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Compile Data Set for Download or QSAR

Found 129 hits of ic50 data for polymerid = 2181,2182,2183,2184,50000642   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptide deformylase


(Staphylococcus aureus)
BDBM50383996
PNG
(CHEMBL2032134)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NC1CCCC1)C=O
Show InChI InChI=1S/C21H34N4O5/c26-14-24(30)13-16(12-15-6-1-2-7-15)20(28)25-11-5-10-18(25)19(27)23-21(29)22-17-8-3-4-9-17/h14-18,30H,1-13H2,(H2,22,23,27,29)/t16-,18+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383999
PNG
(CHEMBL2032137)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1ccccc1)C=O
Show InChI InChI=1S/C24H34N4O5/c29-17-27(33)16-20(15-19-9-4-5-10-19)23(31)28-14-6-11-21(28)22(30)26-24(32)25-13-12-18-7-2-1-3-8-18/h1-3,7-8,17,19-21,33H,4-6,9-16H2,(H2,25,26,30,32)/t20-,21+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383995
PNG
(CHEMBL2032133)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NC1CCC1)C=O
Show InChI InChI=1S/C20H32N4O5/c25-13-23(29)12-15(11-14-5-1-2-6-14)19(27)24-10-4-9-17(24)18(26)22-20(28)21-16-7-3-8-16/h13-17,29H,1-12H2,(H2,21,22,26,28)/t15-,17+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383997
PNG
(CHEMBL2032135)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NC1CCCCC1)C=O
Show InChI InChI=1S/C22H36N4O5/c27-15-25(31)14-17(13-16-7-4-5-8-16)21(29)26-12-6-11-19(26)20(28)24-22(30)23-18-9-2-1-3-10-18/h15-19,31H,1-14H2,(H2,23,24,28,30)/t17-,19+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50384000
PNG
(CHEMBL2032138)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCCc1ccccc1)C=O
Show InChI InChI=1S/C25H36N4O5/c30-18-28(34)17-21(16-20-10-4-5-11-20)24(32)29-15-7-13-22(29)23(31)27-25(33)26-14-6-12-19-8-2-1-3-9-19/h1-3,8-9,18,20-22,34H,4-7,10-17H2,(H2,26,27,31,33)/t21-,22+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383994
PNG
(CHEMBL2032132)
Show SMILES CC(C)(C)NC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C20H34N4O5/c1-20(2,3)22-19(28)21-17(26)16-9-6-10-24(16)18(27)15(12-23(29)13-25)11-14-7-4-5-8-14/h13-16,29H,4-12H2,1-3H3,(H2,21,22,26,28)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383966
PNG
(CHEMBL2032148)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1cnc[nH]1)C=O
Show InChI InChI=1S/C21H32N6O5/c28-14-26(32)12-16(10-15-4-1-2-5-15)20(30)27-9-3-6-18(27)19(29)25-21(31)23-8-7-17-11-22-13-24-17/h11,13-16,18,32H,1-10,12H2,(H,22,24)(H2,23,25,29,31)/t16-,18+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383969
PNG
(CHEMBL2032143)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1cnccn1)C=O
Show InChI InChI=1S/C22H32N6O5/c29-15-27(33)14-17(12-16-4-1-2-5-16)21(31)28-11-3-6-19(28)20(30)26-22(32)25-8-7-18-13-23-9-10-24-18/h9-10,13,15-17,19,33H,1-8,11-12,14H2,(H2,25,26,30,32)/t17-,19+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383987
PNG
(CHEMBL2032125)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)OC1CCCC1)C=O
Show InChI InChI=1S/C21H33N3O6/c25-14-23(29)13-16(12-15-6-1-2-7-15)20(27)24-11-5-10-18(24)19(26)22-21(28)30-17-8-3-4-9-17/h14-18,29H,1-13H2,(H,22,26,28)/t16-,18+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50384002
PNG
(CHEMBL2032141)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1cccnc1)C=O
Show InChI InChI=1S/C23H33N5O5/c29-16-27(33)15-19(13-17-5-1-2-6-17)22(31)28-12-4-8-20(28)21(30)26-23(32)25-11-9-18-7-3-10-24-14-18/h3,7,10,14,16-17,19-20,33H,1-2,4-6,8-9,11-13,15H2,(H2,25,26,30,32)/t19-,20+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50384003
PNG
(CHEMBL2032142)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1ccccn1)C=O
Show InChI InChI=1S/C23H33N5O5/c29-16-27(33)15-18(14-17-6-1-2-7-17)22(31)28-13-5-9-20(28)21(30)26-23(32)25-12-10-19-8-3-4-11-24-19/h3-4,8,11,16-18,20,33H,1-2,5-7,9-10,12-15H2,(H2,25,26,30,32)/t18-,20+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383988
PNG
(CHEMBL2032126)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)OC1CCCCC1)C=O
Show InChI InChI=1S/C22H35N3O6/c26-15-24(30)14-17(13-16-7-4-5-8-16)21(28)25-12-6-11-19(25)20(27)23-22(29)31-18-9-2-1-3-10-18/h15-19,30H,1-14H2,(H,23,27,29)/t17-,19+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383993
PNG
(CHEMBL2032131)
Show SMILES CC(C)NC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C19H32N4O5/c1-13(2)20-19(27)21-17(25)16-8-5-9-23(16)18(26)15(11-22(28)12-24)10-14-6-3-4-7-14/h12-16,28H,3-11H2,1-2H3,(H2,20,21,25,27)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383998
PNG
(CHEMBL2032136)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCc1ccccc1)C=O
Show InChI InChI=1S/C23H32N4O5/c28-16-26(32)15-19(13-17-7-4-5-8-17)22(30)27-12-6-11-20(27)21(29)25-23(31)24-14-18-9-2-1-3-10-18/h1-3,9-10,16-17,19-20,32H,4-8,11-15H2,(H2,24,25,29,31)/t19-,20+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383968
PNG
(CHEMBL2032140)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCCc1ccncc1)C=O
Show InChI InChI=1S/C23H33N5O5/c29-16-27(33)15-19(14-18-4-1-2-5-18)22(31)28-13-3-6-20(28)21(30)26-23(32)25-12-9-17-7-10-24-11-8-17/h7-8,10-11,16,18-20,33H,1-6,9,12-15H2,(H2,25,26,30,32)/t19-,20+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383992
PNG
(CHEMBL2032130)
Show SMILES CCNC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C18H30N4O5/c1-2-19-18(26)20-16(24)15-8-5-9-22(15)17(25)14(11-21(27)12-23)10-13-6-3-4-7-13/h12-15,27H,2-11H2,1H3,(H2,19,20,24,26)/t14-,15+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383967
PNG
(CHEMBL2032122)
Show SMILES CC(C)OC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C19H31N3O6/c1-13(2)28-19(26)20-17(24)16-8-5-9-22(16)18(25)15(11-21(27)12-23)10-14-6-3-4-7-14/h12-16,27H,3-11H2,1-2H3,(H,20,24,26)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383965
PNG
(CHEMBL2032129)
Show SMILES CNC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C17H28N4O5/c1-18-17(25)19-15(23)14-7-4-8-21(14)16(24)13(10-20(26)11-22)9-12-5-2-3-6-12/h11-14,26H,2-10H2,1H3,(H2,18,19,23,25)/t13-,14+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383984
PNG
(CHEMBL2032121)
Show SMILES CCOC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C18H29N3O6/c1-2-27-18(25)19-16(23)15-8-5-9-21(15)17(24)14(11-20(26)12-22)10-13-6-3-4-7-13/h12-15,26H,2-11H2,1H3,(H,19,23,25)/t14-,15+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383991
PNG
(CHEMBL2029376)
Show SMILES NC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C16H26N4O5/c17-16(24)18-14(22)13-6-3-7-20(13)15(23)12(9-19(25)10-21)8-11-4-1-2-5-11/h10-13,25H,1-9H2,(H3,17,18,22,24)/t12-,13+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383979
PNG
(CHEMBL2032116)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)C1CC1)C=O
Show InChI InChI=1S/C19H29N3O5/c23-12-21(27)11-15(10-13-4-1-2-5-13)19(26)22-9-3-6-16(22)18(25)20-17(24)14-7-8-14/h12-16,27H,1-11H2,(H,20,24,25)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383972
PNG
(CHEMBL2032146)
Show SMILES NCCNC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C18H31N5O5/c19-7-8-20-18(27)21-16(25)15-6-3-9-23(15)17(26)14(11-22(28)12-24)10-13-4-1-2-5-13/h12-15,28H,1-11,19H2,(H2,20,21,25,27)/t14-,15+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383986
PNG
(CHEMBL2032124)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)OC1CCC1)C=O
Show InChI InChI=1S/C20H31N3O6/c24-13-22(28)12-15(11-14-5-1-2-6-14)19(26)23-10-4-9-17(23)18(25)21-20(27)29-16-7-3-8-16/h13-17,28H,1-12H2,(H,21,25,27)/t15-,17+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383980
PNG
(CHEMBL2032117)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)C1CCCC1)C=O
Show InChI InChI=1S/C21H33N3O5/c25-14-23(29)13-17(12-15-6-1-2-7-15)21(28)24-11-5-10-18(24)20(27)22-19(26)16-8-3-4-9-16/h14-18,29H,1-13H2,(H,22,26,27)/t17-,18+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383971
PNG
(CHEMBL2032145)
Show SMILES OCCCNC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C19H32N4O6/c24-10-4-8-20-19(28)21-17(26)16-7-3-9-23(16)18(27)15(12-22(29)13-25)11-14-5-1-2-6-14/h13-16,24,29H,1-12H2,(H2,20,21,26,28)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383973
PNG
(CHEMBL2032147)
Show SMILES NC(=O)CCNC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C19H31N5O6/c20-16(26)7-8-21-19(29)22-17(27)15-6-3-9-24(15)18(28)14(11-23(30)12-25)10-13-4-1-2-5-13/h12-15,30H,1-11H2,(H2,20,26)(H2,21,22,27,29)/t14-,15+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383985
PNG
(CHEMBL2032123)
Show SMILES CC(C)(C)OC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C20H33N3O6/c1-20(2,3)29-19(27)21-17(25)16-9-6-10-23(16)18(26)15(12-22(28)13-24)11-14-7-4-5-8-14/h13-16,28H,4-12H2,1-3H3,(H,21,25,27)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383981
PNG
(CHEMBL2032118)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)C1CCCCC1)C=O
Show InChI InChI=1S/C22H35N3O5/c26-15-24(30)14-18(13-16-7-4-5-8-16)22(29)25-12-6-11-19(25)21(28)23-20(27)17-9-2-1-3-10-17/h15-19,30H,1-14H2,(H,23,27,28)/t18-,19+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383970
PNG
(CHEMBL2032144)
Show SMILES OCCNC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C18H30N4O6/c23-9-7-19-18(27)20-16(25)15-6-3-8-22(15)17(26)14(11-21(28)12-24)10-13-4-1-2-5-13/h12-15,23,28H,1-11H2,(H2,19,20,25,27)/t14-,15+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383976
PNG
(CHEMBL2032113)
Show SMILES CC(C)CC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C20H33N3O5/c1-14(2)10-18(25)21-19(26)17-8-5-9-23(17)20(27)16(12-22(28)13-24)11-15-6-3-4-7-15/h13-17,28H,3-12H2,1-2H3,(H,21,25,26)/t16-,17+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383989
PNG
(CHEMBL2032127)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)OC1CCOCC1)C=O
Show InChI InChI=1S/C21H33N3O7/c25-14-23(29)13-16(12-15-4-1-2-5-15)20(27)24-9-3-6-18(24)19(26)22-21(28)31-17-7-10-30-11-8-17/h14-18,29H,1-13H2,(H,22,26,28)/t16-,18+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383983
PNG
(CHEMBL2032120)
Show SMILES COC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C17H27N3O6/c1-26-17(24)18-15(22)14-7-4-8-20(14)16(23)13(10-19(25)11-21)9-12-5-2-3-6-12/h11-14,25H,2-10H2,1H3,(H,18,22,24)/t13-,14+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383978
PNG
(CHEMBL2032115)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)C1CCC1)C=O
Show InChI InChI=1S/C20H31N3O5/c24-13-22(28)12-16(11-14-5-1-2-6-14)20(27)23-10-4-9-17(23)19(26)21-18(25)15-7-3-8-15/h13-17,28H,1-12H2,(H,21,25,26)/t16-,17+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383975
PNG
(CHEMBL2032112)
Show SMILES CC(C)C(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C19H31N3O5/c1-13(2)17(24)20-18(25)16-8-5-9-22(16)19(26)15(11-21(27)12-23)10-14-6-3-4-7-14/h12-16,27H,3-11H2,1-2H3,(H,20,24,25)/t15-,16+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50224038
PNG
(CHEMBL38016)
Show SMILES ONC(=O)CC1Sc2ccccc2N(CCC2OCCO2)C1=O
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50224041
PNG
(CHEMBL34538)
Show SMILES CC(C)CCCN1C(=O)C(CC(=O)NO)Sc2ccccc12
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50224040
PNG
(CHEMBL286441)
Show SMILES CCCCCN1C(=O)C(CC(=O)NO)Sc2ccccc12
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50224039
PNG
(CHEMBL36605)
Show SMILES ONC(=O)CC1Sc2ccccc2N(CCc2ccccc2)C1=O
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50141373
PNG
(CHEMBL37719 | N-Hydroxy-2-(3-oxo-3,4-dihydro-2H-be...)
Show SMILES ONC(=O)CC1Sc2ccccc2NC1=O
Show InChI InChI=1S/C10H10N2O3S/c13-9(12-15)5-8-10(14)11-6-3-1-2-4-7(6)16-8/h1-4,8,15H,5H2,(H,11,14)(H,12,13)
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50224043
PNG
(CHEMBL36229)
Show SMILES COCCN1C(=O)C(CC(=O)NO)Sc2ccccc12
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50089194
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
Show SMILES CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
Show InChI InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50224042
PNG
(CHEMBL36140)
Show SMILES CC(C)CCN1C(=O)C(CC(=O)NO)Sc2ccccc12
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL




Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383982
PNG
(CHEMBL2032119)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)c1ccccc1)C=O
Show InChI InChI=1S/C22H29N3O5/c26-15-24(30)14-18(13-16-7-4-5-8-16)22(29)25-12-6-11-19(25)21(28)23-20(27)17-9-2-1-3-10-17/h1-3,9-10,15-16,18-19,30H,4-8,11-14H2,(H,23,27,28)/t18-,19+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383990
PNG
(CHEMBL2032128)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)OC1CCNCC1)C=O
Show InChI InChI=1S/C21H34N4O6/c26-14-24(30)13-16(12-15-4-1-2-5-15)20(28)25-11-3-6-18(25)19(27)23-21(29)31-17-7-9-22-10-8-17/h14-18,22,30H,1-13H2,(H,23,27,29)/t16-,18+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383964
PNG
(CHEMBL2032111)
Show SMILES COCC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C18H29N3O6/c1-27-11-16(23)19-17(24)15-7-4-8-21(15)18(25)14(10-20(26)12-22)9-13-5-2-3-6-13/h12-15,26H,2-11H2,1H3,(H,19,23,24)/t14-,15+/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50141359
PNG
(CHEMBL285938 | N-Hydroxy-N-(3-oxo-3,4-dihydro-2H-b...)
Show SMILES ON(CC1Sc2ccccc2NC1=O)C=O
Show InChI InChI=1S/C10H10N2O3S/c13-6-12(15)5-9-10(14)11-7-3-1-2-4-8(7)16-9/h1-4,6,9,15H,5H2,(H,11,14)
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n/an/a 10n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus


Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383977
PNG
(CHEMBL2032114)
Show SMILES CC(C)(C)C(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C20H33N3O5/c1-20(2,3)19(27)21-17(25)16-9-6-10-23(16)18(26)15(12-22(28)13-24)11-14-7-4-5-8-14/h13-16,28H,4-12H2,1-3H3,(H,21,25,27)/t15-,16+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50384001
PNG
(CHEMBL2032139)
Show SMILES ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)NCC=C)C=O
Show InChI InChI=1S/C19H30N4O5/c1-2-9-20-19(27)21-17(25)16-8-5-10-23(16)18(26)15(12-22(28)13-24)11-14-6-3-4-7-14/h2,13-16,28H,1,3-12H2,(H2,20,21,25,27)/t15-,16+/m1/s1
PDB
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))
BDBM50141360
PNG
(2-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin...)
Show SMILES ONC(=O)CC1Sc2ccccc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C17H16N2O3S/c20-16(18-22)10-15-17(21)19(11-12-6-2-1-3-7-12)13-8-4-5-9-14(13)23-15/h1-9,15,22H,10-11H2,(H,18,20)
PDB
MMDB

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n/an/a 12n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus


Bioorg Med Chem Lett 14: 1477-81 (2004)

More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus)
BDBM50383974
PNG
(CHEMBL2032110)
Show SMILES CC(=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)CN(O)C=O
Show InChI InChI=1S/C17H27N3O5/c1-12(22)18-16(23)15-7-4-8-20(15)17(24)14(10-19(25)11-21)9-13-5-2-3-6-13/h11,13-15,25H,2-10H2,1H3,(H,18,22,23)/t14-,15+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay


Bioorg Med Chem Lett 22: 4028-32 (2012)

More data for this
Ligand-Target Pair
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