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Compile Data Set for Download or QSAR

Found 226 hits with Last Name = 'witherbee' and Initial = 'bj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128131
PNG
((R)-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-...)
Show SMILES CCc1cc(Oc2cccc(c2)N(C[C@@H](O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl
Show InChI InChI=1S/C26H23ClF7NO3/c1-2-17-12-20(9-10-22(17)27)37-19-7-4-6-18(13-19)35(15-23(36)25(30,31)32)14-16-5-3-8-21(11-16)38-26(33,34)24(28)29/h3-13,23-24,36H,2,14-15H2,1H3/t23-/m1/s1
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n/an/a 0.770n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer with <1 nM [CETP] for 18 ...


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50094519
PNG
((R)-1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,...)
Show SMILES O[C@H](CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H20F7NO3/c25-22(26)24(30,31)35-20-11-4-6-16(12-20)14-32(15-21(33)23(27,28)29)17-7-5-10-19(13-17)34-18-8-2-1-3-9-18/h1-13,21-22,33H,14-15H2/t21-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Pharmacia Discovery Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CETP-mediated transfer of [3H]-CE from HDL to LDL


J Med Chem 43: 4575-8 (2001)


BindingDB Entry DOI: 10.7270/Q2X0669S
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50094519
PNG
((R)-1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,...)
Show SMILES O[C@H](CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H20F7NO3/c25-22(26)24(30,31)35-20-11-4-6-16(12-20)14-32(15-21(33)23(27,28)29)17-7-5-10-19(13-17)34-18-8-2-1-3-9-18/h1-13,21-22,33H,14-15H2/t21-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer.


J Med Chem 45: 3891-904 (2002)


BindingDB Entry DOI: 10.7270/Q2JW8D7P
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128175
PNG
(1,1,1-Trifluoro-3-{[3-(3-isopropyl-phenoxy)-phenyl...)
Show SMILES CC(C)c1cccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C27H26F7NO3/c1-17(2)19-7-4-9-21(13-19)37-22-10-5-8-20(14-22)35(16-24(36)26(30,31)32)15-18-6-3-11-23(12-18)38-27(33,34)25(28)29/h3-14,17,24-25,36H,15-16H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128135
PNG
(3-((3-(2,3-dichlorophenoxy)phenyl)(3-(1,1,2,2-tetr...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(Cl)c2Cl)c1)C(F)(F)F
Show InChI InChI=1S/C24H18Cl2F7NO3/c25-18-8-3-9-19(21(18)26)36-16-6-2-5-15(11-16)34(13-20(35)23(29,30)31)12-14-4-1-7-17(10-14)37-24(32,33)22(27)28/h1-11,20,22,35H,12-13H2
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n/an/a 30n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128141
PNG
(1,1,1-Trifluoro-3-{[3-(4-fluoro-phenoxy)-phenyl]-[...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(F)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H19F8NO3/c25-16-7-9-18(10-8-16)35-19-5-2-4-17(12-19)33(14-21(34)23(28,29)30)13-15-3-1-6-20(11-15)36-24(31,32)22(26)27/h1-12,21-22,34H,13-14H2
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n/an/a 30n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128164
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-chlo...)
Show SMILES CCc1cc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl
Show InChI InChI=1S/C26H23ClF7NO3/c1-2-17-12-20(9-10-22(17)27)37-19-7-4-6-18(13-19)35(15-23(36)25(30,31)32)14-16-5-3-8-21(11-16)38-26(33,34)24(28)29/h3-13,23-24,36H,2,14-15H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128154
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(OC(F)(F)F)c2)c1)C(F)(F)F
Show InChI InChI=1S/C25H19F10NO4/c26-22(27)24(31,32)39-19-8-1-4-15(10-19)13-36(14-21(37)23(28,29)30)16-5-2-6-17(11-16)38-18-7-3-9-20(12-18)40-25(33,34)35/h1-12,21-22,37H,13-14H2
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n/an/a 30n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128176
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2cccc(OC(F)(F)F)c2)c1)C(F)(F)F
Show InChI InChI=1S/C26H21F10NO4/c27-23(28)25(32,33)40-20-8-1-4-16(10-20)13-37(14-22(38)24(29,30)31)18-6-3-7-19(12-18)39-15-17-5-2-9-21(11-17)41-26(34,35)36/h1-12,22-23,38H,13-15H2
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n/an/a 60n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128146
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-ethy...)
Show SMILES CCc1cccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C26H24F7NO3/c1-2-17-6-3-9-20(12-17)36-21-10-5-8-19(14-21)34(16-23(35)25(29,30)31)15-18-7-4-11-22(13-18)37-26(32,33)24(27)28/h3-14,23-24,35H,2,15-16H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128136
PNG
(3-((3-(3,5-dimethylphenoxy)phenyl)(3-(1,1,2,2-tetr...)
Show SMILES Cc1cc(C)cc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C26H24F7NO3/c1-16-9-17(2)11-22(10-16)36-20-7-4-6-19(13-20)34(15-23(35)25(29,30)31)14-18-5-3-8-21(12-18)37-26(32,33)24(27)28/h3-13,23-24,35H,14-15H2,1-2H3
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n/an/a 70n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128131
PNG
((R)-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-...)
Show SMILES CCc1cc(Oc2cccc(c2)N(C[C@@H](O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl
Show InChI InChI=1S/C26H23ClF7NO3/c1-2-17-12-20(9-10-22(17)27)37-19-7-4-6-18(13-19)35(15-23(36)25(30,31)32)14-16-5-3-8-21(11-16)38-26(33,34)24(28)29/h3-13,23-24,36H,2,14-15H2,1H3/t23-/m1/s1
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n/an/a 73n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in hamster serum


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128167
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3,4-di...)
Show SMILES Cc1ccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)cc1C
Show InChI InChI=1S/C26H24F7NO3/c1-16-9-10-21(11-17(16)2)36-20-7-4-6-19(13-20)34(15-23(35)25(29,30)31)14-18-5-3-8-22(12-18)37-26(32,33)24(27)28/h3-13,23-24,35H,14-15H2,1-2H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128185
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-ethy...)
Show SMILES CCc1cc(C)cc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C27H26F7NO3/c1-3-18-10-17(2)11-23(12-18)37-21-8-5-7-20(14-21)35(16-24(36)26(30,31)32)15-19-6-4-9-22(13-19)38-27(33,34)25(28)29/h4-14,24-25,36H,3,15-16H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128131
PNG
((R)-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-...)
Show SMILES CCc1cc(Oc2cccc(c2)N(C[C@@H](O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl
Show InChI InChI=1S/C26H23ClF7NO3/c1-2-17-12-20(9-10-22(17)27)37-19-7-4-6-18(13-19)35(15-23(36)25(30,31)32)14-16-5-3-8-21(11-16)38-26(33,34)24(28)29/h3-13,23-24,36H,2,14-15H2,1H3/t23-/m1/s1
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in rabbit serum


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128156
PNG
(3-((3-(3,4-dichlorophenoxy)phenyl)(3-(1,1,2,2-tetr...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18Cl2F7NO3/c25-19-8-7-17(11-20(19)26)36-16-5-2-4-15(10-16)34(13-21(35)23(29,30)31)12-14-3-1-6-18(9-14)37-24(32,33)22(27)28/h1-11,21-22,35H,12-13H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128152
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-tert...)
Show SMILES CC(C)(C)c1cccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C28H28F7NO3/c1-26(2,3)19-8-5-10-21(14-19)38-22-11-6-9-20(15-22)36(17-24(37)27(31,32)33)16-18-7-4-12-23(13-18)39-28(34,35)25(29)30/h4-15,24-25,37H,16-17H2,1-3H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128169
PNG
(1,1,1-Trifluoro-3-{[3-(4-fluoro-3-methyl-phenoxy)-...)
Show SMILES Cc1cc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1F
Show InChI InChI=1S/C25H21F8NO3/c1-15-10-19(8-9-21(15)26)36-18-6-3-5-17(12-18)34(14-22(35)24(29,30)31)13-16-4-2-7-20(11-16)37-25(32,33)23(27)28/h2-12,22-23,35H,13-14H2,1H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128166
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc3CCCCc3c2)c1)C(F)(F)F
Show InChI InChI=1S/C28H26F7NO3/c29-26(30)28(34,35)39-24-10-3-5-18(13-24)16-36(17-25(37)27(31,32)33)21-8-4-9-22(15-21)38-23-12-11-19-6-1-2-7-20(19)14-23/h3-5,8-15,25-26,37H,1-2,6-7,16-17H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128143
PNG
(1,1,1-Trifluoro-3-[[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES Cc1cccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C25H22F7NO3/c1-16-5-2-8-19(11-16)35-20-9-4-7-18(13-20)33(15-22(34)24(28,29)30)14-17-6-3-10-21(12-17)36-25(31,32)23(26)27/h2-13,22-23,34H,14-15H2,1H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128139
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2cccc(c2)C(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1S/C26H21F10NO3/c27-23(28)26(35,36)40-21-9-2-4-16(11-21)13-37(14-22(38)25(32,33)34)19-7-3-8-20(12-19)39-15-17-5-1-6-18(10-17)24(29,30)31/h1-12,22-23,38H,13-15H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128168
PNG
(1,1,1-Trifluoro-3-[[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES Cc1ccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)cc1
Show InChI InChI=1S/C25H22F7NO3/c1-16-8-10-19(11-9-16)35-20-6-3-5-18(13-20)33(15-22(34)24(28,29)30)14-17-4-2-7-21(12-17)36-25(31,32)23(26)27/h2-13,22-23,34H,14-15H2,1H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128153
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(2,3-di...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(F)c2F)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F9NO3/c25-18-8-3-9-19(21(18)26)36-16-6-2-5-15(11-16)34(13-20(35)23(29,30)31)12-14-4-1-7-17(10-14)37-24(32,33)22(27)28/h1-11,20,22,35H,12-13H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128162
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(cc2)C(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1S/C25H19F10NO3/c26-22(27)25(34,35)39-20-6-1-3-15(11-20)13-36(14-21(37)24(31,32)33)17-4-2-5-19(12-17)38-18-9-7-16(8-10-18)23(28,29)30/h1-12,21-22,37H,13-14H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128148
PNG
(1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-p...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(F)c2[N+]([O-])=O)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F8N2O5/c25-18-8-3-9-19(21(18)34(36)37)38-16-6-2-5-15(11-16)33(13-20(35)23(28,29)30)12-14-4-1-7-17(10-14)39-24(31,32)22(26)27/h1-11,20,22,35H,12-13H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50094513
PNG
(1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H20F7NO3/c25-22(26)24(30,31)35-20-11-4-6-16(12-20)14-32(15-21(33)23(27,28)29)17-7-5-10-19(13-17)34-18-8-2-1-3-9-18/h1-13,21-22,33H,14-15H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50094513
PNG
(1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H20F7NO3/c25-22(26)24(30,31)35-20-11-4-6-16(12-20)14-32(15-21(33)23(27,28)29)17-7-5-10-19(13-17)34-18-8-2-1-3-9-18/h1-13,21-22,33H,14-15H2
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Pharmacia

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer.


J Med Chem 45: 3891-904 (2002)


BindingDB Entry DOI: 10.7270/Q2JW8D7P
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128173
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-chlo...)
Show SMILES Cc1cc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl
Show InChI InChI=1S/C25H21ClF7NO3/c1-15-10-19(8-9-21(15)26)36-18-6-3-5-17(12-18)34(14-22(35)24(29,30)31)13-16-4-2-7-20(11-16)37-25(32,33)23(27)28/h2-12,22-23,35H,13-14H2,1H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128177
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(cycloh...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCC2CCCCC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H28F7NO3/c26-23(27)25(31,32)36-21-11-4-8-18(12-21)14-33(15-22(34)24(28,29)30)19-9-5-10-20(13-19)35-16-17-6-2-1-3-7-17/h4-5,8-13,17,22-23,34H,1-3,6-7,14-16H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128132
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3,5-di...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cc(F)cc(F)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F9NO3/c25-15-8-16(26)10-20(9-15)36-18-5-2-4-17(11-18)34(13-21(35)23(29,30)31)12-14-3-1-6-19(7-14)37-24(32,33)22(27)28/h1-11,21-22,35H,12-13H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128184
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-(dim...)
Show SMILES CN(C)c1cccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1
Show InChI InChI=1S/C26H25F7N2O3/c1-34(2)18-7-4-9-20(13-18)37-21-10-5-8-19(14-21)35(16-23(36)25(29,30)31)15-17-6-3-11-22(12-17)38-26(32,33)24(27)28/h3-14,23-24,36H,15-16H2,1-2H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128165
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(c2)C(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1S/C25H19F10NO3/c26-22(27)25(34,35)39-20-9-1-4-15(10-20)13-36(14-21(37)24(31,32)33)17-6-3-8-19(12-17)38-18-7-2-5-16(11-18)23(28,29)30/h1-12,21-22,37H,13-14H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50094513
PNG
(1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H20F7NO3/c25-22(26)24(30,31)35-20-11-4-6-16(12-20)14-32(15-21(33)23(27,28)29)17-7-5-10-19(13-17)34-18-8-2-1-3-9-18/h1-13,21-22,33H,14-15H2
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Pharmacia Discovery Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CETP-mediated transfer of [3H]-CE from HDL to LDL


J Med Chem 43: 4575-8 (2001)


BindingDB Entry DOI: 10.7270/Q2X0669S
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50094513
PNG
(1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H20F7NO3/c25-22(26)24(30,31)35-20-11-4-6-16(12-20)14-32(15-21(33)23(27,28)29)17-7-5-10-19(13-17)34-18-8-2-1-3-9-18/h1-13,21-22,33H,14-15H2
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Pharmacia

Curated by ChEMBL


Assay Description
In vitro human CETP inhibitory activity of the compound was assessed by measuring the rate of [3H]-cholesteryl ester ([3H]-CE) from HDL donor particl...


Bioorg Med Chem Lett 11: 1625-8 (2001)


BindingDB Entry DOI: 10.7270/Q2W09579
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128133
PNG
(1,1,1-Trifluoro-3-{[3-(4-isopropyl-3-methyl-phenox...)
Show SMILES CC(C)c1ccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)cc1C
Show InChI InChI=1S/C28H28F7NO3/c1-17(2)24-11-10-22(12-18(24)3)38-21-8-5-7-20(14-21)36(16-25(37)27(31,32)33)15-19-6-4-9-23(13-19)39-28(34,35)26(29)30/h4-14,17,25-26,37H,15-16H2,1-3H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128138
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(benzyl...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C25H22F7NO3/c26-23(27)25(31,32)36-21-11-4-8-18(12-21)14-33(15-22(34)24(28,29)30)19-9-5-10-20(13-19)35-16-17-6-2-1-3-7-17/h1-13,22-23,34H,14-16H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128155
PNG
(1,1,1-Trifluoro-3-{[3-(4-propyl-phenoxy)-phenyl]-[...)
Show SMILES CCCc1ccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)cc1
Show InChI InChI=1S/C27H26F7NO3/c1-2-5-18-10-12-21(13-11-18)37-22-8-4-7-20(15-22)35(17-24(36)26(30,31)32)16-19-6-3-9-23(14-19)38-27(33,34)25(28)29/h3-4,6-15,24-25,36H,2,5,16-17H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128183
PNG
(1,1,1-Trifluoro-3-{(3-isopropoxy-phenyl)-[3-(1,1,2...)
Show SMILES CC(C)Oc1cccc(c1)N(CC(O)C(F)(F)F)Cc1cccc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C21H22F7NO3/c1-13(2)31-16-7-4-6-15(10-16)29(12-18(30)20(24,25)26)11-14-5-3-8-17(9-14)32-21(27,28)19(22)23/h3-10,13,18-19,30H,11-12H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128182
PNG
(1,1,1-Trifluoro-3-{[3-(3-fluoro-phenoxy)-phenyl]-[...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(F)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H19F8NO3/c25-16-5-2-7-18(11-16)35-19-8-3-6-17(12-19)33(14-21(34)23(28,29)30)13-15-4-1-9-20(10-15)36-24(31,32)22(26)27/h1-12,21-22,34H,13-14H2
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n/an/a 300n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50118037
PNG
(3-((3-cyclopentylbenzyl)(3-phenoxyphenyl)amino)-1,...)
Show SMILES OC(CN(Cc1cccc(c1)C1CCCC1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C27H28F3NO2/c28-27(29,30)26(32)19-31(18-20-8-6-11-22(16-20)21-9-4-5-10-21)23-12-7-15-25(17-23)33-24-13-2-1-3-14-24/h1-3,6-8,11-17,21,26,32H,4-5,9-10,18-19H2
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n/an/a 300n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer.


J Med Chem 45: 3891-904 (2002)


BindingDB Entry DOI: 10.7270/Q2JW8D7P
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128159
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(2-chlo...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2Cl)c1)C(F)(F)F
Show InChI InChI=1S/C24H19ClF7NO3/c25-19-9-1-2-10-20(19)35-17-7-4-6-16(12-17)33(14-21(34)23(28,29)30)13-15-5-3-8-18(11-15)36-24(31,32)22(26)27/h1-12,21-22,34H,13-14H2
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n/an/a 300n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128145
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-chlo...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(Cl)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H19ClF7NO3/c25-16-7-9-18(10-8-16)35-19-5-2-4-17(12-19)33(14-21(34)23(28,29)30)13-15-3-1-6-20(11-15)36-24(31,32)22(26)27/h1-12,21-22,34H,13-14H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128157
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2ccc(OC(F)(F)F)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C26H21F10NO4/c27-23(28)25(32,33)40-21-6-1-3-17(11-21)13-37(14-22(38)24(29,30)31)18-4-2-5-20(12-18)39-15-16-7-9-19(10-8-16)41-26(34,35)36/h1-12,22-23,38H,13-15H2
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n/an/a 300n/an/an/an/an/an/a



Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50118045
PNG
(1,1,1-Trifluoro-3-[(3-isopropoxy-benzyl)-(3-phenox...)
Show SMILES CC(C)Oc1cccc(CN(CC(O)C(F)(F)F)c2cccc(Oc3ccccc3)c2)c1
Show InChI InChI=1S/C25H26F3NO3/c1-18(2)31-22-12-6-8-19(14-22)16-29(17-24(30)25(26,27)28)20-9-7-13-23(15-20)32-21-10-4-3-5-11-21/h3-15,18,24,30H,16-17H2,1-2H3
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n/an/a 350n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer.


J Med Chem 45: 3891-904 (2002)


BindingDB Entry DOI: 10.7270/Q2JW8D7P
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50118044
PNG
(1,1,1-Trifluoro-3-[(3-phenoxy-phenyl)-(3-trifluoro...)
Show SMILES OC(CN(Cc1cccc(SC(F)(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Show InChI InChI=1S/C23H19F6NO2S/c24-22(25,26)21(31)15-30(14-16-6-4-11-20(12-16)33-23(27,28)29)17-7-5-10-19(13-17)32-18-8-2-1-3-9-18/h1-13,21,31H,14-15H2
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n/an/a 390n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer.


J Med Chem 45: 3891-904 (2002)


BindingDB Entry DOI: 10.7270/Q2JW8D7P
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128171
PNG
(1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(OC(F)(F)F)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C25H19F10NO4/c26-22(27)24(31,32)39-20-6-1-3-15(11-20)13-36(14-21(37)23(28,29)30)16-4-2-5-19(12-16)38-17-7-9-18(10-8-17)40-25(33,34)35/h1-12,21-22,37H,13-14H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128180
PNG
(1,1,1-Trifluoro-3-{[3-(2-nitro-phenoxy)-phenyl]-[3...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2[N+]([O-])=O)c1)C(F)(F)F
Show InChI InChI=1S/C24H19F7N2O5/c25-22(26)24(30,31)38-18-8-3-5-15(11-18)13-32(14-21(34)23(27,28)29)16-6-4-7-17(12-16)37-20-10-2-1-9-19(20)33(35)36/h1-12,21-22,34H,13-14H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128181
PNG
(1,1,1-Trifluoro-3-{[3-(4-propoxy-phenoxy)-phenyl]-...)
Show SMILES CCCOc1ccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)cc1
Show InChI InChI=1S/C27H26F7NO4/c1-2-13-37-20-9-11-21(12-10-20)38-22-7-4-6-19(15-22)35(17-24(36)26(30,31)32)16-18-5-3-8-23(14-18)39-27(33,34)25(28)29/h3-12,14-15,24-25,36H,2,13,16-17H2,1H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128150
PNG
(3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(cyclop...)
Show SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OC2CCCC2)c1)C(F)(F)F
Show InChI InChI=1S/C23H24F7NO3/c24-21(25)23(29,30)34-19-10-3-5-15(11-19)13-31(14-20(32)22(26,27)28)16-6-4-9-18(12-16)33-17-7-1-2-8-17/h3-6,9-12,17,20-21,32H,1-2,7-8,13-14H2
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50128134
PNG
(1,1,1-Trifluoro-3-{[3-(4-isopropyl-phenoxy)-phenyl...)
Show SMILES CC(C)c1ccc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)cc1
Show InChI InChI=1S/C27H26F7NO3/c1-17(2)19-9-11-21(12-10-19)37-22-7-4-6-20(14-22)35(16-24(36)26(30,31)32)15-18-5-3-8-23(13-18)38-27(33,34)25(28)29/h3-14,17,24-25,36H,15-16H2,1-2H3
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Pharmacia Discovery Research (Pfizer Global Research and Development)

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer


J Med Chem 46: 2152-68 (2003)


Article DOI: 10.1021/jm020528+
BindingDB Entry DOI: 10.7270/Q2QV3KWK
More data for this
Ligand-Target Pair
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