Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM21340 (6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum ODCase at 25 degreeC by competitive binding assay | J Med Chem 49: 4937-45 (2006) Article DOI: 10.1021/jm060202r BindingDB Entry DOI: 10.7270/Q2J9676J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM21340 (6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 1.10E+3 | -8.45 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM21337 (6-Azido-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | 2.00E+3 | -8.08 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM21338 (6-Amino-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 2.10E+3 | -8.05 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM50398698 (CHEMBL2178721) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium vivax (malaria parasite P. vivax)) | BDBM21339 (6-Methyl-uridine 5-O-Monophosphate | C6-Uridine De...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM21335 (6-cyanouridine 5-monophosphate | C6-Uridine Deriva...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.60E+4 | -6.50 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM21339 (6-Methyl-uridine 5-O-Monophosphate | C6-Uridine De...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 3.41E+4 | -6.34 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium vivax (malaria parasite P. vivax)) | BDBM21335 (6-cyanouridine 5-monophosphate | C6-Uridine Deriva...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM50398699 (CHEMBL214393) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM50398697 (CHEMBL2178722) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM50310540 (((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM50378785 (CHEMBL1164065) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 9.10E+8 | -0.0558 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum uridine 5'-monophosphate synthase after overnight incubation at room temperature by VP-ITC microcalorimetry | Bioorg Med Chem 18: 4032-41 (2010) Article DOI: 10.1016/j.bmc.2010.04.017 BindingDB Entry DOI: 10.7270/Q24T6KBX | |||||||||||
More data for this Ligand-Target Pair |