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Compile Data Set for Download or QSAR

Found 3313 hits of ic50 data for polymerid = 1506,2828,5478   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141001
PNG
(US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
Show InChI InChI=1/C31H33N7O3/c1-2-4-29(40)33-22-6-3-5-20(15-22)30-35-28-10-8-25(41-14-13-38-12-11-24(39)19-38)17-26(28)31(36-30)34-23-7-9-27-21(16-23)18-32-37-27/h3,5-10,15-18,24,39H,2,4,11-14,19H2,1H3,(H,32,37)(H,33,40)(H,34,35,36)
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n/an/a 0.00000800n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141005
PNG
(US8916576, 210)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CC[C@@H](C3)N(C)C)c(OC)cc2n1
Show InChI InChI=1/C34H40N8O3/c1-5-7-32(43)36-24-9-6-8-22(16-24)33-38-29-19-30(44-4)31(45-15-14-42-13-12-26(21-42)41(2)3)18-27(29)34(39-33)37-25-10-11-28-23(17-25)20-35-40-28/h6,8-11,16-20,26H,5,7,12-15,21H2,1-4H3,(H,35,40)(H,36,43)(H,37,38,39)/t26-/s2
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n/an/a 0.0000100n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140996
PNG
(US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
PDB
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n/an/a 0.0000100n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141001
PNG
(US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
Show InChI InChI=1/C31H33N7O3/c1-2-4-29(40)33-22-6-3-5-20(15-22)30-35-28-10-8-25(41-14-13-38-12-11-24(39)19-38)17-26(28)31(36-30)34-23-7-9-27-21(16-23)18-32-37-27/h3,5-10,15-18,24,39H,2,4,11-14,19H2,1H3,(H,32,37)(H,33,40)(H,34,35,36)
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n/an/a 0.0000110n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
PDB
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n/an/a 0.0000110n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140996
PNG
(US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
PDB
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n/an/a 0.0000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141001
PNG
(US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
Show InChI InChI=1/C31H33N7O3/c1-2-4-29(40)33-22-6-3-5-20(15-22)30-35-28-10-8-25(41-14-13-38-12-11-24(39)19-38)17-26(28)31(36-30)34-23-7-9-27-21(16-23)18-32-37-27/h3,5-10,15-18,24,39H,2,4,11-14,19H2,1H3,(H,32,37)(H,33,40)(H,34,35,36)
PDB
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n/an/a 0.0000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140999
PNG
(US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
PDB
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n/an/a 0.0000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140999
PNG
(US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
PDB
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n/an/a 0.0000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140999
PNG
(US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
PDB
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n/an/a 0.0000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140997
PNG
(US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
PDB
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n/an/a 0.0000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141001
PNG
(US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
Show InChI InChI=1/C31H33N7O3/c1-2-4-29(40)33-22-6-3-5-20(15-22)30-35-28-10-8-25(41-14-13-38-12-11-24(39)19-38)17-26(28)31(36-30)34-23-7-9-27-21(16-23)18-32-37-27/h3,5-10,15-18,24,39H,2,4,11-14,19H2,1H3,(H,32,37)(H,33,40)(H,34,35,36)
PDB
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n/an/a 0.0000130n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140997
PNG
(US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
PDB
MMDB

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n/an/a 0.0000140n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141004
PNG
(US8916576, 209)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)c(OC)cc2n1
Show InChI InChI=1S/C33H38N8O3/c1-4-6-31(42)35-24-8-5-7-22(17-24)32-37-28-20-29(43-3)30(44-16-15-41-13-11-40(2)12-14-41)19-26(28)33(38-32)36-25-9-10-27-23(18-25)21-34-39-27/h5,7-10,17-21H,4,6,11-16H2,1-3H3,(H,34,39)(H,35,42)(H,36,37,38)
PDB
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n/an/a 0.0000140n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141004
PNG
(US8916576, 209)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)c(OC)cc2n1
Show InChI InChI=1S/C33H38N8O3/c1-4-6-31(42)35-24-8-5-7-22(17-24)32-37-28-20-29(43-3)30(44-16-15-41-13-11-40(2)12-14-41)19-26(28)33(38-32)36-25-9-10-27-23(18-25)21-34-39-27/h5,7-10,17-21H,4,6,11-16H2,1-3H3,(H,34,39)(H,35,42)(H,36,37,38)
PDB
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n/an/a 0.0000160n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140997
PNG
(US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
PDB
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n/an/a 0.0000170n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141005
PNG
(US8916576, 210)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CC[C@@H](C3)N(C)C)c(OC)cc2n1
Show InChI InChI=1/C34H40N8O3/c1-5-7-32(43)36-24-9-6-8-22(16-24)33-38-29-19-30(44-4)31(45-15-14-42-13-12-26(21-42)41(2)3)18-27(29)34(39-33)37-25-10-11-28-23(17-25)20-35-40-28/h6,8-11,16-20,26H,5,7,12-15,21H2,1-4H3,(H,35,40)(H,36,43)(H,37,38,39)/t26-/s2
PDB
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n/an/a 0.0000180n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141036
PNG
(US8916576, 262)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OC)c(OCCOC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-26(39-12-11-37-2)25(38-3)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
PDB
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n/an/a 0.0000240n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140996
PNG
(US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
PDB
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n/an/a 0.0000260n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141034
PNG
(US8916576, 259)
Show SMILES CCCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O/c1-2-3-11-24(33)28-19-8-6-7-17(14-19)25-30-23-10-5-4-9-21(23)26(31-25)29-20-12-13-22-18(15-20)16-27-32-22/h4-10,12-16H,2-3,11H2,1H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a 0.0000290n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141003
PNG
(US8916576, 207)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 0.0000290n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.0000320n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140997
PNG
(US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 0.0000320n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.0000350n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141003
PNG
(US8916576, 207)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 0.0000440n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141002
PNG
(US8916576, 206)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)c(OC)cc2n1
Show InChI InChI=1S/C32H33N7O4/c1-3-6-29(40)34-22-8-4-7-20(15-22)31-36-26-18-27(42-2)28(43-14-13-39-12-5-9-30(39)41)17-24(26)32(37-31)35-23-10-11-25-21(16-23)19-33-38-25/h4,7-8,10-11,15-19H,3,5-6,9,12-14H2,1-2H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 0.0000480n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.0000510n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141003
PNG
(US8916576, 207)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 0.0000610n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141002
PNG
(US8916576, 206)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)c(OC)cc2n1
Show InChI InChI=1S/C32H33N7O4/c1-3-6-29(40)34-22-8-4-7-20(15-22)31-36-26-18-27(42-2)28(43-14-13-39-12-5-9-30(39)41)17-24(26)32(37-31)35-23-10-11-25-21(16-23)19-33-38-25/h4,7-8,10-11,15-19H,3,5-6,9,12-14H2,1-2H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 0.0000640n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.0000640n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141000
PNG
(US8916576, 204)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)ccc2n1
Show InChI InChI=1S/C31H31N7O3/c1-2-5-28(39)33-22-7-3-6-20(16-22)30-35-27-12-10-24(41-15-14-38-13-4-8-29(38)40)18-25(27)31(36-30)34-23-9-11-26-21(17-23)19-32-37-26/h3,6-7,9-12,16-19H,2,4-5,8,13-15H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 0.0000670n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.0000680n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.0000950n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141000
PNG
(US8916576, 204)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)ccc2n1
Show InChI InChI=1S/C31H31N7O3/c1-2-5-28(39)33-22-7-3-6-20(16-22)30-35-27-12-10-24(41-15-14-38-13-4-8-29(38)40)18-25(27)31(36-30)34-23-9-11-26-21(17-23)19-32-37-26/h3,6-7,9-12,16-19H,2,4-5,8,13-15H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 0.000106n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM140998
PNG
(US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 0.000120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141006
PNG
(US8916576, 211)
Show SMILES CCCC(=O)Oc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C25H21N5O2/c1-2-6-23(31)32-19-8-5-7-16(14-19)24-28-22-10-4-3-9-20(22)25(29-24)27-18-11-12-21-17(13-18)15-26-30-21/h3-5,7-15H,2,6H2,1H3,(H,26,30)(H,27,28,29)
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n/an/a 0.000129n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141000
PNG
(US8916576, 204)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)ccc2n1
Show InChI InChI=1S/C31H31N7O3/c1-2-5-28(39)33-22-7-3-6-20(16-22)30-35-27-12-10-24(41-15-14-38-13-4-8-29(38)40)18-25(27)31(36-30)34-23-9-11-26-21(17-23)19-32-37-26/h3,6-7,9-12,16-19H,2,4-5,8,13-15H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 0.000151n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141033
PNG
(US8916576, 258)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1
Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 0.000182n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141033
PNG
(US8916576, 258)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1
Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 0.000255n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141035
PNG
(US8916576, 261)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(ncc3c2)C(=O)OC(C)(C)C)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C34H38N6O6/c1-7-9-30(41)36-23-11-8-10-21(16-23)31-38-26-19-28(44-6)29(45-15-14-43-5)18-25(26)32(39-31)37-24-12-13-27-22(17-24)20-35-40(27)33(42)46-34(2,3)4/h8,10-13,16-20H,7,9,14-15H2,1-6H3,(H,36,41)(H,37,38,39)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141032
PNG
(US8916576, 243)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1
Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141020
PNG
(US8916576, 225)
Show SMILES COCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C24H20N6O2/c1-32-14-22(31)27-20-8-4-2-6-17(20)24-28-21-9-5-3-7-18(21)23(29-24)26-16-10-11-19-15(12-16)13-25-30-19/h2-13H,14H2,1H3,(H,25,30)(H,27,31)(H,26,28,29)
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n/an/a 0.00170n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141024
PNG
(US8916576, 233)
Show SMILES Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C21H15N5O/c27-19-8-4-2-6-16(19)21-24-18-7-3-1-5-15(18)20(25-21)23-14-9-10-17-13(11-14)12-22-26-17/h1-12,27H,(H,22,26)(H,23,24,25)
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n/an/a 0.00200n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141024
PNG
(US8916576, 233)
Show SMILES Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C21H15N5O/c27-19-8-4-2-6-16(19)21-24-18-7-3-1-5-15(18)20(25-21)23-14-9-10-17-13(11-14)12-22-26-17/h1-12,27H,(H,22,26)(H,23,24,25)
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n/an/a 0.00250n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141014
PNG
(US8916576, 219)
Show SMILES COC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H18N6O2/c1-31-23(30)27-20-9-5-3-7-17(20)22-26-19-8-4-2-6-16(19)21(28-22)25-15-10-11-18-14(12-15)13-24-29-18/h2-13H,1H3,(H,24,29)(H,27,30)(H,25,26,28)
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n/an/a 0.00290n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141023
PNG
(US8916576, 232)
Show SMILES CC(C)NC(=O)COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-23-10-6-4-8-20(23)26-30-22-9-5-3-7-19(22)25(31-26)29-18-11-12-21-17(13-18)14-27-32-21/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141021
PNG
(US8916576, 230)
Show SMILES CC(C)NC(=O)CNc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H25N7O/c1-16(2)29-24(34)15-27-19-7-5-6-17(12-19)25-31-23-9-4-3-8-21(23)26(32-25)30-20-10-11-22-18(13-20)14-28-33-22/h3-14,16,27H,15H2,1-2H3,(H,28,33)(H,29,34)(H,30,31,32)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141022
PNG
(US8916576, 231)
Show SMILES O=C(CN1CCOCC1)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C27H25N7O2/c35-25(17-34-11-13-36-14-12-34)30-23-7-3-1-5-20(23)27-31-24-8-4-2-6-21(24)26(32-27)29-19-9-10-22-18(15-19)16-28-33-22/h1-10,15-16H,11-14,17H2,(H,28,33)(H,30,35)(H,29,31,32)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141025
PNG
(US8916576, 234)
Show SMILES COCCNC(=O)COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O3/c1-34-13-12-27-24(33)16-35-23-9-5-3-7-20(23)26-30-22-8-4-2-6-19(22)25(31-26)29-18-10-11-21-17(14-18)15-28-32-21/h2-11,14-15H,12-13,16H2,1H3,(H,27,33)(H,28,32)(H,29,30,31)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM141039
PNG
(US8916576, 267)
Show SMILES Oc1ccc2nc(nc(Nc3ccc4[nH]ncc4c3)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H15N5O/c27-16-7-9-19-17(11-16)21(25-20(24-19)13-4-2-1-3-5-13)23-15-6-8-18-14(10-15)12-22-26-18/h1-12,27H,(H,22,26)(H,23,24,25)
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n/an/a 0.00390n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).


Citation and Details
More data for this
Ligand-Target Pair
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