Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21337 (6-Azido-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 190 | -10.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21337 (6-Azido-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 200 | -10.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM27944 (uridine derivative, 41 | {[(2R,3S,4R,5R)-5-(6-azid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 360 | -9.67 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50341908 (((2S,3S,4R,5R)-5-(5-azido-2,4-dioxo-3,4-dihydropyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Irreversible inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase | J Med Chem 54: 2891-901 (2011) Article DOI: 10.1021/jm101642g BindingDB Entry DOI: 10.7270/Q2V98924 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21338 (6-Amino-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 840 | -9.12 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21338 (6-Amino-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase at 55 degreeC by competitive binding assay | J Med Chem 49: 4937-45 (2006) Article DOI: 10.1021/jm060202r BindingDB Entry DOI: 10.7270/Q2J9676J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21338 (6-Amino-uridine 5-O-Monophosphate | C6-Uridine Der...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 840 | -9.12 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50459997 (47599 | CHEBI:90284 | Pirazofurin | Pyrazofurin) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase | Bioorg Med Chem 26: 551-565 (2018) Article DOI: 10.1016/j.bmc.2017.11.037 BindingDB Entry DOI: 10.7270/Q2639SBX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM47402 (2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase | Bioorg Med Chem 26: 551-565 (2018) Article DOI: 10.1016/j.bmc.2017.11.037 BindingDB Entry DOI: 10.7270/Q2639SBX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50398698 (CHEMBL2178721) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM27945 (uridine derivative, 42 | {[(2R,3S,4R,5R)-5-(6-amin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.14E+4 | -7.42 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21340 (6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.24E+4 | -7.36 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21340 (6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase at 55 degreeC by competitive binding assay | J Med Chem 49: 4937-45 (2006) Article DOI: 10.1021/jm060202r BindingDB Entry DOI: 10.7270/Q2J9676J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21335 (6-cyanouridine 5-monophosphate | C6-Uridine Deriva...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase at 55 degreeC by competitive binding assay | J Med Chem 49: 4937-45 (2006) Article DOI: 10.1021/jm060202r BindingDB Entry DOI: 10.7270/Q2J9676J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21335 (6-cyanouridine 5-monophosphate | C6-Uridine Deriva...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 2.90E+4 | -6.81 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21335 (6-cyanouridine 5-monophosphate | C6-Uridine Deriva...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 2.90E+4 | -6.81 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM27946 (uridine derivative, 43 | {[(2R,3S,4R,5R)-5-(6-ethy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.90E+4 | -6.81 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50341905 (CHEMBL1765124 | ammonium 6-Cyano-2'-deoxy-2'-fluor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase by VP-ITC microcalorimeter | J Med Chem 54: 2891-901 (2011) Article DOI: 10.1021/jm101642g BindingDB Entry DOI: 10.7270/Q2V98924 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21339 (6-Methyl-uridine 5-O-Monophosphate | C6-Uridine De...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.34E+5 | -5.81 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM21339 (6-Methyl-uridine 5-O-Monophosphate | C6-Uridine De...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.34E+5 | -5.81 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50398699 (CHEMBL214393) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 3.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50341907 (CHEMBL1765122 | ammonium 5-Cyano-2'-deoxy-2'-fluor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 3.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase by VP-ITC microcalorimeter | J Med Chem 54: 2891-901 (2011) Article DOI: 10.1021/jm101642g BindingDB Entry DOI: 10.7270/Q2V98924 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM27943 (uridine derivative, 39 | {[(2R,3S,4R,5R)-5-(5-fluo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 6.45E+5 | -4.79 | n/a | n/a | n/a | n/a | n/a | 7.5 | 55 |
Toronto General Research Institute | Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p... | J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50341909 (CHEMBL1765126 | ammonium 6-Azido-2'-deoxy-2'-fluor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Irreversible inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase | J Med Chem 54: 2891-901 (2011) Article DOI: 10.1021/jm101642g BindingDB Entry DOI: 10.7270/Q2V98924 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50310540 (((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry | J Med Chem 55: 9988-97 (2012) Article DOI: 10.1021/jm301176r BindingDB Entry DOI: 10.7270/Q2DR2WPD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50341906 (Ammonium 6-Amido-2'-deoxy-2'-fluoro-beta-D-uridine...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.32E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase by VP-ITC microcalorimeter | J Med Chem 54: 2891-901 (2011) Article DOI: 10.1021/jm101642g BindingDB Entry DOI: 10.7270/Q2V98924 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum) | BDBM50341905 (CHEMBL1765124 | ammonium 6-Cyano-2'-deoxy-2'-fluor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network Curated by ChEMBL | Assay Description Irreversible inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase | J Med Chem 54: 2891-901 (2011) Article DOI: 10.1021/jm101642g BindingDB Entry DOI: 10.7270/Q2V98924 | |||||||||||
More data for this Ligand-Target Pair |