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Compile Data Set for Download or QSAR

Found 76 hits with Last Name = 'van der meer' and Initial = 't'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361010
PNG
(CHEMBL1935572)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C17H19N5S/c1-21-5-7-22(8-6-21)16-14-3-2-12(13-4-9-23-11-13)10-15(14)19-17(18)20-16/h2-4,9-11H,5-8H2,1H3,(H2,18,19,20)
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3n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361010
PNG
(CHEMBL1935572)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C17H19N5S/c1-21-5-7-22(8-6-21)16-14-3-2-12(13-4-9-23-11-13)10-15(14)19-17(18)20-16/h2-4,9-11H,5-8H2,1H3,(H2,18,19,20)
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4n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361035
PNG
(CHEMBL1935571)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C17H19N5O/c1-21-5-7-22(8-6-21)16-14-3-2-12(13-4-9-23-11-13)10-15(14)19-17(18)20-16/h2-4,9-11H,5-8H2,1H3,(H2,18,19,20)
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4n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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4n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361015
PNG
(CHEMBL592379)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C21H25ClN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25)
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4n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM26396
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...)
Show SMILES N[C@@H]1CCN(C1)c1nc(N)nc-2c1CCCc1ccccc-21 |r|
Show InChI InChI=1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1
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5n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361011
PNG
(CHEMBL1935573)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccco1
Show InChI InChI=1S/C17H19N5O/c1-21-6-8-22(9-7-21)16-13-5-4-12(15-3-2-10-23-15)11-14(13)19-17(18)20-16/h2-5,10-11H,6-9H2,1H3,(H2,18,19,20)
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5n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361011
PNG
(CHEMBL1935573)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccco1
Show InChI InChI=1S/C17H19N5O/c1-21-6-8-22(9-7-21)16-13-5-4-12(15-3-2-10-23-15)11-14(13)19-17(18)20-16/h2-5,10-11H,6-9H2,1H3,(H2,18,19,20)
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5n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361035
PNG
(CHEMBL1935571)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C17H19N5O/c1-21-5-7-22(8-6-21)16-14-3-2-12(13-4-9-23-11-13)10-15(14)19-17(18)20-16/h2-4,9-11H,5-8H2,1H3,(H2,18,19,20)
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6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361014
PNG
(CHEMBL260549 | VUF-10214)
Show SMILES CN1CCN(CC1)c1nc2cc(Cl)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C13H14Cl2N4O/c1-18-2-4-19(5-3-18)12-13(20)17-11-7-9(15)8(14)6-10(11)16-12/h6-7H,2-5H2,1H3,(H,17,20)
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6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361013
PNG
(CHEMBL1935450)
Show SMILES Nc1nc(N2CCNCC2)c2CCC3=C([C@H]4CCCC[C@H]4O3)c2n1 |r,t:14|
Show InChI InChI=1S/C18H25N5O/c19-18-21-16-12(17(22-18)23-9-7-20-8-10-23)5-6-14-15(16)11-3-1-2-4-13(11)24-14/h11,13,20H,1-10H2,(H2,19,21,22)/t11-,13+/m0/s1
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6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to human histamine H4 receptor


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50191289
PNG
(7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Oc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-12-13(19)6-7-15(17)20-18/h2-7,12H,8-11H2,1H3
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6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361012
PNG
(CHEMBL1935574)
Show SMILES Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1
Show InChI InChI=1S/C16H17N5O/c17-16-19-13-10-11(14-2-1-9-22-14)3-4-12(13)15(20-16)21-7-5-18-6-8-21/h1-4,9-10,18H,5-8H2,(H2,17,19,20)
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7n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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9n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50433359
PNG
(CHEMBL2376804)
Show SMILES CNC1CN(C1)c1nc(N)nc2cc(cnc12)C1CC1
Show InChI InChI=1S/C14H18N6/c1-16-10-6-20(7-10)13-12-11(18-14(15)19-13)4-9(5-17-12)8-2-3-8/h4-5,8,10,16H,2-3,6-7H2,1H3,(H2,15,18,19)
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15n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to mouse histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361034
PNG
(CHEMBL1935570)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1cccc(c1)C(C)=O
Show InChI InChI=1S/C21H23N5O/c1-14(27)15-4-3-5-16(12-15)17-6-7-18-19(13-17)23-21(22)24-20(18)26-10-8-25(2)9-11-26/h3-7,12-13H,8-11H2,1-2H3,(H2,22,23,24)
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15n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361012
PNG
(CHEMBL1935574)
Show SMILES Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1
Show InChI InChI=1S/C16H17N5O/c17-16-19-13-10-11(14-2-1-9-22-14)3-4-12(13)15(20-16)21-7-5-18-6-8-21/h1-4,9-10,18H,5-8H2,(H2,17,19,20)
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16n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361029
PNG
(CHEMBL1935565)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(Br)ccc12
Show InChI InChI=1S/C13H16BrN5/c1-18-4-6-19(7-5-18)12-10-3-2-9(14)8-11(10)16-13(15)17-12/h2-3,8H,4-7H2,1H3,(H2,15,16,17)
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17n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361030
PNG
(CHEMBL1935566)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C19H21N5/c1-23-9-11-24(12-10-23)18-16-8-7-15(14-5-3-2-4-6-14)13-17(16)21-19(20)22-18/h2-8,13H,9-12H2,1H3,(H2,20,21,22)
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19n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50433358
PNG
(CHEMBL2376803)
Show SMILES CNC1CN(C1)c1nc(N)nc2cc(cnc12)C1CCCC1
Show InChI InChI=1S/C16H22N6/c1-18-12-8-22(9-12)15-14-13(20-16(17)21-15)6-11(7-19-14)10-4-2-3-5-10/h6-7,10,12,18H,2-5,8-9H2,1H3,(H2,17,20,21)
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20n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to mouse histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50361012
PNG
(CHEMBL1935574)
Show SMILES Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1
Show InChI InChI=1S/C16H17N5O/c17-16-19-13-10-11(14-2-1-9-22-14)3-4-12(13)15(20-16)21-7-5-18-6-8-21/h1-4,9-10,18H,5-8H2,(H2,17,19,20)
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23n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from mouse H4R


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361028
PNG
(CHEMBL1935564)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(C)ccc12
Show InChI InChI=1S/C14H19N5/c1-10-3-4-11-12(9-10)16-14(15)17-13(11)19-7-5-18(2)6-8-19/h3-4,9H,5-8H2,1-2H3,(H2,15,16,17)
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24n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50179335
PNG
((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Show SMILES CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16)
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26n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50433358
PNG
(CHEMBL2376803)
Show SMILES CNC1CN(C1)c1nc(N)nc2cc(cnc12)C1CCCC1
Show InChI InChI=1S/C16H22N6/c1-18-12-8-22(9-12)15-14-13(20-16(17)21-15)6-11(7-19-14)10-4-2-3-5-10/h6-7,10,12,18H,2-5,8-9H2,1H3,(H2,17,20,21)
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28n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361032
PNG
(CHEMBL1935568)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H20N6/c1-25-8-10-26(11-9-25)19-17-7-6-16(12-18(17)23-20(22)24-19)15-4-2-14(13-21)3-5-15/h2-7,12H,8-11H2,1H3,(H2,22,23,24)
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29n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50433359
PNG
(CHEMBL2376804)
Show SMILES CNC1CN(C1)c1nc(N)nc2cc(cnc12)C1CC1
Show InChI InChI=1S/C14H18N6/c1-16-10-6-20(7-10)13-12-11(18-14(15)19-13)4-9(5-17-12)8-2-3-8/h4-5,8,10,16H,2-3,6-7H2,1H3,(H2,15,18,19)
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30n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361016
PNG
(CHEMBL501882 | US8796297, 13)
Show SMILES CN1CCN(CC1)c1ccnc(N)n1
Show InChI InChI=1S/C9H15N5/c1-13-4-6-14(7-5-13)8-2-3-11-9(10)12-8/h2-3H,4-7H2,1H3,(H2,10,11,12)
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31n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361021
PNG
(CHEMBL1935557)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c(cccc12)-c1ccccc1
Show InChI InChI=1S/C19H21N5/c1-23-10-12-24(13-11-23)18-16-9-5-8-15(14-6-3-2-4-7-14)17(16)21-19(20)22-18/h2-9H,10-13H2,1H3,(H2,20,21,22)
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32n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361018
PNG
(CHEMBL281590)
Show SMILES CN1CCN(CC1)c1nc(N)nc2ccccc12
Show InChI InChI=1S/C13H17N5/c1-17-6-8-18(9-7-17)12-10-4-2-3-5-11(10)15-13(14)16-12/h2-5H,6-9H2,1H3,(H2,14,15,16)
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32n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50433357
PNG
(CHEMBL2376800)
Show SMILES CCc1cnc2c(nc(N)nc2c1)N1CC(C1)NC
Show InChI InChI=1S/C13H18N6/c1-3-8-4-10-11(16-5-8)12(18-13(14)17-10)19-6-9(7-19)15-2/h4-5,9,15H,3,6-7H2,1-2H3,(H2,14,17,18)
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50n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to mouse histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361033
PNG
(CHEMBL1935569)
Show SMILES COc1ccc(cc1)-c1ccc2c(nc(N)nc2c1)N1CCN(C)CC1
Show InChI InChI=1S/C20H23N5O/c1-24-9-11-25(12-10-24)19-17-8-5-15(13-18(17)22-20(21)23-19)14-3-6-16(26-2)7-4-14/h3-8,13H,9-12H2,1-2H3,(H2,21,22,23)
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55n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50356884
PNG
(CHEMBL1915540)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(N)n1 |r|
Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
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55n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to mouse histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50356884
PNG
(CHEMBL1915540)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(N)n1 |r|
Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
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55n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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63n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS binding


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50361010
PNG
(CHEMBL1935572)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C17H19N5S/c1-21-5-7-22(8-6-21)16-14-3-2-12(13-4-9-23-11-13)10-15(14)19-17(18)20-16/h2-4,9-11H,5-8H2,1H3,(H2,18,19,20)
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63n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50433357
PNG
(CHEMBL2376800)
Show SMILES CCc1cnc2c(nc(N)nc2c1)N1CC(C1)NC
Show InChI InChI=1S/C13H18N6/c1-3-8-4-10-11(16-5-8)12(18-13(14)17-10)19-6-9(7-19)15-2/h4-5,9,15H,3,6-7H2,1-2H3,(H2,14,17,18)
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71n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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79n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50433356
PNG
(CHEMBL2376801)
Show SMILES CCc1cnc2c(nc(N)nc2c1)N1CC[C@H](C1)NC |r|
Show InChI InChI=1S/C14H20N6/c1-3-9-6-11-12(17-7-9)13(19-14(15)18-11)20-5-4-10(8-20)16-2/h6-7,10,16H,3-5,8H2,1-2H3,(H2,15,18,19)/t10-/m1/s1
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85n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to mouse histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361031
PNG
(CHEMBL1935567)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1c(C)cccc1C
Show InChI InChI=1S/C21H25N5/c1-14-5-4-6-15(2)19(14)16-7-8-17-18(13-16)23-21(22)24-20(17)26-11-9-25(3)10-12-26/h4-8,13H,9-12H2,1-3H3,(H2,22,23,24)
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90n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361019
PNG
(CHEMBL1935555)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c(C)cccc12
Show InChI InChI=1S/C14H19N5/c1-10-4-3-5-11-12(10)16-14(15)17-13(11)19-8-6-18(2)7-9-19/h3-5H,6-9H2,1-2H3,(H2,15,16,17)
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91n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50361011
PNG
(CHEMBL1935573)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccco1
Show InChI InChI=1S/C17H19N5O/c1-21-6-8-22(9-7-21)16-13-5-4-12(15-3-2-10-23-15)11-14(13)19-17(18)20-16/h2-5,10-11H,6-9H2,1H3,(H2,18,19,20)
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98n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361026
PNG
(CHEMBL1935562)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c(cccc12)-c1ccoc1
Show InChI InChI=1S/C17H19N5O/c1-21-6-8-22(9-7-21)16-14-4-2-3-13(12-5-10-23-11-12)15(14)19-17(18)20-16/h2-5,10-11H,6-9H2,1H3,(H2,18,19,20)
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109n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361020
PNG
(CHEMBL1935556)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c(Br)cccc12
Show InChI InChI=1S/C13H16BrN5/c1-18-5-7-19(8-6-18)12-9-3-2-4-10(14)11(9)16-13(15)17-12/h2-4H,5-8H2,1H3,(H2,15,16,17)
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111n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50433356
PNG
(CHEMBL2376801)
Show SMILES CCc1cnc2c(nc(N)nc2c1)N1CC[C@H](C1)NC |r|
Show InChI InChI=1S/C14H20N6/c1-3-9-6-11-12(17-7-9)13(19-14(15)18-11)20-5-4-10(8-20)16-2/h6-7,10,16H,3-5,8H2,1-2H3,(H2,15,18,19)/t10-/m1/s1
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138n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


Bioorg Med Chem Lett 23: 2663-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50361012
PNG
(CHEMBL1935574)
Show SMILES Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1
Show InChI InChI=1S/C16H17N5O/c17-16-19-13-10-11(14-2-1-9-22-14)3-4-12(13)15(20-16)21-7-5-18-6-8-21/h1-4,9-10,18H,5-8H2,(H2,17,19,20)
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174n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from rat H4R


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50361035
PNG
(CHEMBL1935571)
Show SMILES CN1CCN(CC1)c1nc(N)nc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C17H19N5O/c1-21-5-7-22(8-6-21)16-14-3-2-12(13-4-9-23-11-13)10-15(14)19-17(18)20-16/h2-4,9-11H,5-8H2,1H3,(H2,18,19,20)
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188n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H3 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50361022
PNG
(CHEMBL1935558)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c(cccc12)-c1c(C)cccc1C |(-3.46,5.07,;-3.46,3.53,;-2.13,2.76,;-2.13,1.23,;-3.46,.46,;-4.8,1.22,;-4.8,2.76,;-3.46,-1.07,;-2.12,-1.84,;-2.12,-3.39,;-.78,-4.15,;-3.45,-4.16,;-4.79,-3.39,;-6.11,-4.15,;-7.45,-3.39,;-7.45,-1.84,;-6.11,-1.08,;-4.78,-1.85,;-6.11,-5.69,;-4.78,-6.45,;-3.45,-5.68,;-4.77,-7.99,;-6.11,-8.77,;-7.45,-8,;-7.45,-6.46,;-8.78,-5.69,)|
Show InChI InChI=1S/C21H25N5/c1-14-6-4-7-15(2)18(14)16-8-5-9-17-19(16)23-21(22)24-20(17)26-12-10-25(3)11-13-26/h4-9H,10-13H2,1-3H3,(H2,22,23,24)
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221n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50257496
PNG
(4-(4-methylpiperazin-1-yl)quinazoline | CHEMBL5069...)
Show SMILES CN1CCN(CC1)c1ncnc2ccccc12
Show InChI InChI=1S/C13H16N4/c1-16-6-8-17(9-7-16)13-11-4-2-3-5-12(11)14-10-15-13/h2-5,10H,6-9H2,1H3
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328n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes


Bioorg Med Chem Lett 22: 461-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.104
BindingDB Entry DOI: 10.7270/Q2D79BT2
More data for this
Ligand-Target Pair
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