Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470573 (US10815215, Example 233 | US11130745, Example 233 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19... | Citation and Details BindingDB Entry DOI: 10.7270/Q20C4ZXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50554026 (CHEMBL4744558) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127589 BindingDB Entry DOI: 10.7270/Q29G5RGH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549950 (CHEMBL4751541 | US11505536, Example 66) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.169 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549950 (CHEMBL4751541 | US11505536, Example 66) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <0.169 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00669 BindingDB Entry DOI: 10.7270/Q2VM4GWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50581628 (CHEMBL5077700) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.179 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00017 BindingDB Entry DOI: 10.7270/Q2SQ948N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530430 (6-(6-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070068 | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GM8BGM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50581627 (CHEMBL5085549) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00017 BindingDB Entry DOI: 10.7270/Q2SQ948N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50581625 (CHEMBL5075013) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.192 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00017 BindingDB Entry DOI: 10.7270/Q2SQ948N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50581624 (CHEMBL5083643) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.195 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00017 BindingDB Entry DOI: 10.7270/Q2SQ948N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50598905 (CHEMBL5180161) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00788 BindingDB Entry DOI: 10.7270/Q26M3BWM | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50575252 (CHEMBL4854356) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00532 BindingDB Entry DOI: 10.7270/Q2RF5ZT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50581626 (CHEMBL5092899) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.202 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00017 BindingDB Entry DOI: 10.7270/Q2SQ948N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530461 (N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070069 | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2BV7KSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549954 (CHEMBL4791380 | US11505536, Example 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.222 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549954 (CHEMBL4791380 | US11505536, Example 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.222 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00669 BindingDB Entry DOI: 10.7270/Q2VM4GWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50581628 (CHEMBL5077700) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.225 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00017 BindingDB Entry DOI: 10.7270/Q2SQ948N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581533 (6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.226 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581522 (2-(2-Chloro-3-methoxyphenyl)-6-(4-ethyl-3-(hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549949 (CHEMBL4753279 | US11505536, Example 82) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.249 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549949 (CHEMBL4753279 | US11505536, Example 82) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.249 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00669 BindingDB Entry DOI: 10.7270/Q2VM4GWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581554 ((R)-6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530462 (N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070069 | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2BV7KSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549951 (CHEMBL4745588 | US11505536, Example 52) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.265 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549951 (CHEMBL4745588 | US11505536, Example 52) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.265 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00669 BindingDB Entry DOI: 10.7270/Q2VM4GWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549952 (CHEMBL4752247 | US11505536, Example 51) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.267 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549952 (CHEMBL4752247 | US11505536, Example 51) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.267 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00669 BindingDB Entry DOI: 10.7270/Q2VM4GWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581532 (2-(2-Chloro-6-fluoro-3-methoxyphenyl)-6-(4-ethyl-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.273 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581512 (2-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-6-(4-ethyl-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.286 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581539 (2-(2,5-Dimethylphenyl)-6-(4-ethyl-3-(hydroxymethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.292 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530459 (N-(2-Chloro-6-fluorophenyl)-5-fluoro-4-(3-((S*)-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070069 | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2BV7KSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50575251 (CHEMBL4852401) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00532 BindingDB Entry DOI: 10.7270/Q2RF5ZT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50598923 (CHEMBL5193821) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00788 BindingDB Entry DOI: 10.7270/Q26M3BWM | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50598917 (CHEMBL5171223) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00788 BindingDB Entry DOI: 10.7270/Q26M3BWM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581479 (2-(2-Chloro-6-fluorophenyl)-6-(4-ethyl-3-(hydroxym...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581488 (6-(2-Chloro-6-fluorophenyl)-2-(4-ethyl-3-(hydroxym...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.356 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530463 ((S)-N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070069 | n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2BV7KSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530432 (7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070068 | n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GM8BGM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50575254 (CHEMBL4851260) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00532 BindingDB Entry DOI: 10.7270/Q2RF5ZT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549953 (CHEMBL4751399 | US11505536, Example 93) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.396 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549953 (CHEMBL4751399 | US11505536, Example 93) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.396 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00669 BindingDB Entry DOI: 10.7270/Q2VM4GWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50575250 (CHEMBL4859161) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00532 BindingDB Entry DOI: 10.7270/Q2RF5ZT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50575249 (CHEMBL4855859) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00532 BindingDB Entry DOI: 10.7270/Q2RF5ZT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581569 (2-(2-Chlorophenyl)-6-(4-ethyl-3-(hydroxymethyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.418 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581506 (2-(2-Chloro-6-fluorophenyl)-6-(4-ethyl-3-(hydroxym...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.433 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581521 (6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.435 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581535 (6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.444 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530442 (7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022070068 | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GM8BGM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581516 (6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.459 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM50549953 (CHEMBL4751399 | US11505536, Example 93) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.463 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM581490 ((R)-2-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.464 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WS8Z24 | |||||||||||
More data for this Ligand-Target Pair |
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