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Compile Data Set for Download or QSAR

Found 702 hits with Last Name = 'vankayalapati' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445346
PNG
(CHEMBL3104250)
Show SMILES CC(=NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc(Cl)ccc1O |w:2.2|
Show InChI InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)
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14n/an/an/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 1 ...


J Med Chem 56: 9496-508 (2014)


Article DOI: 10.1021/jm400870h
BindingDB Entry DOI: 10.7270/Q2Z60QJ7
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445346
PNG
(CHEMBL3104250)
Show SMILES CC(=NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc(Cl)ccc1O |w:2.2|
Show InChI InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)
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32n/an/an/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 10...


J Med Chem 56: 9496-508 (2014)


Article DOI: 10.1021/jm400870h
BindingDB Entry DOI: 10.7270/Q2Z60QJ7
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445346
PNG
(CHEMBL3104250)
Show SMILES CC(=NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc(Cl)ccc1O |w:2.2|
Show InChI InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)
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35n/an/an/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 3 ...


J Med Chem 56: 9496-508 (2014)


Article DOI: 10.1021/jm400870h
BindingDB Entry DOI: 10.7270/Q2Z60QJ7
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445346
PNG
(CHEMBL3104250)
Show SMILES CC(=NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc(Cl)ccc1O |w:2.2|
Show InChI InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)
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35n/an/an/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 30...


J Med Chem 56: 9496-508 (2014)


Article DOI: 10.1021/jm400870h
BindingDB Entry DOI: 10.7270/Q2Z60QJ7
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445346
PNG
(CHEMBL3104250)
Show SMILES CC(=NNC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc(Cl)ccc1O |w:2.2|
Show InChI InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)
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55n/an/an/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 10...


J Med Chem 56: 9496-508 (2014)


Article DOI: 10.1021/jm400870h
BindingDB Entry DOI: 10.7270/Q2Z60QJ7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a<1n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine series of compounds and analogues in Table 3B were synthesized and tested in 10-dose IC50 mode with 3 fold serial dilutions...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a<1n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine series of compounds and analogues in Table 3B were synthesized and tested in 10-dose IC50 mode with 3 fold serial dilutions...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a<1n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine series of compounds and analogues in Table 3B were synthesized and tested in 10-dose IC50 mode with 3 fold serial dilutions...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 1.01n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM28031
PNG
(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1
Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


ACS Med Chem Lett 2: 907-912 (2011)


Article DOI: 10.1021/ml200198x
BindingDB Entry DOI: 10.7270/Q2DZ099R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382425
PNG
(CHEMBL2022968)
Show SMILES CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl
Show InChI InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Aurora A


ACS Med Chem Lett 2: 907-912 (2011)


Article DOI: 10.1021/ml200198x
BindingDB Entry DOI: 10.7270/Q2DZ099R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM214693
PNG
(US9296703, 1)
Show SMILES Oc1cc(Nc2ncc(Cl)c(n2)-c2cccc(NC(=O)C=C)c2)ccc1N1CCOCC1
Show InChI InChI=1S/C23H22ClN5O3/c1-2-21(31)26-16-5-3-4-15(12-16)22-18(24)14-25-23(28-22)27-17-6-7-19(20(30)13-17)29-8-10-32-11-9-29/h2-7,12-14,30H,1,8-11H2,(H,26,31)(H,25,27,28)
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n/an/a 4n/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...


US Patent US9296703 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81BW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 4.02n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine series of compounds and analogues in Table 3B were synthesized and tested in 10-dose IC50 mode with 3 fold serial dilutions...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195840
PNG
(US9206188, 91)
Show SMILES CC#CC(=O)Nc1cccc(n1)-c1cnc2[nH]cc(C)c2c1
Show InChI InChI=1S/C17H14N4O/c1-3-5-16(22)21-15-7-4-6-14(20-15)12-8-13-11(2)9-18-17(13)19-10-12/h4,6-10H,1-2H3,(H,18,19)(H,20,21,22)
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n/an/a<5n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195903
PNG
(US9206188, 140)
Show SMILES COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C24H20FN3O2/c1-4-23(29)28-17-7-5-6-15(9-17)16-10-19-20(13-27-24(19)26-12-16)18-8-14(2)21(25)11-22(18)30-3/h4-13H,1H2,2-3H3,(H,26,27)(H,28,29)
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n/an/a<5n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195906
PNG
(US9206188, 150)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2NC(=O)Cc2c1
Show InChI InChI=1S/C16H13N3O2/c1-2-14(20)18-13-5-3-4-10(7-13)12-6-11-8-15(21)19-16(11)17-9-12/h2-7,9H,1,8H2,(H,18,20)(H,17,19,21)
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n/an/a<5n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195777
PNG
(US9206188, 28)
Show SMILES CCN(CC)S(=O)(=O)c1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C26H26N4O3S/c1-4-25(31)29-21-11-7-9-18(13-21)20-15-23-24(17-28-26(23)27-16-20)19-10-8-12-22(14-19)34(32,33)30(5-2)6-3/h4,7-17H,1,5-6H2,2-3H3,(H,27,28)(H,29,31)
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n/an/a<5n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195778
PNG
(US9206188, 29)
Show SMILES CCOC(=O)c1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C25H21N3O3/c1-3-23(29)28-20-10-6-7-16(12-20)19-13-21-22(15-27-24(21)26-14-19)17-8-5-9-18(11-17)25(30)31-4-2/h3,5-15H,1,4H2,2H3,(H,26,27)(H,28,29)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195779
PNG
(US9206188, 30)
Show SMILES COc1c(F)cc(F)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H17F2N3O2/c1-3-21(29)28-16-6-4-5-13(7-16)14-8-18-19(12-27-23(18)26-11-14)17-9-15(24)10-20(25)22(17)30-2/h3-12H,1H2,2H3,(H,26,27)(H,28,29)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195780
PNG
(US9206188, 31)
Show SMILES CCC#CC(=O)Nc1cc(ccc1F)-c1cnc2[nH]cc(C)c2c1
Show InChI InChI=1S/C19H16FN3O/c1-3-4-5-18(24)23-17-9-13(6-7-16(17)20)14-8-15-12(2)10-21-19(15)22-11-14/h6-11H,3H2,1-2H3,(H,21,22)(H,23,24)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195781
PNG
(US9206188, 32)
Show SMILES CCC#CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(c3)S(=O)(=O)N(C)C(C)(C)C)c2c1
Show InChI InChI=1S/C29H30N4O3S/c1-6-7-14-27(34)32-23-12-8-10-20(15-23)22-17-25-26(19-31-28(25)30-18-22)21-11-9-13-24(16-21)37(35,36)33(5)29(2,3)4/h8-13,15-19H,6H2,1-5H3,(H,30,31)(H,32,34)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195782
PNG
(US9206188, 33)
Show SMILES CN(C(C)(C)C)S(=O)(=O)c1cccc(c1)-c1c[nH]c2ncc(nc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C26H27N5O3S/c1-6-23(32)29-19-11-7-10-18(13-19)22-16-28-25-24(30-22)21(15-27-25)17-9-8-12-20(14-17)35(33,34)31(5)26(2,3)4/h6-16H,1H2,2-5H3,(H,27,28)(H,29,32)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195797
PNG
(US9206188, 48)
Show SMILES CN(C)\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H19N5O/c1-12-16-10-14(11-19-18(16)22-21-12)13-5-4-6-15(9-13)20-17(24)7-8-23(2)3/h4-11H,1-3H3,(H,20,24)(H,19,21,22)/b8-7+
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195798
PNG
(US9206188, 49)
Show SMILES CN(C)\C=C\C(=O)Nc1cc(ccc1Cl)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H18ClN5O/c1-11-14-8-13(10-20-18(14)23-22-11)12-4-5-15(19)16(9-12)21-17(25)6-7-24(2)3/h4-10H,1-3H3,(H,21,25)(H,20,22,23)/b7-6+
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195799
PNG
(US9206188, 50)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1ccc(Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C16H13ClN4O/c1-3-15(22)19-14-7-10(4-5-13(14)17)11-6-12-9(2)20-21-16(12)18-8-11/h3-8H,1H2,2H3,(H,19,22)(H,18,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195800
PNG
(US9206188, 51)
Show SMILES CC\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H18N4O/c1-3-4-8-17(23)20-15-7-5-6-13(9-15)14-10-16-12(2)21-22-18(16)19-11-14/h4-11H,3H2,1-2H3,(H,20,23)(H,19,21,22)/b8-4+
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195806
PNG
(US9206188, 57)
Show SMILES C=CC(=O)Nc1cccc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H12N4O/c1-2-14(20)19-13-5-3-4-12(18-13)11-8-10-6-7-16-15(10)17-9-11/h2-9H,1H2,(H,16,17)(H,18,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195807
PNG
(US9206188, 58)
Show SMILES Clc1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)n1
Show InChI InChI=1S/C15H11ClN4O/c1-2-14(21)20-13-5-3-4-12(19-13)9-6-10-11(16)8-18-15(10)17-7-9/h2-8H,1H2,(H,17,18)(H,19,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195808
PNG
(US9206188, 59)
Show SMILES Fc1ccc(cc1NC(=O)C=C)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H12FN3O/c1-2-15(21)20-14-8-10(3-4-13(14)17)12-7-11-5-6-18-16(11)19-9-12/h2-9H,1H2,(H,18,19)(H,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195809
PNG
(US9206188, 60)
Show SMILES Fc1ccc(cc1NC(=O)C=C)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C16H11ClFN3O/c1-2-15(22)21-14-6-9(3-4-13(14)18)10-5-11-12(17)8-20-16(11)19-7-10/h2-8H,1H2,(H,19,20)(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195815
PNG
(US9206188, 66)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C24H18N4O/c1-2-23(29)27-18-8-5-7-15(10-18)17-11-19-20(14-26-24(19)25-13-17)22-12-16-6-3-4-9-21(16)28-22/h2-14,28H,1H2,(H,25,26)(H,27,29)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195824
PNG
(US9206188, 75)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C25H20N4O/c1-3-24(30)28-19-6-4-5-16(10-19)18-11-20-21(14-27-25(20)26-13-18)23-12-17-8-7-15(2)9-22(17)29-23/h3-14,29H,1H2,2H3,(H,26,27)(H,28,30)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195826
PNG
(US9206188, 77)
Show SMILES O=C(Nc1cccc(n1)-c1cnc2[nH]ccc2c1)C#C
Show InChI InChI=1S/C15H10N4O/c1-2-14(20)19-13-5-3-4-12(18-13)11-8-10-6-7-16-15(10)17-9-11/h1,3-9H,(H,16,17)(H,18,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195827
PNG
(US9206188, 78)
Show SMILES CCC#CC(=O)Nc1cccc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H14N4O/c1-2-3-7-16(22)21-15-6-4-5-14(20-15)13-10-12-8-9-18-17(12)19-11-13/h4-6,8-11H,2H2,1H3,(H,18,19)(H,20,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195828
PNG
(US9206188, 79)
Show SMILES Clc1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C#C)n1
Show InChI InChI=1S/C15H9ClN4O/c1-2-14(21)20-13-5-3-4-12(19-13)9-6-10-11(16)8-18-15(10)17-7-9/h1,3-8H,(H,17,18)(H,19,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195829
PNG
(US9206188, 80)
Show SMILES CCC#CC(=O)Nc1cccc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C17H13ClN4O/c1-2-3-7-16(23)22-15-6-4-5-14(21-15)11-8-12-13(18)10-20-17(12)19-9-11/h4-6,8-10H,2H2,1H3,(H,19,20)(H,21,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195830
PNG
(US9206188, 81)
Show SMILES CC#CC(=O)Nc1cccc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H12N4O/c1-2-4-15(21)20-14-6-3-5-13(19-14)12-9-11-7-8-17-16(11)18-10-12/h3,5-10H,1H3,(H,17,18)(H,19,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195831
PNG
(US9206188, 82)
Show SMILES CC#CC(=O)Nc1cccc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C16H11ClN4O/c1-2-4-15(22)21-14-6-3-5-13(20-14)10-7-11-12(17)9-19-16(11)18-8-10/h3,5-9H,1H3,(H,18,19)(H,20,21,22)
PDB

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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195832
PNG
(US9206188, 83)
Show SMILES Fc1ccc(cc1NC(=O)C#C)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H10FN3O/c1-2-15(21)20-14-8-10(3-4-13(14)17)12-7-11-5-6-18-16(11)19-9-12/h1,3-9H,(H,18,19)(H,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195833
PNG
(US9206188, 84)
Show SMILES Fc1ccc(cc1NC(=O)C#C)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C16H9ClFN3O/c1-2-15(22)21-14-6-9(3-4-13(14)18)10-5-11-12(17)8-20-16(11)19-7-10/h1,3-8H,(H,19,20)(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195834
PNG
(US9206188, 85)
Show SMILES CCC#CC(=O)Nc1cc(ccc1F)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C18H14FN3O/c1-2-3-4-17(23)22-16-10-12(5-6-15(16)19)14-9-13-7-8-20-18(13)21-11-14/h5-11H,2H2,1H3,(H,20,21)(H,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195835
PNG
(US9206188, 86)
Show SMILES CCC#CC(=O)Nc1cc(ccc1F)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C18H13ClFN3O/c1-2-3-4-17(24)23-16-8-11(5-6-15(16)20)12-7-13-14(19)10-22-18(13)21-9-12/h5-10H,2H2,1H3,(H,21,22)(H,23,24)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195836
PNG
(US9206188, 87)
Show SMILES CC#CC(=O)Nc1cc(ccc1F)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H12FN3O/c1-2-3-16(22)21-15-9-11(4-5-14(15)18)13-8-12-6-7-19-17(12)20-10-13/h4-10H,1H3,(H,19,20)(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195837
PNG
(US9206188, 88)
Show SMILES CC#CC(=O)Nc1cc(ccc1F)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C17H11ClFN3O/c1-2-3-16(23)22-15-7-10(4-5-14(15)19)11-6-12-13(18)9-21-17(12)20-8-11/h4-9H,1H3,(H,20,21)(H,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195838
PNG
(US9206188, 89)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C#C)n1
Show InChI InChI=1S/C16H12N4O/c1-3-15(21)20-14-6-4-5-13(19-14)11-7-12-10(2)8-17-16(12)18-9-11/h1,4-9H,2H3,(H,17,18)(H,19,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195839
PNG
(US9206188, 90)
Show SMILES CCC#CC(=O)Nc1cccc(n1)-c1cnc2[nH]cc(C)c2c1
Show InChI InChI=1S/C18H16N4O/c1-3-4-8-17(23)22-16-7-5-6-15(21-16)13-9-14-12(2)10-19-18(14)20-11-13/h5-7,9-11H,3H2,1-2H3,(H,19,20)(H,21,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195841
PNG
(US9206188, 92)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1ccc(F)c(NC(=O)C#C)c1
Show InChI InChI=1S/C17H12FN3O/c1-3-16(22)21-15-7-11(4-5-14(15)18)12-6-13-10(2)8-19-17(13)20-9-12/h1,4-9H,2H3,(H,19,20)(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195901
PNG
(US9206188, 133)
Show SMILES COc1c(F)cc(F)cc1-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)\C=C\CN(C)C)ccc1F
Show InChI InChI=1S/C26H23F3N4O2/c1-33(2)8-4-5-24(34)32-17-6-7-22(28)18(12-17)15-9-20-21(14-31-26(20)30-13-15)19-10-16(27)11-23(29)25(19)35-3/h4-7,9-14H,8H2,1-3H3,(H,30,31)(H,32,34)/b5-4+
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195902
PNG
(US9206188, 138)
Show SMILES COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C27H27FN4O2/c1-17-11-21(25(34-4)14-24(17)28)23-16-30-27-22(23)13-19(15-29-27)18-7-5-8-20(12-18)31-26(33)9-6-10-32(2)3/h5-9,11-16H,10H2,1-4H3,(H,29,30)(H,31,33)/b9-6+
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM195904
PNG
(US9206188, 145)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(C)c3F)c2c1
Show InChI InChI=1S/C26H25FN4O/c1-17-7-4-10-21(25(17)27)23-16-29-26-22(23)14-19(15-28-26)18-8-5-9-20(13-18)30-24(32)11-6-12-31(2)3/h4-11,13-16H,12H2,1-3H3,(H,28,29)(H,30,32)/b11-6+
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...


US Patent US9206188 (2015)


BindingDB Entry DOI: 10.7270/Q2057DRT
More data for this
Ligand-Target Pair
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