Found 2753 hits of ki for UniProtKB: P23977 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50007404
(1-(3-Chloro-phenyl)-4-phenethyl-piperazine | CHEMB...)Show InChI InChI=1S/C18H21ClN2/c19-17-7-4-8-18(15-17)21-13-11-20(12-14-21)10-9-16-5-2-1-3-6-16/h1-8,15H,9-14H2 | Reactome pathway
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| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN 35428 from dopamine transporter in rat striatum after 120 mins by liquid scintillation counting analysis |
Bioorg Med Chem Lett 23: 6920-6922 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.038
BindingDB Entry DOI: 10.7270/Q2J969B5 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway
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| Article
PubMed
| 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals International
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]GBR-12395 displacement. |
J Med Chem 39: 543-8 (1996)
Article DOI: 10.1021/jm9505324
BindingDB Entry DOI: 10.7270/Q2KD1ZJ5 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50494706
(CHEMBL3093268)Show InChI InChI=1S/C18H21ClN2/c19-17-8-4-5-9-18(17)21-14-12-20(13-15-21)11-10-16-6-2-1-3-7-16/h1-9H,10-15H2 | Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN 35428 from dopamine transporter in rat striatum after 120 mins by liquid scintillation counting analysis |
Bioorg Med Chem Lett 23: 6920-6922 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.038
BindingDB Entry DOI: 10.7270/Q2J969B5 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032539
((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-((Z)-styryl...)Show SMILES CN1C2CCC1[C@@H](\C=C/c1ccccc1)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,0:1:6.15.16:4.3| Show InChI InChI=1S/C22H24ClN/c1-24-19-12-14-22(24)20(13-7-16-5-3-2-4-6-16)21(15-19)17-8-10-18(23)11-9-17/h2-11,13,19-22H,12,14-15H2,1H3/b13-7-/t19?,20-,21+,22?/m0/s1 | Reactome pathway
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| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50041293
(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2C |THB:22:21:4.10.9:6.7,11:10:21:6.7,2:4:21:6.7| Show InChI InChI=1S/C21H25NO/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21H,3,10-11,13H2,1-2H3 | Reactome pathway
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| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wake Forest University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 293: 686-96 (2000)
BindingDB Entry DOI: 10.7270/Q2H993QF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway
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| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 301: 1097-102 (2002)
Article DOI: 10.1124/jpet.301.3.1097
BindingDB Entry DOI: 10.7270/Q2ZW1JH0 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032536
((2R,3S)-3-(4-Chloro-phenyl)-2-((Z)-2-chloro-vinyl)...)Show SMILES CN1C2CCC1[C@@H](\C=C/Cl)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,0:1:6.10.11:4.3| Show InChI InChI=1S/C16H19Cl2N/c1-19-13-6-7-16(19)14(8-9-17)15(10-13)11-2-4-12(18)5-3-11/h2-5,8-9,13-16H,6-7,10H2,1H3/b9-8-/t13?,14-,15+,16?/m0/s1 | Reactome pathway
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| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50035766
(3-(4-Bromo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oc...)Show SMILES COC(=O)C1C2CCC(CC1c1ccc(Br)cc1)N2C |TLB:19:18:4.10.9:6.7,THB:2:4:18:6.7,11:10:18:6.7| Show InChI InChI=1S/C16H20BrNO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3 | Reactome pathway
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate |
Bioorg Med Chem Lett 14: 5635-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032539
((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-((Z)-styryl...)Show SMILES CN1C2CCC1[C@@H](\C=C/c1ccccc1)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,0:1:6.15.16:4.3| Show InChI InChI=1S/C22H24ClN/c1-24-19-12-14-22(24)20(13-7-16-5-3-2-4-6-16)21(15-19)17-8-10-18(23)11-9-17/h2-11,13,19-22H,12,14-15H2,1H3/b13-7-/t19?,20-,21+,22?/m0/s1 | Reactome pathway
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporter |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032534
((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-((E)-styryl...)Show SMILES CN1C2CCC1[C@@H](\C=C\c1ccccc1)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,0:1:6.15.16:4.3| Show InChI InChI=1S/C22H24ClN/c1-24-19-12-14-22(24)20(13-7-16-5-3-2-4-6-16)21(15-19)17-8-10-18(23)11-9-17/h2-11,13,19-22H,12,14-15H2,1H3/b13-7+/t19?,20-,21+,22?/m0/s1 | Reactome pathway
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50334460
(((1R,2S,3S,5S)-3-(4-iodophenyl)-8-methyl-8-azabicy...)Show SMILES CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)c1ccc(I)cc1)C(=O)N1CCCC1 |r,TLB:0:1:7.8.6:3.4| Show InChI InChI=1S/C19H25IN2O/c1-21-15-8-9-17(21)18(19(23)22-10-2-3-11-22)16(12-15)13-4-6-14(20)7-5-13/h4-7,15-18H,2-3,8-12H2,1H3/t15-,16+,17+,18-/m0/s1 | Reactome pathway
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| 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1229-36 (1999)
BindingDB Entry DOI: 10.7270/Q2TX3CWQ |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50006784
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)Show SMILES CC(C)OC(=O)[C@@H]1C2CC[C@H](C[C@@H]1c1ccc(I)cc1)N2C |TLB:21:20:6.12.11:8.9,THB:4:6:20:8.9,13:12:20:8.9| Show InChI InChI=1S/C18H24INO2/c1-11(2)22-18(21)17-15(12-4-6-13(19)7-5-12)10-14-8-9-16(17)20(14)3/h4-7,11,14-17H,8-10H2,1-3H3/t14-,15-,16?,17+/m1/s1 | Reactome pathway
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1229-36 (1999)
BindingDB Entry DOI: 10.7270/Q2TX3CWQ |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50004167
((2R,3S)-3-(4-Chloro-phenyl)-2-((E)-2-chloro-vinyl)...)Show SMILES CN1C2CCC1[C@@H](\C=C\Cl)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,THB:12:10:1:4.3,0:1:6.10.11:4.3| Show InChI InChI=1S/C16H19Cl2N/c1-19-13-6-7-16(19)14(8-9-17)15(10-13)11-2-4-12(18)5-3-11/h2-5,8-9,13-16H,6-7,10H2,1H3/b9-8+/t13?,14-,15+,16?/m0/s1 | Reactome pathway
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| 0.420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50156916
((1R)-3beta-(4-bromophenyl)tropane-2beta-carboxylic...)Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Br)cc1)N2C |TLB:11:10:18:7.6,THB:2:4:18:7.6| Show InChI InChI=1S/C16H20BrNO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12?,13-,14?,15+/m1/s1 | Reactome pathway
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| 0.420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN 35428 from DAT in rat striatal membrane |
J Med Chem 49: 6621-5 (2006)
Article DOI: 10.1021/jm0603973
BindingDB Entry DOI: 10.7270/Q2CZ36SM |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22167
(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)pip...)Show SMILES C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1 Show InChI InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2 | Reactome pathway
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| 0.420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wake Forest University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 293: 686-96 (2000)
BindingDB Entry DOI: 10.7270/Q2H993QF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway
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| 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wake Forest University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 293: 686-96 (2000)
BindingDB Entry DOI: 10.7270/Q2H993QF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50155457
(3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)Show SMILES COC(=O)C1C2CCC(CC1c1ccc(Br)cc1)N2 |TLB:11:10:18:6.7,THB:2:4:18:6.7| Show InChI InChI=1S/C15H18BrNO2/c1-19-15(18)14-12(8-11-6-7-13(14)17-11)9-2-4-10(16)5-3-9/h2-5,11-14,17H,6-8H2,1H3 | Reactome pathway
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| 0.520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate |
Bioorg Med Chem Lett 14: 5635-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50155454
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCOS(=O)(=O)c1ccccc1 |TLB:0:1:6.7.8:4.3,16:6:1:4.3,THB:9:7:1:4.3| Show InChI InChI=1S/C23H26INO5S/c1-25-18-11-12-21(25)22(20(15-18)16-7-9-17(24)10-8-16)23(26)29-13-14-30-31(27,28)19-5-3-2-4-6-19/h2-10,18,20-22H,11-15H2,1H3 | Reactome pathway
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| 0.520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate |
Bioorg Med Chem Lett 14: 5635-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50155459
(3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)Show SMILES FCCOC(=O)C1C2CCC(CC1c1ccc(Br)cc1)N2 |TLB:13:12:20:8.9,THB:4:6:20:8.9| Show InChI InChI=1S/C16H19BrFNO2/c17-11-3-1-10(2-4-11)13-9-12-5-6-14(19-12)15(13)16(20)21-8-7-18/h1-4,12-15,19H,5-9H2 | Reactome pathway
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| 0.570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate |
Bioorg Med Chem Lett 14: 5635-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50004169
((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza...)Show SMILES CN1C2CCC1[C@@H](C=C)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,THB:11:9:1:4.3,0:1:6.9.10:4.3| Show InChI InChI=1S/C16H20ClN/c1-3-14-15(11-4-6-12(17)7-5-11)10-13-8-9-16(14)18(13)2/h3-7,13-16H,1,8-10H2,2H3/t13?,14-,15+,16?/m0/s1 | Reactome pathway
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| 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50052170
((S)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-[1,2,...)Show SMILES CN1C2CCC1[C@H](C(C2)c1ccc(Cl)cc1)c1nc(no1)-c1ccccc1 |TLB:0:1:6.7.8:4.3,16:6:1:4.3,THB:9:7:1:4.3| Show InChI InChI=1S/C22H22ClN3O/c1-26-17-11-12-19(26)20(18(13-17)14-7-9-16(23)10-8-14)22-24-21(25-27-22)15-5-3-2-4-6-15/h2-10,17-20H,11-13H2,1H3/t17?,18?,19?,20-/m0/s1 | Reactome pathway
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| 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description
Ability to inhibit [3H]dopamine uptake into rat striatal synaptosomes |
J Med Chem 39: 2753-63 (1996)
Article DOI: 10.1021/jm960160e
BindingDB Entry DOI: 10.7270/Q2N87BDF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway
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| 0.620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wake Forest University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 293: 686-96 (2000)
BindingDB Entry DOI: 10.7270/Q2H993QF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM85419
(RTI-110)Show SMILES COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1c1ccc(Cl)cc1)N2 |TLB:2:4:18:6.7,THB:11:10:18:6.7| Show InChI InChI=1S/C15H18ClNO2/c1-19-15(18)14-12(8-11-6-7-13(14)17-11)9-2-4-10(16)5-3-9/h2-5,11-14,17H,6-8H2,1H3/t11-,12+,13+,14-/m0/s1 | Reactome pathway
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| 0.620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1229-36 (1999)
BindingDB Entry DOI: 10.7270/Q2TX3CWQ |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50106857
(3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-car...)Show SMILES COC(=O)C1C2CCC(CC1c1ccc(I)cc1)N2 |THB:2:4:18:6.7| Show InChI InChI=1S/C15H18INO2/c1-19-15(18)14-12(8-11-6-7-13(14)17-11)9-2-4-10(16)5-3-9/h2-5,11-14,17H,6-8H2,1H3 | Reactome pathway
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| 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to dopamine transporter (DAT) in rat forebrain tissue |
Bioorg Med Chem Lett 14: 2117-20 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.043
BindingDB Entry DOI: 10.7270/Q2WS8SQK |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50106857
(3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-car...)Show SMILES COC(=O)C1C2CCC(CC1c1ccc(I)cc1)N2 |THB:2:4:18:6.7| Show InChI InChI=1S/C15H18INO2/c1-19-15(18)14-12(8-11-6-7-13(14)17-11)9-2-4-10(16)5-3-9/h2-5,11-14,17H,6-8H2,1H3 | Reactome pathway
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| 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcohol and Drug Abuse Research Center
Curated by ChEMBL
| Assay Description
Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate |
Bioorg Med Chem Lett 11: 3049-53 (2001)
BindingDB Entry DOI: 10.7270/Q23N22PN |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50041293
(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2C |THB:22:21:4.10.9:6.7,11:10:21:6.7,2:4:21:6.7| Show InChI InChI=1S/C21H25NO/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21H,3,10-11,13H2,1-2H3 | Reactome pathway
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| 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wake Forest University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 293: 686-96 (2000)
BindingDB Entry DOI: 10.7270/Q2H993QF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032534
((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-((E)-styryl...)Show SMILES CN1C2CCC1[C@@H](\C=C\c1ccccc1)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,0:1:6.15.16:4.3| Show InChI InChI=1S/C22H24ClN/c1-24-19-12-14-22(24)20(13-7-16-5-3-2-4-6-16)21(15-19)17-8-10-18(23)11-9-17/h2-11,13,19-22H,12,14-15H2,1H3/b13-7+/t19?,20-,21+,22?/m0/s1 | Reactome pathway
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| 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporter |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50041604
(3-(4-Chloro-phenyl)-8-((E)-3-iodo-allyl)-8-aza-bic...)Show SMILES COC(=O)C1C2CCC(CC1c1ccc(Cl)cc1)N2C\C=C\I |TLB:19:18:4.10.9:6.7,THB:2:4:18:6.7,11:10:18:6.7| Show InChI InChI=1S/C18H21ClINO2/c1-23-18(22)17-15(12-3-5-13(19)6-4-12)11-14-7-8-16(17)21(14)10-2-9-20/h2-6,9,14-17H,7-8,10-11H2,1H3/b9-2+ | Reactome pathway
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| 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee Medical Center at Knoxville 37920.
Curated by ChEMBL
| Assay Description
Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranes |
J Med Chem 37: 1535-42 (1994)
BindingDB Entry DOI: 10.7270/Q2SX6DVH |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50118599
(4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(naphtha...)Show SMILES Fc1ccc(cc1)C(OCCC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C31H31F2NO/c32-29-11-7-26(8-12-29)31(27-9-13-30(33)14-10-27)35-20-17-23-15-18-34(19-16-23)22-24-5-6-25-3-1-2-4-28(25)21-24/h1-14,21,23,31H,15-20,22H2 | Reactome pathway
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Affinity at rat dopamine transporter using [125I]-RTI-55 displacement. |
J Med Chem 46: 1465-9 (2003)
Article DOI: 10.1021/jm020419v
BindingDB Entry DOI: 10.7270/Q2WQ035D |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50056569
(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperaz...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(Cc2cc3ccccc3[nH]2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H29F2N3O/c29-24-9-5-21(6-10-24)28(22-7-11-25(30)12-8-22)34-18-17-32-13-15-33(16-14-32)20-26-19-23-3-1-2-4-27(23)31-26/h1-12,19,28,31H,13-18,20H2 | Reactome pathway
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Heights
Curated by ChEMBL
| Assay Description
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes |
Bioorg Med Chem 15: 1146-59 (2006)
Article DOI: 10.1016/j.bmc.2006.09.070
BindingDB Entry DOI: 10.7270/Q2M61JXC |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50057628
((2S,8R)-3-(3,4-Dichloro-phenyl)-8-((E)-3-iodo-ally...)Show SMILES COC(=O)[C@@H]1C2CCC(CC1c1ccc(Cl)c(Cl)c1)N2C\C=C\I |THB:11:10:19:6.7,2:4:19:6.7| Show InChI InChI=1S/C18H20Cl2INO2/c1-24-18(23)17-13(11-3-5-14(19)15(20)9-11)10-12-4-6-16(17)22(12)8-2-7-21/h2-3,5,7,9,12-13,16-17H,4,6,8,10H2,1H3/b7-2+/t12?,13?,16?,17-/m0/s1 | Reactome pathway
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INSERM U316
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 282: 467-74 (1997)
BindingDB Entry DOI: 10.7270/Q2X928VC |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50118599
(4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(naphtha...)Show SMILES Fc1ccc(cc1)C(OCCC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C31H31F2NO/c32-29-11-7-26(8-12-29)31(27-9-13-30(33)14-10-27)35-20-17-23-15-18-34(19-16-23)22-24-5-6-25-3-1-2-4-28(25)21-24/h1-14,21,23,31H,15-20,22H2 | Reactome pathway
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| 0.710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Heights
Curated by ChEMBL
| Assay Description
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes |
Bioorg Med Chem 15: 1146-59 (2006)
Article DOI: 10.1016/j.bmc.2006.09.070
BindingDB Entry DOI: 10.7270/Q2M61JXC |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50155452
(3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)Show SMILES FCCCOC(=O)C1C2CCC(CC1c1ccc(Br)cc1)N2 |TLB:14:13:21:9.10,THB:5:7:21:9.10| Show InChI InChI=1S/C17H21BrFNO2/c18-12-4-2-11(3-5-12)14-10-13-6-7-15(20-13)16(14)17(21)22-9-1-8-19/h2-5,13-16,20H,1,6-10H2 | Reactome pathway
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| 0.720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate |
Bioorg Med Chem Lett 14: 5635-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50118600
(2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperid...)Show SMILES Fc1ccc(cc1)C(OCCC1CCN(Cc2cc3ccccc3[nH]2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C29H30F2N2O/c30-25-9-5-22(6-10-25)29(23-7-11-26(31)12-8-23)34-18-15-21-13-16-33(17-14-21)20-27-19-24-3-1-2-4-28(24)32-27/h1-12,19,21,29,32H,13-18,20H2 | Reactome pathway
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| 0.730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Heights
Curated by ChEMBL
| Assay Description
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes |
Bioorg Med Chem 15: 1146-59 (2006)
Article DOI: 10.1016/j.bmc.2006.09.070
BindingDB Entry DOI: 10.7270/Q2M61JXC |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50021895
(4-(3,4-Dichloro-phenyl)-7-methoxy-2-methyl-1,2,3,4...)Show InChI InChI=1S/C17H17Cl2NO/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11/h3-8,15H,9-10H2,1-2H3 | Reactome pathway
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| 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck AIS
Curated by PDSP Ki Database
| |
J Neurochem 44: 1615-22 (1985)
Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22170
((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)Show SMILES O[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r| Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-31-14-16-32(17-15-31)21-27(33)20-22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m0/s1 | Reactome pathway
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| 0.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
| Assay Description
Binding affinity for dopamine transporter |
J Med Chem 45: 1321-9 (2002)
BindingDB Entry DOI: 10.7270/Q2K073KD |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22170
((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)Show SMILES O[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r| Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-31-14-16-32(17-15-31)21-27(33)20-22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m0/s1 | Reactome pathway
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| 0.75 | -11.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
National Taiwan University
| Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated... |
J Med Chem 51: 2795-806 (2008)
Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50123395
((S)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}...)Show SMILES O[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-31-14-16-32(17-15-31)21-27(33)20-22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m0/s1 | Reactome pathway
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National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
| Assay Description
Binding affinity for dopamine transporter (DAT) |
Bioorg Med Chem Lett 13: 553-6 (2003)
BindingDB Entry DOI: 10.7270/Q2J102JX |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22167
(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)pip...)Show SMILES C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1 Show InChI InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2 | Reactome pathway
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| 0.760 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wake Forest University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 293: 686-96 (2000)
BindingDB Entry DOI: 10.7270/Q2H993QF |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50101075
((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)N2C |THB:11:10:19:6.7,2:4:19:6.7| Show InChI InChI=1S/C16H19Cl2NO2/c1-19-10-4-6-14(19)15(16(20)21-2)11(8-10)9-3-5-12(17)13(18)7-9/h3,5,7,10-11,14-15H,4,6,8H2,1-2H3/t10?,11-,14?,15+/m1/s1 | Reactome pathway
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| 0.790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1229-36 (1999)
BindingDB Entry DOI: 10.7270/Q2TX3CWQ |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50183539
(CHEMBL381256 | CHEMBL429492 | trans-(R,R)-4-[2-[bi...)Show SMILES Fc1ccc(cc1)C(OCCC1CCN(C[C@@H]2C[C@H]2c2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C30H33F2NO/c31-27-10-6-24(7-11-27)30(25-8-12-28(32)13-9-25)34-19-16-22-14-17-33(18-15-22)21-26-20-29(26)23-4-2-1-3-5-23/h1-13,22,26,29-30H,14-21H2/t26-,29-/m0/s1 | Reactome pathway
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| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Heights
Curated by ChEMBL
| Assay Description
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes |
Bioorg Med Chem 15: 1146-59 (2006)
Article DOI: 10.1016/j.bmc.2006.09.070
BindingDB Entry DOI: 10.7270/Q2M61JXC |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50349799
(CHEMBL1812745 | RTI-112)Show SMILES COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1c1ccc(Cl)c(C)c1)N2C |r,TLB:20:19:6.7:4.10.9| Show InChI InChI=1S/C17H22ClNO2/c1-10-8-11(4-6-14(10)18)13-9-12-5-7-15(19(12)2)16(13)17(20)21-3/h4,6,8,12-13,15-16H,5,7,9H2,1-3H3/t12-,13+,15+,16-/m0/s1 | Reactome pathway
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Virginia Commonwealth University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1229-36 (1999)
BindingDB Entry DOI: 10.7270/Q2TX3CWQ |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22166
(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)Show SMILES [H][C@]12CC[C@]([H])([C@H]([C@H](C1)c1ccc(I)cc1)C(=O)OC)N2C |TLB:16:6:20:3.2| Show InChI InChI=1S/C16H20INO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12-,13+,14+,15-/m0/s1 | Reactome pathway
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NIH
Curated by PDSP Ki Database
| |
Synapse 39: 32-41 (2001)
Article DOI: 10.1002/1098-2396(20010101)39:1
BindingDB Entry DOI: 10.7270/Q2NV9GT3 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50035738
((R)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)Show SMILES COC(=O)C1C2CCC(CC1c1ccc(Cl)cc1)N2C |TLB:11:10:18:6.7,THB:2:4:18:6.7| Show InChI InChI=1S/C16H20ClNO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3 | Reactome pathway
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Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032538
((2S,3S)-2-Butyl-3-(4-chloro-phenyl)-8-methyl-8-aza...)Show SMILES CCCC[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)cc1)N2C |TLB:19:18:10.4.9:6.7,THB:3:4:18:6.7| Show InChI InChI=1S/C18H26ClN/c1-3-4-5-16-17(13-6-8-14(19)9-7-13)12-15-10-11-18(16)20(15)2/h6-9,15-18H,3-5,10-12H2,1-2H3/t15?,16-,17+,18?/m0/s1 | Reactome pathway
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| 0.840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporter |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50155461
(3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-car...)Show SMILES FCCOC(=O)C1C2CCC(CC1c1ccc(I)cc1)N2 |TLB:13:12:20:8.9,THB:4:6:20:8.9| Show InChI InChI=1S/C16H19FINO2/c17-7-8-21-16(20)15-13(9-12-5-6-14(15)19-12)10-1-3-11(18)4-2-10/h1-4,12-15,19H,5-9H2 | Reactome pathway
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| 0.850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate |
Bioorg Med Chem Lett 14: 5635-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50367584
(CHEMBL1743810)Show SMILES Nc1ccc(cc1)[C@@H]1CN2CCC[C@@H]2c2ccccc12 |r| Show InChI InChI=1S/C18H20N2/c19-14-9-7-13(8-10-14)17-12-20-11-3-6-18(20)16-5-2-1-4-15(16)17/h1-2,4-5,7-10,17-18H,3,6,11-12,19H2/t17-,18+/m0/s1 | Reactome pathway
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes |
J Med Chem 30: 1433-54 (1987)
BindingDB Entry DOI: 10.7270/Q2D50NJ3 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50452190
(CHEMBL2093944)Show SMILES Br.[H][C@@]12CCCN1C[C@H](c1ccc(N)cc1)c1ccccc21 |r| Show InChI InChI=1S/C18H20N2.BrH/c19-14-9-7-13(8-10-14)17-12-20-11-3-6-18(20)16-5-2-1-4-15(16)17;/h1-2,4-5,7-10,17-18H,3,6,11-12,19H2;1H/t17-,18+;/m1./s1 | Reactome pathway
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of dopamine (DA) uptake into rat brain synaptosomes |
J Med Chem 27: 943-6 (1984)
BindingDB Entry DOI: 10.7270/Q2VT1SPH |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway
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University of Tennessee Medical Center at Knoxville 37920.
Curated by ChEMBL
| Assay Description
Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranes |
J Med Chem 37: 1535-42 (1994)
BindingDB Entry DOI: 10.7270/Q2SX6DVH |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50032536
((2R,3S)-3-(4-Chloro-phenyl)-2-((Z)-2-chloro-vinyl)...)Show SMILES CN1C2CCC1[C@@H](\C=C/Cl)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3,0:1:6.10.11:4.3| Show InChI InChI=1S/C16H19Cl2N/c1-19-13-6-7-16(19)14(8-9-17)15(10-13)11-2-4-12(18)5-3-11/h2-5,8-9,13-16H,6-7,10H2,1H3/b9-8-/t13?,14-,15+,16?/m0/s1 | Reactome pathway
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Mayo Foundation for Medical Education and Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporter |
J Med Chem 38: 3086-93 (1995)
BindingDB Entry DOI: 10.7270/Q2KS6S69 |
More data for this
Ligand-Target Pair | |
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