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Compile Data Set for Download or QSAR

Found 994 hits with Last Name = 'williams' and Initial = 'jg'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM142607
PNG
(US8933228, 14)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ncccc12)C(C)(C)C
Show InChI InChI=1S/C30H28N8O4/c1-30(2,3)23-16-24(38(37-23)17-7-9-18(41-4)10-8-17)34-28(39)33-20-11-12-21(25-19(20)6-5-14-31-25)42-22-13-15-32-27-26(22)35-29(40)36-27/h5-16H,1-4H3,(H2,33,34,39)(H2,32,35,36,40)
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n/an/a 0.800n/an/an/an/an/an/a



Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


US Patent US8933228 (2015)


BindingDB Entry DOI: 10.7270/Q2RV0MDW
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM142602
PNG
(US8933228, 4)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ncccc23)n(n1)-c1ccccc1
Show InChI InChI=1S/C29H26N8O3/c1-29(2,3)22-16-23(37(36-22)17-8-5-4-6-9-17)33-27(38)32-19-11-12-20(24-18(19)10-7-14-30-24)40-21-13-15-31-26-25(21)34-28(39)35-26/h4-16H,1-3H3,(H2,32,33,38)(H2,31,34,35,39)
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Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


US Patent US8933228 (2015)


BindingDB Entry DOI: 10.7270/Q2RV0MDW
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM205262
PNG
(US9249125, 15)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(n1)-c1ccc(OCCN2CCOCC2)nc1
Show InChI InChI=1S/C40H41N11O4/c1-40(2,3)34-23-35(51(49-34)28-9-13-36(42-25-28)54-21-18-50-16-19-53-20-17-50)46-39(52)45-32-11-12-33(30-7-5-4-6-29(30)32)55-37-14-15-41-38(47-37)44-27-8-10-31-26(22-27)24-43-48-31/h4-15,22-25H,16-21H2,1-3H3,(H,43,48)(H,41,44,47)(H2,45,46,52)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM142601
PNG
(US8933228, 3)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H31N7O3/c1-19-10-12-20(13-11-19)39-27(18-26(37-39)32(2,3)4)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)42-25-16-17-33-29-28(25)38(5)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40)
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n/an/a 1n/an/an/an/an/an/a



Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


US Patent US8933228 (2015)


BindingDB Entry DOI: 10.7270/Q2RV0MDW
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247111
PNG
(3-((4-((4-(3-(1-(3,4-dimethylphenyl)-3-isopropyl-1...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)c(C)c4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247112
PNG
(3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)nc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247113
PNG
(3-methoxy-5-((4-((4-(3-(1-(4-methoxyphenyl)-3-(tet...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1CCCO1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247113
PNG
(3-methoxy-5-((4-((4-(3-(1-(4-methoxyphenyl)-3-(tet...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1CCCO1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247114
PNG
(3-methoxy-5-((4-((4-(3-(1-(4-methoxyphenyl)-3-(tet...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1CCOC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247123
PNG
(3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)N(C)CCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247123
PNG
(3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)N(C)CCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247124
PNG
(1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)N1CCN(C)CC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247126
PNG
(3-((6-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)ncn2)cc(c1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247127
PNG
(3-((6-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)ncn2)cc(c1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247085
PNG
(3-((4-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazo...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(ccc3OC)C(=O)NCCN(C)C)n2)c2ccccc12)C(C)(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247086
PNG
(3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5...)
Show SMILES COc1ccc(cc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)C)c3ccccc23)n1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247088
PNG
(N-(2-hydroxyethyl)-3-((4-((4-(3-(3-isopropyl-1-(p-...)
Show SMILES COc1ccc(cc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)C)c3ccccc23)n1)C(=O)NCCO
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247090
PNG
(N-(2-hydroxyethyl)-3-((4-((4-(3-(3-isopropyl-1-(4-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(ccc3OC)C(=O)NCCO)n2)c2ccccc12)C(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247091
PNG
(N-(2-(dimethylamino)ethyl)-4-((4-((4-(3-(3-isoprop...)
Show SMILES COc1cc(ccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)C)c3ccccc23)n1)C(=O)NCCN(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247091
PNG
(N-(2-(dimethylamino)ethyl)-4-((4-((4-(3-(3-isoprop...)
Show SMILES COc1cc(ccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)C)c3ccccc23)n1)C(=O)NCCN(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247100
PNG
(3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)cc(c4)C(=O)NCCN4CCOCC4)n3)c3ccccc23)n(n1)-c1ccc(C)cc1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247104
PNG
(3-((4-((4-(3-(3-ethyl-1-(p-tolyl)-1H-pyrazol-5-yl)...)
Show SMILES CCc1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(c4)C(=O)NCCN4CCOCC4)n3)c3ccccc23)n(n1)-c1ccc(C)cc1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247105
PNG
(3-((4-((4-(3-(3-cyclopropyl-1-(p-tolyl)-1H-pyrazol...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C4CC4)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247106
PNG
(3-methoxy-5-((4-((4-(3-(3-(1-methylcyclopropyl)-1-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C4(C)CC4)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247108
PNG
(3-((4-((4-(3-(3-isopropyl-1-(4-methoxyphenyl)-1H-p...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247062
PNG
(N-(2-(Dimethylamino)ethyl)-3-((4-((4-(3-(3-isoprop...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)C(=O)NCCN(C)C)n2)c2ccccc12)C(C)C
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n/an/a 1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247064
PNG
(3-((4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247070
PNG
(3-((6-((4-(3-(3-isopropyl-1-(4-methoxyphenyl)-1H-p...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2cc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)ncn2)c2ccccc12)C(C)(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247078
PNG
(3-((4-((4-(3-(3-(3-methyloxetan-3-yl)-1-(p-tolyl)-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1(C)COC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247078
PNG
(3-((4-((4-(3-(3-(3-methyloxetan-3-yl)-1-(p-tolyl)-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1(C)COC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247079
PNG
(3-((4-((4-(3-(1-(4-methoxyphenyl)-3-(3-methyloxeta...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1(C)COC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247079
PNG
(3-((4-((4-(3-(1-(4-methoxyphenyl)-3-(3-methyloxeta...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C1(C)COC1
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247080
PNG
(3-((4-((4-(3-(3-(tert-butyl)-1-(4-methylthiophen-2...)
Show SMILES Cc1csc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C(C)(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247084
PNG
(N-(2-(dimethylamino)ethyl)-3-((4-((4-(3-(3-isoprop...)
Show SMILES COc1ccc(cc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)C)c3ccccc23)n1)C(=O)NCCN(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247084
PNG
(N-(2-(dimethylamino)ethyl)-3-((4-((4-(3-(3-isoprop...)
Show SMILES COc1ccc(cc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)C)c3ccccc23)n1)C(=O)NCCN(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247085
PNG
(3-((4-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazo...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(ccc3OC)C(=O)NCCN(C)C)n2)c2ccccc12)C(C)(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50156158
PNG
(CHEMBL3781244)
Show SMILES CN(C)CC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Show InChI InChI=1S/C35H39N7O3/c1-23-11-13-25(14-12-23)42-32(20-30(40-42)35(2,3)4)39-34(44)37-28-15-16-29(27-10-8-7-9-26(27)28)45-22-24-17-18-36-31(19-24)38-33(43)21-41(5)6/h7-20H,21-22H2,1-6H3,(H,36,38,43)(H2,37,39,44)
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n/an/a 1n/an/an/an/an/an/a



Sygnature Discovery Limited

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...


J Med Chem 59: 1727-46 (2016)


BindingDB Entry DOI: 10.7270/Q2319XRB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM247059
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazo...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C(=O)NCCN3CCOCC3)n2)c2ccccc12)C(C)(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM247061
PNG
(N-(2-(Dimethylamino)ethyl)-3-((4-((4-(3-(3-isoprop...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN(C)C
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RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent




US Patent US9701670 (2017)


BindingDB Entry DOI: 10.7270/Q2JM2CP2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205337
PNG
(US9249125, 90)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5CC(=O)Nc5c4)n3)c3ccccc23)n(n1)-c1ccc(OCCN2CCOCC2)nc1
Show InChI InChI=1S/C41H42N10O5/c1-41(2,3)34-24-35(51(49-34)28-10-13-37(43-25-28)55-21-18-50-16-19-54-20-17-50)47-40(53)46-31-11-12-33(30-7-5-4-6-29(30)31)56-38-14-15-42-39(48-38)44-27-9-8-26-22-36(52)45-32(26)23-27/h4-15,23-25H,16-22H2,1-3H3,(H,45,52)(H,42,44,48)(H2,46,47,53)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205338
PNG
(US9249125, 91)
Show SMILES Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OCCN5CCOCC5)nc4)C(C)(C)C)c4ccccc34)n2)cc2cn[nH]c12
Show InChI InChI=1S/C41H43N11O4/c1-26-21-28(22-27-24-44-49-38(26)27)45-39-42-14-13-37(48-39)56-33-11-10-32(30-7-5-6-8-31(30)33)46-40(53)47-35-23-34(41(2,3)4)50-52(35)29-9-12-36(43-25-29)55-20-17-51-15-18-54-19-16-51/h5-14,21-25H,15-20H2,1-4H3,(H,44,49)(H,42,45,48)(H2,46,47,53)
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n/an/a 1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205339
PNG
(US9249125, 92)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5n(CCN6CCOCC6)ncc5c4)n3)c3ccccc23)n(n1)-c1ccc(OCCN2CCOCC2)nc1
Show InChI InChI=1S/C46H52N12O5/c1-46(2,3)40-29-41(58(54-40)34-9-13-42(48-31-34)62-27-22-56-20-25-61-26-21-56)52-45(59)51-37-10-12-39(36-7-5-4-6-35(36)37)63-43-14-15-47-44(53-43)50-33-8-11-38-32(28-33)30-49-57(38)17-16-55-18-23-60-24-19-55/h4-15,28-31H,16-27H2,1-3H3,(H,47,50,53)(H2,51,52,59)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM205305
PNG
(US9249125, 58)
Show SMILES CN(C)CCOc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)c4[nH]ncc4c3)c2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C41H43N9O3/c1-26-21-28(22-27-25-43-47-39(26)27)44-37-23-31(17-18-42-37)53-35-16-15-34(32-9-7-8-10-33(32)35)45-40(51)46-38-24-36(41(2,3)4)48-50(38)29-11-13-30(14-12-29)52-20-19-49(5)6/h7-18,21-25H,19-20H2,1-6H3,(H,42,44)(H,43,47)(H2,45,46,51)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the l...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM205337
PNG
(US9249125, 90)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5CC(=O)Nc5c4)n3)c3ccccc23)n(n1)-c1ccc(OCCN2CCOCC2)nc1
Show InChI InChI=1S/C41H42N10O5/c1-41(2,3)34-24-35(51(49-34)28-10-13-37(43-25-28)55-21-18-50-16-19-54-20-17-50)47-40(53)46-31-11-12-33(30-7-5-4-6-29(30)31)56-38-14-15-42-39(48-38)44-27-9-8-26-22-36(52)45-32(26)23-27/h4-15,23-25H,16-22H2,1-3H3,(H,45,52)(H,42,44,48)(H2,46,47,53)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM205338
PNG
(US9249125, 91)
Show SMILES Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OCCN5CCOCC5)nc4)C(C)(C)C)c4ccccc34)n2)cc2cn[nH]c12
Show InChI InChI=1S/C41H43N11O4/c1-26-21-28(22-27-24-44-49-38(26)27)45-39-42-14-13-37(48-39)56-33-11-10-32(30-7-5-6-8-31(30)33)46-40(53)47-35-23-34(41(2,3)4)50-52(35)29-9-12-36(43-25-29)55-20-17-51-15-18-54-19-16-51/h5-14,21-25H,15-20H2,1-4H3,(H,44,49)(H,42,45,48)(H2,46,47,53)
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n/an/a 1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM205339
PNG
(US9249125, 92)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5n(CCN6CCOCC6)ncc5c4)n3)c3ccccc23)n(n1)-c1ccc(OCCN2CCOCC2)nc1
Show InChI InChI=1S/C46H52N12O5/c1-46(2,3)40-29-41(58(54-40)34-9-13-42(48-31-34)62-27-22-56-20-25-61-26-21-56)52-45(59)51-37-10-12-39(36-7-5-4-6-35(36)37)63-43-14-15-47-44(53-43)50-33-8-11-38-32(28-33)30-49-57(38)17-16-55-18-23-60-24-19-55/h4-15,28-31H,16-27H2,1-3H3,(H,47,50,53)(H2,51,52,59)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205298
PNG
(US9249125, 51)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)c3)c3ccccc23)n(n1)-c1cccc(OCCN2CCOCC2)c1
Show InChI InChI=1S/C41H41N9O4/c1-27(2)37-25-40(50(48-37)30-6-5-7-31(23-30)53-21-18-49-16-19-52-20-17-49)46-41(51)45-36-12-13-38(34-9-4-3-8-33(34)36)54-32-14-15-42-39(24-32)44-29-10-11-35-28(22-29)26-43-47-35/h3-15,22-27H,16-21H2,1-2H3,(H,42,44)(H,43,47)(H2,45,46,51)
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n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205302
PNG
(US9249125, 55)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)n(n1)-c1cccc(OCCN2CCOCC2)c1
Show InChI InChI=1S/C41H42N10O4/c1-26(2)35-24-37(51(49-35)30-7-6-8-31(23-30)54-20-17-50-15-18-53-19-16-50)46-41(52)45-34-11-12-36(33-10-5-4-9-32(33)34)55-38-13-14-42-40(47-38)44-29-21-27(3)39-28(22-29)25-43-48-39/h4-14,21-26H,15-20H2,1-3H3,(H,43,48)(H,42,44,47)(H2,45,46,52)
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US Patent
n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205314
PNG
(US9249125, 67)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)c3)c3ccccc23)n(n1)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C42H43N9O4/c1-42(2,3)38-26-40(51(49-38)30-9-11-31(12-10-30)54-23-20-50-18-21-53-22-19-50)47-41(52)46-36-14-15-37(34-7-5-4-6-33(34)36)55-32-16-17-43-39(25-32)45-29-8-13-35-28(24-29)27-44-48-35/h4-17,24-27H,18-23H2,1-3H3,(H,43,45)(H,44,48)(H2,46,47,52)
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US Patent
n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205315
PNG
(US9249125, 68)
Show SMILES Cc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OCCN5CCOCC5)cc4)C(C)(C)C)c4ccccc34)ccn2)cc2cn[nH]c12
Show InChI InChI=1S/C43H45N9O4/c1-28-23-30(24-29-27-45-49-41(28)29)46-39-25-33(15-16-44-39)56-37-14-13-36(34-7-5-6-8-35(34)37)47-42(53)48-40-26-38(43(2,3)4)50-52(40)31-9-11-32(12-10-31)55-22-19-51-17-20-54-21-18-51/h5-16,23-27H,17-22H2,1-4H3,(H,44,46)(H,45,49)(H2,47,48,53)
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US Patent
n/an/a<1n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair
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