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Compile Data Set for Download or QSAR

Found 433 hits with Last Name = 'xiang' and Initial = 'ax'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168303
PNG
(US9669031, 129 8-chloro-1′-methyl-6-(pyrimid...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C16H17ClN6O2/c1-22-6-3-16(4-7-22)21-14(24)13-10(17)8-11(15(25)23(13)16)20-12-2-5-18-9-19-12/h2,5,8-9H,3-4,6-7H2,1H3,(H,21,24)(H,18,19,20)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168304
PNG
(US9669031, 130 1′,8-dimethyl-6-(pyrimidin-4-...)
Show SMILES CN1CCCC2(C1)NC(=O)c1c(C)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1/C17H20N6O2/c1-11-8-12(20-13-4-6-18-10-19-13)16(25)23-14(11)15(24)21-17(23)5-3-7-22(2)9-17/h4,6,8,10H,3,5,7,9H2,1-2H3,(H,21,24)(H,18,19,20)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168305
PNG
(US9669031, 131 6′-(pyrimidin-4-ylamino)-1...)
Show SMILES O=c1c(Nc2ccncn2)ccc2C(=S)NC3(CCCCC3)n12
Show InChI InChI=1S/C16H17N5OS/c22-15-11(19-13-6-9-17-10-18-13)4-5-12-14(23)20-16(21(12)15)7-2-1-3-8-16/h4-6,9-10H,1-3,7-8H2,(H,20,23)(H,17,18,19)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168306
PNG
(US9669031, 133 8′-chloro-6′-(pyrimidin...)
Show SMILES Clc1cc(Nc2ccncn2)c(=S)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5OS/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168308
PNG
(US9669031, 142 4-((8′-chloro-1′,5̸...)
Show SMILES Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H15ClN6O2/c18-11-6-12(22-14-10(7-19)8-20-9-21-14)16(26)24-13(11)15(25)23-17(24)4-2-1-3-5-17/h6,8-9H,1-5H2,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168308
PNG
(US9669031, 142 4-((8′-chloro-1′,5̸...)
Show SMILES Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H15ClN6O2/c18-11-6-12(22-14-10(7-19)8-20-9-21-14)16(26)24-13(11)15(25)23-17(24)4-2-1-3-5-17/h6,8-9H,1-5H2,(H,23,25)(H,20,21,22)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168309
PNG
(US9669031, 143 8′-chloro-6′-((5-(1-met...)
Show SMILES Cn1cc(cn1)-c1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C20H20ClN7O2/c1-27-10-12(8-24-27)13-9-22-11-23-17(13)25-15-7-14(21)16-18(29)26-20(28(16)19(15)30)5-3-2-4-6-20/h7-11H,2-6H2,1H3,(H,26,29)(H,22,23,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168309
PNG
(US9669031, 143 8′-chloro-6′-((5-(1-met...)
Show SMILES Cn1cc(cn1)-c1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C20H20ClN7O2/c1-27-10-12(8-24-27)13-9-22-11-23-17(13)25-15-7-14(21)16-18(29)26-20(28(16)19(15)30)5-3-2-4-6-20/h7-11H,2-6H2,1H3,(H,26,29)(H,22,23,25)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168301
PNG
(US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168301
PNG
(US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168311
PNG
(US9669031, 146 8-chloro-6-(3H-triazolo[4,5-d]pyrim...)
Show SMILES CC(C)C(=O)N(COCC[Si](C)(C)C)c1ncnc2n(COCC[Si](C)(C)C)nnc12
Show InChI InChI=1S/C20H38N6O3Si2/c1-16(2)20(27)25(14-28-9-11-30(3,4)5)18-17-19(22-13-21-18)26(24-23-17)15-29-10-12-31(6,7)8/h13,16H,9-12,14-15H2,1-8H3
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168311
PNG
(US9669031, 146 8-chloro-6-(3H-triazolo[4,5-d]pyrim...)
Show SMILES CC(C)C(=O)N(COCC[Si](C)(C)C)c1ncnc2n(COCC[Si](C)(C)C)nnc12
Show InChI InChI=1S/C20H38N6O3Si2/c1-16(2)20(27)25(14-28-9-11-30(3,4)5)18-17-19(22-13-21-18)26(24-23-17)15-29-10-12-31(6,7)8/h13,16H,9-12,14-15H2,1-8H3
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168317
PNG
(US9669031, 155 8-chloro-1′-(2-hydroxyethyl)-...)
Show SMILES CC(C)(C)[Si](C)(C)OCCN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C23H33ClN6O3Si/c1-22(2,3)34(4,5)33-13-12-29-10-7-23(8-11-29)28-20(31)19-16(24)14-17(21(32)30(19)23)27-18-6-9-25-15-26-18/h6,9,14-15H,7-8,10-13H2,1-5H3,(H,28,31)(H,25,26,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168321
PNG
(US9669031, 157 8-chloro-6-(pyrimidin-4-ylamino)-1&...)
Show SMILES FC(F)(F)CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C17H16ClF3N6O2/c18-10-7-11(24-12-1-4-22-9-23-12)15(29)27-13(10)14(28)25-16(27)2-5-26(6-3-16)8-17(19,20)21/h1,4,7,9H,2-3,5-6,8H2,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168325
PNG
(US9669031, 160 2-(8-chloro-1,5-dioxo-6-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCN(CC#N)CC1
Show InChI InChI=1S/C17H16ClN7O2/c18-11-9-12(22-13-1-5-20-10-21-13)16(27)25-14(11)15(26)23-17(25)2-6-24(7-3-17)8-4-19/h1,5,9-10H,2-3,6-8H2,(H,23,26)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168331
PNG
(US9669031, 164 8′-chloro-1′,5′-d...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCN(CC1)C#N
Show InChI InChI=1S/C16H14ClN7O2/c17-10-7-11(21-12-1-4-19-9-20-12)15(26)24-13(10)14(25)22-16(24)2-5-23(8-18)6-3-16/h1,4,7,9H,2-3,5-6H2,(H,22,25)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168333
PNG
(US9669031, 169 6′-((6-amino-5-fluoropyrimidi...)
Show SMILES Fc1c(NC(=O)C2CC2)ncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C20H20ClFN6O3/c21-11-8-12(19(31)28-14(11)18(30)27-20(28)6-2-1-3-7-20)25-15-13(22)16(24-9-23-15)26-17(29)10-4-5-10/h8-10H,1-7H2,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168335
PNG
(US9669031, 170 6-[(6-aminopyrimidin-4-yl)amino]-1&...)
Show SMILES CN1CCCC2(C1)NC(=O)c1c(C)cc(Nc3cc(NC(=O)OC(C)(C)C)ncn3)c(=O)n21
Show InChI InChI=1/C22H29N7O4/c1-13-9-14(25-15-10-16(24-12-23-15)26-20(32)33-21(2,3)4)19(31)29-17(13)18(30)27-22(29)7-6-8-28(5)11-22/h9-10,12H,6-8,11H2,1-5H3,(H,27,30)(H2,23,24,25,26,32)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168335
PNG
(US9669031, 170 6-[(6-aminopyrimidin-4-yl)amino]-1&...)
Show SMILES CN1CCCC2(C1)NC(=O)c1c(C)cc(Nc3cc(NC(=O)OC(C)(C)C)ncn3)c(=O)n21
Show InChI InChI=1/C22H29N7O4/c1-13-9-14(25-15-10-16(24-12-23-15)26-20(32)33-21(2,3)4)19(31)29-17(13)18(30)27-22(29)7-6-8-28(5)11-22/h9-10,12H,6-8,11H2,1-5H3,(H,27,30)(H2,23,24,25,26,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168338
PNG
(US9669031, 187 8-chloro-6-[(5-methoxypyrimidin-4-y...)
Show SMILES COc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C17H18ClN5O3/c1-26-12-8-19-9-20-14(12)21-11-7-10(18)13-15(24)22-17(23(13)16(11)25)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168338
PNG
(US9669031, 187 8-chloro-6-[(5-methoxypyrimidin-4-y...)
Show SMILES COc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C17H18ClN5O3/c1-26-12-8-19-9-20-14(12)21-11-7-10(18)13-15(24)22-17(23(13)16(11)25)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168339
PNG
(US9669031, 188 6′-((6-amino-5-ethylpyrimidin...)
Show SMILES CCc1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H37ClN6O6/c1-8-16-20(30-15-31-21(16)34(24(38)40-26(2,3)4)25(39)41-27(5,6)7)32-18-14-17(29)19-22(36)33-28(35(19)23(18)37)12-10-9-11-13-28/h14-15H,8-13H2,1-7H3,(H,33,36)(H,30,31,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168340
PNG
(US9669031, 189 6′-((6-amino-5-isopropylpyrim...)
Show SMILES CC(C)c1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H39ClN6O6/c1-16(2)19-21(31-15-32-22(19)35(25(39)41-27(3,4)5)26(40)42-28(6,7)8)33-18-14-17(30)20-23(37)34-29(36(20)24(18)38)12-10-9-11-13-29/h14-16H,9-13H2,1-8H3,(H,34,37)(H,31,32,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168342
PNG
(US9669031, 191 8′-chloro-6′-(pyrimidin...)
Show SMILES FC(F)(F)C1CCCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1/C17H15ClF3N5O2/c18-9-7-10(24-12-4-6-22-8-23-12)15(28)26-13(9)14(27)25-16(26)5-2-1-3-11(16)17(19,20)21/h4,6-8,11H,1-3,5H2,(H,25,27)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168343
PNG
(US9669031, 192 8-chloro-3-methyl-3-(2-methylprop-1...)
Show SMILES [#6]\[#6](-[#6])=[#6]\C1([#6])[#7]-[#6](=O)-c2c(Cl)cc(-[#7]-c3ccncn3)c(=O)n12
Show InChI InChI=1/C16H16ClN5O2/c1-9(2)7-16(3)21-14(23)13-10(17)6-11(15(24)22(13)16)20-12-4-5-18-8-19-12/h4-8H,1-3H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168344
PNG
(US9669031, 193 6′-((6-amino-5-methylpyrimidi...)
Show SMILES Cc1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H35ClN6O6/c1-15-19(29-14-30-20(15)33(23(37)39-25(2,3)4)24(38)40-26(5,6)7)31-17-13-16(28)18-21(35)32-27(34(18)22(17)36)11-9-8-10-12-27/h13-14H,8-12H2,1-7H3,(H,32,35)(H,29,30,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168345
PNG
(US9669031, 194 8′-chloro-6′-((5-ethylp...)
Show SMILES CCc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C18H20ClN5O2/c1-2-11-9-20-10-21-15(11)22-13-8-12(19)14-16(25)23-18(24(14)17(13)26)6-4-3-5-7-18/h8-10H,2-7H2,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168346
PNG
(US9669031, 195 6′-((6-amino-5-methoxypyrimid...)
Show SMILES COc1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H35ClN6O7/c1-25(2,3)40-23(37)33(24(38)41-26(4,5)6)20-18(39-7)19(29-14-30-20)31-16-13-15(28)17-21(35)32-27(34(17)22(16)36)11-9-8-10-12-27/h13-14H,8-12H2,1-7H3,(H,32,35)(H,29,30,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168347
PNG
(US9669031, 196 8′-chloro-6′-((5-ethoxy...)
Show SMILES CCOc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C18H20ClN5O3/c1-2-27-13-9-20-10-21-15(13)22-12-8-11(19)14-16(25)23-18(24(14)17(12)26)6-4-3-5-7-18/h8-10H,2-7H2,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168348
PNG
(US9669031, 197 8′-chloro-6′-((5-isopro...)
Show SMILES CC(C)Oc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C19H22ClN5O3/c1-11(2)28-14-9-21-10-22-16(14)23-13-8-12(20)15-17(26)24-19(25(15)18(13)27)6-4-3-5-7-19/h8-11H,3-7H2,1-2H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168355
PNG
(US9669031, 206 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCC(O)CC1 |(4.87,-20.91,;4.87,-22.45,;3.54,-23.22,;3.54,-24.76,;2.21,-25.53,;.89,-24.76,;-.45,-25.53,;-1.78,-24.76,;-3.11,-25.53,;-1.78,-23.22,;-.45,-22.45,;.89,-23.22,;4.87,-25.53,;4.87,-27.07,;6.21,-24.76,;6.21,-23.22,;7.67,-22.74,;8.44,-21.41,;8.58,-23.99,;7.67,-25.23,;6.58,-26.32,;6.98,-27.81,;8.47,-28.21,;8.87,-29.7,;9.56,-27.12,;9.16,-25.63,)|
Show InChI InChI=1S/C17H20N6O3/c1-9-6-11(21-13-7-12(18)19-8-20-13)16(26)23-14(9)15(25)22-17(23)4-2-10(24)3-5-17/h6-8,10,24H,2-5H2,1H3,(H,22,25)(H3,18,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168357
PNG
(US9669031, 208 6′-((5-cyclopropylpyrimidin-4...)
Show SMILES Cc1cc(Nc2ncncc2C2CC2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H23N5O2/c1-12-9-15(23-17-14(13-5-6-13)10-21-11-22-17)19(27)25-16(12)18(26)24-20(25)7-3-2-4-8-20/h9-11,13H,2-8H2,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168367
PNG
(US9669031, 219 6-((6-aminopyrimidin-4-yl)amino)-1&...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(C)cc(Nc3cc(ncn3)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(=O)n21
Show InChI InChI=1S/C27H37N7O6/c1-16-13-17(22(36)34-20(16)21(35)31-27(34)9-11-32(8)12-10-27)30-18-14-19(29-15-28-18)33(23(37)39-25(2,3)4)24(38)40-26(5,6)7/h13-15H,9-12H2,1-8H3,(H,31,35)(H,28,29,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168368
PNG
(US9669031, 220 6-((6-amino-5-methylpyrimidin-4-yl)...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(C)cc(Nc3ncnc(NC(=O)C4CC4)c3C)c(=O)n21
Show InChI InChI=1S/C22H27N7O3/c1-12-10-15(25-17-13(2)18(24-11-23-17)26-19(30)14-4-5-14)21(32)29-16(12)20(31)27-22(29)6-8-28(3)9-7-22/h10-11,14H,4-9H2,1-3H3,(H,27,31)(H2,23,24,25,26,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168371
PNG
(US9669031, 225 2-(6-((6-aminopyrimidin-4-yl)amino)...)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCN(CC#N)CC1
Show InChI InChI=1S/C18H20N8O2/c1-11-8-12(23-14-9-13(20)21-10-22-14)17(28)26-15(11)16(27)24-18(26)2-5-25(6-3-18)7-4-19/h8-10H,2-3,5-7H2,1H3,(H,24,27)(H3,20,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168372
PNG
(US9669031, 226 6-((6-aminopyrimidin-4-yl)amino)-1&...)
Show SMILES Cc1cc(Nc2cc(ncn2)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(=O)n2c1C(=O)NC21CCN(CC(F)F)CC1
Show InChI InChI=1S/C28H37F2N7O6/c1-16-12-17(23(39)37-21(16)22(38)34-28(37)8-10-35(11-9-28)14-18(29)30)33-19-13-20(32-15-31-19)36(24(40)42-26(2,3)4)25(41)43-27(5,6)7/h12-13,15,18H,8-11,14H2,1-7H3,(H,34,38)(H,31,32,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168373
PNG
(US9669031, 230 1′-(2,2-difluoroethyl)-6-((5-...)
Show SMILES COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)F)CC3)n2c1=O
Show InChI InChI=1S/C19H22F2N6O3/c1-11-7-12(24-16-13(30-2)8-22-10-23-16)18(29)27-15(11)17(28)25-19(27)3-5-26(6-4-19)9-14(20)21/h7-8,10,14H,3-6,9H2,1-2H3,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168374
PNG
(US9669031, 231 6′-((6-amino-5-methoxypyrimid...)
Show SMILES COc1c(NC(=O)C2CC2)ncnc1Nc1cc(C)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C22H26N6O4/c1-12-10-14(21(31)28-15(12)20(30)27-22(28)8-4-3-5-9-22)25-17-16(32-2)18(24-11-23-17)26-19(29)13-6-7-13/h10-11,13H,3-9H2,1-2H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168375
PNG
(US9669031, 232 6-((6-aminopyrimidin-4-yl)amino)-8-...)
Show SMILES Cc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C22H24F3N7O3/c1-12-8-14(28-15-9-16(27-11-26-15)29-18(33)13-2-3-13)20(35)32-17(12)19(34)30-21(32)4-6-31(7-5-21)10-22(23,24)25/h8-9,11,13H,2-7,10H2,1H3,(H,30,34)(H2,26,27,28,29,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168376
PNG
(US9669031, 233 6-((6-amino-5-methylpyrimidin-4-yl)...)
Show SMILES Cc1cc(Nc2ncnc(NC(=O)C3CC3)c2C)c(=O)n2c1C(=O)NC21CCN(CC(F)F)CC1
Show InChI InChI=1S/C23H27F2N7O3/c1-12-9-15(28-18-13(2)19(27-11-26-18)29-20(33)14-3-4-14)22(35)32-17(12)21(34)30-23(32)5-7-31(8-6-23)10-16(24)25/h9,11,14,16H,3-8,10H2,1-2H3,(H,30,34)(H2,26,27,28,29,33)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168379
PNG
(US9669031, 234 6-((6-amino-5-methoxypyrimidin-4-yl...)
Show SMILES COc1c(NC(=O)C2CC2)ncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)(F)F)CC3)n2c1=O
Show InChI InChI=1S/C23H26F3N7O4/c1-12-9-14(29-17-16(37-2)18(28-11-27-17)30-19(34)13-3-4-13)21(36)33-15(12)20(35)31-22(33)5-7-32(8-6-22)10-23(24,25)26/h9,11,13H,3-8,10H2,1-2H3,(H,31,35)(H2,27,28,29,30,34)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168380
PNG
(US9669031, 235 6-((5-methoxypyrimidin-4-yl)amino)-...)
Show SMILES COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)(F)F)CC3)n2c1=O
Show InChI InChI=1S/C19H21F3N6O3/c1-11-7-12(25-15-13(31-2)8-23-10-24-15)17(30)28-14(11)16(29)26-18(28)3-5-27(6-4-18)9-19(20,21)22/h7-8,10H,3-6,9H2,1-2H3,(H,26,29)(H,23,24,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168381
PNG
(US9669031, 236 6-((6-amino-5-methylpyrimidin-4-yl)...)
Show SMILES Cc1cc(Nc2ncnc(NC(=O)C3CC3)c2C)c(=O)n2c1C(=O)NC21CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C23H26F3N7O3/c1-12-9-15(29-17-13(2)18(28-11-27-17)30-19(34)14-3-4-14)21(36)33-16(12)20(35)31-22(33)5-7-32(8-6-22)10-23(24,25)26/h9,11,14H,3-8,10H2,1-2H3,(H,31,35)(H2,27,28,29,30,34)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168369
PNG
(US9669031, 222 6′-((6-amino-5-methylpyrimidi...)
Show SMILES Cc1cc(Nc2ncnc(NC(=O)C3CC3)c2C)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C22H26N6O3/c1-12-10-15(21(31)28-16(12)20(30)27-22(28)8-4-3-5-9-22)25-17-13(2)18(24-11-23-17)26-19(29)14-6-7-14/h10-11,14H,3-9H2,1-2H3,(H,27,30)(H2,23,24,25,26,29)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168370
PNG
(US9669031, 223 6′-((6-amino-5-chloropyrimidi...)
Show SMILES Cc1cc(Nc2ncnc(N)c2Cl)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H19ClN6O2/c1-9-7-10(22-14-11(18)13(19)20-8-21-14)16(26)24-12(9)15(25)23-17(24)5-3-2-4-6-17/h7-8H,2-6H2,1H3,(H,23,25)(H3,19,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168266
PNG
(US9669031, 94 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Show SMILES CC(C)(C)OC(=O)Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C20H23ClN6O4/c1-19(2,3)31-18(30)25-14-9-13(22-10-23-14)24-12-8-11(21)15-16(28)26-20(6-4-5-7-20)27(15)17(12)29/h8-10H,4-7H2,1-3H3,(H,26,28)(H2,22,23,24,25,30)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168266
PNG
(US9669031, 94 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Show SMILES CC(C)(C)OC(=O)Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C20H23ClN6O4/c1-19(2,3)31-18(30)25-14-9-13(22-10-23-14)24-12-8-11(21)15-16(28)26-20(6-4-5-7-20)27(15)17(12)29/h8-10H,4-7H2,1-3H3,(H,26,28)(H2,22,23,24,25,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168267
PNG
(US9669031, 95 N-[6-[(8-chloro-1,1′,5-trioxo-...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CS(=O)C1
Show InChI InChI=1S/C17H15ClN6O4S/c18-9-3-10(16(27)24-13(9)15(26)23-17(24)5-29(28)6-17)21-11-4-12(20-7-19-11)22-14(25)8-1-2-8/h3-4,7-8H,1-2,5-6H2,(H,23,26)(H2,19,20,21,22,25)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
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