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Compile Data Set for Download or QSAR

Found 588 hits with Last Name = 'yang' and Initial = 'll'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351665
PNG
(CHEMBL1822369)
Show SMILES OC[C@H]1CCCN1CCCNC(=O)c1cc2NC(=O)C(=NNC(=O)Cc3ccc4OCCc4c3)c2c(Br)c1 |r,w:20.21|
Show InChI InChI=1S/C27H30BrN5O5/c28-20-13-18(26(36)29-7-2-9-33-8-1-3-19(33)15-34)14-21-24(20)25(27(37)30-21)32-31-23(35)12-16-4-5-22-17(11-16)6-10-38-22/h4-5,11,13-14,19,34H,1-3,6-10,12,15H2,(H,29,36)(H,31,35)(H,30,32,37)/t19-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351662
PNG
(CHEMBL1822366)
Show SMILES Brc1cc(cc2NC(=O)C(=NNC(=O)Cc3ccc4OCCc4c3)c12)C(=O)NCN1CCOCC1 |w:10.10|
Show InChI InChI=1S/C24H24BrN5O5/c25-17-11-16(23(32)26-13-30-4-7-34-8-5-30)12-18-21(17)22(24(33)27-18)29-28-20(31)10-14-1-2-19-15(9-14)3-6-35-19/h1-2,9,11-12H,3-8,10,13H2,(H,26,32)(H,28,31)(H,27,29,33)
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n/an/a 0.700n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351664
PNG
(CHEMBL1822368)
Show SMILES O[C@@H]1CCN(CCCNC(=O)c2cc3NC(=O)C(=NNC(=O)Cc4ccc5OCCc5c4)c3c(Br)c2)C1 |r,w:18.18|
Show InChI InChI=1S/C26H28BrN5O5/c27-19-12-17(25(35)28-6-1-7-32-8-4-18(33)14-32)13-20-23(19)24(26(36)29-20)31-30-22(34)11-15-2-3-21-16(10-15)5-9-37-21/h2-3,10,12-13,18,33H,1,4-9,11,14H2,(H,28,35)(H,30,34)(H,29,31,36)/t18-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50429477
PNG
(CHEMBL2332840)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl
Show InChI InChI=1S/C19H12ClF3N6O2/c20-15-6-3-11(7-14(15)19(21,22)23)28-18(30)27-10-1-4-12(5-2-10)31-17-13-8-26-29-16(13)24-9-25-17/h1-9H,(H2,27,28,30)(H,24,25,26,29)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of Erk1/2 phosphorylation after 20 hrs by Western blotting analysis


J Med Chem 56: 1641-55 (2013)


Article DOI: 10.1021/jm301537p
BindingDB Entry DOI: 10.7270/Q29S1SC5
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351602
PNG
(CHEMBL1822791)
Show SMILES CN(C)CCNC(=O)c1cc2NC(=O)C(=NNC(=O)Cc3ccc4OCCc4c3)c2c(Br)c1 |w:15.15|
Show InChI InChI=1S/C23H24BrN5O4/c1-29(2)7-6-25-22(31)15-11-16(24)20-17(12-15)26-23(32)21(20)28-27-19(30)10-13-3-4-18-14(9-13)5-8-33-18/h3-4,9,11-12H,5-8,10H2,1-2H3,(H,25,31)(H,27,30)(H,26,28,32)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28028
PNG
(2-aminopyridine analogue, 7 | N-{4-[(2-amino-3-eth...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1C#C
Show InChI InChI=1S/C25H16F2N4O3/c1-2-18-21(11-12-29-23(18)28)34-22-10-7-16(14-20(22)27)30-24(32)19-4-3-13-31(25(19)33)17-8-5-15(26)6-9-17/h1,3-14H,(H2,28,29)(H,30,32)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28030
PNG
(2-aminopyridine analogue, 9 | N-{4-[(2-amino-3-chl...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1Cl
Show InChI InChI=1S/C23H15ClF2N4O3/c24-20-19(9-10-28-21(20)27)33-18-8-5-14(12-17(18)26)29-22(31)16-2-1-11-30(23(16)32)15-6-3-13(25)4-7-15/h1-12H,(H2,27,28)(H,29,31)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24459
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C28H23FN4O4/c1-17-26(28(35)33(32(17)2)19-7-5-4-6-8-19)27(34)31-18-9-12-25(22(29)15-18)37-24-13-14-30-23-16-20(36-3)10-11-21(23)24/h4-16H,1-3H3,(H,31,34)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24460
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H27FN4O4/c1-4-16-34-19(2)28(30(37)35(34)21-8-6-5-7-9-21)29(36)33-20-10-13-27(24(31)17-20)39-26-14-15-32-25-18-22(38-3)11-12-23(25)26/h5-15,17-18H,4,16H2,1-3H3,(H,33,36)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24462
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 |r|
Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351579
PNG
(CHEMBL494985)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1ccc2nnc(Cc3ccc(O)cc3)n2n1
Show InChI InChI=1S/C20H16ClN5O2/c1-22-20(28)15-7-4-13(11-16(15)21)17-8-9-18-23-24-19(26(18)25-17)10-12-2-5-14(27)6-3-12/h2-9,11,27H,10H2,1H3,(H,22,28)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351650
PNG
(CHEMBL1823252)
Show SMILES O[C@H]1CCN(CCCNC(=O)c2cc3NC(=O)C(=NNC(=O)Cc4ccc5OCCc5c4)c3c(Br)c2)C1 |r,w:18.18|
Show InChI InChI=1S/C26H28BrN5O5/c27-19-12-17(25(35)28-6-1-7-32-8-4-18(33)14-32)13-20-23(19)24(26(36)29-20)31-30-22(34)11-15-2-3-21-16(10-15)5-9-37-21/h2-3,10,12-13,18,33H,1,4-9,11,14H2,(H,28,35)(H,30,34)(H,29,31,36)/t18-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351641
PNG
(CHEMBL1823128)
Show SMILES CN1CCN(CCCNC(=O)c2cc3NC(=O)C(=NNC(=O)Cc4ccc5OCCc5c4)c3c(Br)c2)CC1 |w:18.18|
Show InChI InChI=1S/C27H31BrN6O4/c1-33-8-10-34(11-9-33)7-2-6-29-26(36)19-15-20(28)24-21(16-19)30-27(37)25(24)32-31-23(35)14-17-3-4-22-18(13-17)5-12-38-22/h3-4,13,15-16H,2,5-12,14H2,1H3,(H,29,36)(H,31,35)(H,30,32,37)
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351633
PNG
(CHEMBL497118)
Show SMILES Cc1csc(c1)-c1ccc2nnc(Cc3ccc(O)cc3)n2n1
Show InChI InChI=1S/C17H14N4OS/c1-11-8-15(23-10-11)14-6-7-16-18-19-17(21(16)20-14)9-12-2-4-13(22)5-3-12/h2-8,10,22H,9H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24463
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 |r|
Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24457
PNG
(2-[(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}p...)
Show SMILES [O-][n+]1c(cccc1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C25H17FN4O3/c26-19-15-17(9-10-23(19)33-22-12-14-28-24-18(22)11-13-27-24)29-25(31)21-8-4-7-20(30(21)32)16-5-2-1-3-6-16/h1-15H,(H,27,28)(H,29,31)
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n/an/a 1.30n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24464
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C30H25FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16H,17H2,1-3H3,(H,33,37)
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n/an/a 1.30n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235550
PNG
(1-(4-(5-((4-aminocyclohexylidene)methyl)pyrrolo[1,...)
Show InChI InChI=1S/C28H26F2N6O3/c29-20-5-1-18(2-6-20)14-25(37)35-28(38)34-22-9-10-24(23(30)15-22)39-27-26-19(11-12-36(26)33-16-32-27)13-17-3-7-21(31)8-4-17/h1-2,5-6,9-13,15-16,21H,3-4,7-8,14,31H2,(H2,34,35,37,38)/b17-13-
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n/an/a 1.5n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351667
PNG
(CHEMBL1822371)
Show SMILES CN(C)CCCNC(=O)c1cc2NC(=O)C(=NNC(=O)Cc3ccc4occc4c3)c2c(Br)c1 |w:16.16|
Show InChI InChI=1S/C24H24BrN5O4/c1-30(2)8-3-7-26-23(32)16-12-17(25)21-18(13-16)27-24(33)22(21)29-28-20(31)11-14-4-5-19-15(10-14)6-9-34-19/h4-6,9-10,12-13H,3,7-8,11H2,1-2H3,(H,26,32)(H,28,31)(H,27,29,33)
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n/an/a 1.60n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24440
PNG
(2-pyridone analogue, 2 | JMC521251 Compound 1 | N-...)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1=O
Show InChI InChI=1S/C25H16F2N4O3/c26-15-3-6-17(7-4-15)31-13-1-2-19(25(31)33)24(32)30-16-5-8-22(20(27)14-16)34-21-10-12-29-23-18(21)9-11-28-23/h1-14H,(H,28,29)(H,30,32)
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n/an/a 1.80n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24458
PNG
(2-[(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}p...)
Show SMILES [O-][n+]1c(cccc1-c1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C25H16F2N4O3/c26-16-6-4-15(5-7-16)20-2-1-3-21(31(20)33)25(32)30-17-8-9-23(19(27)14-17)34-22-11-13-29-24-18(22)10-12-28-24/h1-14H,(H,28,29)(H,30,32)
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n/an/a 1.80n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24441
PNG
(2-pyridone analogue, 13 | N-(3-fluoro-4-{1H-pyrrol...)
Show SMILES Fc1cc(NC(=O)c2cccn(-c3ccccc3)c2=O)ccc1Oc1ccnc2[nH]ccc12
Show InChI InChI=1S/C25H17FN4O3/c26-20-15-16(8-9-22(20)33-21-11-13-28-23-18(21)10-12-27-23)29-24(31)19-7-4-14-30(25(19)32)17-5-2-1-3-6-17/h1-15H,(H,27,28)(H,29,31)
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n/an/a 1.90n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351749
PNG
(CHEMBL523386)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2cccs2)cc1
Show InChI InChI=1S/C16H12N4OS/c21-12-5-3-11(4-6-12)10-16-18-17-15-8-7-13(19-20(15)16)14-2-1-9-22-14/h1-9,21H,10H2
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50184869
PNG
(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C26H23N3O4S/c1-31-23-15-20-21(16-24(23)32-2)27-13-12-22(20)33-19-10-8-18(9-11-19)28-26(34)29-25(30)14-17-6-4-3-5-7-17/h3-13,15-16H,14H2,1-2H3,(H2,28,29,30,34)
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50271981
PNG
(1-(3-fluoro-4-(3-(pyridin-3-yl)-1H-pyrrolo[2,3-b]p...)
Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ccnc4[nH]cc(-c5cccnc5)c34)c(F)c2)cc1
Show InChI InChI=1S/C27H19F2N5O3/c28-18-5-3-16(4-6-18)12-24(35)34-27(36)33-19-7-8-22(21(29)13-19)37-23-9-11-31-26-25(23)20(15-32-26)17-2-1-10-30-14-17/h1-11,13-15H,12H2,(H,31,32)(H2,33,34,35,36)
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50272012
PNG
(1-(3-fluoro-4-(2-(pyridin-3-yl)-1H-pyrrolo[2,3-b]p...)
Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)-c3cccnc3)c(F)c2)cc1
Show InChI InChI=1S/C27H19F2N5O3/c28-18-5-3-16(4-6-18)12-25(35)34-27(36)32-19-7-8-24(21(29)13-19)37-23-9-11-31-26-20(23)14-22(33-26)17-2-1-10-30-15-17/h1-11,13-15H,12H2,(H,31,33)(H2,32,34,35,36)
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50272049
PNG
(1-(4-(2-amino-3-ethynylpyridin-4-yloxy)-3-fluoroph...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)c1C#C
Show InChI InChI=1S/C22H16F2N4O3/c1-2-16-18(9-10-26-21(16)25)31-19-8-7-15(12-17(19)24)27-22(30)28-20(29)11-13-3-5-14(23)6-4-13/h1,3-10,12H,11H2,(H2,25,26)(H2,27,28,29,30)
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351666
PNG
(CHEMBL1822370)
Show SMILES OC1CCN(CCCNC(=O)c2cc3NC(=O)C(=NNC(=O)Cc4ccc5OCCc5c4)c3c(Br)c2)CC1 |w:18.18|
Show InChI InChI=1S/C27H30BrN5O5/c28-20-14-18(26(36)29-7-1-8-33-9-4-19(34)5-10-33)15-21-24(20)25(27(37)30-21)32-31-23(35)13-16-2-3-22-17(12-16)6-11-38-22/h2-3,12,14-15,19,34H,1,4-11,13H2,(H,29,36)(H,31,35)(H,30,32,37)
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n/an/a 2n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24454
PNG
(1-(3-fluoro-4-methoxyphenyl)-N-(3-fluoro-4-{1H-pyr...)
Show SMILES COc1ccc(cc1F)-n1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(=O)c(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H21F3N4O4/c1-42-28-9-7-21(15-26(28)35)39-16-23(18-2-4-19(33)5-3-18)30(40)24(17-39)32(41)38-20-6-8-29(25(34)14-20)43-27-11-13-37-31-22(27)10-12-36-31/h2-17H,1H3,(H,36,37)(H,38,41)
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n/an/a 2.30n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351599
PNG
(CHEMBL1823478)
Show SMILES Clc1ccc(Cl)c(c1)C1=NN(CC1)C(=O)Cc1cccc(NC(=O)OCCCN2CCOCC2)c1 |t:9|
Show InChI InChI=1S/C25H28Cl2N4O4/c26-19-5-6-22(27)21(17-19)23-7-9-31(29-23)24(32)16-18-3-1-4-20(15-18)28-25(33)35-12-2-8-30-10-13-34-14-11-30/h1,3-6,15,17H,2,7-14,16H2,(H,28,33)
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n/an/a 2.5n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28033
PNG
(2-aminopyridine analogue, 12 | N-{4-[(2-amino-3-ch...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3c(OCCO)ccn(-c4ccc(F)cc4)c3=O)cc2F)c1Cl
Show InChI InChI=1S/C25H19ClF2N4O5/c26-22-20(7-9-30-23(22)29)37-18-6-3-15(13-17(18)28)31-24(34)21-19(36-12-11-33)8-10-32(25(21)35)16-4-1-14(27)2-5-16/h1-10,13,33H,11-12H2,(H2,29,30)(H,31,34)
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n/an/a 2.60n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24465
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26/h5-17,39H,18H2,1-4H3,(H,34,37)
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n/an/a 2.70n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28026
PNG
(2-aminopyridine analogue, 5 | N-(4-{[2-amino-3-(3-...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1C#CCO
Show InChI InChI=1S/C26H18F2N4O4/c27-16-5-8-18(9-6-16)32-13-1-3-20(26(32)35)25(34)31-17-7-10-23(21(28)15-17)36-22-11-12-30-24(29)19(22)4-2-14-33/h1,3,5-13,15,33H,14H2,(H2,29,30)(H,31,34)
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n/an/a 2.70n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24449
PNG
(4-pyridone analogue, 3 | N-(3-fluoro-4-{1H-pyrrolo...)
Show SMILES Oc1c(cncc1-c1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C25H16F2N4O3/c26-15-3-1-14(2-4-15)18-12-28-13-19(23(18)32)25(33)31-16-5-6-22(20(27)11-16)34-21-8-10-30-24-17(21)7-9-29-24/h1-13H,(H,28,32)(H,29,30)(H,31,33)
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n/an/a 2.80n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351748
PNG
(CHEMBL494984)
Show SMILES CNC(=O)c1ccc(cc1F)-c1ccc2nnc(Cc3ccc(O)cc3)n2n1
Show InChI InChI=1S/C20H16FN5O2/c1-22-20(28)15-7-4-13(11-16(15)21)17-8-9-18-23-24-19(26(18)25-17)10-12-2-5-14(27)6-3-12/h2-9,11,27H,10H2,1H3,(H,22,28)
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n/an/a 3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24483
PNG
(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-9-18(29-25-12)15-5-6-19-22-23-20(26(19)24-15)11-28-17-7-8-21-16-10-13(27-2)3-4-14(16)17/h3-10H,11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50429477
PNG
(CHEMBL2332840)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl
Show InChI InChI=1S/C19H12ClF3N6O2/c20-15-6-3-11(7-14(15)19(21,22)23)28-18(30)27-10-1-4-12(5-2-10)31-17-13-8-26-29-16(13)24-9-25-17/h1-9H,(H2,27,28,30)(H,24,25,26,29)
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n/an/a 3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of FLT3 phosphorylation in human MV4-11 cells after 20 hrs by Western blotting analysis


J Med Chem 56: 1641-55 (2013)


Article DOI: 10.1021/jm301537p
BindingDB Entry DOI: 10.7270/Q29S1SC5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50429477
PNG
(CHEMBL2332840)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl
Show InChI InChI=1S/C19H12ClF3N6O2/c20-15-6-3-11(7-14(15)19(21,22)23)28-18(30)27-10-1-4-12(5-2-10)31-17-13-8-26-29-16(13)24-9-25-17/h1-9H,(H2,27,28,30)(H,24,25,26,29)
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n/an/a 3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of STAT5 phosphorylation after 20 hrs by Western blotting analysis


J Med Chem 56: 1641-55 (2013)


Article DOI: 10.1021/jm301537p
BindingDB Entry DOI: 10.7270/Q29S1SC5
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50272013
PNG
(1-(4-(2-amino-3-(3-hydroxyprop-1-ynyl)pyridin-4-yl...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)c1C#CCO
Show InChI InChI=1S/C23H18F2N4O4/c24-15-5-3-14(4-6-15)12-21(31)29-23(32)28-16-7-8-20(18(25)13-16)33-19-9-10-27-22(26)17(19)2-1-11-30/h3-10,13,30H,11-12H2,(H2,26,27)(H2,28,29,31,32)
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n/an/a 3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24450
PNG
(4-pyridone analogue, 34 | N-(3-fluoro-4-{1H-pyrrol...)
Show SMILES Cn1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(=O)c(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H18F2N4O3/c1-32-13-19(15-2-4-16(27)5-3-15)24(33)20(14-32)26(34)31-17-6-7-23(21(28)12-17)35-22-9-11-30-25-18(22)8-10-29-25/h2-14H,1H3,(H,29,30)(H,31,34)
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n/an/a 3.10n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28032
PNG
(2-aminopyridine analogue, 11 | N-{4-[(2-amino-3-ch...)
Show SMILES CC(C)Oc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1
Show InChI InChI=1S/C26H21ClF2N4O4/c1-14(2)36-20-10-12-33(17-6-3-15(28)4-7-17)26(35)22(20)25(34)32-16-5-8-19(18(29)13-16)37-21-9-11-31-24(30)23(21)27/h3-14H,1-2H3,(H2,30,31)(H,32,34)
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n/an/a 3.20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28027
PNG
(2-aminopyridine analogue, 6 | N-(4-{[2-amino-3-(hy...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1CO
Show InChI InChI=1S/C24H18F2N4O4/c25-14-3-6-16(7-4-14)30-11-1-2-17(24(30)33)23(32)29-15-5-8-21(19(26)12-15)34-20-9-10-28-22(27)18(20)13-31/h1-12,31H,13H2,(H2,27,28)(H,29,32)
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n/an/a 3.40n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24452
PNG
(1-cyclopropyl-N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyri...)
Show SMILES Fc1ccc(cc1)-c1cn(cc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1=O)C1CC1
Show InChI InChI=1S/C28H20F2N4O3/c29-17-3-1-16(2-4-17)21-14-34(19-6-7-19)15-22(26(21)35)28(36)33-18-5-8-25(23(30)13-18)37-24-10-12-32-27-20(24)9-11-31-27/h1-5,8-15,19H,6-7H2,(H,31,32)(H,33,36)
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n/an/a 3.40n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28029
PNG
(2-aminopyridine analogue, 8 | N-(4-{[2-amino-3-(pr...)
Show SMILES CC(C)c1c(N)nccc1Oc1ccc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc1F
Show InChI InChI=1S/C26H22F2N4O3/c1-15(2)23-22(11-12-30-24(23)29)35-21-10-7-17(14-20(21)28)31-25(33)19-4-3-13-32(26(19)34)18-8-5-16(27)6-9-18/h3-15H,1-2H3,(H2,29,30)(H,31,33)
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n/an/a 3.40n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24451
PNG
(4-pyridone analogue, 37 | N-(3-fluoro-4-{1H-pyrrol...)
Show SMILES OCCn1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(=O)c(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20F2N4O4/c28-17-3-1-16(2-4-17)20-14-33(11-12-34)15-21(25(20)35)27(36)32-18-5-6-24(22(29)13-18)37-23-8-10-31-26-19(23)7-9-30-26/h1-10,13-15,34H,11-12H2,(H,30,31)(H,32,36)
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n/an/a 3.80n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28025
PNG
(2-aminopyridine analogue, 4 | N-(4-{[2-amino-3-(3-...)
Show SMILES NCC#Cc1c(N)nccc1Oc1ccc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc1F
Show InChI InChI=1S/C26H19F2N5O3/c27-16-5-8-18(9-6-16)33-14-2-4-20(26(33)35)25(34)32-17-7-10-23(21(28)15-17)36-22-11-13-31-24(30)19(22)3-1-12-29/h2,4-11,13-15H,12,29H2,(H2,30,31)(H,32,34)
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n/an/a 3.80n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28031
PNG
(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1
Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
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n/an/a 3.90n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24476
PNG
(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C22H14F3N5O2/c1-31-13-2-3-14-18(10-13)26-7-6-19(14)32-11-21-28-27-20-5-4-17(29-30(20)21)12-8-15(23)22(25)16(24)9-12/h2-10H,11H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351750
PNG
(CHEMBL497117)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2ccsc2)cc1
Show InChI InChI=1S/C16H12N4OS/c21-13-3-1-11(2-4-13)9-16-18-17-15-6-5-14(19-20(15)16)12-7-8-22-10-12/h1-8,10,21H,9H2
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n/an/a 4n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
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