BindingDB PrimarySearch

Found 20 hits of kd for UniProtKB: P08684
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119125 (GS4) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50576970 (CHEMBL4863066) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CYP3A4 assessed as dissociation constant				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113496 BindingDB Entry DOI: 10.7270/Q2S1869N
TBA					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119126 (GS5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119126 (GS5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	7.30E+3	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119127 (GS6) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119128 (GS7) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	40	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119129 (GS8) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	160	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176903 (CHEMBL3814877) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176904 (CHEMBL3814479) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176905 (CHEMBL3814345) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176907 (CHEMBL3814729) Show SMILES NCCCCCC(=O)NCc1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176908 (CHEMBL3814075) Show SMILES CC(C)(C)OC(=O)NCCCCCC(=O)NCc1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50417104 (CHEMBL1256004) Show SMILES NCCc1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	2.50E+6	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176909 (CHEBI:16227 \| Pyridine) Show SMILES c1ccncc1 Show InChI InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.50E+6	n/a	n/a	n/a	n/a	n/a
University of California-Irvine Curated by ChEMBL					Assay Description Binding affinity to C-terminal four-histidine tagged human CYP3A4delta3 to 24 residues expressed in Escherichia coli assessed as spectral dissociatio...				J Med Chem 59: 4210-20 (2016) Article DOI: 10.1021/acs.jmedchem.5b01146 BindingDB Entry DOI: 10.7270/Q2Q52RKB
University of California-Irvine Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM8610 (1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to His-tagged CYP3A4 (unknown origin) expressed in Escherichia coli DH5alpha assessed as type 2 spectral shift by measuring dissocia...				J Med Chem 63: 1415-1433 (2020) Article DOI: 10.1021/acs.jmedchem.9b02067 BindingDB Entry DOI: 10.7270/Q2NS0Z6Q
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50576966 (CHEMBL4864434) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CYP3A4 assessed as dissociation constant				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113496 BindingDB Entry DOI: 10.7270/Q2S1869N
TBA					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50576967 (CHEMBL4862783) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CYP3A4 assessed as dissociation constant				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113496 BindingDB Entry DOI: 10.7270/Q2S1869N
TBA					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50576968 (CHEMBL4871524) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CYP3A4 assessed as dissociation constant				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113496 BindingDB Entry DOI: 10.7270/Q2S1869N
TBA					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50576969 (CHEMBL4863362) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CYP3A4 assessed as dissociation constant				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113496 BindingDB Entry DOI: 10.7270/Q2S1869N
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM119125 (GS4) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.31E+4	n/a	n/a	n/a	7.4	n/a
University of California at Irvine					Assay Description Ligand binidng to CYP3A4 was monitored in 50 mM phosphate (pH 7.4) containing 20% glycerol and 1 mM DTT. The protein was titrated with small aliquots...				Biochemistry 52: 4474-81 (2013) Article DOI: 10.1021/bi4005396 BindingDB Entry DOI: 10.7270/Q2PZ57GJ
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)