Compile Data Set for Download or QSAR

Found 137 hits of ki data for polymerid = 1719,50000362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50520051 (CHEMBL4592765) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2 Show InChI InChI=1S/C70H98N18O21S2/c1-3-36(2)56-66(106)84-48-35-111-110-34-47(83-58(98)40(13-7-25-74-70(72)73)76-53(92)32-75-57(97)44(31-55(95)96)80-64(104)49-14-8-26-86(49)68(108)45(81-63(48)103)30-37-11-5-4-6-12-37)62(102)77-41(21-23-52(71)91)59(99)79-43(29-38-17-19-39(90)20-18-38)60(100)82-46(33-89)61(101)78-42(22-24-54(93)94)67(107)88-28-10-16-51(88)69(109)87-27-9-15-50(87)65(105)85-56/h4-6,11-12,17-20,36,40-51,56,89-90H,3,7-10,13-16,21-35H2,1-2H3,(H2,71,91)(H,75,97)(H,76,92)(H,77,102)(H,78,101)(H,79,99)(H,80,104)(H,81,103)(H,82,100)(H,83,98)(H,84,106)(H,85,105)(H,93,94)(H,95,96)(H4,72,73,74)/t36-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,56-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098853 (2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(OC)c1 Show InChI InChI=1S/C31H27N5O7/c1-41-21-10-6-9-19(14-21)28-33-16-22(32)30(39)36(28)17-26(37)34-24(13-18-7-4-3-5-8-18)27(38)29-35-23-15-20(31(40)42-2)11-12-25(23)43-29/h3-12,14-16,24H,13,17,32H2,1-2H3,(H,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description Inhibitory activity against canine skin chymase				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068901 (3-[2,2-Difluoro-4-({(S)-1-[(S)-3-methyl-2-(3-pheny...) Show SMILES CC(C)[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C37H40F2N4O7/c1-23(2)31(42-30(44)19-18-24-11-5-3-6-12-24)34(47)43-20-10-17-29(43)33(46)41-28(21-25-13-7-4-8-14-25)32(45)37(38,39)36(50)40-27-16-9-15-26(22-27)35(48)49/h3-9,11-16,22-23,28-29,31H,10,17-21H2,1-2H3,(H,40,50)(H,41,46)(H,42,44)(H,48,49)/t28?,29-,31-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520048 (CHEMBL4450993) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N2 Show InChI InChI=1S/C71H92N14O20S2/c1-4-38(2)58-68(102)81-51-37-107-106-36-50(80-61(95)45(30-40-14-7-5-8-15-40)74-55(88)34-72-60(94)47(33-57(91)92)77-66(100)52-18-11-27-83(52)70(104)48(78-65(51)99)32-41-16-9-6-10-17-41)64(98)73-39(3)59(93)76-46(31-42-21-23-43(87)24-22-42)62(96)79-49(35-86)63(97)75-44(25-26-56(89)90)69(103)85-29-13-20-54(85)71(105)84-28-12-19-53(84)67(101)82-58/h5-10,14-17,21-24,38-39,44-54,58,86-87H,4,11-13,18-20,25-37H2,1-3H3,(H,72,94)(H,73,98)(H,74,88)(H,75,97)(H,76,93)(H,77,100)(H,78,99)(H,79,96)(H,80,95)(H,81,102)(H,82,101)(H,89,90)(H,91,92)/t38-,39-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520049 (CHEMBL4560112) Show SMILES NC(=O)CC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2 |r| Show InChI InChI=1S/C69H93ClN18O22S2/c70-37-16-14-36(15-17-37)28-42-60(102)83-45(32-89)61(103)79-41(20-23-54(94)95)66(108)88-27-7-13-50(88)68(110)87-26-6-12-49(87)64(106)78-40(19-22-53(92)93)59(101)85-47-34-112-111-33-46(62(104)77-39(58(100)80-42)18-21-51(71)90)84-57(99)38(10-4-24-74-69(72)73)76-52(91)31-75-56(98)43(30-55(96)97)81-65(107)48-11-5-25-86(48)67(109)44(82-63(47)105)29-35-8-2-1-3-9-35/h1-3,8-9,14-17,38-50,89H,4-7,10-13,18-34H2,(H2,71,90)(H,75,98)(H,76,91)(H,77,104)(H,78,106)(H,79,103)(H,80,100)(H,81,107)(H,82,105)(H,83,102)(H,84,99)(H,85,101)(H,92,93)(H,94,95)(H,96,97)(H4,72,73,74)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520060 (CHEMBL4465306) Show SMILES Cc1ccc(C[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N3)cc1 |r| Show InChI InChI=1S/C70H96N18O22S2/c1-36-15-17-38(18-16-36)29-43-61(102)83-46(33-89)62(103)79-42(21-24-55(94)95)67(108)88-28-8-14-51(88)69(110)87-27-7-13-50(87)65(106)78-41(20-23-54(92)93)60(101)85-48-35-112-111-34-47(63(104)77-40(59(100)80-43)19-22-52(71)90)84-58(99)39(11-5-25-74-70(72)73)76-53(91)32-75-57(98)44(31-56(96)97)81-66(107)49-12-6-26-86(49)68(109)45(82-64(48)105)30-37-9-3-2-4-10-37/h2-4,9-10,15-18,39-51,89H,5-8,11-14,19-35H2,1H3,(H2,71,90)(H,75,98)(H,76,91)(H,77,104)(H,78,106)(H,79,103)(H,80,100)(H,81,107)(H,82,105)(H,83,102)(H,84,99)(H,85,101)(H,92,93)(H,94,95)(H,96,97)(H4,72,73,74)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50208224 (2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...) Show SMILES CN(C1CCN(CC1)C(=O)c1ccc2ccccc2c1)C(=O)c1cc2ccccc2cc1C(=O)C(c1cccc2ccccc12)P(O)(O)=O Show InChI InChI=1S/C40H35N2O6P/c1-41(32-19-21-42(22-20-32)39(44)31-18-17-26-9-2-3-11-28(26)23-31)40(45)36-25-30-13-5-4-12-29(30)24-35(36)37(43)38(49(46,47)48)34-16-8-14-27-10-6-7-15-33(27)34/h2-18,23-25,32,38H,19-22H2,1H3,(H2,46,47,48)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Chymase (Homo sapiens (Human))	BDBM50139758 ((2-Naphthalen-2-yl-1-naphthalen-1-yl-2-oxo-ethyl)-...) Show SMILES OP(O)(=O)C(C(=O)c1ccc2ccccc2c1)c1cccc2ccccc12 Show InChI InChI=1S/C22H17O4P/c23-21(18-13-12-15-6-1-2-8-17(15)14-18)22(27(24,25)26)20-11-5-9-16-7-3-4-10-19(16)20/h1-14,22H,(H2,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indian Institute of Technology (BHU) Curated by ChEMBL					Assay Description Inhibition of chymase in human mast cells using Suc-Ala-Ala-Pro-Phe-(p-nitroanilide) as substrate for 15 mins by spectrophotometric method				Eur J Med Chem 161: 252-276 (2019) Article DOI: 10.1016/j.ejmech.2018.10.018 BindingDB Entry DOI: 10.7270/Q25M690C
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098874 (4-{2-[5-Amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimid...) Show SMILES Nc1cnc(-c2cccc(Cl)c2)n(CC(=O)NC(Cc2ccccc2)C(=O)C(F)(F)C(=O)NCc2ccccc2)c1=O Show InChI InChI=1S/C30H26ClF2N5O4/c31-22-13-7-12-21(15-22)27-35-17-23(34)28(41)38(27)18-25(39)37-24(14-19-8-3-1-4-9-19)26(40)30(32,33)29(42)36-16-20-10-5-2-6-11-20/h1-13,15,17,24H,14,16,18,34H2,(H,36,42)(H,37,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.62	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068918 ((S)-4-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-p...) Show SMILES CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)OC Show InChI InChI=1S/C34H44N4O9/c1-4-22(2)29(37-34(45)47-21-24-14-9-6-10-15-24)31(42)35-25(17-18-28(39)40)32(43)38-19-11-16-27(38)30(41)36-26(33(44)46-3)20-23-12-7-5-8-13-23/h5-10,12-15,22,25-27,29H,4,11,16-21H2,1-3H3,(H,35,42)(H,36,41)(H,37,45)(H,39,40)/t22-,25-,26-,27-,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 919-24 (1999) BindingDB Entry DOI: 10.7270/Q2BZ656D
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068899 (3-(4-{[(S)-1-((S)-2-Benzoylamino-3-methyl-butyryl)...) Show SMILES CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C35H36F2N4O7/c1-21(2)28(40-30(43)23-13-7-4-8-14-23)32(45)41-18-10-17-27(41)31(44)39-26(19-22-11-5-3-6-12-22)29(42)35(36,37)34(48)38-25-16-9-15-24(20-25)33(46)47/h3-9,11-16,20-21,26-28H,10,17-19H2,1-2H3,(H,38,48)(H,39,44)(H,40,43)(H,46,47)/t26?,27-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098868 (4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...) Show SMILES Cc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)NCC(=O)N1CCCCCC1 Show InChI InChI=1S/C32H36F2N6O5/c1-21-10-9-13-23(16-21)29-36-18-24(35)30(44)40(29)20-26(41)38-25(17-22-11-5-4-6-12-22)28(43)32(33,34)31(45)37-19-27(42)39-14-7-2-3-8-15-39/h4-6,9-13,16,18,25H,2-3,7-8,14-15,17,19-20,35H2,1H3,(H,37,45)(H,38,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098847 (2-(2-{2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyri...) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccc(F)cc1 Show InChI InChI=1S/C30H24FN5O6/c1-41-30(40)19-9-12-24-22(14-19)35-28(42-24)26(38)23(13-17-5-3-2-4-6-17)34-25(37)16-36-27(33-15-21(32)29(36)39)18-7-10-20(31)11-8-18/h2-12,14-15,23H,13,16,32H2,1H3,(H,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description Inhibitory activity against canine skin chymase				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068919 (3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...) Show SMILES CC(C)(C)OC(=O)NC(CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C33H38F2N4O10/c1-32(2,3)49-31(48)38-22(14-15-25(40)41)28(44)39-16-8-13-24(39)27(43)37-23(17-19-9-5-4-6-10-19)26(42)33(34,35)30(47)36-21-12-7-11-20(18-21)29(45)46/h4-7,9-12,18,22-24H,8,13-17H2,1-3H3,(H,36,47)(H,37,43)(H,38,48)(H,40,41)(H,45,46)/t22?,23?,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 919-24 (1999) BindingDB Entry DOI: 10.7270/Q2BZ656D
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50374400 (CHEMBL402185) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(OC)c1 Show InChI InChI=1S/C31H27N5O7/c1-41-21-10-6-9-19(14-21)28-33-16-22(32)30(39)36(28)17-26(37)34-24(13-18-7-4-3-5-8-18)27(38)29-35-23-15-20(31(40)42-2)11-12-25(23)43-29/h3-12,14-16,24H,13,17,32H2,1-2H3,(H,34,37)/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human chymase				Bioorg Med Chem 16: 1562-95 (2008) Article DOI: 10.1016/j.bmc.2007.11.015 BindingDB Entry DOI: 10.7270/Q21J9BNH
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098853 (2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(OC)c1 Show InChI InChI=1S/C31H27N5O7/c1-41-21-10-6-9-19(14-21)28-33-16-22(32)30(39)36(28)17-26(37)34-24(13-18-7-4-3-5-8-18)27(38)29-35-23-15-20(31(40)42-2)11-12-25(23)43-29/h3-12,14-16,24H,13,17,32H2,1-2H3,(H,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description Inhibitory activity evaluated against chymase from human heart.				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098854 (2-{2-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)...) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1 Show InChI InChI=1S/C30H25N5O6/c1-40-30(39)20-12-13-24-22(15-20)34-28(41-24)26(37)23(14-18-8-4-2-5-9-18)33-25(36)17-35-27(19-10-6-3-7-11-19)32-16-21(31)29(35)38/h2-13,15-16,23H,14,17,31H2,1H3,(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description Inhibitory activity evaluated against chymase from human heart.				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098841 (2-(2-{2-[5-Amino-2-(3-amino-phenyl)-6-oxo-6H-pyrim...) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(N)c1 Show InChI InChI=1S/C30H26N6O6/c1-41-30(40)19-10-11-24-22(14-19)35-28(42-24)26(38)23(12-17-6-3-2-4-7-17)34-25(37)16-36-27(33-15-21(32)29(36)39)18-8-5-9-20(31)13-18/h2-11,13-15,23H,12,16,31-32H2,1H3,(H,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description Inhibitory activity evaluated against chymase from human heart.				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50374284 (CHEMBL256270) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1 Show InChI InChI=1S/C30H25N5O6/c1-40-30(39)20-12-13-24-22(15-20)34-28(41-24)26(37)23(14-18-8-4-2-5-9-18)33-25(36)17-35-27(19-10-6-3-7-11-19)32-16-21(31)29(35)38/h2-13,15-16,23H,14,17,31H2,1H3,(H,33,36)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human chymase				Bioorg Med Chem 16: 1562-95 (2008) Article DOI: 10.1016/j.bmc.2007.11.015 BindingDB Entry DOI: 10.7270/Q21J9BNH
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068894 (3-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...) Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C33H40F2N4O8/c1-19(2)25(38-31(46)47-32(3,4)5)28(42)39-16-10-15-24(39)27(41)37-23(17-20-11-7-6-8-12-20)26(40)33(34,35)30(45)36-22-14-9-13-21(18-22)29(43)44/h6-9,11-14,18-19,23-25H,10,15-17H2,1-5H3,(H,36,45)(H,37,41)(H,38,46)(H,43,44)/t23?,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068911 (3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-3-methyl-...) Show SMILES CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C33H40F2N4O8/c1-19(2)25(38-31(46)47-32(3,4)5)28(42)39-16-10-15-24(39)27(41)37-23(17-20-11-7-6-8-12-20)26(40)33(34,35)30(45)36-22-14-9-13-21(18-22)29(43)44/h6-9,11-14,18-19,23-25H,10,15-17H2,1-5H3,(H,36,45)(H,37,41)(H,38,46)(H,43,44)/t23?,24-,25?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 919-24 (1999) BindingDB Entry DOI: 10.7270/Q2BZ656D
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068894 (3-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...) Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C33H40F2N4O8/c1-19(2)25(38-31(46)47-32(3,4)5)28(42)39-16-10-15-24(39)27(41)37-23(17-20-11-7-6-8-12-20)26(40)33(34,35)30(45)36-22-14-9-13-21(18-22)29(43)44/h6-9,11-14,18-19,23-25H,10,15-17H2,1-5H3,(H,36,45)(H,37,41)(H,38,46)(H,43,44)/t23?,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520063 (CHEMBL4586444) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O Show InChI InChI=1S/C69H97N17O21S2/c1-4-35(2)54-64(103)81-46-33-108-109-34-47(80-57(96)40(14-8-24-72-69(70)71)74-51(90)31-73-56(95)43(30-53(93)94)76-62(101)48-15-9-25-84(48)67(106)44(78-60(46)99)29-37-12-6-5-7-13-37)61(100)83-55(36(3)88)65(104)77-42(28-38-18-20-39(89)21-19-38)58(97)79-45(32-87)59(98)75-41(22-23-52(91)92)66(105)86-27-11-17-50(86)68(107)85-26-10-16-49(85)63(102)82-54/h5-7,12-13,18-21,35-36,40-50,54-55,87-89H,4,8-11,14-17,22-34H2,1-3H3,(H,73,95)(H,74,90)(H,75,98)(H,76,101)(H,77,104)(H,78,99)(H,79,97)(H,80,96)(H,81,103)(H,82,102)(H,83,100)(H,91,92)(H,93,94)(H4,70,71,72)/t35-,36+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,54-,55-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068917 (5-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...) Show SMILES CC(C)(C)OC(=O)NC(CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cc(cs1)C(O)=O Show InChI InChI=1S/C31H36F2N4O10S/c1-30(2,3)47-29(46)35-19(11-12-23(38)39)26(42)37-13-7-10-21(37)25(41)34-20(14-17-8-5-4-6-9-17)24(40)31(32,33)28(45)36-22-15-18(16-48-22)27(43)44/h4-6,8-9,15-16,19-21H,7,10-14H2,1-3H3,(H,34,41)(H,35,46)(H,36,45)(H,38,39)(H,43,44)/t19?,20?,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 919-24 (1999) BindingDB Entry DOI: 10.7270/Q2BZ656D
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068889 (3-(4-{[(S)-1-((S)-2-Benzenesulfonylamino-3-methyl-...) Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C34H36F2N4O8S/c1-21(2)28(39-49(47,48)25-15-7-4-8-16-25)31(43)40-18-10-17-27(40)30(42)38-26(19-22-11-5-3-6-12-22)29(41)34(35,36)33(46)37-24-14-9-13-23(20-24)32(44)45/h3-9,11-16,20-21,26-28,39H,10,17-19H2,1-2H3,(H,37,46)(H,38,42)(H,44,45)/t26?,27-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068896 ((4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methy...) Show SMILES COC(=O)CNC(=O)C(F)(F)C(=O)C(Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C Show InChI InChI=1S/C29H40F2N4O8/c1-17(2)22(34-27(41)43-28(3,4)5)25(39)35-14-10-13-20(35)24(38)33-19(15-18-11-8-7-9-12-18)23(37)29(30,31)26(40)32-16-21(36)42-6/h7-9,11-12,17,19-20,22H,10,13-16H2,1-6H3,(H,32,40)(H,33,38)(H,34,41)/t19?,20-,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520050 (CHEMBL4457132) Show SMILES NC(=O)CC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2 Show InChI InChI=1S/C69H94N18O23S2/c70-51(90)21-18-39-58(100)79-42(28-36-14-16-37(89)17-15-36)60(102)82-45(32-88)61(103)78-41(20-23-54(94)95)66(108)87-27-7-13-50(87)68(110)86-26-6-12-49(86)64(106)77-40(19-22-53(92)93)59(101)84-47-34-112-111-33-46(62(104)76-39)83-57(99)38(10-4-24-73-69(71)72)75-52(91)31-74-56(98)43(30-55(96)97)80-65(107)48-11-5-25-85(48)67(109)44(81-63(47)105)29-35-8-2-1-3-9-35/h1-3,8-9,14-17,38-50,88-89H,4-7,10-13,18-34H2,(H2,70,90)(H,74,98)(H,75,91)(H,76,104)(H,77,106)(H,78,103)(H,79,100)(H,80,107)(H,81,105)(H,82,102)(H,83,99)(H,84,101)(H,92,93)(H,94,95)(H,96,97)(H4,71,72,73)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068915 (5-{(S)-2-[1-Benzyl-3-(3-carboxymethyl-phenylcarbam...) Show SMILES CC(C)(C)OC(=O)NC(CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(CC(O)=O)c1 Show InChI InChI=1S/C34H40F2N4O10/c1-33(2,3)50-32(49)39-23(14-15-26(41)42)30(47)40-16-8-13-25(40)29(46)38-24(18-20-9-5-4-6-10-20)28(45)34(35,36)31(48)37-22-12-7-11-21(17-22)19-27(43)44/h4-7,9-12,17,23-25H,8,13-16,18-19H2,1-3H3,(H,37,48)(H,38,46)(H,39,49)(H,41,42)(H,43,44)/t23?,24?,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 919-24 (1999) BindingDB Entry DOI: 10.7270/Q2BZ656D
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068887 (4-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...) Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1ccc(cc1)C(O)=O Show InChI InChI=1S/C33H40F2N4O8/c1-19(2)25(38-31(46)47-32(3,4)5)28(42)39-17-9-12-24(39)27(41)37-23(18-20-10-7-6-8-11-20)26(40)33(34,35)30(45)36-22-15-13-21(14-16-22)29(43)44/h6-8,10-11,13-16,19,23-25H,9,12,17-18H2,1-5H3,(H,36,45)(H,37,41)(H,38,46)(H,43,44)/t23?,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068892 (3-(4-{[(S)-1-((S)-2-Acetylamino-3-methyl-butyryl)-...) Show SMILES CC(C)[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C30H34F2N4O7/c1-17(2)24(33-18(3)37)27(40)36-14-8-13-23(36)26(39)35-22(15-19-9-5-4-6-10-19)25(38)30(31,32)29(43)34-21-12-7-11-20(16-21)28(41)42/h4-7,9-12,16-17,22-24H,8,13-15H2,1-3H3,(H,33,37)(H,34,43)(H,35,39)(H,41,42)/t22?,23-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520064 (CHEMBL4590739) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2 Show InChI InChI=1S/C68H93N17O23S2/c1-34(87)54-64(105)77-41(27-36-15-17-37(88)18-16-36)58(99)79-44(31-86)59(100)75-40(20-22-52(92)93)65(106)85-26-8-14-49(85)67(108)84-25-7-13-48(84)62(103)74-39(19-21-51(90)91)57(98)80-45-32-109-110-33-46(61(102)82-54)81-56(97)38(11-5-23-71-68(69)70)73-50(89)30-72-55(96)42(29-53(94)95)76-63(104)47-12-6-24-83(47)66(107)43(78-60(45)101)28-35-9-3-2-4-10-35/h2-4,9-10,15-18,34,38-49,54,86-88H,5-8,11-14,19-33H2,1H3,(H,72,96)(H,73,89)(H,74,103)(H,75,100)(H,76,104)(H,77,105)(H,78,101)(H,79,99)(H,80,98)(H,81,97)(H,82,102)(H,90,91)(H,92,93)(H,94,95)(H4,69,70,71)/t34-,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,54+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098892 (4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...) Show SMILES CCNC(=O)CNC(=O)C(F)(F)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(C)c1 Show InChI InChI=1S/C28H30F2N6O5/c1-3-32-22(37)15-34-27(41)28(29,30)24(39)21(13-18-9-5-4-6-10-18)35-23(38)16-36-25(33-14-20(31)26(36)40)19-11-7-8-17(2)12-19/h4-12,14,21H,3,13,15-16,31H2,1-2H3,(H,32,37)(H,34,41)(H,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098879 (4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...) Show SMILES CCN(CC)C(=O)CNC(=O)C(F)(F)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(C)c1 Show InChI InChI=1S/C30H34F2N6O5/c1-4-37(5-2)25(40)17-35-29(43)30(31,32)26(41)23(15-20-11-7-6-8-12-20)36-24(39)18-38-27(34-16-22(33)28(38)42)21-13-9-10-19(3)14-21/h6-14,16,23H,4-5,15,17-18,33H2,1-3H3,(H,35,43)(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9.32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098880 (3-{4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl...) Show SMILES Cc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O Show InChI InChI=1S/C31H27F2N5O6/c1-18-7-5-10-20(13-18)27-35-16-23(34)28(41)38(27)17-25(39)37-24(14-19-8-3-2-4-9-19)26(40)31(32,33)30(44)36-22-12-6-11-21(15-22)29(42)43/h2-13,15-16,24H,14,17,34H2,1H3,(H,36,44)(H,37,39)(H,42,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520066 (CHEMBL4442550) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N2 Show InChI InChI=1S/C70H90N14O20S2/c1-4-37(2)57-67(101)80-50-36-106-105-35-49(79-60(94)43(28-39-14-7-5-8-15-39)73-54(87)33-71-59(93)45(31-55(88)89)75-65(99)51-18-11-25-82(51)68(102)46(76-64(50)98)30-40-16-9-6-10-17-40)63(97)72-38(3)58(92)74-44(29-41-21-23-42(86)24-22-41)61(95)78-48(34-85)62(96)77-47(32-56(90)91)69(103)84-27-13-20-53(84)70(104)83-26-12-19-52(83)66(100)81-57/h5-10,14-17,21-24,37-38,43-53,57,85-86H,4,11-13,18-20,25-36H2,1-3H3,(H,71,93)(H,72,97)(H,73,87)(H,74,92)(H,75,99)(H,76,98)(H,77,96)(H,78,95)(H,79,94)(H,80,101)(H,81,100)(H,88,89)(H,90,91)/t37-,38-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,57-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098870 (CHEMBL26182 | {4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-py...) Show SMILES COC(=O)CNC(=O)C(F)(F)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(C)c1 Show InChI InChI=1S/C27H27F2N5O6/c1-16-7-6-10-18(11-16)24-31-13-19(30)25(38)34(24)15-21(35)33-20(12-17-8-4-3-5-9-17)23(37)27(28,29)26(39)32-14-22(36)40-2/h3-11,13,20H,12,14-15,30H2,1-2H3,(H,32,39)(H,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098878 (4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...) Show SMILES Cc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)NCC(=O)N1CCCCC1 Show InChI InChI=1S/C31H34F2N6O5/c1-20-9-8-12-22(15-20)28-35-17-23(34)29(43)39(28)19-25(40)37-24(16-21-10-4-2-5-11-21)27(42)31(32,33)30(44)36-18-26(41)38-13-6-3-7-14-38/h2,4-5,8-12,15,17,24H,3,6-7,13-14,16,18-19,34H2,1H3,(H,36,44)(H,37,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50208222 ((E)-2-(3-chloro-5-fluorostyrylamino)-1-(5-chlorobe...) Show SMILES CP(O)(=O)C(C(=O)NC=Cc1cc(F)cc(Cl)c1)c1csc2ccc(Cl)cc12 |w:9.9| Show InChI InChI=1S/C19H15Cl2FNO3PS/c1-27(25,26)18(16-10-28-17-3-2-12(20)9-15(16)17)19(24)23-5-4-11-6-13(21)8-14(22)7-11/h2-10,18H,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human skin chymase				J Med Chem 50: 1727-30 (2007) Article DOI: 10.1021/jm0700619 BindingDB Entry DOI: 10.7270/Q26W99RF
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50520059 (CHEMBL4561218) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)CC Show InChI InChI=1S/C71H102N18O19S2/c1-5-37(3)56-67(105)84-49-36-110-109-35-48(83-59(97)42(16-10-26-75-71(73)74)77-54(93)33-76-58(96)45(32-55(94)95)80-65(103)50-17-11-27-87(50)68(106)46(81-64(49)102)31-39-14-8-7-9-15-39)63(101)78-43(24-25-53(72)92)60(98)79-44(30-40-20-22-41(91)23-21-40)61(99)82-47(34-90)62(100)86-57(38(4)6-2)70(108)89-29-13-19-52(89)69(107)88-28-12-18-51(88)66(104)85-56/h7-9,14-15,20-23,37-38,42-52,56-57,90-91H,5-6,10-13,16-19,24-36H2,1-4H3,(H2,72,92)(H,76,96)(H,77,93)(H,78,101)(H,79,98)(H,80,103)(H,81,102)(H,82,99)(H,83,97)(H,84,105)(H,85,104)(H,86,100)(H,94,95)(H4,73,74,75)/t37-,38-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...				J Med Chem 63: 816-826 (2020) Article DOI: 10.1021/acs.jmedchem.9b01811 BindingDB Entry DOI: 10.7270/Q2RX9GG7
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098875 (4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...) Show SMILES Cc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)NCC(N)=O Show InChI InChI=1S/C26H26F2N6O5/c1-15-6-5-9-17(10-15)23-31-12-18(29)24(38)34(23)14-21(36)33-19(11-16-7-3-2-4-8-16)22(37)26(27,28)25(39)32-13-20(30)35/h2-10,12,19H,11,13-14,29H2,1H3,(H2,30,35)(H,32,39)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068903 ((4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methy...) Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)NCC(O)=O Show InChI InChI=1S/C28H38F2N4O8/c1-16(2)21(33-26(41)42-27(3,4)5)24(39)34-13-9-12-19(34)23(38)32-18(14-17-10-7-6-8-11-17)22(37)28(29,30)25(40)31-15-20(35)36/h6-8,10-11,16,18-19,21H,9,12-15H2,1-5H3,(H,31,40)(H,32,38)(H,33,41)(H,35,36)/t18?,19-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068905 ((4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methy...) Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)NCC(=O)OCc1ccccc1 Show InChI InChI=1S/C35H44F2N4O8/c1-22(2)28(40-33(47)49-34(3,4)5)31(45)41-18-12-17-26(41)30(44)39-25(19-23-13-8-6-9-14-23)29(43)35(36,37)32(46)38-20-27(42)48-21-24-15-10-7-11-16-24/h6-11,13-16,22,25-26,28H,12,17-21H2,1-5H3,(H,38,46)(H,39,44)(H,40,47)/t25?,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM87059 (CHEMBL247767 | Chymostatin) Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C1CCNC(N)=N1)C(=O)N[C@@H](Cc1ccccc1)C=O |c:30| Show InChI InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description inhibitory activity was evaluated against chymase from human heart.				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM87059 (CHEMBL247767 | Chymostatin) Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C1CCNC(N)=N1)C(=O)N[C@@H](Cc1ccccc1)C=O |c:30| Show InChI InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098882 (4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...) Show SMILES Cc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(N)=O Show InChI InChI=1S/C24H23F2N5O4/c1-14-6-5-9-16(10-14)21-29-12-17(27)22(34)31(21)13-19(32)30-18(11-15-7-3-2-4-8-15)20(33)24(25,26)23(28)35/h2-10,12,18H,11,13,27H2,1H3,(H2,28,35)(H,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	13.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098877 (4-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimi...) Show SMILES COc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)NCc1ccccc1 Show InChI InChI=1S/C31H29F2N5O5/c1-43-23-14-8-13-22(16-23)28-35-18-24(34)29(41)38(28)19-26(39)37-25(15-20-9-4-2-5-10-20)27(40)31(32,33)30(42)36-17-21-11-6-3-7-12-21/h2-14,16,18,25H,15,17,19,34H2,1H3,(H,36,42)(H,37,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068912 (3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...) Show SMILES CC(C)(C)OC(=O)NC(CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cc(C(O)=O)c2ccccc2c1 Show InChI InChI=1S/C37H40F2N4O10/c1-36(2,3)53-35(52)42-26(15-16-29(44)45)32(48)43-17-9-14-28(43)31(47)41-27(18-21-10-5-4-6-11-21)30(46)37(38,39)34(51)40-23-19-22-12-7-8-13-24(22)25(20-23)33(49)50/h4-8,10-13,19-20,26-28H,9,14-18H2,1-3H3,(H,40,51)(H,41,47)(H,42,52)(H,44,45)(H,49,50)/t26?,27?,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 919-24 (1999) BindingDB Entry DOI: 10.7270/Q2BZ656D
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098849 (2-(2-{2-[5-Amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyri...) Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(F)c1 Show InChI InChI=1S/C30H24FN5O6/c1-41-30(40)19-10-11-24-22(14-19)35-28(42-24)26(38)23(12-17-6-3-2-4-7-17)34-25(37)16-36-27(33-15-21(32)29(36)39)18-8-5-9-20(31)13-18/h2-11,13-15,23H,12,16,32H2,1H3,(H,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	14.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description Inhibitory activity evaluated against chymase from human heart.				J Med Chem 44: 1286-96 (2001) BindingDB Entry DOI: 10.7270/Q26H4J4K
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50098876 (4-{2-[5-Amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimid...) Show SMILES Nc1cnc(-c2cccc(F)c2)n(CC(=O)NC(Cc2ccccc2)C(=O)C(F)(F)C(=O)NCc2ccccc2)c1=O Show InChI InChI=1S/C30H26F3N5O4/c31-22-13-7-12-21(15-22)27-35-17-23(34)28(41)38(27)18-25(39)37-24(14-19-8-3-1-4-9-19)26(40)30(32,33)29(42)36-16-20-10-5-2-6-11-20/h1-13,15,17,24H,14,16,18,34H2,(H,36,42)(H,37,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	15.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Welfide Corporation Curated by ChEMBL					Assay Description In vitro inhibitory activity was determined against human heart chymase				J Med Chem 44: 1297-304 (2001) BindingDB Entry DOI: 10.7270/Q22R3SCD
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50068908 (CHEMBL352917 | {(S)-1-[(S)-2-(1-Benzyl-3,3-difluor...) Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1ccccc1 Show InChI InChI=1S/C32H40F2N4O6/c1-20(2)25(37-30(43)44-31(3,4)5)28(41)38-18-12-17-24(38)27(40)36-23(19-21-13-8-6-9-14-21)26(39)32(33,34)29(42)35-22-15-10-7-11-16-22/h6-11,13-16,20,23-25H,12,17-19H2,1-5H3,(H,35,42)(H,36,40)(H,37,43)/t23?,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against human heart chymase (HHC)				Bioorg Med Chem Lett 8: 913-8 (1999) BindingDB Entry DOI: 10.7270/Q2GQ6WXB
					More data for this Ligand-Target Pair

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