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Compile Data Set for Download or QSAR

Found 935 hits with Last Name = 'voight' and Initial = 'ea'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143965
PNG
(US8969325, 166)
Show SMILES CN1C(=O)NCc2c(NC(=O)N[C@@H]3C[C@@](C)(Oc4ccccc34)C(F)(F)F)cccc12
Show InChI InChI=1S/C21H21F3N4O3/c1-20(21(22,23)24)10-15(12-6-3-4-9-17(12)31-20)27-18(29)26-14-7-5-8-16-13(14)11-25-19(30)28(16)2/h3-9,15H,10-11H2,1-2H3,(H,25,30)(H2,26,27,29)/t15-,20-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056351
PNG
(CHEMBL3326569)
Show SMILES CC1(C)C[C@@H](NC(=O)Nc2cccc3cnccc23)c2cc(F)ccc2O1 |r|
Show InChI InChI=1/C21H20FN3O2/c1-21(2)11-18(16-10-14(22)6-7-19(16)27-21)25-20(26)24-17-5-3-4-13-12-23-9-8-15(13)17/h3-10,12,18H,11H2,1-2H3,(H2,24,25,26)/t18-/s2
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128907
PNG
(US8802711, 76)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC[C@@H](C3)c3cccc(F)c3)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-9-19-16(12-25-13)6-8-20(24)21(19)27-22(28)26-18-7-5-15(11-18)14-3-2-4-17(23)10-14/h2-4,6,8-10,12,15,18H,5,7,11H2,1H3,(H2,26,27,28)/t15-,18+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128912
PNG
(US8802711, 81)
Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CC[C@H](C3)c3ccccc3F)c2ccc1=O
Show InChI InChI=1S/C22H22FN3O2/c1-26-20-8-4-7-19(17(20)11-12-21(26)27)25-22(28)24-15-10-9-14(13-15)16-5-2-3-6-18(16)23/h2-8,11-12,14-15H,9-10,13H2,1H3,(H2,24,25,28)/t14-,15-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056358
PNG
(CHEMBL3326581)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(C)(C)Oc4cc(F)ccc34)cccc2cn1 |r|
Show InChI InChI=1/C22H22FN3O2/c1-13-9-17-14(12-24-13)5-4-6-18(17)25-21(27)26-19-11-22(2,3)28-20-10-15(23)7-8-16(19)20/h4-10,12,19H,11H2,1-3H3,(H2,25,26,27)/t19-/s2
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n/an/a 3n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143964
PNG
(US8969325, 165)
Show SMILES CN1C(=O)NCc2c(NC(=O)N[C@@H]3C[C@](C)(Oc4ccccc34)C(F)(F)F)cccc12
Show InChI InChI=1S/C21H21F3N4O3/c1-20(21(22,23)24)10-15(12-6-3-4-9-17(12)31-20)27-18(29)26-14-7-5-8-16-13(14)11-25-19(30)28(16)2/h3-9,15H,10-11H2,1-2H3,(H,25,30)(H2,26,27,29)/t15-,20+/m1/s1
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n/an/a 3n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128913
PNG
(US8802711, 82)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC[C@H](C3)c3ccccc3F)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-10-18-15(12-25-13)7-9-20(24)21(18)27-22(28)26-16-8-6-14(11-16)17-4-2-3-5-19(17)23/h2-5,7,9-10,12,14,16H,6,8,11H2,1H3,(H2,26,27,28)/t14-,16-/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128905
PNG
(US8802711, 74)
Show SMILES Cc1cc2c(NC(=O)N[C@H]3CC[C@@H](C3)c3cccc(F)c3)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-9-19-16(12-25-13)6-8-20(24)21(19)27-22(28)26-18-7-5-15(11-18)14-3-2-4-17(23)10-14/h2-4,6,8-10,12,15,18H,5,7,11H2,1H3,(H2,26,27,28)/t15-,18-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056434
PNG
(CHEMBL3326575)
Show SMILES CC1(C)C[C@@H](NC(=O)Nc2cccc3cnccc23)c2ccccc2O1 |r|
Show InChI InChI=1/C21H21N3O2/c1-21(2)12-18(16-7-3-4-9-19(16)26-21)24-20(25)23-17-8-5-6-14-13-22-11-10-15(14)17/h3-11,13,18H,12H2,1-2H3,(H2,23,24,25)/t18-/s2
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056352
PNG
(CHEMBL3326570)
Show SMILES CC1(C)C[C@@H](NC(=O)Nc2cccc3cnccc23)c2ccc(F)cc2O1 |r|
Show InChI InChI=1/C21H20FN3O2/c1-21(2)11-18(16-7-6-14(22)10-19(16)27-21)25-20(26)24-17-5-3-4-13-12-23-9-8-15(13)17/h3-10,12,18H,11H2,1-2H3,(H2,24,25,26)/t18-/s2
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n/an/a 4n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50232114
PNG
((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Show SMILES CC(C)(C)c1ccc2[C@@H](CCc2c1)NC(=O)Nc1cccc2[nH]ncc12
Show InChI InChI=1S/C21H24N4O/c1-21(2,3)14-8-9-15-13(11-14)7-10-18(15)24-20(26)23-17-5-4-6-19-16(17)12-22-25-19/h4-6,8-9,11-12,18H,7,10H2,1-3H3,(H,22,25)(H2,23,24,26)/t18-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143829
PNG
(US8969325, 30)
Show SMILES C[C@@]1(C[C@@H](NC(=O)Nc2ccc3CCC(=O)Nc3c2)c2ccc(Cl)cc2O1)C(F)F
Show InChI InChI=1S/C21H20ClF2N3O3/c1-21(19(23)24)10-16(14-6-4-12(22)8-17(14)30-21)27-20(29)25-13-5-2-11-3-7-18(28)26-15(11)9-13/h2,4-6,8-9,16,19H,3,7,10H2,1H3,(H,26,28)(H2,25,27,29)/t16-,21-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128837
PNG
(US8802711, 6)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC[C@@H](C3)c3ccccc3)c(F)ccc2cn1
Show InChI InChI=1S/C22H22FN3O/c1-14-11-19-17(13-24-14)8-10-20(23)21(19)26-22(27)25-18-9-7-16(12-18)15-5-3-2-4-6-15/h2-6,8,10-11,13,16,18H,7,9,12H2,1H3,(H2,25,26,27)/t16-,18+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128976
PNG
(US8802711, A)
Show SMILES O[C@@H]1CCc2cccc(NC(=O)N[C@H]3CC[C@@H](C3)c3ccccc3)c2C1
Show InChI InChI=1S/C22H26N2O2/c25-19-12-10-16-7-4-8-21(20(16)14-19)24-22(26)23-18-11-9-17(13-18)15-5-2-1-3-6-15/h1-8,17-19,25H,9-14H2,(H2,23,24,26)/t17-,18-,19+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128982
PNG
(US8802711, G)
Show SMILES O[C@@H]1CCc2cccc(NC(=O)N[C@@H]3CC[C@@H](C3)c3ccccc3)c2C1
Show InChI InChI=1S/C22H26N2O2/c25-19-12-10-16-7-4-8-21(20(16)14-19)24-22(26)23-18-11-9-17(13-18)15-5-2-1-3-6-15/h1-8,17-19,25H,9-14H2,(H2,23,24,26)/t17-,18+,19+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143834
PNG
(US8969325, 35)
Show SMILES FC(F)(F)c1ccc2[C@@H](CCc2c1)NC(=O)Nc1ccc2CCC(=O)Nc2c1
Show InChI InChI=1S/C20H18F3N3O2/c21-20(22,23)13-4-6-15-12(9-13)2-7-16(15)26-19(28)24-14-5-1-11-3-8-18(27)25-17(11)10-14/h1,4-6,9-10,16H,2-3,7-8H2,(H,25,27)(H2,24,26,28)/t16-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM144122
PNG
(US8969325, 323)
Show SMILES FCC1(CF)C[C@@H](NC(=O)Nc2cccc3NC(=O)COc23)c2ccc(Cl)cc2O1
Show InChI InChI=1S/C20H18ClF2N3O4/c21-11-4-5-12-15(7-20(9-22,10-23)30-16(12)6-11)26-19(28)25-14-3-1-2-13-18(14)29-8-17(27)24-13/h1-6,15H,7-10H2,(H,24,27)(H2,25,26,28)/t15-/m1/s1
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n/an/a 4.5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056387
PNG
(CHEMBL3326582)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(C)(C)Oc4c(F)c(F)ccc34)cccc2cn1 |r|
Show InChI InChI=1/C22H21F2N3O2/c1-12-9-15-13(11-25-12)5-4-6-17(15)26-21(28)27-18-10-22(2,3)29-20-14(18)7-8-16(23)19(20)24/h4-9,11,18H,10H2,1-3H3,(H2,26,27,28)/t18-/s2
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143966
PNG
(US8969325, 167)
Show SMILES CN1Cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(Cl)ccc34)cccc2N(C)C1=O
Show InChI InChI=1S/C22H23ClF2N4O3/c1-28-10-15-16(4-3-5-18(15)29(2)21(28)31)26-20(30)27-17-9-22(11-24,12-25)32-19-8-13(23)6-7-14(17)19/h3-8,17H,9-12H2,1-2H3,(H2,26,27,30)/t17-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056426
PNG
(CHEMBL3326589)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(ccc34)C3CC3)cccc2cn1 |r|
Show InChI InChI=1/C25H25F2N3O2/c1-15-9-20-18(12-28-15)3-2-4-21(20)29-24(31)30-22-11-25(13-26,14-27)32-23-10-17(16-5-6-16)7-8-19(22)23/h2-4,7-10,12,16,22H,5-6,11,13-14H2,1H3,(H2,29,30,31)/t22-/s2
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056408
PNG
(CHEMBL3326587)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(F)ccc34)cccc2cn1 |r|
Show InChI InChI=1/C22H20F3N3O2/c1-13-7-17-14(10-26-13)3-2-4-18(17)27-21(29)28-19-9-22(11-23,12-24)30-20-8-15(25)5-6-16(19)20/h2-8,10,19H,9,11-12H2,1H3,(H2,27,28,29)/t19-/s2
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056389
PNG
(CHEMBL3326584)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(C)(C)Oc4c(F)c(ccc34)C(F)(F)F)cccc2cn1 |r|
Show InChI InChI=1/C23H21F4N3O2/c1-12-9-15-13(11-28-12)5-4-6-17(15)29-21(31)30-18-10-22(2,3)32-20-14(18)7-8-16(19(20)24)23(25,26)27/h4-9,11,18H,10H2,1-3H3,(H2,29,30,31)/t18-/s2
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128851
PNG
(US8802711, 20)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC[C@H](C3)c3ccccc3)c(F)ccc2cn1
Show InChI InChI=1S/C22H22FN3O/c1-14-11-19-17(13-24-14)8-10-20(23)21(19)26-22(27)25-18-9-7-16(12-18)15-5-3-2-4-6-15/h2-6,8,10-11,13,16,18H,7,9,12H2,1H3,(H2,25,26,27)/t16-,18-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128980
PNG
(US8802711, E)
Show SMILES O[C@@H]1CCc2cccc(NC(=O)N[C@@H]3CC[C@H](C3)c3ccccc3)c2C1
Show InChI InChI=1S/C22H26N2O2/c25-19-12-10-16-7-4-8-21(20(16)14-19)24-22(26)23-18-11-9-17(13-18)15-5-2-1-3-6-15/h1-8,17-19,25H,9-14H2,(H2,23,24,26)/t17-,18-,19-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128981
PNG
(US8802711, F)
Show SMILES O[C@H]1CCc2cccc(NC(=O)N[C@@H]3CC[C@H](C3)c3ccccc3)c2C1
Show InChI InChI=1S/C22H26N2O2/c25-19-12-10-16-7-4-8-21(20(16)14-19)24-22(26)23-18-11-9-17(13-18)15-5-2-1-3-6-15/h1-8,17-19,25H,9-14H2,(H2,23,24,26)/t17-,18-,19+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128978
PNG
(US8802711, C)
Show SMILES O[C@H]1CCc2cccc(NC(=O)N[C@@H]3CC[C@@H](C3)c3ccccc3)c2C1
Show InChI InChI=1S/C22H26N2O2/c25-19-12-10-16-7-4-8-21(20(16)14-19)24-22(26)23-18-11-9-17(13-18)15-5-2-1-3-6-15/h1-8,17-19,25H,9-14H2,(H2,23,24,26)/t17-,18+,19-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128914
PNG
(US8802711, 83)
Show SMILES Cc1cc2c(NC(=O)N[C@H]3CC[C@H](C3)c3ccccc3F)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-10-18-15(12-25-13)7-9-20(24)21(18)27-22(28)26-16-8-6-14(11-16)17-4-2-3-5-19(17)23/h2-5,7,9-10,12,14,16H,6,8,11H2,1H3,(H2,26,27,28)/t14-,16+/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128915
PNG
(US8802711, 84)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC[C@H](C3)c3cccc(F)c3)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-9-19-16(12-25-13)6-8-20(24)21(19)27-22(28)26-18-7-5-15(11-18)14-3-2-4-17(23)10-14/h2-4,6,8-10,12,15,18H,5,7,11H2,1H3,(H2,26,27,28)/t15-,18-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128901
PNG
(US8802711, 70)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC[C@@H](C3)c3ccccc3F)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-10-18-15(12-25-13)7-9-20(24)21(18)27-22(28)26-16-8-6-14(11-16)17-4-2-3-5-19(17)23/h2-5,7,9-10,12,14,16H,6,8,11H2,1H3,(H2,26,27,28)/t14-,16+/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056354
PNG
(CHEMBL3326577)
Show SMILES CCC1(CC)C[C@@H](NC(=O)Nc2cccc3cnccc23)c2cc(F)ccc2O1 |r|
Show InChI InChI=1/C23H24FN3O2/c1-3-23(4-2)13-20(18-12-16(24)8-9-21(18)29-23)27-22(28)26-19-7-5-6-15-14-25-11-10-17(15)19/h5-12,14,20H,3-4,13H2,1-2H3,(H2,26,27,28)/t20-/s2
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n/an/a 6n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056353
PNG
(CHEMBL3326576)
Show SMILES CC1(C)C[C@@H](NC(=O)Nc2cccc3cnccc23)c2ccc(OC(F)(F)F)cc2O1 |r|
Show InChI InChI=1/C22H20F3N3O3/c1-21(2)11-18(16-7-6-14(10-19(16)31-21)30-22(23,24)25)28-20(29)27-17-5-3-4-13-12-26-9-8-15(13)17/h3-10,12,18H,11H2,1-2H3,(H2,27,28,29)/t18-/s2
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128977
PNG
(US8802711, B)
Show SMILES O[C@H]1CCc2cccc(NC(=O)N[C@H]3CC[C@H](C3)c3ccccc3)c2C1
Show InChI InChI=1S/C22H26N2O2/c25-19-12-10-16-7-4-8-21(20(16)14-19)24-22(26)23-18-11-9-17(13-18)15-5-2-1-3-6-15/h1-8,17-19,25H,9-14H2,(H2,23,24,26)/t17-,18+,19+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128909
PNG
(US8802711, 78)
Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CC[C@H](C3)c3cccc(F)c3)c2ccc1=O
Show InChI InChI=1S/C22H22FN3O2/c1-26-20-7-3-6-19(18(20)10-11-21(26)27)25-22(28)24-17-9-8-15(13-17)14-4-2-5-16(23)12-14/h2-7,10-12,15,17H,8-9,13H2,1H3,(H2,24,25,28)/t15-,17-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056435
PNG
(CHEMBL3326574)
Show SMILES CC1(C)C[C@@H](NC(=O)Nc2cccc3CC[C@H](O)Cc23)c2ccc(F)cc2O1 |r|
Show InChI InChI=1/C22H25FN2O3/c1-22(2)12-19(16-9-7-14(23)10-20(16)28-22)25-21(27)24-18-5-3-4-13-6-8-15(26)11-17(13)18/h3-5,7,9-10,15,19,26H,6,8,11-12H2,1-2H3,(H2,24,25,27)/t15-,19+/s2
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n/an/a 7n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056436
PNG
(CHEMBL3326573)
Show SMILES CC1(C)C[C@@H](NC(=O)Nc2cccc3CC[C@@H](O)Cc23)c2ccc(F)cc2O1 |r|
Show InChI InChI=1/C22H25FN2O3/c1-22(2)12-19(16-9-7-14(23)10-20(16)28-22)25-21(27)24-18-5-3-4-13-6-8-15(26)11-17(13)18/h3-5,7,9-10,15,19,26H,6,8,11-12H2,1-2H3,(H2,24,25,27)/t15-,19-/s2
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n/an/a 7n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128858
PNG
(US8802711, 27)
Show SMILES Cc1cc2c(NC(=O)N[C@H]3CC[C@H](C3)c3ccccc3)c(F)ccc2cn1
Show InChI InChI=1S/C22H22FN3O/c1-14-11-19-17(13-24-14)8-10-20(23)21(19)26-22(27)25-18-9-7-16(12-18)15-5-3-2-4-6-15/h2-6,8,10-11,13,16,18H,7,9,12H2,1H3,(H2,25,26,27)/t16-,18+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143833
PNG
(US8969325, 34)
Show SMILES C[C@@]1(C[C@@H](NC(=O)Nc2ccc3CCC(=O)Nc3c2)c2ccccc2O1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O3/c1-20(21(22,23)24)11-16(14-4-2-3-5-17(14)30-20)27-19(29)25-13-8-6-12-7-9-18(28)26-15(12)10-13/h2-6,8,10,16H,7,9,11H2,1H3,(H,26,28)(H2,25,27,29)/t16-,20-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056437
PNG
(CHEMBL3326572)
Show SMILES CN1N=CC2C1C=CC=C2NC(=O)N[C@@H]1CC(C)(C)Oc2cc(F)ccc12 |r,c:2,7,9|
Show InChI InChI=1/C20H23FN4O2/c1-20(2)10-16(13-8-7-12(21)9-18(13)27-20)24-19(26)23-15-5-4-6-17-14(15)11-22-25(17)3/h4-9,11,14,16-17H,10H2,1-3H3,(H2,23,24,26)/t14?,16-,17?/s2
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n/an/a 7n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143895
PNG
(US8969325, 96)
Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CCc4cc(Cl)ccc34)c2ccc1=O
Show InChI InChI=1S/C20H18ClN3O2/c1-24-18-4-2-3-16(15(18)8-10-19(24)25)22-20(26)23-17-9-5-12-11-13(21)6-7-14(12)17/h2-4,6-8,10-11,17H,5,9H2,1H3,(H2,22,23,26)/t17-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143933
PNG
(US8969325, 134)
Show SMILES C[C@H]1Oc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(Cl)ccc34)cccc2NC1=O
Show InChI InChI=1S/C21H20ClF2N3O4/c1-11-19(28)25-14-3-2-4-15(18(14)30-11)26-20(29)27-16-8-21(9-23,10-24)31-17-7-12(22)5-6-13(16)17/h2-7,11,16H,8-10H2,1H3,(H,25,28)(H2,26,27,29)/t11-,16-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128896
PNG
(US8802711, 65)
Show SMILES Fc1cccc(c1)[C@H]1CC[C@H](C1)NC(=O)Nc1cccc2[nH]ncc12
Show InChI InChI=1S/C19H19FN4O/c20-14-4-1-3-12(9-14)13-7-8-15(10-13)22-19(25)23-17-5-2-6-18-16(17)11-21-24-18/h1-6,9,11,13,15H,7-8,10H2,(H,21,24)(H2,22,23,25)/t13-,15+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128897
PNG
(US8802711, 66)
Show SMILES Fc1ccccc1[C@@H]1CC[C@H](C1)NC(=O)Nc1cccc2[nH]ncc12
Show InChI InChI=1S/C19H19FN4O/c20-16-5-2-1-4-14(16)12-8-9-13(10-12)22-19(25)23-17-6-3-7-18-15(17)11-21-24-18/h1-7,11-13H,8-10H2,(H,21,24)(H2,22,23,25)/t12-,13-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128902
PNG
(US8802711, 71)
Show SMILES Cc1cc2c(NC(=O)N[C@H]3CC[C@@H](C3)c3ccccc3F)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-10-18-15(12-25-13)7-9-20(24)21(18)27-22(28)26-16-8-6-14(11-16)17-4-2-3-5-19(17)23/h2-5,7,9-10,12,14,16H,6,8,11H2,1H3,(H2,26,27,28)/t14-,16-/m0/s1
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n/an/a 8.60n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128916
PNG
(US8802711, 85)
Show SMILES Cc1cc2c(NC(=O)N[C@H]3CC[C@H](C3)c3cccc(F)c3)c(F)ccc2cn1
Show InChI InChI=1S/C22H21F2N3O/c1-13-9-19-16(12-25-13)6-8-20(24)21(19)27-22(28)26-18-7-5-15(11-18)14-3-2-4-17(23)10-14/h2-4,6,8-10,12,15,18H,5,7,11H2,1H3,(H2,26,27,28)/t15-,18+/m1/s1
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n/an/a 8.90n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128838
PNG
(US8802711, 7)
Show SMILES O=C(N[C@@H]1CC[C@@H](C1)c1ccccc1)Nc1cccc2[nH]ncc12
Show InChI InChI=1S/C19H20N4O/c24-19(22-17-7-4-8-18-16(17)12-20-23-18)21-15-10-9-14(11-15)13-5-2-1-3-6-13/h1-8,12,14-15H,9-11H2,(H,20,23)(H2,21,22,24)/t14-,15+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056425
PNG
(CHEMBL3326588)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(Cl)ccc34)cccc2cn1 |r|
Show InChI InChI=1/C22H20ClF2N3O2/c1-13-7-17-14(10-26-13)3-2-4-18(17)27-21(29)28-19-9-22(11-24,12-25)30-20-8-15(23)5-6-16(19)20/h2-8,10,19H,9,11-12H2,1H3,(H2,27,28,29)/t19-/s2
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n/an/a 9n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50056386
PNG
(CHEMBL3325460)
Show SMILES Cc1cc2c(NC(=O)N[C@@H]3CC(C)(C)Oc4cc(ccc34)C(F)(F)F)cccc2cn1 |r|
Show InChI InChI=1/C23H22F3N3O2/c1-13-9-17-14(12-27-13)5-4-6-18(17)28-21(30)29-19-11-22(2,3)31-20-10-15(23(24,25)26)7-8-16(19)20/h4-10,12,19H,11H2,1-3H3,(H2,28,29,30)/t19-/s2
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n/an/a 10n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay


J Med Chem 57: 7412-24 (2014)


Article DOI: 10.1021/jm500916t
BindingDB Entry DOI: 10.7270/Q2Z3219J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143885
PNG
(US8969325, 86)
Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CCc4cc(ccc34)C(F)(F)F)c2ccc1=O
Show InChI InChI=1S/C21H18F3N3O2/c1-27-18-4-2-3-16(15(18)8-10-19(27)28)25-20(29)26-17-9-5-12-11-13(21(22,23)24)6-7-14(12)17/h2-4,6-8,10-11,17H,5,9H2,1H3,(H2,25,26,29)/t17-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM128911
PNG
(US8802711, 80)
Show SMILES Cn1c2cccc(NC(=O)N[C@H]3CC[C@H](C3)c3ccccc3F)c2ccc1=O
Show InChI InChI=1S/C22H22FN3O2/c1-26-20-8-4-7-19(17(20)11-12-21(26)27)25-22(28)24-15-10-9-14(13-15)16-5-2-3-6-18(16)23/h2-8,11-12,14-15H,9-10,13H2,1H3,(H2,24,25,28)/t14-,15+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2+]i) using the Fluorescenc...


US Patent US8802711 (2014)


BindingDB Entry DOI: 10.7270/Q2QZ28NC
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM143818
PNG
(US8969325, 19)
Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CC(C)(C)Oc4cc(F)ccc34)c2ccc1=O
Show InChI InChI=1S/C22H22FN3O3/c1-22(2)12-17(15-8-7-13(23)11-19(15)29-22)25-21(28)24-16-5-4-6-18-14(16)9-10-20(27)26(18)3/h4-11,17H,12H2,1-3H3,(H2,24,25,28)/t17-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...


US Patent US8969325 (2015)


BindingDB Entry DOI: 10.7270/Q29P30BX
More data for this
Ligand-Target Pair
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