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Compile Data Set for Download or QSAR

Found 29 hits of ki for UniProtKB: Q63207   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor X


(Rattus norvegicus (rat))		BDBM17135
PNG
(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Show SMILES CNc1nccn1Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl
Show InChI InChI=1S/C23H19Cl3N6O3S/c1-27-23-28-5-6-32(23)10-12-11-36-20(18(12)26)22(34)31-19-15(7-14(25)8-16(19)35-2)21(33)30-17-4-3-13(24)9-29-17/h3-9,11H,10H2,1-2H3,(H,27,28)(H,31,34)(H,29,30,33)
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 0.0600n/an/an/an/an/an/an/an/a



Berlex Biosciences



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...

J Med Chem 50: 2967-80 (2007)


Article DOI: 10.1021/jm070125f
BindingDB Entry DOI: 10.7270/Q2J101F5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor X


(Rattus norvegicus (rat))		BDBM17111
PNG
(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Show SMILES COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCO2)c1Cl |t:31|
Show InChI InChI=1S/C23H20Cl3N5O4S/c1-31(23-27-5-6-35-23)10-12-11-36-20(18(12)26)22(33)30-19-15(7-14(25)8-16(19)34-2)21(32)29-17-4-3-13(24)9-28-17/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,30,33)(H,28,29,32)
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 0.290n/an/an/an/an/an/an/an/a



Berlex Biosciences



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...

J Med Chem 50: 2967-80 (2007)


Article DOI: 10.1021/jm070125f
BindingDB Entry DOI: 10.7270/Q2J101F5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor X


(Rattus norvegicus (rat))		BDBM17090
PNG
(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Show SMILES CNCc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl
Show InChI InChI=1S/C20H17Cl3N4O3S/c1-24-7-10-9-31-18(16(10)23)20(29)27-17-13(5-12(22)6-14(17)30-2)19(28)26-15-4-3-11(21)8-25-15/h3-6,8-9,24H,7H2,1-2H3,(H,27,29)(H,25,26,28)
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 2.5 -11.6n/an/an/an/an/a7.522



Berlex Biosciences



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...

J Med Chem 50: 2967-80 (2007)


Article DOI: 10.1021/jm070125f
BindingDB Entry DOI: 10.7270/Q2J101F5
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM294039
PNG
(Process 1 | US10106557, Compound 1)
Show SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O
Show InChI InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23)
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 2.87n/an/an/an/an/an/a8.3n/a



NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD.

US Patent


Assay Description
The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...

US Patent US10106557 (2018)


BindingDB Entry DOI: 10.7270/Q2X63Q0W
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM294042
PNG
(US10106557, Compound 8)
Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1ccccc1=O |r|
Show InChI InChI=1S/C21H16ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h1-9,14,16H,10-11H2,(H,23,27)/t14-,16-/m0/s1
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 3.17n/an/an/an/an/an/a8.3n/a



NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD.

US Patent


Assay Description
The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...

US Patent US10106557 (2018)


BindingDB Entry DOI: 10.7270/Q2X63Q0W
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM50024354
PNG
(CHEMBL3330444 | US10106557, Compound 2)
Show SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O |r|
Show InChI InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1
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 4.45n/an/an/an/an/an/a8.3n/a



NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD.

US Patent


Assay Description
The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...

US Patent US10106557 (2018)


BindingDB Entry DOI: 10.7270/Q2X63Q0W
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM35743
PNG
(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Show SMILES CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 |r|
Show InChI InChI=1S/C26H31ClN6O3S/c1-32(2)26(36)14-4-6-18(29-23(34)21-12-15-10-16(27)5-7-17(15)28-21)20(11-14)30-24(35)25-31-19-8-9-33(3)13-22(19)37-25/h5,7,10,12,14,18,20,28H,4,6,8-9,11,13H2,1-3H3,(H,29,34)(H,30,35)/t14-,18-,20+/m0/s1
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 8.77n/an/an/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat factor 10a by Lineweaver-Burk plot

Bioorg Med Chem 17: 1193-206 (2009)


Article DOI: 10.1016/j.bmc.2008.12.037
BindingDB Entry DOI: 10.7270/Q2V69JGR
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387083
PNG
(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES Fc1cc2ccccc2cc1-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c27-20-13-16-3-1-2-4-17(16)14-21(20)35-23-19(24(31-35)26(28,29)30)7-10-33(25(23)37)18-5-8-32(9-6-18)34-11-12-38-15-22(34)36/h1-4,13-14,18H,5-12,15H2
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387082
PNG
(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387080
PNG
(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O4/c24-23(25,26)20-15-5-8-31(13-3-6-30(7-4-13)32-9-10-36-12-18(32)34)22(35)19(15)33(28-20)14-1-2-17-16(11-14)21(27)29-37-17/h1-2,11,13H,3-10,12H2,(H2,27,29)
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387078
PNG
(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C26H25ClF3N5O3/c27-18-3-1-17-14-20(4-2-16(17)13-18)35-23-21(24(31-35)26(28,29)30)7-10-33(25(23)37)19-5-8-32(9-6-19)34-11-12-38-15-22(34)36/h1-4,13-14,19H,5-12,15H2
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387054
PNG
(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3/c1-34-17-6-4-16(5-7-17)31-20-18(21(27-31)23(24,25)26)10-14-29(22(20)33)15-8-12-28(13-9-15)30-11-2-3-19(30)32/h4-7,15H,2-3,8-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387050
PNG
(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3/c1-35-18-7-5-17(6-8-18)32-21-19(22(28-32)24(25,26)27)11-15-30(23(21)34)16-9-13-29(14-10-16)31-12-3-2-4-20(31)33/h5-8,16H,2-4,9-15H2,1H3
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387049
PNG
(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O4/c1-34-17-4-2-16(3-5-17)31-20-18(21(27-31)23(24,25)26)8-11-29(22(20)33)15-6-9-28(10-7-15)30-12-13-35-14-19(30)32/h2-5,15H,6-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM294041
PNG
(US10106557, Compound 7)
Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCNC1=O |r|
Show InChI InChI=1S/C20H19ClN4O5S/c21-17-5-4-16(31-17)18(26)23-9-15-13-10-29-14-8-11(24-7-1-6-22-19(24)27)2-3-12(14)25(13)20(28)30-15/h2-5,8,13,15H,1,6-7,9-10H2,(H,22,27)(H,23,26)/t13-,15-/m0/s1
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 16.5n/an/an/an/an/an/a8.3n/a



NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD.

US Patent


Assay Description
The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...

US Patent US10106557 (2018)


BindingDB Entry DOI: 10.7270/Q2X63Q0W
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM294043
PNG
(US10106557, Compound 30)
Show SMILES COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r|
Show InChI InChI=1S/C22H24ClN3O5S/c1-29-11-14-3-2-8-25(14)13-4-5-15-17(9-13)30-12-16-18(31-22(28)26(15)16)10-24-21(27)19-6-7-20(23)32-19/h4-7,9,14,16,18H,2-3,8,10-12H2,1H3,(H,24,27)/t14-,16+,18+/m1/s1
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 21.5n/an/an/an/an/an/a8.3n/a



NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD.

US Patent


Assay Description
The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...

US Patent US10106557 (2018)


BindingDB Entry DOI: 10.7270/Q2X63Q0W
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387058
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O5/c1-33-17-4-2-16(3-5-17)29-21-18(20(25-29)22(24)31)8-11-27(23(21)32)15-6-9-26(10-7-15)28-12-13-34-14-19(28)30/h2-5,15H,6-14H2,1H3,(H2,24,31)
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 30n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12 |w:24.25|
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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 30n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12 |w:24.25|
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387065
PNG
(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387085
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES NC(=O)c1cccc(c1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)20-17-6-9-30(15-4-7-29(8-5-15)31-10-11-36-13-18(31)33)22(35)19(17)32(28-20)16-3-1-2-14(12-16)21(27)34/h1-3,12,15H,4-11,13H2,(H2,27,34)
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387077
PNG
(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Show SMILES FC(F)Oc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N5O4/c24-22(25)37-16-3-1-15(2-4-16)33-19-17(20(29-33)23(26,27)28)7-10-31(21(19)35)14-5-8-30(9-6-14)32-11-12-36-13-18(32)34/h1-4,14,22H,5-13H2
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387057
PNG
(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Show SMILES COc1ccc(cc1)-n1nc(\C(N)=N/C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C25H30N8O3/c1-36-19-7-5-18(6-8-19)33-23-20(22(29-33)24(27)28-16-26)11-15-31(25(23)35)17-9-13-30(14-10-17)32-12-3-2-4-21(32)34/h5-8,17H,2-4,9-15H2,1H3,(H2,27,28)
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387055
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-28(24(22)33)16-9-13-27(14-10-16)29-12-3-2-4-20(29)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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 30n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387056
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O3/c1-33-19-7-5-18(6-8-19)30-23-20(21(16-25)26-30)11-15-28(24(23)32)17-9-13-27(14-10-17)29-12-3-2-4-22(29)31/h5-8,17H,2-4,9-15H2,1H3
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM19023
PNG
(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
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 30n/an/an/an/an/an/an/an/a



Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor X


(Rattus norvegicus (rat))		BDBM50324743
PNG
((3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DIC...)
Show SMILES FC(F)CN1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 |r|
Show InChI InChI=1S/C24H21ClF3N5O3/c25-14-4-7-21(29-10-14)31-24(36)17-12-32(13-20(27)28)11-16(17)23(35)30-19-6-5-15(9-18(19)26)33-8-2-1-3-22(33)34/h1-10,16-17,20H,11-13H2,(H,30,35)(H,29,31,36)/t16-,17-/m0/s1
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 100n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Binding affinity to rat factor 10a

Bioorg Med Chem Lett 20: 5313-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.126
BindingDB Entry DOI: 10.7270/Q2542NSG
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387064
PNG
(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O5/c24-23(25,26)37-16-3-1-15(2-4-16)32-20-17(19(28-32)21(27)34)7-10-30(22(20)35)14-5-8-29(9-6-14)31-11-12-36-13-18(31)33/h1-4,14H,5-13H2,(H2,27,34)
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))		BDBM387068
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(N3CCC(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-29(24(22)33)27-13-9-16(10-14-27)28-12-3-2-4-20(28)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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Amgen



Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2F1921P
More data for this
Ligand-Target Pair