Found 881 hits of ec50 data for polymerid = 1991 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412965
(CHEMBL480821)Show SMILES Cc1ccc(o1)-c1ccc(cc1F)S(=O)(=O)N1CCCC[C@H]1C(=O)N1CC[C@@H](N)C1 |r| Show InChI InChI=1S/C21H26FN3O4S/c1-14-5-8-20(29-14)17-7-6-16(12-18(17)22)30(27,28)25-10-3-2-4-19(25)21(26)24-11-9-15(23)13-24/h5-8,12,15,19H,2-4,9-11,13,23H2,1H3/t15-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0501 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50280856
(CHEMBL4172656)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@@H]1[C@H](Cc2ccccc12)NC(=O)c1cc2cc(C)ccc2[nH]1 |r| Show InChI InChI=1S/C26H30N4O2/c1-16-9-10-21-18(12-16)14-23(28-21)25(31)29-22-13-17-6-3-4-8-20(17)24(22)26(32)27-19-7-5-11-30(2)15-19/h3-4,6,8-10,12,14,19,22,24,28H,5,7,11,13,15H2,1-2H3,(H,27,32)(H,29,31)/t19-,22-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats |
J Med Chem 61: 5974-5987 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00322
BindingDB Entry DOI: 10.7270/Q2WD433X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50280856
(CHEMBL4172656)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@@H]1[C@H](Cc2ccccc12)NC(=O)c1cc2cc(C)ccc2[nH]1 |r| Show InChI InChI=1S/C26H30N4O2/c1-16-9-10-21-18(12-16)14-23(28-21)25(31)29-22-13-17-6-3-4-8-20(17)24(22)26(32)27-19-7-5-11-30(2)15-19/h3-4,6,8-10,12,14,19,22,24,28H,5,7,11,13,15H2,1-2H3,(H,27,32)(H,29,31)/t19-,22-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis |
J Med Chem 61: 5974-5987 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00322
BindingDB Entry DOI: 10.7270/Q2WD433X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544367
(CHEMBL4641513)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@H]1CN(CC[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C28H34ClN5O4S/c1-18-9-10-23-19(14-18)15-25(31-23)28(36)32-24-11-13-34(39(37,38)26-8-4-3-7-22(26)29)17-21(24)27(35)30-20-6-5-12-33(2)16-20/h3-4,7-10,14-15,20-21,24,31H,5-6,11-13,16-17H2,1-2H3,(H,30,35)(H,32,36)/t20-,21-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.145 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412954
(CHEMBL251572 | SB-791016 | SB-791016A)Show SMILES COc1cc2CCN(c2cc1N1C[C@H](C)N[C@H](C)C1)S(=O)(=O)c1ccc(s1)-c1ccccn1 |r| Show InChI InChI=1S/C24H28N4O3S2/c1-16-14-27(15-17(2)26-16)21-13-20-18(12-22(21)31-3)9-11-28(20)33(29,30)24-8-7-23(32-24)19-6-4-5-10-25-19/h4-8,10,12-13,16-17,26H,9,11,14-15H2,1-3H3/t16-,17+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.158 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412966
(CHEMBL481013)Show SMILES Cc1ccc(o1)-c1ccc(cc1F)S(=O)(=O)N1CCCC[C@H]1C(=O)N1CC[C@H](N)C1 |r| Show InChI InChI=1S/C21H26FN3O4S/c1-14-5-8-20(29-14)17-7-6-16(12-18(17)22)30(27,28)25-10-3-2-4-19(25)21(26)24-11-9-15(23)13-24/h5-8,12,15,19H,2-4,9-11,13,23H2,1H3/t15-,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.158 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412954
(CHEMBL251572 | SB-791016 | SB-791016A)Show SMILES COc1cc2CCN(c2cc1N1C[C@H](C)N[C@H](C)C1)S(=O)(=O)c1ccc(s1)-c1ccccn1 |r| Show InChI InChI=1S/C24H28N4O3S2/c1-16-14-27(15-17(2)26-16)21-13-20-18(12-22(21)31-3)9-11-28(20)33(29,30)24-8-7-23(32-24)19-6-4-5-10-25-19/h4-8,10,12-13,16-17,26H,9,11,14-15H2,1-3H3/t16-,17+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.158 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at GSHR by FLIPR assay |
Bioorg Med Chem Lett 17: 6584-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.067
BindingDB Entry DOI: 10.7270/Q2MW2KX2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544367
(CHEMBL4641513)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@H]1CN(CC[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C28H34ClN5O4S/c1-18-9-10-23-19(14-18)15-25(31-23)28(36)32-24-11-13-34(39(37,38)26-8-4-3-7-22(26)29)17-21(24)27(35)30-20-6-5-12-33(2)16-20/h3-4,7-10,14-15,20-21,24,31H,5-6,11-13,16-17H2,1-2H3,(H,30,35)(H,32,36)/t20-,21-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.158 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544361
(CHEMBL4635542)Show SMILES CN1CCC[C@H]1CNC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-15-20-7-6-12-31(20)2/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.158 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544361
(CHEMBL4635542)Show SMILES CN1CCC[C@H]1CNC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-15-20-7-6-12-31(20)2/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.168 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50477764
(CHEMBL401134)Show SMILES COc1cc2CCN(c2cc1N1C[C@H](C)N[C@H](C)C1)S(=O)(=O)c1ccc(cc1)-c1ccccn1 Show InChI InChI=1S/C26H30N4O3S/c1-18-16-29(17-19(2)28-18)25-15-24-21(14-26(25)33-3)11-13-30(24)34(31,32)22-9-7-20(8-10-22)23-6-4-5-12-27-23/h4-10,12,14-15,18-19,28H,11,13,16-17H2,1-3H3/t18-,19+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at GSHR by FLIPR assay |
Bioorg Med Chem Lett 17: 6584-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.067
BindingDB Entry DOI: 10.7270/Q2MW2KX2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544368
(CHEMBL4638297)Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)N[C@H]1CCN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C27H32ClN5O4S/c1-17-8-9-22-18(13-17)14-24(31-22)27(35)32-23-10-12-33(38(36,37)25-7-3-2-6-21(25)28)16-20(23)26(34)30-19-5-4-11-29-15-19/h2-3,6-9,13-14,19-20,23,29,31H,4-5,10-12,15-16H2,1H3,(H,30,34)(H,32,35)/t19-,20-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376760
(CHEMBL410074)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO Show InChI InChI=1S/C22H35N7O6S/c1-22(2,23)21(32)25-18(16-35-15-17-7-4-3-5-8-17)20-26-27-28-29(20)11-6-9-19(31)24-10-13-36(33,34)14-12-30/h3-5,7-8,18,30H,6,9-16,23H2,1-2H3,(H,24,31)(H,25,32)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412978
(CHEMBL518774)Show SMILES Cc1ccc(o1)-c1ccc(cc1F)S(=O)(=O)N1CC[C@H](O)[C@H]1C(=O)N1CC[C@@H](N)C1 |r| Show InChI InChI=1S/C20H24FN3O5S/c1-12-2-5-18(29-12)15-4-3-14(10-16(15)21)30(27,28)24-9-7-17(25)19(24)20(26)23-8-6-13(22)11-23/h2-5,10,13,17,19,25H,6-9,11,22H2,1H3/t13-,17+,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376783
(CHEMBL259166)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO Show InChI InChI=1S/C22H35N7O4S/c1-22(2,23)21(32)25-18(16-33-15-17-7-4-3-5-8-17)20-26-27-28-29(20)11-6-9-19(31)24-10-13-34-14-12-30/h3-5,7-8,18,30H,6,9-16,23H2,1-2H3,(H,24,31)(H,25,32)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376781
(CHEMBL410085)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1 Show InChI InChI=1S/C26H35N7O4/c1-26(2,27)25(36)29-22(18-37-17-20-8-4-3-5-9-20)24-30-31-32-33(24)15-7-12-23(35)28-14-13-19-10-6-11-21(34)16-19/h3-6,8-11,16,22,34H,7,12-15,17-18,27H2,1-2H3,(H,28,35)(H,29,36)/t22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544368
(CHEMBL4638297)Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)N[C@H]1CCN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C27H32ClN5O4S/c1-17-8-9-22-18(13-17)14-24(31-22)27(35)32-23-10-12-33(38(36,37)25-7-3-2-6-21(25)28)16-20(23)26(34)30-19-5-4-11-29-15-19/h2-3,6-9,13-14,19-20,23,29,31H,4-5,10-12,15-16H2,1H3,(H,30,34)(H,32,35)/t19-,20-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544379
(CHEMBL4643530)Show SMILES Clc1ccc(-c2cc(no2)C(=O)N[C@H]2CN(C[C@@H]2C(=O)N[C@H]2CCCNC2)S(=O)(=O)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C26H27Cl2N5O5S/c27-16-8-9-19(21(28)11-16)24-12-22(32-38-24)26(35)31-23-15-33(39(36,37)18-6-2-1-3-7-18)14-20(23)25(34)30-17-5-4-10-29-13-17/h1-3,6-9,11-12,17,20,23,29H,4-5,10,13-15H2,(H,30,34)(H,31,35)/t17-,20-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.235 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412963
(CHEMBL481796)Show SMILES Cc1ccc(o1)-c1ccc(cc1)S(=O)(=O)N1CCCC[C@H]1C(=O)N1CC[C@@H](N)C1 |r| Show InChI InChI=1S/C21H27N3O4S/c1-15-5-10-20(28-15)16-6-8-18(9-7-16)29(26,27)24-12-3-2-4-19(24)21(25)23-13-11-17(22)14-23/h5-10,17,19H,2-4,11-14,22H2,1H3/t17-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.251 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544363
(CHEMBL4640507)Show SMILES CN1CCC[C@H](C1)NC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-20-7-6-12-31(2)15-20/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22+,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.251 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544379
(CHEMBL4643530)Show SMILES Clc1ccc(-c2cc(no2)C(=O)N[C@H]2CN(C[C@@H]2C(=O)N[C@H]2CCCNC2)S(=O)(=O)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C26H27Cl2N5O5S/c27-16-8-9-19(21(28)11-16)24-12-22(32-38-24)26(35)31-23-15-33(39(36,37)18-6-2-1-3-7-18)14-20(23)25(34)30-17-5-4-10-29-13-17/h1-3,6-9,11-12,17,20,23,29H,4-5,10,13-15H2,(H,30,34)(H,31,35)/t17-,20-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.251 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50243597
((R)-2-(5-(1-(2-amino-2-methylpropanamido)-4,4-difl...)Show SMILES CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO |r| Show InChI InChI=1S/C22H33F2N7O4/c1-21(2,25)19(33)27-17(10-11-22(23,24)16-8-4-3-5-9-16)18-28-29-30-31(18)13-15-35-20(34)26-12-6-7-14-32/h3-5,8-9,17,32H,6-7,10-15,25H2,1-2H3,(H,26,34)(H,27,33)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a |
Princ
Curated by ChEMBL
| Assay Description
Agonist activity at GHS receptor |
Bioorg Med Chem Lett 18: 4072-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.100
BindingDB Entry DOI: 10.7270/Q2DR2WF8 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544363
(CHEMBL4640507)Show SMILES CN1CCC[C@H](C1)NC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-20-7-6-12-31(2)15-20/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22+,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.274 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50206768
(4-((R)-1-{(R)-1-[((S)-carbamoyl-phenyl-methyl)-car...)Show SMILES NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CC[NH2+]CC1)c1ccccc1 Show InChI InChI=1S/C40H41N5O4/c41-37(46)36(30-10-2-1-3-11-30)45-40(49)35(25-27-15-17-29-9-5-7-13-33(29)23-27)44-39(48)34(43-38(47)31-18-20-42-21-19-31)24-26-14-16-28-8-4-6-12-32(28)22-26/h1-17,22-23,31,34-36,42H,18-21,24-25H2,(H2,41,46)(H,43,47)(H,44,48)(H,45,49)/p+1/t34-,35-,36+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.280 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS-R1 |
Bioorg Med Chem 15: 3054-64 (2007)
Article DOI: 10.1016/j.bmc.2007.01.057
BindingDB Entry DOI: 10.7270/Q25M66HV |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371684
(CHEMBL270666)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](COc1ccccc1O)CC#N Show InChI InChI=1S/C24H29N7O4/c1-24(2,26)23(33)27-19(16-34-14-17-8-4-3-5-9-17)22-28-29-30-31(22)18(12-13-25)15-35-21-11-7-6-10-20(21)32/h3-11,18-19,32H,12,14-16,26H2,1-2H3,(H,27,33)/t18-,19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412972
(CHEMBL482220)Show SMILES N[C@@H]1CCN(C1)C(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccc(cc1)-c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C22H25Cl2N3O3S/c23-16-6-9-20(24)19(13-16)15-4-7-18(8-5-15)31(29,30)27-11-2-1-3-21(27)22(28)26-12-10-17(25)14-26/h4-9,13,17,21H,1-3,10-12,14,25H2/t17-,21+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.316 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544366
(CHEMBL4647963)Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)N[C@H]1CN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C26H31N5O4S/c1-17-9-10-22-18(12-17)13-23(29-22)26(33)30-24-16-31(36(34,35)20-7-3-2-4-8-20)15-21(24)25(32)28-19-6-5-11-27-14-19/h2-4,7-10,12-13,19,21,24,27,29H,5-6,11,14-16H2,1H3,(H,28,32)(H,30,33)/t19-,21-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.316 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544388
(CHEMBL4645043)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc(on1)-c1ccccc1Cl)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H30ClN5O5S/c1-32-13-7-8-18(15-32)29-26(34)21-16-33(39(36,37)19-9-3-2-4-10-19)17-24(21)30-27(35)23-14-25(38-31-23)20-11-5-6-12-22(20)28/h2-6,9-12,14,18,21,24H,7-8,13,15-17H2,1H3,(H,29,34)(H,30,35)/t18-,21-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >0.316 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544388
(CHEMBL4645043)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc(on1)-c1ccccc1Cl)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H30ClN5O5S/c1-32-13-7-8-18(15-32)29-26(34)21-16-33(39(36,37)19-9-3-2-4-10-19)17-24(21)30-27(35)23-14-25(38-31-23)20-11-5-6-12-22(20)28/h2-6,9-12,14,18,21,24H,7-8,13,15-17H2,1H3,(H,29,34)(H,30,35)/t18-,21-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | <0.320 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544366
(CHEMBL4647963)Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)N[C@H]1CN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C26H31N5O4S/c1-17-9-10-22-18(12-17)13-23(29-22)26(33)30-24-16-31(36(34,35)20-7-3-2-4-8-20)15-21(24)25(32)28-19-6-5-11-27-14-19/h2-4,7-10,12-13,19,21,24,27,29H,5-6,11,14-16H2,1H3,(H,28,32)(H,30,33)/t19-,21-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.335 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50235838
((4-hydroxy-butyl)-carbamic acid 2-{5-[(S)-1-(2-ami...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO Show InChI InChI=1S/C27H37N7O5/c1-27(2,28)25(36)30-23(19-38-18-21-12-6-7-13-22(21)20-10-4-3-5-11-20)24-31-32-33-34(24)15-17-39-26(37)29-14-8-9-16-35/h3-7,10-13,23,35H,8-9,14-19,28H2,1-2H3,(H,29,37)(H,30,36)/t23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
Princ
Curated by ChEMBL
| Assay Description
Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 18: 1825-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.021
BindingDB Entry DOI: 10.7270/Q24B325H |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50066101
(CHEMBL322912 | Piperidine-4-carboxylic acid {(R)-1...)Show SMILES NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1 Show InChI InChI=1S/C42H45N5O4/c43-39(48)28-47(23-20-29-8-2-1-3-9-29)42(51)38(27-31-15-17-33-11-5-7-13-36(33)25-31)46-41(50)37(45-40(49)34-18-21-44-22-19-34)26-30-14-16-32-10-4-6-12-35(32)24-30/h1-17,24-25,34,37-38,44H,18-23,26-28H2,(H2,43,48)(H,45,49)(H,46,50)/t37-,38-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for GH release for effect on human GH secretagogue receptor |
J Med Chem 41: 3103-27 (1998)
Article DOI: 10.1021/jm970342o
BindingDB Entry DOI: 10.7270/Q2D799KH |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544378
(CHEMBL4639111)Show SMILES Clc1ccccc1-c1cc(no1)C(=O)N[C@H]1CN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C26H28ClN5O5S/c27-21-11-5-4-10-19(21)24-13-22(31-37-24)26(34)30-23-16-32(38(35,36)18-8-2-1-3-9-18)15-20(23)25(33)29-17-7-6-12-28-14-17/h1-5,8-11,13,17,20,23,28H,6-7,12,14-16H2,(H,29,33)(H,30,34)/t17-,20-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50412973
(CHEMBL519301)Show SMILES Cc1ccc(o1)-c1ccc(cc1F)S(=O)(=O)N1CCC[C@H]1C(=O)N1CC[C@@H](N)C1 |r| Show InChI InChI=1S/C20H24FN3O4S/c1-13-4-7-19(28-13)16-6-5-15(11-17(16)21)29(26,27)24-9-2-3-18(24)20(25)23-10-8-14(22)12-23/h4-7,11,14,18H,2-3,8-10,12,22H2,1H3/t14-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay |
Bioorg Med Chem Lett 19: 684-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.042
BindingDB Entry DOI: 10.7270/Q2VT1TBF |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544364
(CHEMBL4639229)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-20-7-6-12-31(2)15-20/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50478232
(CHEMBL260819)Show SMILES COc1ccc(F)c(c1)-c1ccc(cc1)S(=O)(=O)Nc1cc(ccc1OC)N1C[C@H](C)N[C@H](C)C1 Show InChI InChI=1S/C26H30FN3O4S/c1-17-15-30(16-18(2)28-17)20-7-12-26(34-4)25(13-20)29-35(31,32)22-9-5-19(6-10-22)23-14-21(33-3)8-11-24(23)27/h5-14,17-18,28-29H,15-16H2,1-4H3/t17-,18+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR1a by FLIPR assay |
Bioorg Med Chem Lett 18: 2203-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.021
BindingDB Entry DOI: 10.7270/Q2KS6VBX |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50049478
(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1 Show InChI InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis |
J Med Chem 61: 5974-5987 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00322
BindingDB Entry DOI: 10.7270/Q2WD433X |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544378
(CHEMBL4639111)Show SMILES Clc1ccccc1-c1cc(no1)C(=O)N[C@H]1CN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C26H28ClN5O5S/c27-21-11-5-4-10-19(21)24-13-22(31-37-24)26(34)30-23-16-32(38(35,36)18-8-2-1-3-9-18)15-20(23)25(33)29-17-7-6-12-28-14-17/h1-5,8-11,13,17,20,23,28H,6-7,12,14-16H2,(H,29,33)(H,30,34)/t17-,20-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544364
(CHEMBL4639229)Show SMILES CN1CCC[C@@H](C1)NC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-20-7-6-12-31(2)15-20/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371686
(CHEMBL271876)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](COc1ccccn1)CC#N Show InChI InChI=1S/C23H28N8O3/c1-23(2,25)22(32)27-19(16-33-14-17-8-4-3-5-9-17)21-28-29-30-31(21)18(11-12-24)15-34-20-10-6-7-13-26-20/h3-10,13,18-19H,11,14-16,25H2,1-2H3,(H,27,32)/t18-,19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50049478
(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1 Show InChI InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis |
J Med Chem 61: 5974-5987 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00322
BindingDB Entry DOI: 10.7270/Q2WD433X |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371688
(CHEMBL404545)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](COc1ccccc1)CC#N Show InChI InChI=1S/C24H29N7O3/c1-24(2,26)23(32)27-21(17-33-15-18-9-5-3-6-10-18)22-28-29-30-31(22)19(13-14-25)16-34-20-11-7-4-8-12-20/h3-12,19,21H,13,15-17,26H2,1-2H3,(H,27,32)/t19-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50235845
((S)-2-(5-(2-(2,4-difluorobenzyloxy)-1-(2-amino-2-m...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO Show InChI InChI=1S/C21H31F2N7O5/c1-21(2,24)19(32)26-17(13-34-12-14-5-6-15(22)11-16(14)23)18-27-28-29-30(18)8-10-35-20(33)25-7-3-4-9-31/h5-6,11,17,31H,3-4,7-10,12-13,24H2,1-2H3,(H,25,33)(H,26,32)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
Princ
Curated by ChEMBL
| Assay Description
Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 18: 1825-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.021
BindingDB Entry DOI: 10.7270/Q24B325H |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50235842
((S)-2-(5-(2-(2-chlorobenzyloxy)-1-(2-amino-2-methy...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO Show InChI InChI=1S/C21H32ClN7O5/c1-21(2,23)19(31)25-17(14-33-13-15-7-3-4-8-16(15)22)18-26-27-28-29(18)10-12-34-20(32)24-9-5-6-11-30/h3-4,7-8,17,30H,5-6,9-14,23H2,1-2H3,(H,24,32)(H,25,31)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a |
Princ
Curated by ChEMBL
| Assay Description
Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 18: 1825-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.021
BindingDB Entry DOI: 10.7270/Q24B325H |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50544362
(CHEMBL4646219)Show SMILES CN1CCC[C@@H]1CNC(=O)[C@H]1CN(C[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H33N5O4S/c1-18-10-11-23-19(13-18)14-24(29-23)27(34)30-25-17-32(37(35,36)21-8-4-3-5-9-21)16-22(25)26(33)28-15-20-7-6-12-31(20)2/h3-5,8-11,13-14,20,22,25,29H,6-7,12,15-17H2,1-2H3,(H,28,33)(H,30,34)/t20-,22+,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.455 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ... |
J Med Chem 63: 9705-9730 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00828
BindingDB Entry DOI: 10.7270/Q2445R3K |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50410108
(CHEMBL179823)Show SMILES COc1cccc(Oc2ccc3C(N(CCc3c2)C(=O)OC(C)(C)C)C(=O)NCCN(C(C)C)C(C)C)c1 Show InChI InChI=1S/C30H43N3O5/c1-20(2)32(21(3)4)17-15-31-28(34)27-26-13-12-25(37-24-11-9-10-23(19-24)36-8)18-22(26)14-16-33(27)29(35)38-30(5,6)7/h9-13,18-21,27H,14-17H2,1-8H3,(H,31,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro effective concentration against human growth hormone secretagogues |
Bioorg Med Chem Lett 15: 1799-802 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.040
BindingDB Entry DOI: 10.7270/Q21837Q4 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50410123
(CHEMBL180094)Show SMILES CC(C)N(CCNC(=O)C1N(CCc2cc(Oc3ccccc3)ccc12)C(=O)OC(C)(C)C)C(C)C Show InChI InChI=1S/C29H41N3O4/c1-20(2)31(21(3)4)18-16-30-27(33)26-25-14-13-24(35-23-11-9-8-10-12-23)19-22(25)15-17-32(26)28(34)36-29(5,6)7/h8-14,19-21,26H,15-18H2,1-7H3,(H,30,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro effective concentration against human growth hormone secretagogues |
Bioorg Med Chem Lett 15: 1799-802 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.040
BindingDB Entry DOI: 10.7270/Q21837Q4 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50410123
(CHEMBL180094)Show SMILES CC(C)N(CCNC(=O)C1N(CCc2cc(Oc3ccccc3)ccc12)C(=O)OC(C)(C)C)C(C)C Show InChI InChI=1S/C29H41N3O4/c1-20(2)31(21(3)4)18-16-30-27(33)26-25-14-13-24(35-23-11-9-8-10-12-23)19-22(25)15-17-32(26)28(34)36-29(5,6)7/h8-14,19-21,26H,15-18H2,1-7H3,(H,30,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vivo effective concentration against human growth hormone secretagogues |
Bioorg Med Chem Lett 15: 1799-802 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.040
BindingDB Entry DOI: 10.7270/Q21837Q4 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50410114
(CHEMBL360547)Show SMILES COc1ccc(Oc2ccc3C(N(CCc3c2)C(=O)OC(C)(C)C)C(=O)NCCN(C(C)C)C(C)C)cc1 Show InChI InChI=1S/C30H43N3O5/c1-20(2)32(21(3)4)18-16-31-28(34)27-26-14-13-25(37-24-11-9-23(36-8)10-12-24)19-22(26)15-17-33(27)29(35)38-30(5,6)7/h9-14,19-21,27H,15-18H2,1-8H3,(H,31,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vivo effective concentration against human growth hormone secretagogues |
Bioorg Med Chem Lett 15: 1799-802 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.040
BindingDB Entry DOI: 10.7270/Q21837Q4 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50410123
(CHEMBL180094)Show SMILES CC(C)N(CCNC(=O)C1N(CCc2cc(Oc3ccccc3)ccc12)C(=O)OC(C)(C)C)C(C)C Show InChI InChI=1S/C29H41N3O4/c1-20(2)31(21(3)4)18-16-30-27(33)26-25-14-13-24(35-23-11-9-8-10-12-23)19-22(25)15-17-32(26)28(34)36-29(5,6)7/h8-14,19-21,26H,15-18H2,1-7H3,(H,30,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro effective concentration against human growth hormone secretagogues |
Bioorg Med Chem Lett 15: 1799-802 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.040
BindingDB Entry DOI: 10.7270/Q21837Q4 |
More data for this
Ligand-Target Pair | |
Search and Browse
