Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461540 (CHEMBL4226033) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461545 (CHEMBL4226876) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50495950 (Danoprevir | R-05190591 | R05190591 | RO-5190591 |...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Inhibitory activity against HIV-1 Mutant Reverse transcriptase K103N | Eur J Med Chem 164: 576-601 (2019) Article DOI: 10.1016/j.ejmech.2018.12.045 BindingDB Entry DOI: 10.7270/Q2RR224D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461549 (CHEMBL4225009) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461552 (CHEMBL4228791) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461537 (CHEMBL4228440) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461556 (CHEMBL4225149) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461547 (CHEMBL4225051) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279568 ((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461555 (CHEMBL4225768) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461554 (CHEMBL4225514) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461539 (CHEMBL4229110) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461551 (CHEMBL4229052) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279570 ((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279562 ((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279573 ((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279572 ((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279567 ((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279565 ((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279566 ((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461542 (CHEMBL4224705) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279563 ((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279564 ((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279561 ((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461541 (CHEMBL4225301) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461564 (CHEMBL4228533) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50287594 (Asunaprevir | BMS 650032 | BMS-650032) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using R... | ACS Med Chem Lett 9: 143-148 (2018) Article DOI: 10.1021/acsmedchemlett.7b00503 BindingDB Entry DOI: 10.7270/Q2668GR7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50287622 (CHEMBL4160876) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using R... | ACS Med Chem Lett 9: 143-148 (2018) Article DOI: 10.1021/acsmedchemlett.7b00503 BindingDB Entry DOI: 10.7270/Q2668GR7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279560 ((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279569 ((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279574 ((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50287594 (Asunaprevir | BMS 650032 | BMS-650032) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279575 ((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279576 ((3S)-3-(3-bromo-5-(trifluoromethoxy)phenyl)-3-(2-(...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461562 (CHEMBL4227396) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461565 (CHEMBL4228402) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-1 [T112H] (Homo sapiens (Human)) | BDBM279571 ((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50485492 (Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells | Eur J Med Chem 164: 576-601 (2019) Article DOI: 10.1016/j.ejmech.2018.12.045 BindingDB Entry DOI: 10.7270/Q2RR224D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50110122 ((S)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
MRL Rome Curated by ChEMBL | Assay Description Inhibitory activity against Hepatitis C NS3/NS4A protease | J Med Chem 46: 345-8 (2003) Article DOI: 10.1021/jm025594q BindingDB Entry DOI: 10.7270/Q2CF9PF1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50122900 ((5R,8S,11S,14S,17S,20S)-20-acetamido-14-benzhydryl...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
MRL Rome Curated by ChEMBL | Assay Description Inhibitory activity against Hepatitis C NS3/NS4A protease | J Med Chem 46: 345-8 (2003) Article DOI: 10.1021/jm025594q BindingDB Entry DOI: 10.7270/Q2CF9PF1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461553 (CHEMBL4228282) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461550 (CHEMBL2403888) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461543 (CHEMBL4229158) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461538 (CHEMBL4227401) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461535 (CHEMBL4226548) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461546 (CHEMBL4225716) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50537589 (CHEMBL4287268) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Inhibitory activity against HIV-1 Y188L reverse transcriptase. | Eur J Med Chem 164: 576-601 (2019) Article DOI: 10.1016/j.ejmech.2018.12.045 BindingDB Entry DOI: 10.7270/Q2RR224D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461558 (CHEMBL4227183) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 2b NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50461536 (CHEMBL4225561) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep... | Bioorg Med Chem Lett 28: 1853-1859 (2018) Article DOI: 10.1016/j.bmcl.2018.04.009 BindingDB Entry DOI: 10.7270/Q2NP272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50122902 (4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{1...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
MRL Rome Curated by ChEMBL | Assay Description Inhibitory activity against Hepatitis C NS3/NS4A protease | J Med Chem 46: 345-8 (2003) Article DOI: 10.1021/jm025594q BindingDB Entry DOI: 10.7270/Q2CF9PF1 | |||||||||||
More data for this Ligand-Target Pair |
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