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Compile Data Set for Download or QSAR

Found 2450 hits of ec50 data for polymerid = 2200   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559837
PNG
(CHEMBL4776349)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 |r|
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n/an/an/an/a 0.0500n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450307
PNG
(US10676431, Example 70 | US11117861, Example 70)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F |r|
Show InChI InChI=1S/C25H21ClF4N3O3P/c1-37(2,36)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)33-11-10-19(24(33)34)32-25(35)31-18-8-6-13(26)12-17(18)28/h3-9,12,19H,10-11H2,1-2H3,(H2,31,32,35)/t19-/m1/s1
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n/an/an/an/a 0.0770n/an/an/an/a


TBA

Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2ZK5KV9
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450307
PNG
(US10676431, Example 70 | US11117861, Example 70)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F |r|
Show InChI InChI=1S/C25H21ClF4N3O3P/c1-37(2,36)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)33-11-10-19(24(33)34)32-25(35)31-18-8-6-13(26)12-17(18)28/h3-9,12,19H,10-11H2,1-2H3,(H2,31,32,35)/t19-/m1/s1
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n/an/an/an/a 0.0770n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)


BindingDB Entry DOI: 10.7270/Q2N58QFS
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559838
PNG
(CHEMBL4790836)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 |r|
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n/an/an/an/a 0.0780n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559814
PNG
(CHEMBL4743917)
Show SMILES COc1ccc(cc1)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccc(F)cc1 |r|
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n/an/an/an/a 0.0850n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559836
PNG
(CHEMBL4755590)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 |r|
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n/an/an/an/a 0.0870n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM620556
PNG
(US20230303513, Example 4)
Show SMILES COc1cc(F)c([C@@H]2CN(C(=O)[C@H]2NC(=O)Nc2ccccc2)c2c(OC)ccn(C)c2=O)c(F)c1 |r|
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n/an/an/an/a 0.100n/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM632092
PNG
(US20230348426, Example 362 | US20230348426, Exampl...)
Show SMILES COc1cc(F)c([C@@H]2CN(C(=O)[C@H]2NC(=O)c2ccc(Cl)cc2)c2c(C)ccn(CC(C)O)c2=O)c(F)c1
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n/an/an/an/a 0.100n/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559830
PNG
(CHEMBL4758920)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 |r|
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n/an/an/an/a 0.110n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559811
PNG
(CHEMBL4784400)
Show SMILES COc1ccc(cc1)[C@@H]1CCNC(=O)[C@H]1NC(=O)Nc1ccc(Cl)cc1 |r|
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n/an/an/an/a 0.110n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454204
PNG
(US10717708, Example 188 | US11186544, Example 188 ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O |r|
Show InChI InChI=1S/C25H24ClFN4O4S/c1-36(34,35)30-21-6-3-2-5-19(21)16-8-11-18(12-9-16)31-14-4-7-23(24(31)32)29-25(33)28-22-13-10-17(26)15-20(22)27/h2-3,5-6,8-13,15,23,30H,4,7,14H2,1H3,(H2,28,29,33)/t23-/m1/s1
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n/an/an/an/a 0.130n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)


BindingDB Entry DOI: 10.7270/Q2FB560G
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454204
PNG
(US10717708, Example 188 | US11186544, Example 188 ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O |r|
Show InChI InChI=1S/C25H24ClFN4O4S/c1-36(34,35)30-21-6-3-2-5-19(21)16-8-11-18(12-9-16)31-14-4-7-23(24(31)32)29-25(33)28-22-13-10-17(26)15-20(22)27/h2-3,5-6,8-13,15,23,30H,4,7,14H2,1H3,(H2,28,29,33)/t23-/m1/s1
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n/an/an/an/a 0.130n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559821
PNG
(CHEMBL4781596)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 |r|
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n/an/an/an/a 0.140n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454192
PNG
(US10717708, Example 86 | US11186544, Example 86 | ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
Show InChI InChI=1S/C25H25ClN4O4S/c1-35(33,34)29-22-6-3-2-5-21(22)17-8-14-20(15-9-17)30-16-4-7-23(24(30)31)28-25(32)27-19-12-10-18(26)11-13-19/h2-3,5-6,8-15,23,29H,4,7,16H2,1H3,(H2,27,28,32)/t23-/m1/s1
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n/an/an/an/a 0.140n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)


BindingDB Entry DOI: 10.7270/Q2FB560G
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454192
PNG
(US10717708, Example 86 | US11186544, Example 86 | ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
Show InChI InChI=1S/C25H25ClN4O4S/c1-35(33,34)29-22-6-3-2-5-21(22)17-8-14-20(15-9-17)30-16-4-7-23(24(30)31)28-25(32)27-19-12-10-18(26)11-13-19/h2-3,5-6,8-15,23,29H,4,7,16H2,1H3,(H2,27,28,32)/t23-/m1/s1
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n/an/an/an/a 0.140n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559820
PNG
(CHEMBL4744835)
Show SMILES COc1cc(F)c(cc1F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccc(F)cc1 |r|
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n/an/an/an/a 0.150n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559835
PNG
(CHEMBL4762030)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 |r|
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n/an/an/an/a 0.160n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM517780
PNG
(US11124494, Example 18)
Show SMILES CS(=O)(=O)NCC1(CC1)c1ccc(cc1F)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
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n/an/an/an/a 0.170n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2668HB8
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM526327
PNG
(US11186544, Example 277)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1C[C@H](O)C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O |r|
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n/an/an/an/a 0.170n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM497407
PNG
(US11008301, Example 77)
Show SMILES CN(C)C1CCCN(C1)c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H32F3N5O2/c1-32(2)22-5-3-15-33(17-22)20-11-13-21(14-12-20)34-16-4-6-23(24(34)35)31-25(36)30-19-9-7-18(8-10-19)26(27,28)29/h7-14,22-23H,3-6,15-17H2,1-2H3,(H2,30,31,36)/t22?,23-/m1/s1
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n/an/an/an/a 0.180n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US11008301 (2021)


BindingDB Entry DOI: 10.7270/Q2HX1GTH
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559810
PNG
(CHEMBL4744094)
Show SMILES COc1ccc(cc1)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccc(Cl)cc1 |r|
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n/an/an/an/a 0.180n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559810
PNG
(CHEMBL4744094)
Show SMILES COc1ccc(cc1)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccc(Cl)cc1 |r|
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n/an/an/an/a 0.180n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559831
PNG
(CHEMBL4761554)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 |r|
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n/an/an/an/a 0.190n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM620557
PNG
(US20230303513, Example 16 | US20230303513, Example...)
Show SMILES COCCn1cccc(N2C[C@H]([C@H](NC(=O)NC3CCc4cc(Cl)ccc4C3)C2=O)c2ccc(OC)cc2)c1=O |r|
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n/an/an/an/a 0.200n/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM632258
PNG
(US20230348426, Example 528)
Show SMILES COc1cc(F)c([C@@H]2[C@H](C)N(C(=O)[C@H]2NC(=O)c2ccc(OC(F)F)cc2)c2cccc(n2)C2CCNCC2)c(F)c1
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n/an/an/an/a 0.200n/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM517783
PNG
(US11124494, Example 42)
Show SMILES CS(=O)(=O)NCC1(CC1)c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
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n/an/an/an/a 0.210n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2668HB8
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450267
PNG
(US10676431, Example 30 | US11117861, Example 30)
Show SMILES COC[C@@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1ccccc1P(C)(C)=O |r|
Show InChI InChI=1S/C27H26ClF3N3O4P/c1-38-14-16-13-21(33-27(36)32-20-10-8-15(28)12-19(20)29)26(35)34(16)22-11-9-18(24(30)25(22)31)17-6-4-5-7-23(17)39(2,3)37/h4-12,16,21H,13-14H2,1-3H3,(H2,32,33,36)/t16-,21+/m0/s1
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n/an/an/an/a 0.220n/an/an/an/a


TBA

Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2ZK5KV9
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450267
PNG
(US10676431, Example 30 | US11117861, Example 30)
Show SMILES COC[C@@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1ccccc1P(C)(C)=O |r|
Show InChI InChI=1S/C27H26ClF3N3O4P/c1-38-14-16-13-21(33-27(36)32-20-10-8-15(28)12-19(20)29)26(35)34(16)22-11-9-18(24(30)25(22)31)17-6-4-5-7-23(17)39(2,3)37/h4-12,16,21H,13-14H2,1-3H3,(H2,32,33,36)/t16-,21+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)


BindingDB Entry DOI: 10.7270/Q2N58QFS
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50563096
PNG
(CHEMBL4794375)
Show SMILES COc1ccc(cc1)[C@@H]1COC[C@@H]1NC(=O)Nc1ccc(F)cc1 |r|
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n/an/an/an/a 0.25n/an/an/an/a


TBA

Assay Description
Agonist activity at FPR2 (unknown origin) by calcium mobilization assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113194
BindingDB Entry DOI: 10.7270/Q2FT8QSZ
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450349
PNG
(US10676431, Example 112 | US11117861, Example 112)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F |r|
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-38(2,37)22-6-4-3-5-16(22)17-8-10-21(24(30)23(17)29)33-15(13-34)12-20(25(33)35)32-26(36)31-19-9-7-14(27)11-18(19)28/h3-11,15,20,34H,12-13H2,1-2H3,(H2,31,32,36)/t15-,20+/m0/s1
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TBA

Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2ZK5KV9
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350655
PNG
(US10208071, Compound 117 | US10434112, Compound 11...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCP(=O)(OCC)OCC |r|
Show InChI InChI=1S/C17H27BrN3O5P/c1-4-7-15(16(22)19-12-27(24,25-5-2)26-6-3)21-17(23)20-14-10-8-13(18)9-11-14/h8-11,15H,4-7,12H2,1-3H3,(H,19,22)(H2,20,21,23)/t15-/m0/s1
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n/an/an/an/a 0.270n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10799518 (2020)


BindingDB Entry DOI: 10.7270/Q2QV3QK6
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450349
PNG
(US10676431, Example 112 | US11117861, Example 112)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F |r|
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-38(2,37)22-6-4-3-5-16(22)17-8-10-21(24(30)23(17)29)33-15(13-34)12-20(25(33)35)32-26(36)31-19-9-7-14(27)11-18(19)28/h3-11,15,20,34H,12-13H2,1-2H3,(H2,31,32,36)/t15-,20+/m0/s1
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n/an/an/an/a 0.270n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)


BindingDB Entry DOI: 10.7270/Q2N58QFS
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350655
PNG
(US10208071, Compound 117 | US10434112, Compound 11...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCP(=O)(OCC)OCC |r|
Show InChI InChI=1S/C17H27BrN3O5P/c1-4-7-15(16(22)19-12-27(24,25-5-2)26-6-3)21-17(23)20-14-10-8-13(18)9-11-14/h8-11,15H,4-7,12H2,1-3H3,(H,19,22)(H2,20,21,23)/t15-/m0/s1
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n/an/an/an/a 0.270n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10434112 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G16
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454206
PNG
(US10717708, Example 199 | US11186544, Example 199 ...)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C26H28N4O5S/c1-35-21-15-11-19(12-16-21)27-26(32)28-24-8-5-17-30(25(24)31)20-13-9-18(10-14-20)22-6-3-4-7-23(22)29-36(2,33)34/h3-4,6-7,9-16,24,29H,5,8,17H2,1-2H3,(H2,27,28,32)/t24-/m1/s1
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n/an/an/an/a 0.280n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)


BindingDB Entry DOI: 10.7270/Q2FB560G
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454206
PNG
(US10717708, Example 199 | US11186544, Example 199 ...)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C26H28N4O5S/c1-35-21-15-11-19(12-16-21)27-26(32)28-24-8-5-17-30(25(24)31)20-13-9-18(10-14-20)22-6-3-4-7-23(22)29-36(2,33)34/h3-4,6-7,9-16,24,29H,5,8,17H2,1-2H3,(H2,27,28,32)/t24-/m1/s1
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n/an/an/an/a 0.280n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559840
PNG
(CHEMBL4760897)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 |r|
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n/an/an/an/a 0.290n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450358
PNG
(US10676431, Example 121 | US10676431, Example 122 ...)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O |r|
Show InChI InChI=1S/C25H23ClF3N4O3P/c1-13-11-19(32-25(35)31-18-8-6-14(26)12-17(18)27)24(34)33(13)20-9-7-15(21(28)22(20)29)16-5-4-10-30-23(16)37(2,3)36/h4-10,12-13,19H,11H2,1-3H3,(H2,31,32,35)/t13?,19-/m1/s1
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n/an/an/an/a 0.300n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)


BindingDB Entry DOI: 10.7270/Q2N58QFS
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450358
PNG
(US10676431, Example 121 | US10676431, Example 122 ...)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O |r|
Show InChI InChI=1S/C25H23ClF3N4O3P/c1-13-11-19(32-25(35)31-18-8-6-14(26)12-17(18)27)24(34)33(13)20-9-7-15(21(28)22(20)29)16-5-4-10-30-23(16)37(2,3)36/h4-10,12-13,19H,11H2,1-3H3,(H2,31,32,35)/t13?,19-/m1/s1
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n/an/an/an/a 0.300n/an/an/an/a


TBA

Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2ZK5KV9
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM497408
PNG
(US11008301, Example 81)
Show SMILES CN(C)C1CCN(C1)c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1 |r|
Show InChI InChI=1S/C24H28ClF2N5O2/c1-30(2)17-9-11-31(14-17)16-6-8-22(19(27)13-16)32-10-3-4-21(23(32)33)29-24(34)28-20-7-5-15(25)12-18(20)26/h5-8,12-13,17,21H,3-4,9-11,14H2,1-2H3,(H2,28,29,34)/t17?,21-/m1/s1
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n/an/an/an/a 0.310n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US11008301 (2021)


BindingDB Entry DOI: 10.7270/Q2HX1GTH
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559842
PNG
(CHEMBL4778725)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 |r|
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n/an/an/an/a 0.320n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454187
PNG
(US10717708, Example 66 | US11186544, Example 66 | ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H25F3N4O4S/c1-38(36,37)32-22-6-3-2-5-21(22)17-8-14-20(15-9-17)33-16-4-7-23(24(33)34)31-25(35)30-19-12-10-18(11-13-19)26(27,28)29/h2-3,5-6,8-15,23,32H,4,7,16H2,1H3,(H2,30,31,35)/t23-/m1/s1
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n/an/an/an/a 0.320n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)


BindingDB Entry DOI: 10.7270/Q2FB560G
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454187
PNG
(US10717708, Example 66 | US11186544, Example 66 | ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H25F3N4O4S/c1-38(36,37)32-22-6-3-2-5-21(22)17-8-14-20(15-9-17)33-16-4-7-23(24(33)34)31-25(35)30-19-12-10-18(11-13-19)26(27,28)29/h2-3,5-6,8-15,23,32H,4,7,16H2,1H3,(H2,30,31,35)/t23-/m1/s1
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TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM526315
PNG
(US11186544, Example 211)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1C[C@H](O)C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
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n/an/an/an/a 0.350n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50559822
PNG
(CHEMBL4753713)
Show SMILES COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 |r|
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n/an/an/an/a 0.360n/an/an/an/a


TBA

Assay Description
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02101
BindingDB Entry DOI: 10.7270/Q2V98CSC
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454196
PNG
(US10717708, Example 145 | US11186544, Example 145 ...)
Show SMILES CN(c1ncccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O)S(C)(=O)=O |r|
Show InChI InChI=1S/C26H26F3N5O4S/c1-33(39(2,37)38)23-21(5-3-15-30-23)17-7-13-20(14-8-17)34-16-4-6-22(24(34)35)32-25(36)31-19-11-9-18(10-12-19)26(27,28)29/h3,5,7-15,22H,4,6,16H2,1-2H3,(H2,31,32,36)/t22-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)


BindingDB Entry DOI: 10.7270/Q2FB560G
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454196
PNG
(US10717708, Example 145 | US11186544, Example 145 ...)
Show SMILES CN(c1ncccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O)S(C)(=O)=O |r|
Show InChI InChI=1S/C26H26F3N5O4S/c1-33(39(2,37)38)23-21(5-3-15-30-23)17-7-13-20(14-8-17)34-16-4-6-22(24(34)35)32-25(36)31-19-11-9-18(10-12-19)26(27,28)29/h3,5,7-15,22H,4,6,16H2,1-2H3,(H2,31,32,36)/t22-/m1/s1
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TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2B56NXP
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450350
PNG
(US10676431, Example 113 | US11117861, Example 113)
Show SMILES CC1(C)CN(C(=O)[C@@H]1NC(=O)Nc1ccc(Cl)cc1F)c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O |r|
Show InChI InChI=1S/C26H25ClF3N4O3P/c1-26(2)13-34(24(35)22(26)33-25(36)32-18-9-7-14(27)12-17(18)28)19-10-8-15(20(29)21(19)30)16-6-5-11-31-23(16)38(3,4)37/h5-12,22H,13H2,1-4H3,(H2,32,33,36)/t22-/m0/s1
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TBA

Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2ZK5KV9
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450350
PNG
(US10676431, Example 113 | US11117861, Example 113)
Show SMILES CC1(C)CN(C(=O)[C@@H]1NC(=O)Nc1ccc(Cl)cc1F)c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O |r|
Show InChI InChI=1S/C26H25ClF3N4O3P/c1-26(2)13-34(24(35)22(26)33-25(36)32-18-9-7-14(27)12-17(18)28)19-10-8-15(20(29)21(19)30)16-6-5-11-31-23(16)38(3,4)37/h5-12,22H,13H2,1-4H3,(H2,32,33,36)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)


BindingDB Entry DOI: 10.7270/Q2N58QFS
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM497409
PNG
(US11008301, Example 83)
Show SMILES CN(C)C1CCN(C1)c1ccc(cc1F)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
Show InChI InChI=1S/C24H29ClFN5O2/c1-29(2)19-11-13-30(15-19)22-10-9-18(14-20(22)26)31-12-3-4-21(23(31)32)28-24(33)27-17-7-5-16(25)6-8-17/h5-10,14,19,21H,3-4,11-13,15H2,1-2H3,(H2,27,28,33)/t19?,21-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US11008301 (2021)


BindingDB Entry DOI: 10.7270/Q2HX1GTH
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM632106
PNG
(US20230348426, Example 376)
Show SMILES COc1ccc([C@@H]2CN(C(=O)[C@H]2NC(=O)c2ccc(OC(F)F)cc2)c2c(C)ccn(CC(F)F)c2=O)c(F)c1
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n/an/an/an/a 0.400n/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
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