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Compile Data Set for Download or QSAR

Found 1469 hits of ic50 for UniProtKB: Q86TI2   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11695
PNG
((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N |r,TLB:9:8:6:3.2.4,4:3:10:7.6.5,4:5:10:3.2.9,THB:9:3:6:10.7.8,11:8:6:3.2.4|
Show InChI InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
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n/an/a 0.120n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant DPP9 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113765
BindingDB Entry DOI: 10.7270/Q2J67MS2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50389480
PNG
(CHEMBL2063040)
Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6@@H](-[#8])-[#6]-[#6@H]-1-[#5](-[#8])-[#8] |r|
Show InChI InChI=1S/C10H22BN5O4/c12-7(2-1-3-15-10(13)14)9(18)16-5-6(17)4-8(16)11(19)20/h6-8,17,19-20H,1-5,12H2,(H4,13,14,15)/t6-,7-,8-/m0/s1
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n/an/a 0.310n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM142093
PNG
(US11096924, DASH-inhibitors 1797 | US11559537, Com...)
Show SMILES N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C12H23BN2O3/c14-11(9-5-2-1-3-6-9)12(16)15-8-4-7-10(15)13(17)18/h9-11,17-18H,1-8,14H2/t10-,11-/m0/s1
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514555
PNG
(US11096924, DASH-inhibitors 4367 | US11583516, Cmp...)
Show SMILES CC1(CC1)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514555
PNG
(US11096924, DASH-inhibitors 4367 | US11583516, Cmp...)
Show SMILES CC1(CC1)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050516
PNG
(Boronic acid derivative | CHEMBL63726 | US11096924...)
Show SMILES NCCCC[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C10H22BN3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9,16-17H,1-7,12-13H2/t8-,9-/m0/s1
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050513
PNG
((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050520
PNG
(Boronic acid derivative | CHEMBL63406 | US11096924...)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C10H21BN2O3/c1-10(2,3)8(12)9(14)13-6-4-5-7(13)11(15)16/h7-8,15-16H,4-6,12H2,1-3H3/t7-,8+/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50369128
PNG
(CHEMBL1790483 | US11096924, DASH-inhibitors 4316 |...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C10H21BN2O3/c1-3-7(2)9(12)10(14)13-6-4-5-8(13)11(15)16/h7-9,15-16H,3-6,12H2,1-2H3/t7-,8-,9-/m0/s1
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50171552
PNG
((S)-2-(S)-Amino-1-(2-boron-dihydroxide-pyrrolidine...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



ActivX Biosciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incubated for 30 min


Bioorg Med Chem Lett 15: 4256-60 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.076
BindingDB Entry DOI: 10.7270/Q2RR1XSW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050513
PNG
((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP9


Bioorg Med Chem Lett 17: 507-10 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.012
BindingDB Entry DOI: 10.7270/Q2T43SQH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50389473
PNG
(CHEMBL2063033)
Show SMILES OB(O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1 |r|
Show InChI InChI=1S/C9H17BN2O4/c13-6-4-8(10(15)16)12(5-6)9(14)7-2-1-3-11-7/h6-8,11,13,15-16H,1-5H2/t6-,7-,8-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050513
PNG
((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514526
PNG
(US11096924, DASH-inhibitors 5362 | US11583516, Cmp...)
Show SMILES CC1(C)CN[C@@H]1C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 2.40n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514526
PNG
(US11096924, DASH-inhibitors 5362 | US11583516, Cmp...)
Show SMILES CC1(C)CN[C@@H]1C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 2.40n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514516
PNG
(US11096924, DASH-inhibitors 4175 CH | US11583516, ...)
Show SMILES CC1(CCCCC1)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514516
PNG
(US11096924, DASH-inhibitors 4175 CH | US11583516, ...)
Show SMILES CC1(CCCCC1)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 2.70n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050525
PNG
((R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic...)
Show SMILES C[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C7H15BN2O3/c1-5(9)7(11)10-4-2-3-6(10)8(12)13/h5-6,12-13H,2-4,9H2,1H3/t5-,6-/m0/s1
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Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM142088
PNG
(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Show SMILES C[C@H](N)C(=S)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C7H15BN2O2S/c1-5(9)7(13)10-4-2-3-6(10)8(11)12/h5-6,11-12H,2-4,9H2,1H3/t5-,6-/m0/s1
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM142092
PNG
(US11096924, DASH-inhibitors 2401 | US11559537, Com...)
Show SMILES CC(C)[C@H](N)C(=S)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C9H19BN2O2S/c1-6(2)8(11)9(15)12-5-3-4-7(12)10(13)14/h6-8,13-14H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050525
PNG
((R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic...)
Show SMILES C[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C7H15BN2O3/c1-5(9)7(11)10-4-2-3-6(10)8(12)13/h5-6,12-13H,2-4,9H2,1H3/t5-,6-/m0/s1
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514518
PNG
(US11096924, DASH-inhibitors 4317 | US11559537, Com...)
Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050515
PNG
(Boronic acid derivative | CHEMBL63652 | US11096924...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H19BN2O3/c15-11(9-10-5-2-1-3-6-10)13(17)16-8-4-7-12(16)14(18)19/h1-3,5-6,11-12,18-19H,4,7-9,15H2/t11-,12-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050525
PNG
((R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic...)
Show SMILES C[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C7H15BN2O3/c1-5(9)7(11)10-4-2-3-6(10)8(12)13/h5-6,12-13H,2-4,9H2,1H3/t5-,6-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50389465
PNG
(CHEMBL2063024)
Show SMILES C[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O |r|
Show InChI InChI=1S/C7H15BN2O4/c1-4(9)7(12)10-3-5(11)2-6(10)8(13)14/h4-6,11,13-14H,2-3,9H2,1H3/t4-,5-,6-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050521
PNG
((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1
Show InChI InChI=1S/C9H17BN2O3/c13-9(7-3-1-5-11-7)12-6-2-4-8(12)10(14)15/h7-8,11,14-15H,1-6H2/t7-,8-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514515
PNG
(US11096924, DASH-inhibitors 3102 C | US11583516, C...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(Cl)(C3)C1)C2 |r,TLB:1:12:20:16.15.17,22:12:20:16.15.17,15:16:21:20.14.13,THB:22:16:20:21.12.13,15:14:21:16.22.17|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514515
PNG
(US11096924, DASH-inhibitors 3102 C | US11583516, C...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(Cl)(C3)C1)C2 |r,TLB:1:12:20:16.15.17,22:12:20:16.15.17,15:16:21:20.14.13,THB:22:16:20:21.12.13,15:14:21:16.22.17|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50243690
PNG
((2S,4S)-1-((S)-2-amino-6-(naphthalen-2-ylamino)hex...)
Show SMILES N[C@@H](CCCCNc1ccc2ccccc2c1)C(=O)N1C[C@H](C[C@H]1C#N)N=[N+]=[N-] |r|
Show InChI InChI=1S/C21H25N7O/c22-13-19-12-18(26-27-24)14-28(19)21(29)20(23)7-3-4-10-25-17-9-8-15-5-1-2-6-16(15)11-17/h1-2,5-6,8-9,11,18-20,25H,3-4,7,10,12,14,23H2/t18-,19-,20-/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50171548
PNG
((S)-2-(S)-Amino-1-(2-boron-dihydroxide-pyrrolidin-...)
Show SMILES CCCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C10H21BN2O3/c1-2-3-5-8(12)10(14)13-7-4-6-9(13)11(15)16/h8-9,15-16H,2-7,12H2,1H3/t8-,9+/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



ActivX Biosciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incubated for 30 min


Bioorg Med Chem Lett 15: 4256-60 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.076
BindingDB Entry DOI: 10.7270/Q2RR1XSW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM12192
PNG
((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Show SMILES N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2C1 |r|
Show InChI InChI=1S/C16H22N2O/c17-15(12-6-2-1-3-7-12)16(19)18-10-13-8-4-5-9-14(13)11-18/h4-5,8-9,12,15H,1-3,6-7,10-11,17H2/t15-/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM589752
PNG
(US11559537, Compound 5291-(8J))
Show SMILES CC[C@@H](C)C(N)C(=O)N1Cc2ccc(F)cc2C1 |r|
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n/an/a 4.70n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514554
PNG
(US11096924, DASH-inhibitors 5363 | US11583516, Cmp...)
Show SMILES CC1(C)CCN[C@@H]1C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 5.20n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514554
PNG
(US11096924, DASH-inhibitors 5363 | US11583516, Cmp...)
Show SMILES CC1(C)CCN[C@@H]1C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 5.20n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514545
PNG
(US11096924, DASH-inhibitors 5333 | US11559537, Com...)
Show SMILES N[C@@H](C1CCCC1)C(=O)N1Cc2ccc(F)cc2C1 |r|
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n/an/a 5.20n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514520
PNG
(US11096924, DASH-inhibitors 4175 CP | US11583516, ...)
Show SMILES CC1(CCCC1)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 5.60n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514520
PNG
(US11096924, DASH-inhibitors 4175 CP | US11583516, ...)
Show SMILES CC1(CCCC1)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
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n/an/a 5.60n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50050527
PNG
(Boronic acid derivative | CHEMBL66032 | US11096924...)
Show SMILES CC[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C8H17BN2O3/c1-2-6(10)8(12)11-5-3-4-7(11)9(13)14/h6-7,13-14H,2-5,10H2,1H3/t6-,7-/m0/s1
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514514
PNG
(US11096924, DASH-inhibitors (formerly 3102 A 2C) |...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(C3)C1)C2 |r,TLB:19:18:21:15.14.13,19:14:21:18.20.17,THB:1:12:15:18.19.17,20:18:15:21.12.13,20:12:15:18.19.17|
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n/an/a 6.10n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514514
PNG
(US11096924, DASH-inhibitors (formerly 3102 A 2C) |...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(C3)C1)C2 |r,TLB:19:18:21:15.14.13,19:14:21:18.20.17,THB:1:12:15:18.19.17,20:18:15:21.12.13,20:12:15:18.19.17|
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n/an/a 6.10n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50243649
PNG
((2S,4S)-1-((2S,3R)-2-amino-3-methylpentanoyl)-4-az...)
Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1C[C@H](C[C@H]1C#N)N=[N+]=[N-] |r|
Show InChI InChI=1S/C11H18N6O/c1-3-7(2)10(13)11(18)17-6-8(15-16-14)4-9(17)5-12/h7-10H,3-4,6,13H2,1-2H3/t7-,8+,9+,10+/m1/s1
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n/an/a 6.30n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50389471
PNG
(CHEMBL2063031)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O |r|
Show InChI InChI=1S/C10H21BN2O4/c1-10(2,3)8(12)9(15)13-5-6(14)4-7(13)11(16)17/h6-8,14,16-17H,4-5,12H2,1-3H3/t6-,7-,8+/m0/s1
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n/an/a 6.40n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM589767
PNG
(US11559537, Compound 5322)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1Cc2ccc(F)cc2C1 |r|
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n/an/a 6.60n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50171555
PNG
((S)-2,4-Diamino-1-(2-boron-dihydroxide-pyrrolidin-...)
Show SMILES NCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C8H18BN3O3/c10-4-3-6(11)8(13)12-5-1-2-7(12)9(14)15/h6-7,14-15H,1-5,10-11H2/t6-,7+/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



ActivX Biosciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incubated for 30 min


Bioorg Med Chem Lett 15: 4256-60 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.076
BindingDB Entry DOI: 10.7270/Q2RR1XSW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514532
PNG
(US11096924, DASH-inhibitors 3102 A | US11583516, C...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(O)(C3)C1)C2 |r,TLB:1:12:20:16.15.17,22:12:20:16.15.17,15:16:21:20.14.13,THB:22:16:20:21.12.13,15:14:21:16.22.17|
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514532
PNG
(US11096924, DASH-inhibitors 3102 A | US11583516, C...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(O)(C3)C1)C2 |r,TLB:1:12:20:16.15.17,22:12:20:16.15.17,15:16:21:20.14.13,THB:22:16:20:21.12.13,15:14:21:16.22.17|
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514540
PNG
(US11096924, DASH-inhibitors 5320 | US11583516, Cmp...)
Show SMILES CC1(CCCCC1)[C@H](N)C(=O)N1Cc2ccc(F)cc2C1 |r|
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514540
PNG
(US11096924, DASH-inhibitors 5320 | US11583516, Cmp...)
Show SMILES CC1(CCCCC1)[C@H](N)C(=O)N1Cc2ccc(F)cc2C1 |r|
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514562
PNG
(US11096924, DASH-inhibitors 5870 | US11583516, Cmp...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(F)(C3)C1)C2 |r,TLB:1:12:20:16.15.17,22:12:20:16.15.17,15:16:21:20.14.13,THB:22:16:20:21.12.13,15:14:21:16.22.17|
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a


TBA

Assay Description
This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...


Citation and Details

BindingDB Entry DOI: 10.7270/Q28W3J7Z
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM514562
PNG
(US11096924, DASH-inhibitors 5870 | US11583516, Cmp...)
Show SMILES N[C@H](C(=O)N1CCC[C@H]1B(O)O)C12CC3CC(CC(F)(C3)C1)C2 |r,TLB:1:12:20:16.15.17,22:12:20:16.15.17,15:16:21:20.14.13,THB:22:16:20:21.12.13,15:14:21:16.22.17|
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a


TBA

Assay Description
Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27P93BT
More data for this
Ligand-Target Pair
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