new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 304 hits with Last Name = 'zavadoski' and Initial = 'wj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))
BDBM50433595
PNG
(CHEMBL2381827)
Show SMILES CCCC(Nc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C26H29F3N4O3/c1-4-5-22(18-6-8-19(9-7-18)25(36)30-11-10-23(34)35)32-21-12-16(2)24(17(3)13-21)33-15-20(14-31-33)26(27,28)29/h6-9,12-15,22,32H,4-5,10-11H2,1-3H3,(H,30,36)(H,34,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
12n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433577
PNG
(CHEMBL2381848)
Show SMILES CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433576
PNG
(CHEMBL2381849)
Show SMILES CCC[C@@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
64n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100805
PNG
(US8507533, 113)
Show SMILES CCCC(Nc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C22H23F3N6O3/c1-2-3-18(14-4-6-15(7-5-14)20(34)26-9-8-19(32)33)30-17-11-27-21(28-12-17)31-13-16(10-29-31)22(23,24)25/h4-7,10-13,18,30H,2-3,8-9H2,1H3,(H,26,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
100n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433598
PNG
(CHEMBL2381821)
Show SMILES CCCC(Nc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H25F3N4O3/c1-2-3-21(16-4-6-17(7-5-16)23(34)28-13-12-22(32)33)30-19-8-10-20(11-9-19)31-15-18(14-29-31)24(25,26)27/h4-11,14-15,21,30H,2-3,12-13H2,1H3,(H,28,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
160n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433589
PNG
(CHEMBL2381834)
Show SMILES CC(C)(C)C(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H26F3N3O4/c1-24(2,3)22(16-4-6-17(7-5-16)23(34)29-13-12-21(32)33)35-20-10-8-19(9-11-20)31-15-18(14-30-31)25(26,27)28/h4-11,14-15,22H,12-13H2,1-3H3,(H,29,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
170n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433597
PNG
(CHEMBL2381822)
Show SMILES CCCC(Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H24F3N5O3/c1-2-3-19(15-4-6-16(7-5-15)22(34)27-11-10-21(32)33)30-18-8-9-20(28-13-18)31-14-17(12-29-31)23(24,25)26/h4-9,12-14,19,30H,2-3,10-11H2,1H3,(H,27,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
170n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100800
PNG
(US8507533, 108)
Show SMILES CCCC(Oc1ccc(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H26F3N3O4/c1-3-4-22(17-5-7-18(8-6-17)24(34)29-12-11-23(32)33)35-20-9-10-21(16(2)13-20)31-15-19(14-30-31)25(26,27)28/h5-10,13-15,22H,3-4,11-12H2,1-2H3,(H,29,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433594
PNG
(CHEMBL2381828)
Show SMILES CCCC(Oc1ccc(cc1)-n1cnc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H24F3N3O4/c1-2-3-20(16-4-6-17(7-5-16)23(33)28-13-12-22(31)32)34-19-10-8-18(9-11-19)30-14-21(29-15-30)24(25,26)27/h4-11,14-15,20H,2-3,12-13H2,1H3,(H,28,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
220n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100793
PNG
(US8507533, 86)
Show SMILES CCCC(Oc1ccc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H23F3N4O4/c1-2-3-19(15-4-6-16(7-5-15)22(33)27-11-10-21(31)32)34-18-8-9-20(28-13-18)30-14-17(12-29-30)23(24,25)26/h4-9,12-14,19H,2-3,10-11H2,1H3,(H,27,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
230n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100817
PNG
(US8507533, 124)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc2ccccc2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H27N3O4/c1-2-5-25(19-8-10-20(11-9-19)27(33)28-17-16-26(31)32)34-23-14-12-22(13-15-23)30-18-21-6-3-4-7-24(21)29-30/h3-4,6-15,18,25H,2,5,16-17H2,1H3,(H,28,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
290n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433590
PNG
(CHEMBL2381833)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)C1CCCC1
Show InChI InChI=1S/C26H26F3N3O4/c27-26(28,29)20-15-31-32(16-20)21-9-11-22(12-10-21)36-24(17-3-1-2-4-17)18-5-7-19(8-6-18)25(35)30-14-13-23(33)34/h5-12,15-17,24H,1-4,13-14H2,(H,30,35)(H,33,34)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
420n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433591
PNG
(CHEMBL2381832)
Show SMILES CC(C)CC(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H26F3N3O4/c1-16(2)13-22(17-3-5-18(6-4-17)24(34)29-12-11-23(32)33)35-21-9-7-20(8-10-21)31-15-19(14-30-31)25(26,27)28/h3-10,14-16,22H,11-13H2,1-2H3,(H,29,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
549n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433596
PNG
(CHEMBL2381826)
Show SMILES CCCC(Nc1ccc(cn1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H24F3N5O3/c1-2-3-19(15-4-6-16(7-5-15)22(34)27-11-10-21(32)33)30-20-9-8-18(13-28-20)31-14-17(12-29-31)23(24,25)26/h4-9,12-14,19H,2-3,10-11H2,1H3,(H,27,34)(H,28,30)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
670n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433599
PNG
(CHEMBL2381820)
Show SMILES CCCC(Nc1ccc(cc1)-n1cnc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H25F3N4O3/c1-2-3-20(16-4-6-17(7-5-16)23(34)28-13-12-22(32)33)30-18-8-10-19(11-9-18)31-14-21(29-15-31)24(25,26)27/h4-11,14-15,20,30H,2-3,12-13H2,1H3,(H,28,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
680n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433578
PNG
(CHEMBL2381846)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc2CCCCc2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H31N3O4/c1-2-5-25(19-8-10-20(11-9-19)27(33)28-17-16-26(31)32)34-23-14-12-22(13-15-23)30-18-21-6-3-4-7-24(21)29-30/h8-15,18,25H,2-7,16-17H2,1H3,(H,28,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
690n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433592
PNG
(CHEMBL2381831)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)C1CCC1
Show InChI InChI=1S/C25H24F3N3O4/c26-25(27,28)19-14-30-31(15-19)20-8-10-21(11-9-20)35-23(16-2-1-3-16)17-4-6-18(7-5-17)24(34)29-13-12-22(32)33/h4-11,14-16,23H,1-3,12-13H2,(H,29,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
700n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433588
PNG
(CHEMBL2381835)
Show SMILES CC(C)C(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H24F3N3O4/c1-15(2)22(16-3-5-17(6-4-16)23(33)28-12-11-21(31)32)34-20-9-7-19(8-10-20)30-14-18(13-29-30)24(25,26)27/h3-10,13-15,22H,11-12H2,1-2H3,(H,28,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
720n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433593
PNG
(CHEMBL2381824)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H24F3N3O4/c1-2-3-21(16-4-6-17(7-5-16)23(33)28-13-12-22(31)32)34-20-10-8-19(9-11-20)30-15-18(14-29-30)24(25,26)27/h4-11,14-15,21H,2-3,12-13H2,1H3,(H,28,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
890n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433585
PNG
(CHEMBL2381838)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(Cl)cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H24ClN3O4/c1-2-3-21(16-4-6-17(7-5-16)23(30)25-13-12-22(28)29)31-20-10-8-19(9-11-20)27-15-18(24)14-26-27/h4-11,14-15,21H,2-3,12-13H2,1H3,(H,25,30)(H,28,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433579
PNG
(CHEMBL2381845)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(c(C)n1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H26F3N3O4/c1-3-4-22(17-5-7-18(8-6-17)24(34)29-14-13-23(32)33)35-20-11-9-19(10-12-20)31-15-21(16(2)30-31)25(26,27)28/h5-12,15,22H,3-4,13-14H2,1-2H3,(H,29,34)(H,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100834
PNG
(CHEMBL2381830 | US8507533, 149)
Show SMILES CCCC(Oc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C22H22F3N5O4/c1-2-3-18(14-4-6-15(7-5-14)20(33)26-9-8-19(31)32)34-17-11-27-21(28-12-17)30-13-16(10-29-30)22(23,24)25/h4-7,10-13,18H,2-3,8-9H2,1H3,(H,26,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433587
PNG
(CHEMBL2381836)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)C1CC1
Show InChI InChI=1S/C24H22F3N3O4/c25-24(26,27)18-13-29-30(14-18)19-7-9-20(10-8-19)34-22(15-1-2-15)16-3-5-17(6-4-16)23(33)28-12-11-21(31)32/h3-10,13-15,22H,1-2,11-12H2,(H,28,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433586
PNG
(CHEMBL2381837)
Show SMILES CCC(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H22F3N3O4/c1-2-20(15-3-5-16(6-4-15)22(32)27-12-11-21(30)31)33-19-9-7-18(8-10-19)29-14-17(13-28-29)23(24,25)26/h3-10,13-14,20H,2,11-12H2,1H3,(H,27,32)(H,30,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.40E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433576
PNG
(CHEMBL2381849)
Show SMILES CCC[C@@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.60E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100790
PNG
(US8507533, 28)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(F)cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H24FN3O4/c1-2-3-21(16-4-6-17(7-5-16)23(30)25-13-12-22(28)29)31-20-10-8-19(9-11-20)27-15-18(24)14-26-27/h4-11,14-15,21H,2-3,12-13H2,1H3,(H,25,30)(H,28,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.70E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433584
PNG
(CHEMBL2381839)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(C)cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H27N3O4/c1-3-4-22(18-5-7-19(8-6-18)24(30)25-14-13-23(28)29)31-21-11-9-20(10-12-21)27-16-17(2)15-26-27/h5-12,15-16,22H,3-4,13-14H2,1-2H3,(H,25,30)(H,28,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.90E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50433577
PNG
(CHEMBL2381848)
Show SMILES CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.16E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to GLP-1 receptor (unknown origin)


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433583
PNG
(CHEMBL2381841)
Show SMILES CCCC(Oc1ccc(cc1)-n1cccn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H25N3O4/c1-2-4-21(30-20-11-9-19(10-12-20)26-16-3-14-25-26)17-5-7-18(8-6-17)23(29)24-15-13-22(27)28/h3,5-12,14,16,21H,2,4,13,15H2,1H3,(H,24,29)(H,27,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433582
PNG
(CHEMBL2381842)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(cn1)C#N)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H24N4O4/c1-2-3-22(18-4-6-19(7-5-18)24(31)26-13-12-23(29)30)32-21-10-8-20(9-11-21)28-16-17(14-25)15-27-28/h4-11,15-16,22H,2-3,12-13H2,1H3,(H,26,31)(H,29,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433581
PNG
(CHEMBL2381843)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(OC)cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H27N3O5/c1-3-4-22(17-5-7-18(8-6-17)24(30)25-14-13-23(28)29)32-20-11-9-19(10-12-20)27-16-21(31-2)15-26-27/h5-12,15-16,22H,3-4,13-14H2,1-2H3,(H,25,30)(H,28,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.40E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433580
PNG
(CHEMBL2381844)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(cn1)C(=O)N(C)C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C26H30N4O5/c1-4-5-23(18-6-8-19(9-7-18)25(33)27-15-14-24(31)32)35-22-12-10-21(11-13-22)30-17-20(16-28-30)26(34)29(2)3/h6-13,16-17,23H,4-5,14-15H2,1-3H3,(H,27,33)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
6.50E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM50259015
PNG
(5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...)
Show SMILES CC(C)c1[nH]nc2c1nc(Cc1cccc(Cl)c1)[nH]c2=O
Show InChI InChI=1S/C15H15ClN4O/c1-8(2)12-13-14(20-19-12)15(21)18-11(17-13)7-9-4-3-5-10(16)6-9/h3-6,8H,7H2,1-2H3,(H,19,20)(H,17,18,21)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE1c


Bioorg Med Chem Lett 19: 2537-41 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.024
BindingDB Entry DOI: 10.7270/Q2RB74GG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438698
PNG
(CHEMBL2414663)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3cnon3)C(=O)c12
Show InChI InChI=1S/C21H21N7O4/c22-18-17-19(24-12-23-18)31-10-9-28(21(17)30)15-3-1-13(2-4-15)14-5-7-27(8-6-14)20(29)16-11-25-32-26-16/h1-4,11-12,14H,5-10H2,(H2,22,23,24)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(-8.41,-1.48,;-8.4,-3.02,;-9.73,-3.79,;-9.73,-5.34,;-8.4,-6.11,;-7.06,-5.34,;-5.73,-6.38,;-4.15,-6.01,;-3.48,-4.52,;-4.27,-3.04,;-3.51,-1.7,;-1.98,-1.68,;-1.22,-.34,;-2.01,.98,;-3.56,.96,;-4.3,-.39,;-1.26,2.32,;-2.05,3.64,;-1.29,4.98,;.25,5,;1.01,6.34,;2.55,6.36,;3.33,5.03,;3.3,7.7,;1.03,3.67,;.28,2.34,;-5.83,-2.78,;-6.22,-1.29,;-7.07,-3.79,)|
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta counting


ACS Med Chem Lett 2: 407-412 (2011)


Article DOI: 10.1021/ml200051p
BindingDB Entry DOI: 10.7270/Q2MW2HM6
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438743
PNG
(CHEMBL2414687)
Show SMILES C[C@@H]1CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1 |r,wU:1.0,10.10,wD:13.14,(24.81,-45.4,;23.9,-44.15,;24.62,-42.79,;23.98,-41.35,;25.01,-40.18,;26.51,-40.48,;27.52,-39.33,;27.01,-37.84,;25.53,-37.59,;24.52,-38.74,;28.04,-36.67,;27.54,-35.23,;28.55,-34.08,;30.06,-34.35,;31.07,-33.19,;32.58,-33.49,;33.07,-34.94,;33.61,-32.31,;30.55,-35.81,;29.54,-36.97,;22.51,-40.98,;22.22,-39.45,;21.26,-41.89,;19.96,-41.07,;20.02,-39.52,;18.59,-41.78,;18.53,-43.33,;19.84,-44.15,;21.21,-43.43,;22.37,-44.44,)|
Show InChI InChI=1S/C22H26N4O4/c1-13-11-26(22(29)19-20(23)24-12-25-21(19)30-13)17-8-6-16(7-9-17)15-4-2-14(3-5-15)10-18(27)28/h6-9,12-15H,2-5,10-11H2,1H3,(H,27,28)(H2,23,24,25)/t13-,14-,15-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(-8.41,-1.48,;-8.4,-3.02,;-9.73,-3.79,;-9.73,-5.34,;-8.4,-6.11,;-7.06,-5.34,;-5.73,-6.38,;-4.15,-6.01,;-3.48,-4.52,;-4.27,-3.04,;-3.51,-1.7,;-1.98,-1.68,;-1.22,-.34,;-2.01,.98,;-3.56,.96,;-4.3,-.39,;-1.26,2.32,;-2.05,3.64,;-1.29,4.98,;.25,5,;1.01,6.34,;2.55,6.36,;3.33,5.03,;3.3,7.7,;1.03,3.67,;.28,2.34,;-5.83,-2.78,;-6.22,-1.29,;-7.07,-3.79,)|
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (Human))
BDBM50158278
PNG
(5-Chloro-1H-indole-2-carboxylic acid {[(1,1-dioxo-...)
Show SMILES OCCN(C1CCS(=O)(=O)CC1)C(=O)CNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C18H22ClN3O5S/c19-13-1-2-15-12(9-13)10-16(21-15)18(25)20-11-17(24)22(5-6-23)14-3-7-28(26,27)8-4-14/h1-2,9-10,14,21,23H,3-8,11H2,(H,20,25)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


Bioorg Med Chem Lett 15: 459-65 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.048
BindingDB Entry DOI: 10.7270/Q26W99K6
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438734
PNG
(CHEMBL2414751)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)NC4CCCC4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(18.45,-49.67,;18.43,-51.23,;17.08,-51.99,;17.06,-53.55,;18.41,-54.34,;19.76,-53.56,;20.96,-54.56,;22.49,-54.23,;23.17,-52.83,;22.49,-51.41,;23.5,-50.2,;25.01,-50.45,;25.99,-49.27,;25.44,-47.79,;23.94,-47.58,;22.96,-48.76,;26.44,-46.58,;25.91,-45.15,;26.89,-43.96,;28.39,-44.18,;29.39,-42.99,;30.92,-43.25,;31.46,-44.69,;31.91,-42.04,;33.43,-42.3,;34.11,-43.68,;35.64,-43.46,;35.9,-41.94,;34.54,-41.22,;28.94,-45.65,;27.95,-46.84,;20.99,-51.06,;20.67,-49.54,;19.77,-52.02,)|
Show InChI InChI=1S/C26H33N5O3/c27-24-23-25(29-16-28-24)34-14-13-31(26(23)33)21-11-9-19(10-12-21)18-7-5-17(6-8-18)15-22(32)30-20-3-1-2-4-20/h9-12,16-18,20H,1-8,13-15H2,(H,30,32)(H2,27,28,29)/t17-,18-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (Human))
BDBM50158249
PNG
(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Show SMILES CC(O)CN(C1CCCC1)C(=O)CNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H24ClN3O3/c1-12(24)11-23(15-4-2-3-5-15)18(25)10-21-19(26)17-9-13-8-14(20)6-7-16(13)22-17/h6-9,12,15,22,24H,2-5,10-11H2,1H3,(H,21,26)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


Bioorg Med Chem Lett 15: 459-65 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.048
BindingDB Entry DOI: 10.7270/Q26W99K6
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM27947
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:19.21,wD:22.25,c:12,(1.74,.99,;.97,2.32,;2.46,2.72,;-.37,1.55,;-1.7,2.32,;-3.03,1.55,;-4.37,2.32,;-4.37,3.86,;-3.03,4.63,;-3.03,6.17,;-1.7,3.86,;-.37,4.63,;.97,3.86,;2.3,4.63,;2.3,6.17,;3.63,6.94,;4.97,6.17,;4.97,4.63,;3.63,3.86,;6.19,6.75,;6.19,8.3,;7.53,9.07,;8.86,8.3,;10.19,9.07,;11.53,8.3,;12.86,9.07,;11.53,6.76,;8.86,6.75,;7.53,5.98,)|
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta counting


ACS Med Chem Lett 2: 407-412 (2011)


Article DOI: 10.1021/ml200051p
BindingDB Entry DOI: 10.7270/Q2MW2HM6
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(-8.41,-1.48,;-8.4,-3.02,;-9.73,-3.79,;-9.73,-5.34,;-8.4,-6.11,;-7.06,-5.34,;-5.73,-6.38,;-4.15,-6.01,;-3.48,-4.52,;-4.27,-3.04,;-3.51,-1.7,;-1.98,-1.68,;-1.22,-.34,;-2.01,.98,;-3.56,.96,;-4.3,-.39,;-1.26,2.32,;-2.05,3.64,;-1.29,4.98,;.25,5,;1.01,6.34,;2.55,6.36,;3.33,5.03,;3.3,7.7,;1.03,3.67,;.28,2.34,;-5.83,-2.78,;-6.22,-1.29,;-7.07,-3.79,)|
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hr...


ACS Med Chem Lett 2: 407-412 (2011)


Article DOI: 10.1021/ml200051p
BindingDB Entry DOI: 10.7270/Q2MW2HM6
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438743
PNG
(CHEMBL2414687)
Show SMILES C[C@@H]1CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1 |r,wU:1.0,10.10,wD:13.14,(24.81,-45.4,;23.9,-44.15,;24.62,-42.79,;23.98,-41.35,;25.01,-40.18,;26.51,-40.48,;27.52,-39.33,;27.01,-37.84,;25.53,-37.59,;24.52,-38.74,;28.04,-36.67,;27.54,-35.23,;28.55,-34.08,;30.06,-34.35,;31.07,-33.19,;32.58,-33.49,;33.07,-34.94,;33.61,-32.31,;30.55,-35.81,;29.54,-36.97,;22.51,-40.98,;22.22,-39.45,;21.26,-41.89,;19.96,-41.07,;20.02,-39.52,;18.59,-41.78,;18.53,-43.33,;19.84,-44.15,;21.21,-43.43,;22.37,-44.44,)|
Show InChI InChI=1S/C22H26N4O4/c1-13-11-26(22(29)19-20(23)24-12-25-21(19)30-13)17-8-6-16(7-9-17)15-4-2-14(3-5-15)10-18(27)28/h6-9,12-15H,2-5,10-11H2,1H3,(H,27,28)(H2,23,24,25)/t13-,14-,15-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(-8.41,-1.48,;-8.4,-3.02,;-9.73,-3.79,;-9.73,-5.34,;-8.4,-6.11,;-7.06,-5.34,;-5.73,-6.38,;-4.15,-6.01,;-3.48,-4.52,;-4.27,-3.04,;-3.51,-1.7,;-1.98,-1.68,;-1.22,-.34,;-2.01,.98,;-3.56,.96,;-4.3,-.39,;-1.26,2.32,;-2.05,3.64,;-1.29,4.98,;.25,5,;1.01,6.34,;2.55,6.36,;3.33,5.03,;3.3,7.7,;1.03,3.67,;.28,2.34,;-5.83,-2.78,;-6.22,-1.29,;-7.07,-3.79,)|
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438726
PNG
(CHEMBL2414684)
Show SMILES Nc1ccnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(25.66,-48.71,;25.59,-50.24,;24.22,-50.95,;24.14,-52.49,;25.45,-53.32,;26.82,-52.61,;27.98,-53.64,;29.5,-53.36,;30.23,-52,;29.61,-50.57,;30.65,-49.4,;32.14,-49.71,;33.15,-48.57,;32.66,-47.09,;31.18,-46.82,;30.16,-47.95,;33.7,-45.92,;33.22,-44.48,;34.23,-43.34,;35.72,-43.61,;36.75,-42.46,;38.25,-42.77,;39.29,-41.61,;38.74,-44.22,;36.2,-45.09,;35.19,-46.23,;28.14,-50.17,;27.87,-48.65,;26.89,-51.08,)|
Show InChI InChI=1S/C22H25N3O4/c23-18-9-10-24-21-20(18)22(28)25(11-12-29-21)17-7-5-16(6-8-17)15-3-1-14(2-4-15)13-19(26)27/h5-10,14-15H,1-4,11-13H2,(H2,23,24)(H,26,27)/t14-,15-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438735
PNG
(CHEMBL2414670)
Show SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1 |r,wU:9.12,wD:6.5,(36.55,-43.27,;35.45,-42.18,;35.71,-40.66,;34.32,-39.96,;33.22,-41.07,;31.72,-40.82,;30.73,-42.03,;29.22,-41.78,;28.26,-42.96,;28.81,-44.42,;30.3,-44.64,;31.27,-43.46,;27.82,-45.63,;26.31,-45.38,;25.34,-46.57,;25.88,-48.02,;27.38,-48.24,;28.35,-47.06,;24.9,-49.22,;25.54,-50.6,;24.91,-52.01,;23.38,-52.34,;22.18,-51.36,;20.84,-52.13,;19.5,-51.35,;19.51,-49.8,;20.86,-49.04,;20.86,-47.5,;22.19,-49.82,;23.4,-48.87,;23.07,-47.35,;33.93,-42.42,)|
Show InChI InChI=1S/C23H26N6O3/c1-14-27-19(32-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438737
PNG
(CHEMBL2414668)
Show SMILES CC(C)(O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:8.11,wD:5.4,(35.63,-43.7,;35.14,-42.24,;36.17,-41.09,;36.63,-42.63,;33.64,-41.93,;32.61,-43.1,;31.12,-42.8,;30.1,-43.94,;30.6,-45.42,;32.08,-45.69,;33.1,-44.55,;29.56,-46.59,;28.07,-46.29,;27.05,-47.44,;27.54,-48.91,;29.04,-49.19,;30.05,-48.04,;26.52,-50.06,;27.13,-51.49,;26.4,-52.84,;24.87,-53.12,;23.72,-52.1,;22.34,-52.82,;21.04,-51.99,;21.11,-50.45,;22.47,-49.73,;22.54,-48.19,;23.78,-50.56,;25.03,-49.66,;24.75,-48.13,)|
Show InChI InChI=1S/C23H30N4O3/c1-23(2,29)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)27-11-12-30-21-19(22(27)28)20(24)25-14-26-21/h7-10,14-16,29H,3-6,11-13H2,1-2H3,(H2,24,25,26)/t15-,16-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438712
PNG
(CHEMBL2414697)
Show SMILES CN(CC(O)=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:12.15,wD:9.8,(30.02,-40.47,;28.5,-40.16,;28.01,-38.69,;29.03,-37.54,;30.54,-37.84,;28.54,-36.06,;27.48,-41.32,;27.98,-42.8,;25.97,-41.01,;24.93,-42.19,;23.45,-41.92,;22.44,-43.07,;22.92,-44.51,;24.42,-44.82,;25.44,-43.67,;21.88,-45.69,;22.38,-47.18,;21.37,-48.32,;19.87,-48.02,;19.39,-46.57,;20.4,-45.43,;18.83,-49.2,;19.46,-50.64,;18.73,-52,;17.2,-52.28,;16.04,-51.26,;14.67,-51.98,;13.35,-51.15,;13.43,-49.6,;14.79,-48.88,;14.86,-47.34,;16.1,-49.72,;17.35,-48.8,;17.07,-47.28,)|
Show InChI InChI=1S/C24H29N5O5/c1-28(13-20(31)32)19(30)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-34-23-21(24(29)33)22(25)26-14-27-23/h6-9,14-16H,2-5,10-13H2,1H3,(H,31,32)(H2,25,26,27)/t15-,16-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (Human))
BDBM50158254
PNG
(5-Chloro-1H-indole-2-carboxylic acid [(cyanomethyl...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NCC(=O)N(CC#N)C1CCCC1
Show InChI InChI=1S/C18H19ClN4O2/c19-13-5-6-15-12(9-13)10-16(22-15)18(25)21-11-17(24)23(8-7-20)14-3-1-2-4-14/h5-6,9-10,14,22H,1-4,8,11H2,(H,21,25)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


Bioorg Med Chem Lett 15: 459-65 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.048
BindingDB Entry DOI: 10.7270/Q26W99K6
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (Human))
BDBM50158255
PNG
(5-Chloro-1H-indole-2-carboxylic acid {[cycloheptyl...)
Show SMILES OCCN(C1CCCCCC1)C(=O)CNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C20H26ClN3O3/c21-15-7-8-17-14(11-15)12-18(23-17)20(27)22-13-19(26)24(9-10-25)16-5-3-1-2-4-6-16/h7-8,11-12,16,23,25H,1-6,9-10,13H2,(H,22,27)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


Bioorg Med Chem Lett 15: 459-65 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.048
BindingDB Entry DOI: 10.7270/Q26W99K6
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 304 total )  |  Next  |  Last  >>
Jump to: