Found 4437 hits of ec50 for UniProtKB: Q13627 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643613
(US20240002391, Compound 771)Show SMILES COc1nc(N[C@H]2CCN(C[C@H]2F)C(C)=O)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643571
(US20240002391, Compound 660)Show SMILES COc1nc(N[C@@H]2CN(C[C@@H]2F)C(C)=O)nn2ccc(-c3ccc4nnn(CCF)c4c3)c12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | <0.200 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643591
(US20240002391, Compound 719)Show SMILES COc1nc(N[C@H]2CC[C@H](O)CC2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r,wU:9.9,wD:6.5,(-.08,.02,;-1.41,-.77,;-1.4,-2.31,;-.04,-3.19,;-.04,-4.73,;1.29,-5.5,;2.63,-4.73,;3.96,-5.5,;5.3,-4.73,;5.3,-3.19,;6.63,-2.42,;3.96,-2.42,;2.63,-3.19,;-1.37,-5.5,;-2.71,-4.73,;-4.17,-5.21,;-5.08,-3.96,;-4.17,-2.72,;-4.65,-1.25,;-6.15,-.93,;-6.63,.53,;-5.6,1.68,;-6.07,3.14,;-5.04,4.29,;-4.09,1.36,;-3.32,2.69,;-1.79,2.85,;-1.16,4.26,;-2.07,5.5,;.37,4.42,;-3.62,-.11,;-2.71,-3.19,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643623
(US20240002391, Compound 798)Show SMILES COc1nc(NC23CCC(O)(CC2)C3)nn2ccc(-c3ccc4nnn(CC(F)F)c4c3)c12 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643602
(US20240002391, Compound 750)Show SMILES COc1nc(NC2CCN(CC2)C2COC2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293423
(US10106527, Compound 461 | US10106527, Compound 9 ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1 Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2SJ1QR6 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385213
(US10287267, Compound 452 | US10508099, Compound 45...)Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive... |
US Patent US10556885 (2020)
BindingDB Entry DOI: 10.7270/Q2ZW1P9Z |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385213
(US10287267, Compound 452 | US10508099, Compound 45...)Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RF5Z63 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293423
(US10106527, Compound 461 | US10106527, Compound 9 ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1 Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2JW8JR2 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643394
(US20240002391, Compound 206)Show SMILES COc1nc(N[C@H]2C[C@@](C)(C2)NC(C)=O)nn2ccc(-c3ccc4nnn(C)c4c3)c12 |r,wU:8.11,wD:6.5,8.8,(-3.65,.72,;-2.32,-.05,;-2.32,-1.59,;-.98,-2.36,;-.98,-3.9,;.35,-4.67,;1.69,-3.9,;3.17,-4.3,;3.57,-2.81,;3.57,-1.27,;2.08,-2.41,;4.91,-2.04,;6.24,-2.81,;7.57,-2.04,;6.24,-4.35,;-2.32,-4.67,;-3.65,-3.9,;-5.11,-4.37,;-6.02,-3.13,;-5.11,-1.88,;-5.59,-.42,;-7.1,-.1,;-7.57,1.37,;-6.54,2.51,;-6.7,4.04,;-5.3,4.67,;-4.27,3.52,;-2.73,3.69,;-5.04,2.19,;-4.56,.73,;-3.65,-2.36,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643423
(US20240002391, Compound 257)Show SMILES COc1nc(N[C@H]2CC[C@](C)(O)CC2)nn2ccc(-c3cnc4nccn4c3)c12 |r,wU:9.10,wD:6.5,9.9,(-2.71,.72,;-1.37,-.05,;-1.37,-1.59,;-.04,-2.36,;-.04,-3.9,;1.29,-4.67,;2.63,-3.9,;3.96,-4.67,;5.3,-3.9,;5.3,-2.36,;5.3,-.82,;6.63,-1.59,;3.96,-1.59,;2.63,-2.36,;-1.37,-4.67,;-2.71,-3.9,;-4.17,-4.37,;-5.08,-3.13,;-4.17,-1.88,;-4.65,-.42,;-6.15,-.1,;-6.63,1.37,;-5.6,2.51,;-5.76,4.04,;-4.35,4.67,;-3.32,3.52,;-4.09,2.19,;-3.62,.73,;-2.71,-2.36,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643610
(US20240002391, Compound 764)Show SMILES COc1nc(N[C@H]2CCN(C[C@H]2F)C2(C)COC2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643637
(US20240002391, Compound 905)Show SMILES COc1nc(N[C@H]2C[C@](C)(C2)NC(C)=O)nn2ccc(-c3ccc4nnn(CC(F)(F)F)c4c3)c12 |r,wU:8.8,wD:6.5,8.11,(-3.61,-.19,;-2.28,-.96,;-2.28,-2.5,;-.95,-3.27,;-.95,-4.81,;.4,-5.56,;1.72,-4.78,;3.21,-5.16,;3.59,-3.66,;3.59,-2.12,;2.1,-3.28,;4.92,-2.88,;6.26,-3.63,;7.58,-2.84,;6.26,-5.17,;-2.28,-5.58,;-3.61,-4.81,;-5.08,-5.28,;-5.98,-4.04,;-5.08,-2.79,;-5.57,-1.33,;-7.09,-1.03,;-7.58,.42,;-6.57,1.58,;-6.75,3.11,;-5.35,3.76,;-4.31,2.63,;-2.78,2.81,;-2.17,4.23,;-1.56,5.64,;-.76,3.62,;-3.59,4.83,;-5.06,1.28,;-4.56,-.17,;-3.61,-3.27,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643658
(US20240002391, Compound 948)Show SMILES COc1nc(NC2CCC(C)(CC2)C#N)nn2ccc(-c3cnc4nccn4c3)c12 |(-1.95,-5.27,;-.62,-4.5,;-.62,-2.96,;.71,-2.19,;.71,-.65,;2.05,.12,;2.05,1.66,;.71,2.43,;.71,3.97,;2.05,4.74,;2.77,6.1,;3.38,3.97,;3.38,2.43,;1.32,6.1,;.6,7.46,;-.62,.12,;-1.95,-.65,;-3.42,-.17,;-4.32,-1.42,;-3.42,-2.67,;-3.9,-4.13,;-2.87,-5.28,;-3.34,-6.74,;-4.85,-7.06,;-5.62,-8.39,;-7.12,-8.07,;-7.28,-6.54,;-5.88,-5.92,;-5.4,-4.45,;-1.95,-2.19,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293423
(US10106527, Compound 461 | US10106527, Compound 9 ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1 Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | 25 |
Samumed, LLC
US Patent
| Assay Description Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ... |
US Patent US10106527 (2018)
BindingDB Entry DOI: 10.7270/Q2PN97Q3 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385213
(US10287267, Compound 452 | US10508099, Compound 45...)Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2MS3W3C |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293423
(US10106527, Compound 461 | US10106527, Compound 9 ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1 Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis... |
Bioorg Med Chem Lett 17: 4442-6 (2007)
BindingDB Entry DOI: 10.7270/Q2862JRD |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385213
(US10287267, Compound 452 | US10508099, Compound 45...)Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... |
US Patent US10508099 (2019)
BindingDB Entry DOI: 10.7270/Q2DJ5J0C |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293423
(US10106527, Compound 461 | US10106527, Compound 9 ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1 Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
US Patent US10544128 (2020)
BindingDB Entry DOI: 10.7270/Q2H134DS |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385213
(US10287267, Compound 452 | US10508099, Compound 45...)Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25X2DVD |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643667
(US20240002391, Compound 1038)Show SMILES CNC(=O)[C@@]1(C)C[C@@H](C1)Nc1nc(OC)c2c(ccn2n1)-c1ccc2ncccc2c1 |r,wU:4.3,wD:7.9,4.4,(7.57,-2.27,;6.24,-3.04,;4.91,-2.27,;4.9,-.73,;3.57,-3.04,;3.57,-1.5,;3.17,-4.52,;1.69,-4.12,;2.08,-2.64,;.35,-4.89,;-.98,-4.12,;-.98,-2.58,;-2.32,-1.81,;-2.32,-.27,;-3.65,.5,;-3.65,-2.58,;-5.11,-2.11,;-6.02,-3.35,;-5.11,-4.6,;-3.65,-4.12,;-2.32,-4.89,;-5.59,-.64,;-7.1,-.32,;-7.57,1.14,;-6.54,2.29,;-7.02,3.75,;-5.99,4.89,;-4.48,4.57,;-4.01,3.11,;-5.04,1.97,;-4.56,.5,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643701
(US20240002391, Compound 1139)Show SMILES COc1nc(N[C@H]2CC[C@](C)(O)CC2)nn2ccc(-c3ccc4ncn(CC(F)F)c4c3)c12 |r,wU:9.10,wD:6.5,9.9,(-2.71,-.11,;-1.37,-.88,;-1.37,-2.42,;-.04,-3.19,;-.04,-4.73,;1.29,-5.5,;2.63,-4.73,;3.96,-5.5,;5.3,-4.73,;5.3,-3.19,;5.3,-1.65,;6.63,-2.42,;3.96,-2.42,;2.63,-3.19,;-1.37,-5.5,;-2.71,-4.73,;-4.17,-5.21,;-5.08,-3.96,;-4.17,-2.72,;-4.65,-1.25,;-6.15,-.93,;-6.63,.53,;-5.6,1.68,;-5.76,3.21,;-4.35,3.84,;-3.32,2.69,;-1.79,2.85,;-1.18,4.27,;-2.11,5.5,;.34,4.45,;-4.09,1.36,;-3.62,-.11,;-2.71,-3.19,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643396
(US20240002391, Compound 208)Show SMILES COCC(=O)N[C@@]1(C)C[C@@H](C1)Nc1nc(OC)c2c(ccn2n1)-c1ccc2nnn(C)c2c1 |r,wU:6.5,wD:9.11,6.6,(8.91,-2.04,;7.57,-2.81,;6.24,-2.04,;4.91,-2.81,;4.91,-4.35,;3.57,-2.04,;2.24,-2.81,;2.24,-1.27,;1.84,-4.3,;.35,-3.9,;.75,-2.41,;-.98,-4.67,;-2.32,-3.9,;-2.32,-2.36,;-3.65,-1.59,;-3.65,-.05,;-4.98,.72,;-4.98,-2.36,;-6.45,-1.88,;-7.35,-3.13,;-6.45,-4.37,;-4.98,-3.9,;-3.65,-4.67,;-6.92,-.42,;-8.43,-.1,;-8.91,1.37,;-7.88,2.51,;-8.04,4.04,;-6.63,4.67,;-5.6,3.52,;-4.07,3.69,;-6.37,2.19,;-5.89,.73,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643619
(US20240002391, Compound 785)Show SMILES COc1nc(N[C@@H]2CCN(CC2(F)F)C2COC2)nn2ccc(-c3ccc4nnn(CC(F)F)c4c3)c12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643588
(US20240002391, Compound 711)Show SMILES COc1nc(N[C@H]2C[C@](C)(O)C2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r,wU:8.9,wD:6.5,8.8,(.31,.02,;-1.02,-.77,;-1.01,-2.31,;.35,-3.19,;.35,-4.73,;1.69,-5.5,;3.02,-4.73,;4.51,-5.13,;4.9,-3.64,;4.9,-2.1,;6.24,-2.87,;3.42,-3.25,;-.98,-5.5,;-2.32,-4.73,;-3.78,-5.21,;-4.69,-3.96,;-3.78,-2.72,;-4.26,-1.25,;-5.76,-.93,;-6.24,.53,;-5.21,1.68,;-5.68,3.14,;-4.65,4.29,;-3.7,1.36,;-2.93,2.69,;-1.4,2.85,;-.77,4.26,;-1.68,5.5,;.76,4.42,;-3.23,-.11,;-2.32,-3.19,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643590
(US20240002391, Compound 718)Show SMILES COc1nc(N[C@@H]2CC[C@H](O)CC2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r,wD:6.5,9.9,(-.08,.02,;-1.41,-.77,;-1.4,-2.31,;-.04,-3.19,;-.04,-4.73,;1.29,-5.5,;2.63,-4.73,;2.63,-3.19,;3.96,-2.42,;5.3,-3.19,;6.63,-2.42,;5.3,-4.73,;3.96,-5.5,;-1.37,-5.5,;-2.71,-4.73,;-4.17,-5.21,;-5.08,-3.96,;-4.17,-2.72,;-4.65,-1.25,;-6.15,-.93,;-6.63,.53,;-5.6,1.68,;-6.07,3.14,;-5.04,4.29,;-4.09,1.36,;-3.32,2.69,;-1.79,2.85,;-1.16,4.26,;-2.07,5.5,;.37,4.42,;-3.62,-.11,;-2.71,-3.19,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643616
(US20240002391, Compound 776)Show SMILES COc1nc(N[C@H]2CCN(C[C@H]2F)C(=O)C2(CC2)C#N)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643415
(US20240002391, Compound 236)Show SMILES CO[C@@H]1C[C@@H](C1)Nc1nc(OC)c2c(ccn2n1)-c1cnc2nccn2c1 |r,wD:4.6,2.1,(6.31,-.46,;6.31,-2,;4.98,-2.77,;4.51,-4.3,;3.02,-3.9,;3.42,-2.41,;1.69,-4.67,;.35,-3.9,;.35,-2.36,;-.98,-1.59,;-.98,-.05,;-2.32,.72,;-2.32,-2.36,;-3.78,-1.88,;-4.69,-3.13,;-3.78,-4.37,;-2.32,-3.9,;-.98,-4.67,;-4.26,-.42,;-5.76,-.1,;-6.24,1.37,;-5.21,2.51,;-5.37,4.04,;-3.96,4.67,;-2.93,3.52,;-3.7,2.19,;-3.23,.73,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643710
(US20240002391, Compound 1148)Show SMILES COc1nc(NC2CCOC(C)(C)C2)nn2ccc(-c3cnc4nccn4c3)c12 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385194
(US10287267, Compound 358 | US10508099, Compound 35...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1 Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive... |
US Patent US10556885 (2020)
BindingDB Entry DOI: 10.7270/Q2ZW1P9Z |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385194
(US10287267, Compound 358 | US10508099, Compound 35...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1 Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25X2DVD |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385194
(US10287267, Compound 358 | US10508099, Compound 35...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1 Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RF5Z63 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293564
(US10106527, Compound 275 | US10544128, Compound 27...)Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2JW8JR2 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643296
(US20240002391, Compound 8)Show SMILES COc1nc(N[C@H]2C[C@](C)(O)C2)nn2ccc(-c3ccn4nccc4c3)c12 |r,wU:8.9,wD:6.5,8.8,(-2.29,.7,;-.95,-.07,;-.95,-1.61,;.38,-2.38,;.38,-3.92,;1.7,-4.69,;3.03,-3.92,;4.52,-4.32,;4.92,-2.83,;4.92,-1.29,;6.25,-2.06,;3.43,-2.43,;-.95,-4.69,;-2.29,-3.92,;-3.72,-4.41,;-4.62,-3.19,;-3.75,-1.86,;-4.24,-.4,;-5.74,-.07,;-6.25,1.42,;-5.22,2.59,;-5.34,4.13,;-3.91,4.72,;-2.91,3.54,;-3.72,2.22,;-3.21,.8,;-2.29,-2.38,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643420
(US20240002391, Compound 250)Show SMILES COc1nc(N[C@H]2CC[C@H](CC2)OC(F)F)nn2ccc(-c3cnc4nccn4c3)c12 |r,wD:6.5,9.12,(-4.04,.72,;-2.71,-.05,;-2.71,-1.59,;-1.37,-2.36,;-1.37,-3.9,;-.04,-4.67,;1.29,-3.9,;2.63,-4.67,;3.96,-3.9,;3.96,-2.36,;2.63,-1.59,;1.29,-2.36,;5.3,-1.59,;6.63,-2.36,;7.96,-1.59,;6.63,-3.9,;-2.71,-4.67,;-4.04,-3.9,;-5.5,-4.37,;-6.41,-3.13,;-5.5,-1.88,;-5.98,-.42,;-7.49,-.1,;-7.96,1.37,;-6.93,2.51,;-7.09,4.04,;-5.69,4.67,;-4.66,3.52,;-5.43,2.19,;-4.95,.73,;-4.04,-2.36,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643440
(US20240002391, Compound 276)Show SMILES COc1nc(NC2CCC3(COC3)CC2)nn2ccc(-c3cnc4nccn4c3)c12 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643594
(US20240002391, Compound 725)Show SMILES COc1nc(N[C@H]2CC[C@](C)(O)CC2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r,wU:9.10,wD:6.5,9.9,(-.08,.02,;-1.41,-.77,;-1.4,-2.31,;-.04,-3.19,;-.04,-4.73,;1.29,-5.5,;2.63,-4.73,;3.96,-5.5,;5.3,-4.73,;5.3,-3.19,;5.3,-1.65,;6.63,-2.42,;3.96,-2.42,;2.63,-3.19,;-1.37,-5.5,;-2.71,-4.73,;-4.17,-5.21,;-5.08,-3.96,;-4.17,-2.72,;-4.65,-1.25,;-6.15,-.93,;-6.63,.53,;-5.6,1.68,;-6.07,3.14,;-5.04,4.29,;-4.09,1.36,;-3.32,2.69,;-1.79,2.85,;-1.16,4.26,;-2.07,5.5,;.37,4.42,;-3.62,-.11,;-2.71,-3.19,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293564
(US10106527, Compound 275 | US10544128, Compound 27...)Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | 25 |
Samumed, LLC
US Patent
| Assay Description Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ... |
US Patent US10106527 (2018)
BindingDB Entry DOI: 10.7270/Q2PN97Q3 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385194
(US10287267, Compound 358 | US10508099, Compound 35...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1 Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2MS3W3C |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293564
(US10106527, Compound 275 | US10544128, Compound 27...)Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis... |
Bioorg Med Chem Lett 17: 4442-6 (2007)
BindingDB Entry DOI: 10.7270/Q2862JRD |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385194
(US10287267, Compound 358 | US10508099, Compound 35...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1 Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... |
US Patent US10508099 (2019)
BindingDB Entry DOI: 10.7270/Q2DJ5J0C |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293564
(US10106527, Compound 275 | US10544128, Compound 27...)Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
US Patent US10544128 (2020)
BindingDB Entry DOI: 10.7270/Q2H134DS |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293564
(US10106527, Compound 275 | US10544128, Compound 27...)Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2SJ1QR6 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643695
(US20240002391, Compound 1099)Show SMILES COc1nc(N[C@H]2C[C@]3(CCN3CC(F)F)C2)nn2ccc(-c3ccc4nccnc4c3)c12 |r,wD:6.5,8.11,(-2.78,1.77,;-1.44,1,;-1.44,-.54,;-.11,-1.31,;-.11,-2.85,;1.22,-3.62,;2.56,-2.85,;4.04,-3.25,;4.44,-1.77,;4.84,-.28,;6.33,-.68,;5.93,-2.16,;6.7,-3.5,;5.93,-4.83,;4.39,-4.83,;6.7,-6.16,;2.96,-1.37,;-1.44,-3.62,;-2.78,-2.85,;-4.24,-3.33,;-5.15,-2.08,;-4.24,-.84,;-4.72,.63,;-6.22,.95,;-6.7,2.41,;-5.67,3.56,;-6.15,5.02,;-5.12,6.16,;-3.61,5.84,;-3.13,4.38,;-4.16,3.24,;-3.69,1.77,;-2.78,-1.31,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293619
(US10106527, Compound 391 | US10544128, Compound 39...)Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1 Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-12-15(4-5-23-20)21(30)26-19-11-18-10-16(22-27-25-14-31-22)2-3-17(18)13-24-19/h2-5,10-14H,6-9H2,1H3,(H,24,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
US Patent US10544128 (2020)
BindingDB Entry DOI: 10.7270/Q2H134DS |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293619
(US10106527, Compound 391 | US10544128, Compound 39...)Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1 Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-12-15(4-5-23-20)21(30)26-19-11-18-10-16(22-27-25-14-31-22)2-3-17(18)13-24-19/h2-5,10-14H,6-9H2,1H3,(H,24,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2SJ1QR6 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293619
(US10106527, Compound 391 | US10544128, Compound 39...)Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1 Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-12-15(4-5-23-20)21(30)26-19-11-18-10-16(22-27-25-14-31-22)2-3-17(18)13-24-19/h2-5,10-14H,6-9H2,1H3,(H,24,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2JW8JR2 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM293479
(US10106527, Compound 93 | US10544128, Compound 93 ...)Show SMILES CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1 Show InChI InChI=1S/C27H29N7O/c1-32-9-6-27(7-10-32)17-34(18-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2JW8JR2 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643323
(US20240002391, Compound 53)Show SMILES COc1nc(N[C@@H]2CC[C@@H](CC2)NC(C)=O)nn2ccc(-c3ccc4nccn4c3)c12 |r,wD:6.5,9.12,(-1.55,.73,;-2.88,-.04,;-2.88,-1.58,;-1.55,-2.35,;-1.55,-3.89,;-.22,-4.66,;1.12,-3.89,;1.12,-2.35,;2.45,-1.58,;3.79,-2.35,;3.79,-3.89,;2.45,-4.66,;5.12,-1.58,;6.45,-2.35,;7.79,-1.58,;6.45,-3.89,;-2.88,-4.66,;-4.22,-3.89,;-5.68,-4.37,;-6.59,-3.12,;-5.68,-1.87,;-6,-.37,;-7.47,.11,;-7.79,1.61,;-6.64,2.64,;-6.64,4.18,;-5.18,4.66,;-4.27,3.41,;-5.18,2.17,;-4.86,.66,;-4.22,-2.35,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM643419
(US20240002391, Compound 245)Show SMILES CO[C@@H]1CC[C@@H](CC1)Nc1nc(OC)c2c(ccn2n1)-c1cnc2nccn2c1 |r,wD:5.8,2.1,(5.96,-.05,;5.96,-1.59,;4.63,-2.36,;4.63,-3.9,;3.3,-4.67,;1.96,-3.9,;1.96,-2.36,;3.3,-1.59,;.63,-4.67,;-.71,-3.9,;-.71,-2.36,;-2.04,-1.59,;-2.04,-.05,;-3.37,.72,;-3.37,-2.36,;-4.84,-1.88,;-5.74,-3.13,;-4.84,-4.37,;-3.37,-3.9,;-2.04,-4.67,;-5.31,-.42,;-6.82,-.1,;-7.3,1.37,;-6.27,2.51,;-6.43,4.04,;-5.02,4.67,;-3.99,3.52,;-4.76,2.19,;-4.28,.73,)| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |