29-30H2
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0.260n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054981
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
Show InChI InChI=1S/C30H32N6O4/c31-11-9-19-15-33-27-7-5-23(13-25(19)27)39-17-29(37)35-21-1-2-22(4-3-21)36-30(38)18-40-24-6-8-28-26(14-24)20(10-12-32)16-34-28/h1-8,13-16,33-34H,9-12,17-18,31-32H2,(H,35,37)(H,36,38)
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0.270n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054980
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(1'-{2-[3...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCC(CC3)C3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C34H44N6O4/c35-11-5-25-19-37-31-3-1-27(17-29(25)31)43-21-33(41)39-13-7-23(8-14-39)24-9-15-40(16-10-24)34(42)22-44-28-2-4-32-30(18-28)26(6-12-36)20-38-32/h1-4,17-20,23-24,37-38H,5-16,21-22,35-36H2
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0.270n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033440
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(2-nit...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3[N+]([O-])=O)cc12
Show InChI InChI=1S/C22H25N5O4/c23-8-7-16-14-24-19-6-5-17(13-18(16)19)31-15-22(28)26-11-9-25(10-12-26)20-3-1-2-4-21(20)27(29)30/h1-6,13-14,24H,7-12,15,23H2
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0.300n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054973
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(3-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C27H34N6O4/c28-8-6-18-14-32-24-4-2-20(12-22(18)24)36-16-26(34)30-10-1-11-31-27(35)17-37-21-3-5-25-23(13-21)19(7-9-29)15-33-25/h2-5,12-15,32-33H,1,6-11,16-17,28-29H2,(H,30,34)(H,31,35)
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0.300n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054973
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(3-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C27H34N6O4/c28-8-6-18-14-32-24-4-2-20(12-22(18)24)36-16-26(34)30-10-1-11-31-27(35)17-37-21-3-5-25-23(13-21)19(7-9-29)15-33-25/h2-5,12-15,32-33H,1,6-11,16-17,28-29H2,(H,30,34)(H,31,35)
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0.300n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033443
PNG
(6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-ami...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(CC3)c3ccc(N)cc3)cc12
Show InChI InChI=1S/C26H35N5O2/c27-12-11-20-19-29-25-10-9-23(18-24(20)25)33-17-3-1-2-4-26(32)31-15-13-30(14-16-31)22-7-5-21(28)6-8-22/h5-10,18-19,29H,1-4,11-17,27-28H2
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0.310n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054978
PNG
(2-(5-{3-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Show SMILES NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-10-8-21-15-31-27-6-4-23(13-25(21)27)33-17-19-2-1-3-20(12-19)18-34-24-5-7-28-26(14-24)22(9-11-30)16-32-28/h1-7,12-16,31-32H,8-11,17-18,29-30H2
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0.320n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033445
PNG
(6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-nit...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)cc12
Show InChI InChI=1S/C26H33N5O4/c27-12-11-20-19-28-25-10-9-23(18-24(20)25)35-17-3-1-2-4-26(32)30-15-13-29(14-16-30)21-5-7-22(8-6-21)31(33)34/h5-10,18-19,28H,1-4,11-17,27H2
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0.340n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054979
PNG
(2-{5-[2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]...)
Show SMILES NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12
Show InChI InChI=1S/C28H38N6O2/c29-7-5-21-19-31-27-3-1-23(17-25(21)27)35-15-13-33-9-11-34(12-10-33)14-16-36-24-2-4-28-26(18-24)22(6-8-30)20-32-28/h1-4,17-20,31-32H,5-16,29-30H2
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0.350n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054978
PNG
(2-(5-{3-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Show SMILES NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-10-8-21-15-31-27-6-4-23(13-25(21)27)33-17-19-2-1-3-20(12-19)18-34-24-5-7-28-26(14-24)22(9-11-30)16-32-28/h1-7,12-16,31-32H,8-11,17-18,29-30H2
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0.350n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054986
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H34N6O4/c29-7-5-19-15-31-25-3-1-21(13-23(19)25)37-17-27(35)33-9-11-34(12-10-33)28(36)18-38-22-2-4-26-24(14-22)20(6-8-30)16-32-26/h1-4,13-16,31-32H,5-12,17-18,29-30H2
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0.360n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033443
PNG
(6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-ami...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(CC3)c3ccc(N)cc3)cc12
Show InChI InChI=1S/C26H35N5O2/c27-12-11-20-19-29-25-10-9-23(18-24(20)25)33-17-3-1-2-4-26(32)31-15-13-30(14-16-31)22-7-5-21(28)6-8-22/h5-10,18-19,29H,1-4,11-17,27-28H2
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0.380n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054985
PNG
(Biphenyl-4,4'-disulfonic acid bis-({6-[3-(2-amino-...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(cc3)-c3ccc(cc3)S(=O)(=O)NCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C44H56N6O6S2/c45-23-21-35-31-47-43-19-13-37(29-41(35)43)55-27-7-3-1-5-25-49-57(51,52)39-15-9-33(10-16-39)34-11-17-40(18-12-34)58(53,54)50-26-6-2-4-8-28-56-38-14-20-44-42(30-38)36(22-24-46)32-48-44/h9-20,29-32,47-50H,1-8,21-28,45-46H2
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0.380n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033434
PNG
(2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-acety...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3C#N)cc12
Show InChI InChI=1S/C23H25N5O2/c24-8-7-18-15-26-21-6-5-19(13-20(18)21)30-16-23(29)28-11-9-27(10-12-28)22-4-2-1-3-17(22)14-25/h1-6,13,15,26H,7-12,16,24H2
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0.390n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054983
PNG
(1,3-Bis-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-et...)
Show SMILES NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C25H32N6O3/c26-7-5-17-15-30-23-3-1-19(13-21(17)23)33-11-9-28-25(32)29-10-12-34-20-2-4-24-22(14-20)18(6-8-27)16-31-24/h1-4,13-16,30-31H,5-12,26-27H2,(H2,28,29,32)
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0.400n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50286671
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-met...)
Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-29-19-4-2-3-18(13-19)26-9-11-27(12-10-26)23(28)16-30-20-5-6-22-21(14-20)17(7-8-24)15-25-22/h2-6,13-15,25H,7-12,16,24H2,1H3
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0.400n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined


Bioorg Med Chem Lett 5: 663-666 (1995)


Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033439
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12
Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2
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0.400n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033435
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-nit...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)cc12
Show InChI InChI=1S/C22H25N5O4/c23-8-7-16-14-24-21-6-5-19(13-20(16)21)31-15-22(28)26-11-9-25(10-12-26)17-1-3-18(4-2-17)27(29)30/h1-6,13-14,24H,7-12,15,23H2
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0.420n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054986
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H34N6O4/c29-7-5-19-15-31-25-3-1-21(13-23(19)25)37-17-27(35)33-9-11-34(12-10-33)28(36)18-38-22-2-4-26-24(14-22)20(6-8-30)16-32-26/h1-4,13-16,31-32H,5-12,17-18,29-30H2
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0.420n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054985
PNG
(Biphenyl-4,4'-disulfonic acid bis-({6-[3-(2-amino-...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(cc3)-c3ccc(cc3)S(=O)(=O)NCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C44H56N6O6S2/c45-23-21-35-31-47-43-19-13-37(29-41(35)43)55-27-7-3-1-5-25-49-57(51,52)39-15-9-33(10-16-39)34-11-17-40(18-12-34)58(53,54)50-26-6-2-4-8-28-56-38-14-20-44-42(30-38)36(22-24-46)32-48-44/h9-20,29-32,47-50H,1-8,21-28,45-46H2
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0.450n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50054977
PNG
(2-(5-{6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-hexyl...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C26H34N4O2/c27-11-9-19-17-29-25-7-5-21(15-23(19)25)31-13-3-1-2-4-14-32-22-6-8-26-24(16-22)20(10-12-28)18-30-26/h5-8,15-18,29-30H,1-4,9-14,27-28H2
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0.460n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033445
PNG
(6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-nit...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)cc12
Show InChI InChI=1S/C26H33N5O4/c27-12-11-20-19-28-25-10-9-23(18-24(20)25)35-17-3-1-2-4-26(32)30-15-13-29(14-16-30)21-5-7-22(8-6-21)31(33)34/h5-10,18-19,28H,1-4,11-17,27H2
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0.470n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50054977
PNG
(2-(5-{6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-hexyl...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C26H34N4O2/c27-11-9-19-17-29-25-7-5-21(15-23(19)25)31-13-3-1-2-4-14-32-22-6-8-26-24(16-22)20(10-12-28)18-30-26/h5-8,15-18,29-30H,1-4,9-14,27-28H2
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0.5n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells


J Med Chem 39: 4920-7 (1997)


Article DOI: 10.1021/jm960552l
BindingDB Entry DOI: 10.7270/Q23B5Z7M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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0.520n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined


Bioorg Med Chem Lett 5: 663-666 (1995)


Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033436
PNG
(CHEMBL120480 | N-[2-(4-{2-[3-(2-Amino-ethyl)-1H-in...)
Show SMILES CS(=O)(=O)NCc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C24H31N5O4S/c1-34(31,32)27-16-19-4-2-3-5-23(19)28-10-12-29(13-11-28)24(30)17-33-20-6-7-22-21(14-20)18(8-9-25)15-26-22/h2-7,14-15,26-27H,8-13,16-17,25H2,1H3
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0.530n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033433
PNG
(CHEMBL121901 | N-[4-(4-{2-[3-(2-Amino-ethyl)-1H-in...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C23H29N5O4S/c1-33(30,31)26-18-2-4-19(5-3-18)27-10-12-28(13-11-27)23(29)16-32-20-6-7-22-21(14-20)17(8-9-24)15-25-22/h2-7,14-15,25-26H,8-13,16,24H2,1H3
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0.560n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033440
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(2-nit...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3[N+]([O-])=O)cc12
Show InChI InChI=1S/C22H25N5O4/c23-8-7-16-14-24-19-6-5-17(13-18(16)19)31-15-22(28)26-11-9-25(10-12-26)20-3-1-2-4-21(20)27(29)30/h1-6,13-14,24H,7-12,15,23H2
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0.580n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50033439
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12
Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2
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0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined


Bioorg Med Chem Lett 5: 663-666 (1995)


Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50069315
PNG
(C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-(...)
Show SMILES CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12
Show InChI InChI=1S/C36H48N6O4S2/c1-39(2)17-15-31-21-37-35-13-11-29(19-33(31)35)25-47(43,44)41(5)23-27-7-9-28(10-8-27)24-42(6)48(45,46)26-30-12-14-36-34(20-30)32(22-38-36)16-18-40(3)4/h7-14,19-22,37-38H,15-18,23-26H2,1-6H3
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0.640n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1B receptor using [3H]-5-CT radioligand


Bioorg Med Chem Lett 8: 675-80 (1999)


BindingDB Entry DOI: 10.7270/Q24B30F8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033383
PNG
((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Show SMILES CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12
Show InChI InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
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0.760n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]-5-CT radioligand


Bioorg Med Chem Lett 8: 675-80 (1999)


BindingDB Entry DOI: 10.7270/Q24B30F8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033447
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3
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0.800n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033435
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-nit...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)cc12
Show InChI InChI=1S/C22H25N5O4/c23-8-7-16-14-24-21-6-5-19(13-20(16)21)31-15-22(28)26-11-9-25(10-12-26)17-1-3-18(4-2-17)27(29)30/h1-6,13-14,24H,7-12,15,23H2
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0.830n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033447
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3
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0.870n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined


Bioorg Med Chem Lett 5: 663-666 (1995)


Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50069315
PNG
(C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-(...)
Show SMILES CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12
Show InChI InChI=1S/C36H48N6O4S2/c1-39(2)17-15-31-21-37-35-13-11-29(19-33(31)35)25-47(43,44)41(5)23-27-7-9-28(10-8-27)24-42(6)48(45,46)26-30-12-14-36-34(20-30)32(22-38-36)16-18-40(3)4/h7-14,19-22,37-38H,15-18,23-26H2,1-6H3
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0.890n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]-5-CT radioligand


Bioorg Med Chem Lett 8: 675-80 (1999)


BindingDB Entry DOI: 10.7270/Q24B30F8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033383
PNG
((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Show SMILES CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12
Show InChI InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
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0.920n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033434
PNG
(2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-acety...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3C#N)cc12
Show InChI InChI=1S/C23H25N5O2/c24-8-7-18-15-26-21-6-5-19(13-20(18)21)30-16-23(29)28-11-9-27(10-12-28)22-4-2-1-3-17(22)14-25/h1-6,13,15,26H,7-12,16,24H2
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0.920n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50033444
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-ami...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccc(CN)cc3)cc12
Show InChI InChI=1S/C23H29N5O2/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19/h1-6,13,15,26H,7-12,14,16,24-25H2
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0.930n/an/an/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha


J Med Chem 38: 3602-7 (1995)


BindingDB Entry DOI: 10.7270/Q25M66C2
More data for this
Ligand-Target Pair
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