BindingDB PrimarySearch

Found 518 hits of ec50 data for polymerid = 2210,49000820
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50255899 (1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0251	n/a	n/a	n/a	n/a
ShanghaiTech University Curated by ChEMBL					Assay Description Agonist activity at human NOPR expressed in human BHK cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by radioimmu...				J Med Chem 61: 9841-9878 (2018) Article DOI: 10.1021/acs.jmedchem.8b00435 BindingDB Entry DOI: 10.7270/Q2F76GX7
ShanghaiTech University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50333098 (CHEMBL1631926) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0400	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay				J Med Chem 53: 8400-8408 (2010) Article DOI: 10.1021/jm101139f BindingDB Entry DOI: 10.7270/Q24Q7V77
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50121247 (CHEMBL414542 \| F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.0600	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475333 (CHEMBL264846) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0661	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475328 (CHEMBL414782) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0676	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475328 (CHEMBL414782) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0759	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM21842 ((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.0800	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes ; Nd: no data				Bioorg Med Chem Lett 12: 3157-60 (2002) BindingDB Entry DOI: 10.7270/Q2KK9C9R
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50121245 (CHEMBL266191 \| F-G-G-F-T-G-Aib-R-K-S-Aib-R-K-L-A-N...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.0800	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546920 (CHEMBL4781235) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0871	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50004178 (Nociceptin \| Nociceptin/orphanin FQ \| ORPHANIN FQ) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0900	n/a	n/a	n/a	n/a
Purdue Pharma LP Curated by ChEMBL					Assay Description Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1				Bioorg Med Chem Lett 14: 5045-50 (2004) Article DOI: 10.1016/j.bmcl.2004.08.001 BindingDB Entry DOI: 10.7270/Q2TM7BV8
Purdue Pharma LP Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475327 (CHEMBL410653) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50304173 (3,4-dichloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropyl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Inverse agonist activity at NOP expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding				Bioorg Med Chem 17: 6671-81 (2009) Article DOI: 10.1016/j.bmc.2009.07.069 BindingDB Entry DOI: 10.7270/Q2PK0H37
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50004178 (Nociceptin \| Nociceptin/orphanin FQ \| ORPHANIN FQ) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.115	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50473478 (CHEMBL409204) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.135	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50121253 (CHEMBL408356 \| F-G-G-F-T-G-A-R-K-S-Aib-R-K-L-A-N-Q...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475327 (CHEMBL410653) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.141	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50473476 (CHEMBL261997) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.158	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50121249 (CHEMBL415845 \| F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475330 (CHEMBL442297) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.209	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106477 (CHEMBL265801 \| FGGFTGARKSARKLADE \| Phe-GGFTGARKSAR...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.219	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50004178 (Nociceptin \| Nociceptin/orphanin FQ \| ORPHANIN FQ) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.230	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...				J Med Chem 59: 3777-92 (2016) Article DOI: 10.1021/acs.jmedchem.5b01976 BindingDB Entry DOI: 10.7270/Q2T72KC6
Vrije Universiteit Brussel Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475325 (CHEMBL262544) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50473472 (CHEMBL412537) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.251	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50473474 (CHEMBL405648) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.269	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50121244 (CHEMBL264084 \| F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.270	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50413782 (CHEMBL1627325) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.282	n/a	n/a	n/a	n/a
National Institute of Neuroscienc Curated by ChEMBL					Assay Description Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellu...				J Med Chem 52: 4068-71 (2009) Article DOI: 10.1021/jm900604g BindingDB Entry DOI: 10.7270/Q2445NQD
National Institute of Neuroscienc Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546925 (CHEMBL4799815) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.288	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546916 (CHEMBL4780822) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.288	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50533341 (CHEMBL4544227) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Astraea Therapeutics Curated by ChEMBL					Assay Description Agonist activity at human nociceptin opioid receptor expressed in HEK293 cell membranes by GTPgamma(35)S binding assay				J Med Chem 59: 7011-28 (2016) Article DOI: 10.1021/acs.jmedchem.5b01499 BindingDB Entry DOI: 10.7270/Q2057KDD
Astraea Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50473477 (CHEMBL427791) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.302	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475330 (CHEMBL442297) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.302	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475333 (CHEMBL264846) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.309	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29986 (arylpyrazole, 31) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.520	n/a	0.310	n/a	n/a	n/a	n/a
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3627-31 (2009) Article DOI: 10.1016/j.bmcl.2009.04.116 BindingDB Entry DOI: 10.7270/Q289145G
Banyu Pharmaceutical Co.					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.324	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50333105 (CHEMBL1631909 \| H-FGGF(4-F)TGARKSARKLKNQ-NH2) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.360	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay				J Med Chem 53: 8400-8408 (2010) Article DOI: 10.1021/jm101139f BindingDB Entry DOI: 10.7270/Q24Q7V77
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50004178 (Nociceptin \| Nociceptin/orphanin FQ \| ORPHANIN FQ) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.389	n/a	n/a	n/a	n/a
National Institute of Neuroscienc Curated by ChEMBL					Assay Description Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellu...				J Med Chem 52: 4068-71 (2009) Article DOI: 10.1021/jm900604g BindingDB Entry DOI: 10.7270/Q2445NQD
National Institute of Neuroscienc Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50255850 (1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.390	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding				J Med Chem 52: 610-25 (2009) Article DOI: 10.1021/jm7012979 BindingDB Entry DOI: 10.7270/Q29K4C5K
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475331 (CHEMBL411649) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.407	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Agonist potency against GTPgammaS binding in CHO cell membranes expressing human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50004178 (Nociceptin \| Nociceptin/orphanin FQ \| ORPHANIN FQ) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.427	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as dynamic mass redistribution by DMR assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02062 BindingDB Entry DOI: 10.7270/Q2KH0S68
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50475328 (CHEMBL414782) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.437	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of electrically evoked contraction of mouse vas deferens				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546910 (CHEMBL4797388) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.437	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM21842 ((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.450	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546946 (CHEMBL4757730) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.457	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50121256 (CHEMBL410979 \| F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.470	n/a	n/a	n/a	n/a
Purdue Pharma L. P. Curated by ChEMBL					Assay Description Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells				J Med Chem 45: 5280-6 (2002) BindingDB Entry DOI: 10.7270/Q2474BKJ
Purdue Pharma L. P. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50475329 (CHEMBL263588) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.479	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)				J Med Chem 48: 1421-7 (2005) Article DOI: 10.1021/jm040106v BindingDB Entry DOI: 10.7270/Q2J38WBW
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50255899 (1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding				J Med Chem 52: 610-25 (2009) Article DOI: 10.1021/jm7012979 BindingDB Entry DOI: 10.7270/Q29K4C5K
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.513	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of calcium mobilization by Fluo-4 AM dye based analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02062 BindingDB Entry DOI: 10.7270/Q2KH0S68
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546911 (CHEMBL4749802) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.525	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50546926 (CHEMBL4747497) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.537	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM30011 (benzimidazole analogue, 7j) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	0.550	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3100-3 (2009) Article DOI: 10.1016/j.bmcl.2009.04.022 BindingDB Entry DOI: 10.7270/Q20R9MRX
Banyu Pharmaceutical Co.					More data for this Ligand-Target Pair

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