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Compile Data Set for Download or QSAR

Found 24 hits of ic50 data for polymerid = 10091,49000907   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234579
PNG
(US9353093, 1)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-16-6-5-8-20(14-16)27-24(30)26-19-12-10-17(11-13-19)22-15-18-7-3-4-9-21(18)28(22)23(25)29/h3-15H,2H2,1H3,(H2,25,29)(H2,26,27,30)
PDB

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US Patent
n/an/a 10n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234580
PNG
(US9353093, 2)
Show SMILES COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1
Show InChI InChI=1S/C25H22N4O4/c1-15-4-3-5-20(12-15)28-25(32)27-19-10-8-16(9-11-19)21-13-17-6-7-18(23(30)33-2)14-22(17)29(21)24(26)31/h3-14H,1-2H3,(H2,26,31)(H2,27,28,32)
PDB

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n/an/a 10n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234589
PNG
(US9353093, 11)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)cc1
Show InChI InChI=1S/C23H20N4O2/c1-15-6-10-18(11-7-15)25-23(29)26-19-12-8-16(9-13-19)21-14-17-4-2-3-5-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
PDB

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n/an/a 11n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234586
PNG
(US9353093, 8)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O3/c1-30-19-7-4-6-18(14-19)26-23(29)25-17-11-9-15(10-12-17)21-13-16-5-2-3-8-20(16)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
PDB

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n/an/a 12n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234581
PNG
(US9353093, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-15-5-4-7-19(13-15)26-23(29)25-18-11-9-16(10-12-18)21-14-17-6-2-3-8-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
PDB

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n/an/a 14n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234582
PNG
(US9353093, 4)
Show SMILES CC(C)c1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C25H24N4O2/c1-16(2)18-7-5-8-21(14-18)28-25(31)27-20-12-10-17(11-13-20)23-15-19-6-3-4-9-22(19)29(23)24(26)30/h3-16H,1-2H3,(H2,26,30)(H2,27,28,31)
PDB

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n/an/a 16n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234583
PNG
(US9353093, 5)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H16ClFN4O2/c23-17-12-16(9-10-18(17)24)27-22(30)26-15-7-5-13(6-8-15)20-11-14-3-1-2-4-19(14)28(20)21(25)29/h1-12H,(H2,25,29)(H2,26,27,30)
PDB

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n/an/a 19n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234585
PNG
(US9353093, 7)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-11-18(24)19(12-14)27-23(30)26-17-9-7-15(8-10-17)21-13-16-4-2-3-5-20(16)28(21)22(25)29/h2-13H,1H3,(H2,25,29)(H2,26,27,30)
PDB

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n/an/a 20n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234588
PNG
(US9353093, 10)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C22H18N4O2/c23-21(27)26-19-9-5-4-6-16(19)14-20(26)15-10-12-18(13-11-15)25-22(28)24-17-7-2-1-3-8-17/h1-14H,(H2,23,27)(H2,24,25,28)
PDB

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n/an/a 23n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234584
PNG
(US9353093, 6)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-5-3-6-18(13-16)29-22(32)28-17-10-8-14(9-11-17)20-12-15-4-1-2-7-19(15)30(20)21(27)31/h1-13H,(H2,27,31)(H2,28,29,32)
PDB

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n/an/a 28n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234587
PNG
(US9353093, 9)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H16F4N4O2/c24-17-10-7-15(23(25,26)27)12-18(17)30-22(33)29-16-8-5-13(6-9-16)20-11-14-3-1-2-4-19(14)31(20)21(28)32/h1-12H,(H2,28,32)(H2,29,30,33)
PDB

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n/an/a 55n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234590
PNG
(US9353093, 12)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cc2ccccc2n1C(N)=O
Show InChI InChI=1S/C23H20N4O2/c1-15-6-2-4-8-19(15)26-23(29)25-18-12-10-16(11-13-18)21-14-17-7-3-5-9-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
PDB

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n/an/a 118n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM99471
PNG
(US8497274, 32)
Show SMILES Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37)
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Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of PDGFR beta (unknown origin) using biotinylated poly-Glu-Tyr (4:1) as substrate preincubated for 5 mins measured after 12 hrs


J Med Chem 56: 6478-94 (2013)


Article DOI: 10.1021/jm400778d
BindingDB Entry DOI: 10.7270/Q2W95BPS
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234602
PNG
(US9353093, 31)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H14ClF3N4O2S/c22-15-6-5-12(8-14(15)21(23,24)25)27-20(31)28-13-9-18(32-10-13)17-7-11-3-1-2-4-16(11)29(17)19(26)30/h1-10H,(H2,26,30)(H2,27,28,31)
PDB

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n/an/a 151n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234598
PNG
(US9353093, 27)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H15F3N4O2S/c22-21(23,24)13-5-3-6-14(9-13)26-20(30)27-15-10-18(31-11-15)17-8-12-4-1-2-7-16(12)28(17)19(25)29/h1-11H,(H2,25,29)(H2,26,27,30)
PDB

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n/an/a 152n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234599
PNG
(US9353093, 28)
Show SMILES CCc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C22H20N4O2S/c1-2-14-6-5-8-16(10-14)24-22(28)25-17-12-20(29-13-17)19-11-15-7-3-4-9-18(15)26(19)21(23)27/h3-13H,2H2,1H3,(H2,23,27)(H2,24,25,28)
PDB

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n/an/a 264n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234597
PNG
(US9353093, 26)
Show SMILES Cc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C21H18N4O2S/c1-13-5-4-7-15(9-13)23-21(27)24-16-11-19(28-12-16)18-10-14-6-2-3-8-17(14)25(18)20(22)26/h2-12H,1H3,(H2,22,26)(H2,23,24,27)
PDB

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n/an/a 1.14E+3n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234595
PNG
(US9353093, 23)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-9-10-18(24)19(11-14)27-23(30)26-17-7-4-6-15(12-17)21-13-16-5-2-3-8-20(16)28(21)22(25)29/h2-13H,1H3,(H2,25,29)(H2,26,27,30)
PDB

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n/an/a 3.03E+3n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234593
PNG
(US9353093, 21)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-7-4-9-18(13-16)29-22(32)28-17-8-3-6-14(11-17)20-12-15-5-1-2-10-19(15)30(20)21(27)31/h1-13H,(H2,27,31)(H2,28,29,32)
PDB

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n/an/a 3.31E+3n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234600
PNG
(US9353093, 29)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C21H17FN4O2S/c1-12-6-7-15(22)16(8-12)25-21(28)24-14-10-19(29-11-14)18-9-13-4-2-3-5-17(13)26(18)20(23)27/h2-11H,1H3,(H2,23,27)(H2,24,25,28)
PDB

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n/an/a 4.61E+3n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234594
PNG
(US9353093, 22)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cccc(NC(=O)Nc2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H16ClFN4O2/c23-17-12-16(8-9-18(17)24)27-22(30)26-15-6-3-5-13(10-15)20-11-14-4-1-2-7-19(14)28(20)21(25)29/h1-12H,(H2,25,29)(H2,26,27,30)
PDB

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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234601
PNG
(US9353093, 30)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(F)c(Cl)c2)cs1
Show InChI InChI=1S/C20H14ClFN4O2S/c21-14-8-12(5-6-15(14)22)24-20(28)25-13-9-18(29-10-13)17-7-11-3-1-2-4-16(11)26(17)19(23)27/h1-10H,(H2,23,27)(H2,24,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234603
PNG
(US9353093, 32)
Show SMILES Cc1ccoc1C(=O)Nc1csc(c1)-c1cc2ccccc2n1C(N)=O
Show InChI InChI=1S/C19H15N3O3S/c1-11-6-7-25-17(11)18(23)21-13-9-16(26-10-13)15-8-12-4-2-3-5-14(12)22(15)19(20)24/h2-10H,1H3,(H2,20,24)(H,21,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B


(Homo sapiens (Human))
BDBM234604
PNG
(US9353093, 33)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1csc(c1)-c1cc2ccccc2n1C(N)=O
Show InChI InChI=1S/C21H16FN3O2S/c1-12-6-7-16(22)15(8-12)20(26)24-14-10-19(28-11-14)18-9-13-4-2-3-5-17(13)25(18)21(23)27/h2-11H,1H3,(H2,23,27)(H,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair