Found 723 hits of ic50 for UniProtKB: P29702 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080742
((S)-2-[(5-{[Benzyl-(5-fluoro-pyridin-3-yl)-amino]-...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cncc(F)c2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H32FN3O3S/c1-22-8-6-7-11-27(22)29-16-24(12-13-28(29)31(37)35-30(32(38)39)14-15-40-2)21-36(20-23-9-4-3-5-10-23)26-17-25(33)18-34-19-26/h3-13,16-19,30H,14-15,20-21H2,1-2H3,(H,35,37)(H,38,39)/t30-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080765
((S)-2-({5-[(Cyclohexylmethyl-pyridin-3-yl-amino)-m...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CC2CCCCC2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H39N3O3S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)31(36)34-30(32(37)38)16-18-39-2)22-35(26-12-8-17-33-20-26)21-24-10-4-3-5-11-24/h6-9,12-15,17,19-20,24,30H,3-5,10-11,16,18,21-22H2,1-2H3,(H,34,36)(H,37,38)/t30-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080764
((S)-2-({5-[(Benzyl-pyridin-3-yl-amino)-methyl]-2'-...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H33N3O3S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)31(36)34-30(32(37)38)16-18-39-2)22-35(26-12-8-17-33-20-26)21-24-10-4-3-5-11-24/h3-15,17,19-20,30H,16,18,21-22H2,1-2H3,(H,34,36)(H,37,38)/t30-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM14453
(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)Show SMILES N#Cc1ccc(Cn2cncc2Cn2ccc3c(C#N)c(ccc23)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C31H21N5/c32-16-22-8-10-23(11-9-22)19-36-21-34-18-25(36)20-35-15-14-29-30(17-33)28(12-13-31(29)35)27-7-3-5-24-4-1-2-6-26(24)27/h1-15,18,21H,19-20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 15: 2033-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127310
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc2ccccc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(22-8-6-20(15-30)7-9-22)35-18-25-12-13-26(16-31)33-28(25)24-11-10-21-4-2-3-5-23(21)14-24/h2-14,17,19,29H,18H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of [3H]-FPP transfer to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50112379
(1-(3-Chloro-phenyl)-4-{2-[3-(2-methoxy-4'-trifluor...)Show SMILES COc1cc(Cn2cncc2CCN2CCN(C(=O)C2)c2cccc(Cl)c2)ccc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C30H28ClF3N4O2/c1-40-28-15-21(5-10-27(28)22-6-8-23(9-7-22)30(32,33)34)18-37-20-35-17-26(37)11-12-36-13-14-38(29(39)19-36)25-4-2-3-24(31)16-25/h2-10,15-17,20H,11-14,18-19H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 12: 1269-73 (2002)
BindingDB Entry DOI: 10.7270/Q2T72GSB |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127321
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc2OC(F)(F)Oc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H17F2N5O3/c1-33-15-31-13-21(33)25(17-4-2-16(11-29)3-5-17)34-14-19-6-8-20(12-30)32-24(19)18-7-9-22-23(10-18)36-26(27,28)35-22/h2-10,13,15,25H,14H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127313
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(18-7-5-17(12-30)6-8-18)35-15-20-9-10-21(13-31)33-24(20)19-3-2-4-22(11-19)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50112387
(3-oxo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22...)Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CC2)ccc4C#N)cc13 Show InChI InChI=1S/C27H23N5O2/c28-14-21-5-4-19-12-26(21)34-23-7-6-20-2-1-3-25(24(20)13-23)32-11-10-30(17-27(32)33)9-8-22-15-29-18-31(22)16-19/h1-7,12-13,15,18H,8-11,16-17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 12: 1269-73 (2002)
BindingDB Entry DOI: 10.7270/Q2T72GSB |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM13389
(4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...)Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM13389
(4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...)Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Bovine farnesyl transeferase |
Bioorg Med Chem Lett 15: 153-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080748
((S)-2-[(5-{[(3,5-Difluoro-benzyl)-thiazol-5-ylmeth...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cncs2)Cc2cc(F)cc(F)c2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H31F2N3O3S2/c1-20-5-3-4-6-26(20)28-13-21(7-8-27(28)30(37)35-29(31(38)39)9-10-40-2)16-36(18-25-15-34-19-41-25)17-22-11-23(32)14-24(33)12-22/h3-8,11-15,19,29H,9-10,16-18H2,1-2H3,(H,35,37)(H,38,39)/t29-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127318
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1nc(N2CCOCC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H25ClN6O2/c1-35-19-33-17-27(35)28(21-7-5-20(15-31)6-8-21)38-18-26-25(22-3-2-4-24(30)13-22)14-23(16-32)29(34-26)36-9-11-37-12-10-36/h2-8,13-14,17,19,28H,9-12,18H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50083595
(3-[3-((R)-2-Amino-3-mercapto-propylamino)-phenoxy]...)Show InChI InChI=1S/C16H18N2O3S/c17-12(10-22)9-18-13-4-2-6-15(8-13)21-14-5-1-3-11(7-14)16(19)20/h1-8,12,18,22H,9-10,17H2,(H,19,20)/t12-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine Farnesyltransferase in vitro. |
Bioorg Med Chem Lett 9: 3301-6 (2000)
BindingDB Entry DOI: 10.7270/Q2Q52NT7 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50112387
(3-oxo-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22...)Show SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CC2)ccc4C#N)cc13 Show InChI InChI=1S/C27H23N5O2/c28-14-21-5-4-19-12-26(21)34-23-7-6-20-2-1-3-25(24(20)13-23)32-11-10-30(17-27(32)33)9-8-22-15-29-18-31(22)16-19/h1-7,12-13,15,18H,8-11,16-17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM. |
Bioorg Med Chem Lett 12: 1269-73 (2002)
BindingDB Entry DOI: 10.7270/Q2T72GSB |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153786
(4-((5-((4-cyanophenoxy)methyl)-1H-imidazol-1-yl)me...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-9-12-26(13-10-21)34-19-25-17-32-20-33(25)18-22-8-11-24(16-31)29(14-22)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067566
((S)-2-{[2'-Ethyl-5-(pyridin-3-yloxymethyl)-bipheny...)Show SMILES CCc1ccccc1-c1cc(COc2cccnc2)ccc1C(=O)N[C@@H](CCSC)C(O)=O Show InChI InChI=1S/C26H28N2O4S/c1-3-19-7-4-5-9-21(19)23-15-18(17-32-20-8-6-13-27-16-20)10-11-22(23)25(29)28-24(26(30)31)12-14-33-2/h4-11,13,15-16,24H,3,12,14,17H2,1-2H3,(H,28,29)(H,30,31)/t24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase from bovine brain |
J Med Chem 41: 4288-300 (1998)
Article DOI: 10.1021/jm980298s BindingDB Entry DOI: 10.7270/Q20G3KTC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126336
(4-{[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3...)Show SMILES Cn1cncc1CN(Cc1ccnc(c1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H22N6/c1-34-20-32-17-26(34)19-35(18-21-11-12-33-24(13-21)16-31)25-10-9-23(15-30)29(14-25)28-8-4-6-22-5-2-3-7-27(22)28/h2-14,17,20H,18-19H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153802
(3'',4''-Dichloro-6-[3-(4-cyano-benzyl)-3H-imidazol...)Show SMILES Clc1ccc(cc1Cl)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H18Cl2N4O/c27-25-8-7-21(10-26(25)28)24-9-20(12-30)5-6-22(24)15-33-16-23-13-31-17-32(23)14-19-3-1-18(11-29)2-4-19/h1-10,13,17H,14-16H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153785
(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)Show SMILES N#Cc1ccc(Cn2cncc2COc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-8-10-22(11-9-21)18-33-20-32-17-25(33)19-34-26-13-12-24(16-31)29(14-26)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126339
(4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETH...)Show SMILES Cn1cncc1CN(Cc1cccc(c1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H23N5/c1-34-21-33-18-27(34)20-35(19-23-7-4-6-22(14-23)16-31)26-13-12-25(17-32)30(15-26)29-11-5-9-24-8-2-3-10-28(24)29/h2-15,18,21H,19-20H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127306
(5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmetho...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-24(34)25(19-7-8-21(12-31)33-13-19)35-15-20-6-5-17(11-30)9-23(20)18-3-2-4-22(10-18)36-26(27,28)29/h2-10,13-14,16,25H,15H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080743
((S)-2-({5-[(Benzyl-thiazol-5-ylmethyl-amino)-methy...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cncs2)Cc2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H33N3O3S2/c1-22-8-6-7-11-26(22)28-16-24(12-13-27(28)30(35)33-29(31(36)37)14-15-38-2)19-34(20-25-17-32-21-39-25)18-23-9-4-3-5-10-23/h3-13,16-17,21,29H,14-15,18-20H2,1-2H3,(H,33,35)(H,36,37)/t29-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080747
((S)-2-[(5-{[(3,5-Difluoro-benzyl)-phenyl-amino]-me...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cc(F)cc(F)c2)c2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H32F2N2O3S/c1-22-8-6-7-11-28(22)30-18-23(12-13-29(30)32(38)36-31(33(39)40)14-15-41-2)20-37(27-9-4-3-5-10-27)21-24-16-25(34)19-26(35)17-24/h3-13,16-19,31H,14-15,20-21H2,1-2H3,(H,36,38)(H,39,40)/t31-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50083589
(3-[4-((S)-2-Amino-3-mercapto-propylamino)-phenoxy]...)Show InChI InChI=1S/C16H18N2O3S/c17-12(10-22)9-18-13-4-6-14(7-5-13)21-15-3-1-2-11(8-15)16(19)20/h1-8,12,18,22H,9-10,17H2,(H,19,20)/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine Farnesyltransferase in vitro. |
Bioorg Med Chem Lett 9: 3301-6 (2000)
BindingDB Entry DOI: 10.7270/Q2Q52NT7 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080750
((S)-2-({5-[(Benzyl-pyrimidin-5-yl-amino)-methyl]-2...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cncnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H32N4O3S/c1-22-8-6-7-11-26(22)28-16-24(12-13-27(28)30(36)34-29(31(37)38)14-15-39-2)20-35(25-17-32-21-33-18-25)19-23-9-4-3-5-10-23/h3-13,16-18,21,29H,14-15,19-20H2,1-2H3,(H,34,36)(H,37,38)/t29-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067563
((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...)Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H26N2O4S/c1-17-6-3-4-8-20(17)22-14-18(16-31-19-7-5-12-26-15-19)9-10-21(22)24(28)27-23(25(29)30)11-13-32-2/h3-10,12,14-15,23H,11,13,16H2,1-2H3,(H,27,28)(H,29,30)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067563
((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...)Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H26N2O4S/c1-17-6-3-4-8-20(17)22-14-18(16-31-19-7-5-12-26-15-19)9-10-21(22)24(28)27-23(25(29)30)11-13-32-2/h3-10,12,14-15,23H,11,13,16H2,1-2H3,(H,27,28)(H,29,30)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase from bovine brain |
J Med Chem 41: 4288-300 (1998)
Article DOI: 10.1021/jm980298s BindingDB Entry DOI: 10.7270/Q20G3KTC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067581
((S)-2-{[2'-Methyl-5-(pyridin-3-ylaminomethyl)-biph...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CNc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H27N3O3S/c1-17-6-3-4-8-20(17)22-14-18(15-27-19-7-5-12-26-16-19)9-10-21(22)24(29)28-23(25(30)31)11-13-32-2/h3-10,12,14,16,23,27H,11,13,15H2,1-2H3,(H,28,29)(H,30,31)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067581
((S)-2-{[2'-Methyl-5-(pyridin-3-ylaminomethyl)-biph...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CNc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H27N3O3S/c1-17-6-3-4-8-20(17)22-14-18(15-27-19-7-5-12-26-16-19)9-10-21(22)24(29)28-23(25(30)31)11-13-32-2/h3-10,12,14,16,23,27H,11,13,15H2,1-2H3,(H,28,29)(H,30,31)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase from bovine brain |
J Med Chem 41: 4288-300 (1998)
Article DOI: 10.1021/jm980298s BindingDB Entry DOI: 10.7270/Q20G3KTC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127315
(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)Show SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(35-18-24-12-9-20(14-30)16-33-24)22-10-11-23(15-31)27(13-22)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153176
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127324
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-18-6-7-22(12-29)31-24(18)19-8-20(26)10-21(27)9-19/h2-10,13,15,25H,14H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126340
(4-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cn1cncc1CN(Cc1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H23ClN4/c1-33-20-32-17-26(33)19-34(18-21-6-4-9-24(30)14-21)25-13-12-23(16-31)29(15-25)28-11-5-8-22-7-2-3-10-27(22)28/h2-15,17,20H,18-19H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50083575
(4-{5-[(4-Benzenesulfonyl-3-methyl-phenylamino)-met...)Show SMILES Cc1ncc(CNc2ccc(c(C)c2)S(=O)(=O)c2ccccc2)n1Cc1ccc(cc1)C#N Show InChI InChI=1S/C26H24N4O2S/c1-19-14-23(12-13-26(19)33(31,32)25-6-4-3-5-7-25)29-17-24-16-28-20(2)30(24)18-22-10-8-21(15-27)9-11-22/h3-14,16,29H,17-18H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine Farnesyltransferase in vitro. |
Bioorg Med Chem Lett 9: 3301-6 (2000)
BindingDB Entry DOI: 10.7270/Q2Q52NT7 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50112383
(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)Show SMILES FC(F)(F)CCCCc1ccc2Cn3cncc3CCN3CCN(C(=O)C3)c3cccc4ccc(Oc1c2)cc34 Show InChI InChI=1S/C31H31F3N4O2/c32-31(33,34)12-2-1-4-24-8-7-22-16-29(24)40-26-10-9-23-5-3-6-28(27(23)17-26)38-15-14-36(20-30(38)39)13-11-25-18-35-21-37(25)19-22/h3,5-10,16-18,21H,1-2,4,11-15,19-20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 12: 1269-73 (2002)
BindingDB Entry DOI: 10.7270/Q2T72GSB |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153172
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM14423
(4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...)Show SMILES CCOc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C28H25N5O3/c1-4-36-23-7-5-6-22(15-23)33-25-14-21(12-13-24(25)32(3)27(33)34)28(35,26-17-30-18-31(26)2)20-10-8-19(16-29)9-11-20/h5-15,17-18,35H,4H2,1-3H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 15: 2918-22 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067584
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1 | PDB MMDB
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UniProtKB/SwissProt
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| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase from bovine brain |
J Med Chem 41: 4288-300 (1998)
Article DOI: 10.1021/jm980298s BindingDB Entry DOI: 10.7270/Q20G3KTC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067559
((S)-4-Methylsulfanyl-2-{[5-(pyridin-3-yloxymethyl)...)Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C(F)(F)F)C(O)=O Show InChI InChI=1S/C25H23F3N2O4S/c1-35-12-10-22(24(32)33)30-23(31)19-9-8-16(15-34-17-5-4-11-29-14-17)13-20(19)18-6-2-3-7-21(18)25(26,27)28/h2-9,11,13-14,22H,10,12,15H2,1H3,(H,30,31)(H,32,33)/t22-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase from bovine brain |
J Med Chem 41: 4288-300 (1998)
Article DOI: 10.1021/jm980298s BindingDB Entry DOI: 10.7270/Q20G3KTC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080759
((S)-2-{[2'-Methyl-4-phenethyl-5-(pyridin-3-yloxyme...)Show SMILES CSCC[C@H](NC(=O)c1cc(CCc2ccccc2)c(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H34N2O4S/c1-23-9-6-7-13-28(23)29-20-26(22-39-27-12-8-17-34-21-27)25(15-14-24-10-4-3-5-11-24)19-30(29)32(36)35-31(33(37)38)16-18-40-2/h3-13,17,19-21,31H,14-16,18,22H2,1-2H3,(H,35,36)(H,37,38)/t31-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935 BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127311
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(nc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(19-4-2-17(12-30)3-5-19)35-15-20-6-9-21(13-31)33-24(20)18-7-10-22(11-8-18)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127320
(5'-(3-Chloro-phenyl)-6'-[(4-cyano-phenyl)-(3-methy...)Show SMILES Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H27ClN6O2/c1-36-19-34-17-28(36)29(21-7-5-20(15-32)6-8-21)39-18-27-26(22-3-2-4-24(31)13-22)14-23(16-33)30(35-27)37-11-9-25(38)10-12-37/h2-8,13-14,17,19,25,29,38H,9-12,18H2,1H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM17327
((2S)-2-({1-[benzyl(1,3-thiazol-5-ylmethyl)carbamoy...)Show SMILES CSCC[C@H](NC(=O)C1=C(CN(CC1)C(=O)N(Cc1cncs1)Cc1ccccc1)c1ccccc1C)C(O)=O |r,t:8| Show InChI InChI=1S/C30H34N4O4S2/c1-21-8-6-7-11-24(21)26-19-33(14-12-25(26)28(35)32-27(29(36)37)13-15-39-2)30(38)34(18-23-16-31-20-40-23)17-22-9-4-3-5-10-22/h3-11,16,20,27H,12-15,17-19H2,1-2H3,(H,32,35)(H,36,37)/t27-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 13: 1359-62 (2003)
Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126335
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB PubMed
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50127304
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES CN1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 Show InChI InChI=1S/C30H28ClN7O/c1-36-10-12-38(13-11-36)30-24(17-33)15-26(23-4-3-5-25(31)14-23)27(35-30)19-39-29(28-18-34-20-37(28)2)22-8-6-21(16-32)7-9-22/h3-9,14-15,18,20,29H,10-13,19H2,1-2H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase |
Bioorg Med Chem Lett 13: 1571-4 (2003)
BindingDB Entry DOI: 10.7270/Q27080TK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153776
(5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...)Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N Show InChI InChI=1S/C27H23N5O2/c1-2-34-26-5-3-4-22(11-26)27-10-20(12-28)6-8-23(27)17-33-18-25-15-30-19-32(25)16-21-7-9-24(13-29)31-14-21/h3-11,14-15,19H,2,16-18H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM14450
(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)Show SMILES N#Cc1cn(Cc2cncn2Cc2ccc(cc2)C#N)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C27H19N5/c28-12-20-8-10-21(11-9-20)15-32-19-30-14-24(32)17-31-16-23(13-29)27(18-31)26-7-3-5-22-4-1-2-6-25(22)26/h1-11,14,16,18-19H,15,17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 15: 2033-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153782
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES Cc1ccc(cc1C)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O/c1-20-3-9-25(11-21(20)2)28-12-24(14-30)8-10-26(28)17-33-18-27-15-31-19-32(27)16-23-6-4-22(13-29)5-7-23/h3-12,15,19H,16-18H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |