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Compile Data Set for Download or QSAR

Found 167 hits with Last Name = 'van lengerich' and Initial = 'b'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364536
PNG
(CHEMBL1950879)
Show SMILES CCCc1cc(n[nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-3-4-19-15-21(31-30-19)17-6-9-23(38-24-8-5-16(12-27(33)34)11-25(24)37-2)22(13-17)32-39(35,36)26-10-7-18(28)14-20(26)29/h5-11,13-15,32H,3-4,12H2,1-2H3,(H,30,31)(H,33,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364525
PNG
(CHEMBL1950868)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc3n(CC(O)=O)ccc3c2)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-2-3-11-30-27(35)18-4-8-24(22(14-18)31-39(36,37)25-9-5-19(28)15-21(25)29)38-20-6-7-23-17(13-20)10-12-32(23)16-26(33)34/h4-10,12-15,31H,2-3,11,16H2,1H3,(H,30,35)(H,33,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364535
PNG
(CHEMBL1950878)
Show SMILES CCCc1nc(c[nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-3-4-26-30-15-21(31-26)17-6-9-22(38-23-8-5-16(12-27(33)34)11-24(23)37-2)20(13-17)32-39(35,36)25-10-7-18(28)14-19(25)29/h5-11,13-15,32H,3-4,12H2,1-2H3,(H,30,31)(H,33,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364528
PNG
(CHEMBL1950871)
Show SMILES CCCCNC(=O)c1ccc(Cc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H28Cl2N2O6S/c1-3-4-11-30-27(34)20-8-7-18(14-19-6-5-17(13-26(32)33)12-24(19)37-2)23(15-20)31-38(35,36)25-10-9-21(28)16-22(25)29/h5-10,12,15-16,31H,3-4,11,13-14H2,1-2H3,(H,30,34)(H,32,33)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50018896
PNG
(CHEMBL3287089)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2NC(=O)Cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2N2O7S/c1-33-19-8-12(9-22(29)30)2-5-17(19)34-18-6-4-16-14(11-21(28)26-16)23(18)27-35(31,32)20-7-3-13(24)10-15(20)25/h2-8,10,27H,9,11H2,1H3,(H,26,28)(H,29,30)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting


Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50302828
PNG
(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting


Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364524
PNG
(CHEMBL1950867)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc3c(CC(O)=O)c[nH]c3c2)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-2-3-10-30-27(35)16-4-8-24(23(11-16)32-39(36,37)25-9-5-18(28)13-21(25)29)38-19-6-7-20-17(12-26(33)34)15-31-22(20)14-19/h4-9,11,13-15,31-32H,2-3,10,12H2,1H3,(H,30,35)(H,33,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363928
PNG
(CHEMBL1951575)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(cc2Cl)C2CC2)c1
Show InChI InChI=1S/C28H27Cl2FN2O6S/c1-28(2,3)32-27(36)17-6-8-23(39-24-14-21(31)18(11-19(24)29)13-26(34)35)22(12-17)33-40(37,38)25-9-7-16(10-20(25)30)15-4-5-15/h6-12,14-15,33H,4-5,13H2,1-3H3,(H,32,36)(H,34,35)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363935
PNG
(CHEMBL1951562)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2C)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O6S/c1-3-4-11-29-26(33)18-6-9-23(36-22-8-5-17(12-16(22)2)13-25(31)32)21(14-18)30-37(34,35)24-10-7-19(27)15-20(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50302828
PNG
(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50364536
PNG
(CHEMBL1950879)
Show SMILES CCCc1cc(n[nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-3-4-19-15-21(31-30-19)17-6-9-23(38-24-8-5-16(12-27(33)34)11-25(24)37-2)22(13-17)32-39(35,36)26-10-7-18(28)14-20(26)29/h5-11,13-15,32H,3-4,12H2,1-2H3,(H,30,31)(H,33,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364534
PNG
(CHEMBL1950877)
Show SMILES CCCc1nnc([nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H24Cl2N4O6S/c1-3-4-24-29-26(31-30-24)16-6-9-20(38-21-8-5-15(12-25(33)34)11-22(21)37-2)19(13-16)32-39(35,36)23-10-7-17(27)14-18(23)28/h5-11,13-14,32H,3-4,12H2,1-2H3,(H,33,34)(H,29,30,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363923
PNG
(CHEMBL1951570)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(cc1Cl)C(F)(F)F)C(=O)NC1CCC1
Show InChI InChI=1S/C27H24ClF3N2O7S/c1-39-23-11-15(12-25(34)35)5-8-22(23)40-21-9-6-16(26(36)32-18-3-2-4-18)13-20(21)33-41(37,38)24-10-7-17(14-19(24)28)27(29,30)31/h5-11,13-14,18,33H,2-4,12H2,1H3,(H,32,36)(H,34,35)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363917
PNG
(CHEMBL1951566)
Show SMILES CCCCNC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2F)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H22Cl2F2N2O6S/c1-2-3-8-30-25(34)14-4-6-21(37-22-13-18(28)15(9-19(22)29)11-24(32)33)20(10-14)31-38(35,36)23-7-5-16(26)12-17(23)27/h4-7,9-10,12-13,31H,2-3,8,11H2,1H3,(H,30,34)(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50302832
PNG
(2-(4-(4-(cyclopropylcarbamoyl)-2-(2,4-dichlorophen...)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1Cl)C(=O)NC1CC1
Show InChI InChI=1S/C25H22Cl2N2O7S/c1-35-22-10-14(11-24(30)31)2-7-21(22)36-20-8-3-15(25(32)28-17-5-6-17)12-19(20)29-37(33,34)23-9-4-16(26)13-18(23)27/h2-4,7-10,12-13,17,29H,5-6,11H2,1H3,(H,28,32)(H,30,31)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363934
PNG
(CHEMBL1951561)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(cc2Cl)C(F)(F)F)c1
Show InChI InChI=1S/C27H26ClF3N2O7S/c1-3-4-11-32-26(36)17-6-9-21(40-22-8-5-16(13-25(34)35)12-23(22)39-2)20(14-17)33-41(37,38)24-10-7-18(15-19(24)28)27(29,30)31/h5-10,12,14-15,33H,3-4,11,13H2,1-2H3,(H,32,36)(H,34,35)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50360671
PNG
(CHEMBL1933766)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C26H27ClN2O7S/c1-3-4-13-28-26(32)18-6-12-22(36-23-11-5-17(15-25(30)31)14-24(23)35-2)21(16-18)29-37(33,34)20-9-7-19(27)8-10-20/h5-12,14,16,29H,3-4,13,15H2,1-2H3,(H,28,32)(H,30,31)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363928
PNG
(CHEMBL1951575)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(cc2Cl)C2CC2)c1
Show InChI InChI=1S/C28H27Cl2FN2O6S/c1-28(2,3)32-27(36)17-6-8-23(39-24-14-21(31)18(11-19(24)29)13-26(34)35)22(12-17)33-40(37,38)25-9-7-16(10-20(25)30)15-4-5-15/h6-12,14-15,33H,4-5,13H2,1-3H3,(H,32,36)(H,34,35)
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364527
PNG
(CHEMBL1950870)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc3c(CC(O)=O)coc3c2)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H24Cl2N2O7S/c1-2-3-10-30-27(34)16-4-8-23(22(11-16)31-39(35,36)25-9-5-18(28)13-21(25)29)38-19-6-7-20-17(12-26(32)33)15-37-24(20)14-19/h4-9,11,13-15,31H,2-3,10,12H2,1H3,(H,30,34)(H,32,33)
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n/an/a 5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363926
PNG
(CHEMBL1951573)
Show SMILES OC(=O)Cc1cc(Cl)c(Oc2ccc(cc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2Cl)C(=O)NC2CCC2)cc1F
Show InChI InChI=1S/C26H20Cl2F4N2O7S/c27-17-8-14(10-24(35)36)19(29)12-22(17)40-21-6-4-13(25(37)33-15-2-1-3-15)9-20(21)34-42(38,39)23-7-5-16(11-18(23)28)41-26(30,31)32/h4-9,11-12,15,34H,1-3,10H2,(H,33,37)(H,35,36)
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363922
PNG
(CHEMBL1951569)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H23Cl3N2O6S/c1-25(2,3)29-24(33)15-5-8-21(36-20-7-4-14(10-17(20)27)11-23(31)32)19(12-15)30-37(34,35)22-9-6-16(26)13-18(22)28/h4-10,12-13,30H,11H2,1-3H3,(H,29,33)(H,31,32)
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363921
PNG
(CHEMBL1951568)
Show SMILES OC(=O)Cc1ccc(Oc2ccc(cc2NS(=O)(=O)c2ccc(Cl)cc2Cl)C(=O)NC2CCC2)c(Cl)c1
Show InChI InChI=1S/C25H21Cl3N2O6S/c26-16-6-9-23(19(28)13-16)37(34,35)30-20-12-15(25(33)29-17-2-1-3-17)5-8-22(20)36-21-7-4-14(10-18(21)27)11-24(31)32/h4-10,12-13,17,30H,1-3,11H2,(H,29,33)(H,31,32)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363929
PNG
(CHEMBL1951556)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-10-22(37-23-9-5-16(13-25(31)32)12-24(23)36-2)21(14-17)30-38(34,35)18-7-8-19(27)20(28)15-18/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50364527
PNG
(CHEMBL1950870)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc3c(CC(O)=O)coc3c2)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H24Cl2N2O7S/c1-2-3-10-30-27(34)16-4-8-23(22(11-16)31-39(35,36)25-9-5-18(28)13-21(25)29)38-19-6-7-20-17(12-26(32)33)15-37-24(20)14-19/h4-9,11,13-15,31H,2-3,10,12H2,1H3,(H,30,34)(H,32,33)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364532
PNG
(CHEMBL1950875)
Show SMILES CCc1nnc([nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H22Cl2N4O6S/c1-3-23-28-25(30-29-23)15-5-8-19(37-20-7-4-14(11-24(32)33)10-21(20)36-2)18(12-15)31-38(34,35)22-9-6-16(26)13-17(22)27/h4-10,12-13,31H,3,11H2,1-2H3,(H,32,33)(H,28,29,30)
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363936
PNG
(CHEMBL1951563)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H23Cl3N2O6S/c1-2-3-10-29-25(33)16-5-8-22(36-21-7-4-15(11-18(21)27)12-24(31)32)20(13-16)30-37(34,35)23-9-6-17(26)14-19(23)28/h4-9,11,13-14,30H,2-3,10,12H2,1H3,(H,29,33)(H,31,32)
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363919
PNG
(CHEMBL1951402)
Show SMILES OC(=O)Cc1ccc(Oc2ccc(cc2NS(=O)(=O)c2ccc(Cl)cc2)C(=O)NC2CCC2)c(Cl)c1
Show InChI InChI=1S/C25H22Cl2N2O6S/c26-17-6-8-19(9-7-17)36(33,34)29-21-14-16(25(32)28-18-2-1-3-18)5-11-23(21)35-22-10-4-15(12-20(22)27)13-24(30)31/h4-12,14,18,29H,1-3,13H2,(H,28,32)(H,30,31)
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363935
PNG
(CHEMBL1951562)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2C)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O6S/c1-3-4-11-29-26(33)18-6-9-23(36-22-8-5-17(12-16(22)2)13-25(31)32)21(14-18)30-37(34,35)24-10-7-19(27)15-20(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50364528
PNG
(CHEMBL1950871)
Show SMILES CCCCNC(=O)c1ccc(Cc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H28Cl2N2O6S/c1-3-4-11-30-27(34)20-8-7-18(14-19-6-5-17(13-26(32)33)12-24(19)37-2)23(15-20)31-38(35,36)25-10-9-21(28)16-22(25)29/h5-10,12,15-16,31H,3-4,11,13-14H2,1-2H3,(H,30,34)(H,32,33)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363918
PNG
(CHEMBL1951567)
Show SMILES OC(=O)Cc1ccc(Oc2ccc(cc2NS(=O)(=O)c2ccc(Cl)cc2Cl)C(=O)NC2CC2)c(Cl)c1
Show InChI InChI=1S/C24H19Cl3N2O6S/c25-15-3-8-22(18(27)12-15)36(33,34)29-19-11-14(24(32)28-16-4-5-16)2-7-21(19)35-20-6-1-13(9-17(20)26)10-23(30)31/h1-3,6-9,11-12,16,29H,4-5,10H2,(H,28,32)(H,30,31)
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363915
PNG
(CHEMBL1951564)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2F)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H23Cl2FN2O6S/c1-2-3-10-29-25(33)16-5-8-22(36-21-7-4-15(11-19(21)28)12-24(31)32)20(13-16)30-37(34,35)23-9-6-17(26)14-18(23)27/h4-9,11,13-14,30H,2-3,10,12H2,1H3,(H,29,33)(H,31,32)
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363917
PNG
(CHEMBL1951566)
Show SMILES CCCCNC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2F)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H22Cl2F2N2O6S/c1-2-3-8-30-25(34)14-4-6-21(37-22-13-18(28)15(9-19(22)29)11-24(32)33)20(10-14)31-38(35,36)23-7-5-16(26)12-17(23)27/h4-7,9-10,12-13,31H,2-3,8,11H2,1H3,(H,30,34)(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50018898
PNG
(CHEMBL3287082)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Show InChI InChI=1S/C26H22Cl2N2O6S/c1-35-23-10-14(11-25(31)32)2-7-21(23)36-22-8-6-19-17(13-20(29-19)15-3-4-15)26(22)30-37(33,34)24-9-5-16(27)12-18(24)28/h2,5-10,12-13,15,29-30H,3-4,11H2,1H3,(H,31,32)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting


Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364536
PNG
(CHEMBL1950879)
Show SMILES CCCc1cc(n[nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-3-4-19-15-21(31-30-19)17-6-9-23(38-24-8-5-16(12-27(33)34)11-25(24)37-2)22(13-17)32-39(35,36)26-10-7-18(28)14-20(26)29/h5-11,13-15,32H,3-4,12H2,1-2H3,(H,30,31)(H,33,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 50% plasma


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363926
PNG
(CHEMBL1951573)
Show SMILES OC(=O)Cc1cc(Cl)c(Oc2ccc(cc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2Cl)C(=O)NC2CCC2)cc1F
Show InChI InChI=1S/C26H20Cl2F4N2O7S/c27-17-8-14(10-24(35)36)19(29)12-22(17)40-21-6-4-13(25(37)33-15-2-1-3-15)9-20(21)34-42(38,39)23-7-5-16(11-18(23)28)41-26(30,31)32/h4-9,11-12,15,34H,1-3,10H2,(H,33,37)(H,35,36)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363928
PNG
(CHEMBL1951575)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(cc2Cl)C2CC2)c1
Show InChI InChI=1S/C28H27Cl2FN2O6S/c1-28(2,3)32-27(36)17-6-8-23(39-24-14-21(31)18(11-19(24)29)13-26(34)35)22(12-17)33-40(37,38)25-9-7-16(10-20(25)30)15-4-5-15/h6-12,14-15,33H,4-5,13H2,1-3H3,(H,32,36)(H,34,35)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363930
PNG
(CHEMBL1951557)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-10-21(37-22-9-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-15-18(27)7-8-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363936
PNG
(CHEMBL1951563)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H23Cl3N2O6S/c1-2-3-10-29-25(33)16-5-8-22(36-21-7-4-15(11-18(21)27)12-24(31)32)20(13-16)30-37(34,35)23-9-6-17(26)14-19(23)28/h4-9,11,13-14,30H,2-3,10,12H2,1H3,(H,29,33)(H,31,32)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50018897
PNG
(CHEMBL3287081)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)ccc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2N2O6S/c1-28-10-9-16-18(28)5-7-20(34-19-6-3-14(12-23(29)30)11-21(19)33-2)24(16)27-35(31,32)22-8-4-15(25)13-17(22)26/h3-11,13,27H,12H2,1-2H3,(H,29,30)
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n/an/a 9n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...


Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363927
PNG
(CHEMBL1951574)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2Cl)c1
Show InChI InChI=1S/C26H22Cl2F4N2O7S/c1-25(2,3)33-24(37)13-4-6-20(40-21-12-18(29)14(8-16(21)27)10-23(35)36)19(9-13)34-42(38,39)22-7-5-15(11-17(22)28)41-26(30,31)32/h4-9,11-12,34H,10H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363920
PNG
(CHEMBL1951555)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C25H24Cl2N2O6S/c1-25(2,3)28-24(32)16-5-11-22(35-21-10-4-15(12-19(21)27)13-23(30)31)20(14-16)29-36(33,34)18-8-6-17(26)7-9-18/h4-12,14,29H,13H2,1-3H3,(H,28,32)(H,30,31)
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363921
PNG
(CHEMBL1951568)
Show SMILES OC(=O)Cc1ccc(Oc2ccc(cc2NS(=O)(=O)c2ccc(Cl)cc2Cl)C(=O)NC2CCC2)c(Cl)c1
Show InChI InChI=1S/C25H21Cl3N2O6S/c26-16-6-9-23(19(28)13-16)37(34,35)30-20-12-15(25(33)29-17-2-1-3-17)5-8-22(20)36-21-7-4-14(10-18(21)27)11-24(31)32/h4-10,12-13,17,30H,1-3,11H2,(H,29,33)(H,31,32)
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363924
PNG
(CHEMBL1951571)
Show SMILES OC(=O)Cc1cc(F)c(Oc2ccc(cc2NS(=O)(=O)c2ccc(cc2Cl)C(F)(F)F)C(=O)NC2CCC2)cc1F
Show InChI InChI=1S/C26H20ClF5N2O6S/c27-17-11-15(26(30,31)32)5-7-23(17)41(38,39)34-20-9-13(25(37)33-16-2-1-3-16)4-6-21(20)40-22-12-18(28)14(8-19(22)29)10-24(35)36/h4-9,11-12,16,34H,1-3,10H2,(H,33,37)(H,35,36)
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50364535
PNG
(CHEMBL1950878)
Show SMILES CCCc1nc(c[nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C27H25Cl2N3O6S/c1-3-4-26-30-15-21(31-26)17-6-9-22(38-23-8-5-16(12-27(33)34)11-24(23)37-2)20(13-17)32-39(35,36)25-10-7-18(28)14-19(25)29/h5-11,13-15,32H,3-4,12H2,1-2H3,(H,30,31)(H,33,34)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50364523
PNG
(CHEMBL1950866)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)nc2)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C24H23Cl2N3O6S/c1-2-3-10-27-24(32)15-4-8-21(35-18-7-6-17(28-14-18)13-23(30)31)20(11-15)29-36(33,34)22-9-5-16(25)12-19(22)26/h4-9,11-12,14,29H,2-3,10,13H2,1H3,(H,27,32)(H,30,31)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50363926
PNG
(CHEMBL1951573)
Show SMILES OC(=O)Cc1cc(Cl)c(Oc2ccc(cc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2Cl)C(=O)NC2CCC2)cc1F
Show InChI InChI=1S/C26H20Cl2F4N2O7S/c27-17-8-14(10-24(35)36)19(29)12-22(17)40-21-6-4-13(25(37)33-15-2-1-3-15)9-20(21)34-42(38,39)23-7-5-16(11-18(23)28)41-26(30,31)32/h4-9,11-12,15,34H,1-3,10H2,(H,33,37)(H,35,36)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum...


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50364534
PNG
(CHEMBL1950877)
Show SMILES CCCc1nnc([nH]1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H24Cl2N4O6S/c1-3-4-24-29-26(31-30-24)16-6-9-20(38-21-8-5-15(12-25(33)34)11-22(21)37-2)19(13-16)32-39(35,36)23-10-7-17(27)14-18(23)28/h5-11,13-14,32H,3-4,12H2,1-2H3,(H,33,34)(H,29,30,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human DP receptor expressed in HEK293 cells by scintillation counting in presence of 0.5% BSA


Bioorg Med Chem Lett 22: 1686-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.107
BindingDB Entry DOI: 10.7270/Q2B858MR
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50302828
PNG
(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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n/an/a 12n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...


Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363922
PNG
(CHEMBL1951569)
Show SMILES CC(C)(C)NC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C25H23Cl3N2O6S/c1-25(2,3)29-24(33)15-5-8-21(36-20-7-4-14(10-17(20)27)11-23(31)32)19(12-15)30-37(34,35)22-9-6-16(26)13-18(22)28/h4-10,12-13,30H,11H2,1-3H3,(H,29,33)(H,31,32)
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50363933
PNG
(CHEMBL1951560)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-12-29-26(33)17-9-11-21(37-22-10-8-16(14-24(31)32)13-23(22)36-2)20(15-17)30-38(34,35)25-18(27)6-5-7-19(25)28/h5-11,13,15,30H,3-4,12,14H2,1-2H3,(H,29,33)(H,31,32)
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin


ACS Med Chem Lett 2: 326-330 (2011)


Article DOI: 10.1021/ml1002234
BindingDB Entry DOI: 10.7270/Q28K79JH
More data for this
Ligand-Target Pair
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