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Compile Data Set for Download or QSAR

Found 92 hits with Last Name = 'waltz' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4900
PNG
(3-(2,4-dimethyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydr...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3cc(ccc23)-c2ccccc2)c(C)c1CCC(O)=O
Show InChI InChI=1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13-
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n/an/a 10n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4882
PNG
((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 20n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4883
PNG
(3-(4-methyl-2-{[(3Z)-4-methyl-2-oxo-2,3-dihydro-1H...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3cccc(C)c23)c1CCC(O)=O
Show InChI InChI=1S/C18H18N2O3/c1-10-4-3-5-14-17(10)13(18(23)20-14)8-15-12(6-7-16(21)22)11(2)9-19-15/h3-5,8-9,19H,6-7H2,1-2H3,(H,20,23)(H,21,22)/b13-8-
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n/an/a 30n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4882
PNG
((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 30n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4896
PNG
(3-(5-{[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-y...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(Br)cc23)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H17BrN2O3/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(19)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)/b14-8-
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n/an/a 60n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4811
PNG
((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9-
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n/an/a 60n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4897
PNG
((3Z)-3-{[4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrol...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)C(O)=O)c(C)c1CCC(O)=O
Show InChI InChI=1S/C19H18N2O5/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(19(25)26)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/b14-8-
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n/an/a 70n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4884
PNG
(3-(2-{[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-y...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccc(Br)cc23)c1CCC(O)=O
Show InChI InChI=1S/C17H15BrN2O3/c1-9-8-19-15(11(9)3-5-16(21)22)7-13-12-6-10(18)2-4-14(12)20-17(13)23/h2,4,6-8,19H,3,5H2,1H3,(H,20,23)(H,21,22)/b13-7-
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n/an/a 80n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4892
PNG
(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-17(7-9-23(27)28)13-25-21(14)12-20-19-8-6-16(11-22(19)26-24(20)29)15-4-3-5-18(10-15)30-2/h3-6,8,10-13,25H,7,9H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 90n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4901
PNG
(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C25H24N2O4/c1-14-19(9-10-24(28)29)15(2)26-22(14)13-21-20-8-7-17(12-23(20)27-25(21)30)16-5-4-6-18(11-16)31-3/h4-8,11-13,26H,9-10H2,1-3H3,(H,27,30)(H,28,29)/b21-13-
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n/an/a 100n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4887
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C17H16N2O3/c1-10-11(6-7-16(20)21)9-18-15(10)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 140n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4890
PNG
(3-(5-{[(3Z)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3...)
Show SMILES COc1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C18H18N2O4/c1-10-11(3-6-17(21)22)9-19-15(10)8-14-13-5-4-12(24-2)7-16(13)20-18(14)23/h4-5,7-9,19H,3,6H2,1-2H3,(H,20,23)(H,21,22)/b14-8-
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n/an/a 140n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4900
PNG
(3-(2,4-dimethyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydr...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3cc(ccc23)-c2ccccc2)c(C)c1CCC(O)=O
Show InChI InChI=1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13-
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n/an/a 140n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4891
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3/c1-14-17(8-10-22(26)27)13-24-20(14)12-19-18-9-7-16(11-21(18)25-23(19)28)15-5-3-2-4-6-15/h2-7,9,11-13,24H,8,10H2,1H3,(H,25,28)(H,26,27)/b19-12-
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n/an/a 160n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4892
PNG
(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-17(7-9-23(27)28)13-25-21(14)12-20-19-8-6-16(11-22(19)26-24(20)29)15-4-3-5-18(10-15)30-2/h3-6,8,10-13,25H,7,9H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 170n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4883
PNG
(3-(4-methyl-2-{[(3Z)-4-methyl-2-oxo-2,3-dihydro-1H...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3cccc(C)c23)c1CCC(O)=O
Show InChI InChI=1S/C18H18N2O3/c1-10-4-3-5-14-17(10)13(18(23)20-14)8-15-12(6-7-16(21)22)11(2)9-19-15/h3-5,8-9,19H,6-7H2,1-2H3,(H,20,23)(H,21,22)/b13-8-
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n/an/a 200n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4888
PNG
((3Z)-3-{[4-(2-carboxyethyl)-3-methyl-1H-pyrrol-2-y...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C18H16N2O5/c1-9-11(3-5-16(21)22)8-19-15(9)7-13-12-6-10(18(24)25)2-4-14(12)20-17(13)23/h2,4,6-8,19H,3,5H2,1H3,(H,20,23)(H,21,22)(H,24,25)/b13-7-
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n/an/a 240n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4897
PNG
((3Z)-3-{[4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrol...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)C(O)=O)c(C)c1CCC(O)=O
Show InChI InChI=1S/C19H18N2O5/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(19(25)26)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/b14-8-
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n/an/a 280n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4898
PNG
(3-(2,4-dimethyl-5-{[(3Z)-2-oxo-5-sulfamoyl-2,3-dih...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H19N3O5S/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(27(19,25)26)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)(H2,19,25,26)/b14-8-
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n/an/a 280n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4891
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3/c1-14-17(8-10-22(26)27)13-24-20(14)12-19-18-9-7-16(11-21(18)25-23(19)28)15-5-3-2-4-6-15/h2-7,9,11-13,24H,8,10H2,1H3,(H,25,28)(H,26,27)/b19-12-
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n/an/a 300n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4901
PNG
(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C25H24N2O4/c1-14-19(9-10-24(28)29)15(2)26-22(14)13-21-20-8-7-17(12-23(20)27-25(21)30)16-5-4-6-18(11-16)31-3/h4-8,11-13,26H,9-10H2,1-3H3,(H,27,30)(H,28,29)/b21-13-
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n/an/a 300n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4884
PNG
(3-(2-{[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-y...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccc(Br)cc23)c1CCC(O)=O
Show InChI InChI=1S/C17H15BrN2O3/c1-9-8-19-15(11(9)3-5-16(21)22)7-13-12-6-10(18)2-4-14(12)20-17(13)23/h2,4,6-8,19H,3,5H2,1H3,(H,20,23)(H,21,22)/b13-7-
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n/an/a 350n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4892
PNG
(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-17(7-9-23(27)28)13-25-21(14)12-20-19-8-6-16(11-22(19)26-24(20)29)15-4-3-5-18(10-15)30-2/h3-6,8,10-13,25H,7,9H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 360n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4894
PNG
(3-(5-{[(3Z)-6-(4-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-17(6-10-23(27)28)13-25-21(14)12-20-19-9-5-16(11-22(19)26-24(20)29)15-3-7-18(30-2)8-4-15/h3-5,7-9,11-13,25H,6,10H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 450n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4885
PNG
(3-(2-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]cc(C)c3CCC(O)=O)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-13-25-21(18(14)8-9-23(27)28)12-20-19-7-6-16(11-22(19)26-24(20)29)15-4-3-5-17(10-15)30-2/h3-7,10-13,25H,8-9H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 450n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4889
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-5-sulfamoyl-2,3-dihydro...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccc(cc12)S(N)(=O)=O
Show InChI InChI=1S/C17H17N3O5S/c1-9-10(2-5-16(21)22)8-19-15(9)7-13-12-6-11(26(18,24)25)3-4-14(12)20-17(13)23/h3-4,6-8,19H,2,5H2,1H3,(H,20,23)(H,21,22)(H2,18,24,25)/b13-7-
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n/an/a 460n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4882
PNG
((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 510n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4903
PNG
(3-(5-{[(3Z)-6-(4-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C25H24N2O4/c1-14-19(10-11-24(28)29)15(2)26-22(14)13-21-20-9-6-17(12-23(20)27-25(21)30)16-4-7-18(31-3)8-5-16/h4-9,12-13,26H,10-11H2,1-3H3,(H,27,30)(H,28,29)/b21-13-
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n/an/a 520n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4899
PNG
(3-(5-{[(3Z)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3...)
Show SMILES COc1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-13(6-7-18(22)23)11(2)20-16(10)9-15-14-5-4-12(25-3)8-17(14)21-19(15)24/h4-5,8-9,20H,6-7H2,1-3H3,(H,21,24)(H,22,23)/b15-9-
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n/an/a 550n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4884
PNG
(3-(2-{[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-y...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccc(Br)cc23)c1CCC(O)=O
Show InChI InChI=1S/C17H15BrN2O3/c1-9-8-19-15(11(9)3-5-16(21)22)7-13-12-6-10(18)2-4-14(12)20-17(13)23/h2,4,6-8,19H,3,5H2,1H3,(H,20,23)(H,21,22)/b13-7-
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n/an/a 620n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4810
PNG
((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
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n/an/a 700n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4888
PNG
((3Z)-3-{[4-(2-carboxyethyl)-3-methyl-1H-pyrrol-2-y...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C18H16N2O5/c1-9-11(3-5-16(21)22)8-19-15(9)7-13-12-6-10(18(24)25)2-4-14(12)20-17(13)23/h2,4,6-8,19H,3,5H2,1H3,(H,20,23)(H,21,22)(H,24,25)/b13-7-
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n/an/a 770n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4889
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-5-sulfamoyl-2,3-dihydro...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccc(cc12)S(N)(=O)=O
Show InChI InChI=1S/C17H17N3O5S/c1-9-10(2-5-16(21)22)8-19-15(9)7-13-12-6-11(26(18,24)25)3-4-14(12)20-17(13)23/h3-4,6-8,19H,2,5H2,1H3,(H,20,23)(H,21,22)(H2,18,24,25)/b13-7-
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n/an/a 920n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4886
PNG
(3-(2-{[(3Z)-6-(3-ethoxyphenyl)-2-oxo-2,3-dihydro-1...)
Show SMILES CCOc1cccc(c1)-c1ccc2\C(=C\c3[nH]cc(C)c3CCC(O)=O)C(=O)Nc2c1
Show InChI InChI=1S/C25H24N2O4/c1-3-31-18-6-4-5-16(11-18)17-7-8-20-21(25(30)27-23(20)12-17)13-22-19(9-10-24(28)29)15(2)14-26-22/h4-8,11-14,26H,3,9-10H2,1-2H3,(H,27,30)(H,28,29)/b21-13-
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n/an/a 1.00E+3n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4903
PNG
(3-(5-{[(3Z)-6-(4-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C25H24N2O4/c1-14-19(10-11-24(28)29)15(2)26-22(14)13-21-20-9-6-17(12-23(20)27-25(21)30)16-4-7-18(31-3)8-5-16/h4-9,12-13,26H,10-11H2,1-3H3,(H,27,30)(H,28,29)/b21-13-
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n/an/a 1.00E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4891
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3/c1-14-17(8-10-22(26)27)13-24-20(14)12-19-18-9-7-16(11-21(18)25-23(19)28)15-5-3-2-4-6-15/h2-7,9,11-13,24H,8,10H2,1H3,(H,25,28)(H,26,27)/b19-12-
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n/an/a 1.05E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4885
PNG
(3-(2-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]cc(C)c3CCC(O)=O)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-13-25-21(18(14)8-9-23(27)28)12-20-19-7-6-16(11-22(19)26-24(20)29)15-4-3-5-17(10-15)30-2/h3-7,10-13,25H,8-9H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 1.20E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4897
PNG
((3Z)-3-{[4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrol...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)C(O)=O)c(C)c1CCC(O)=O
Show InChI InChI=1S/C19H18N2O5/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(19(25)26)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/b14-8-
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n/an/a 1.21E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4898
PNG
(3-(2,4-dimethyl-5-{[(3Z)-2-oxo-5-sulfamoyl-2,3-dih...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H19N3O5S/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(27(19,25)26)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)(H2,19,25,26)/b14-8-
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n/an/a 1.26E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4890
PNG
(3-(5-{[(3Z)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3...)
Show SMILES COc1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C18H18N2O4/c1-10-11(3-6-17(21)22)9-19-15(10)8-14-13-5-4-12(24-2)7-16(13)20-18(14)23/h4-5,7-9,19H,3,6H2,1-2H3,(H,20,23)(H,21,22)/b14-8-
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n/an/a 1.35E+3n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4901
PNG
(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C25H24N2O4/c1-14-19(9-10-24(28)29)15(2)26-22(14)13-21-20-8-7-17(12-23(20)27-25(21)30)16-5-4-6-18(11-16)31-3/h4-8,11-13,26H,9-10H2,1-3H3,(H,27,30)(H,28,29)/b21-13-
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n/an/a 1.40E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4893
PNG
(3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-16(8-10-23(27)28)13-25-20(14)12-19-18-9-7-15(11-21(18)26-24(19)29)17-5-3-4-6-22(17)30-2/h3-7,9,11-13,25H,8,10H2,1-2H3,(H,26,29)(H,27,28)/b19-12-
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n/an/a 1.42E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4893
PNG
(3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-16(8-10-23(27)28)13-25-20(14)12-19-18-9-7-15(11-21(18)26-24(19)29)17-5-3-4-6-22(17)30-2/h3-7,9,11-13,25H,8,10H2,1-2H3,(H,26,29)(H,27,28)/b19-12-
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n/an/a 1.47E+3n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4898
PNG
(3-(2,4-dimethyl-5-{[(3Z)-2-oxo-5-sulfamoyl-2,3-dih...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H19N3O5S/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(27(19,25)26)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)(H2,19,25,26)/b14-8-
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n/an/a 1.53E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4894
PNG
(3-(5-{[(3Z)-6-(4-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccc(cc1)-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-17(6-10-23(27)28)13-25-21(14)12-20-19-9-5-16(11-22(19)26-24(20)29)15-3-7-18(30-2)8-4-15/h3-5,7-9,11-13,25H,6,10H2,1-2H3,(H,26,29)(H,27,28)/b20-12-
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n/an/a 1.54E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4896
PNG
(3-(5-{[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-y...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(Br)cc23)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H17BrN2O3/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(19)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)/b14-8-
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n/an/a 1.73E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4896
PNG
(3-(5-{[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-y...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(Br)cc23)c(C)c1CCC(O)=O
Show InChI InChI=1S/C18H17BrN2O3/c1-9-12(4-6-17(22)23)10(2)20-16(9)8-14-13-7-11(19)3-5-15(13)21-18(14)24/h3,5,7-8,20H,4,6H2,1-2H3,(H,21,24)(H,22,23)/b14-8-
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n/an/a 2.05E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4883
PNG
(3-(4-methyl-2-{[(3Z)-4-methyl-2-oxo-2,3-dihydro-1H...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3cccc(C)c23)c1CCC(O)=O
Show InChI InChI=1S/C18H18N2O3/c1-10-4-3-5-14-17(10)13(18(23)20-14)8-15-12(6-7-16(21)22)11(2)9-19-15/h3-5,8-9,19H,6-7H2,1-2H3,(H,20,23)(H,21,22)/b13-8-
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n/an/a 2.11E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4893
PNG
(3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]cc(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O4/c1-14-16(8-10-23(27)28)13-25-20(14)12-19-18-9-7-15(11-21(18)26-24(19)29)17-5-3-4-6-22(17)30-2/h3-7,9,11-13,25H,8,10H2,1-2H3,(H,26,29)(H,27,28)/b19-12-
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n/an/a 2.13E+3n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4887
PNG
(3-(4-methyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-...)
Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C17H16N2O3/c1-10-11(6-7-16(20)21)9-18-15(10)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 2.14E+3n/an/an/an/a7.522



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair
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